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Found 23 hits Enz. Inhib. hit(s) with Target = 'IAG-nucleoside hydrolase' AND taxid = 5699   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50371003
PNG
(CHEMBL397507)
Show SMILES Cc1c(nnn1CC[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)-c1ccccc1
Show InChI InChI=1S/C16H21N3O4/c1-10-14(11-5-3-2-4-6-11)17-18-19(10)8-7-12-15(21)16(22)13(9-20)23-12/h2-6,12-13,15-16,20-22H,7-9H2,1H3/t12-,13+,15-,16+/m0/s1
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2.30E+3n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase


Bioorg Med Chem Lett 17: 2523-6 (2007)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50234567
PNG
(1,4-dideoxy-1,4-imino-D-ribitol | CHEMBL261634 | I...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4+,5-/m1/s1
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6.10E+3n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260497
PNG
(1,4-Dideoxy-1,4-imino-N-(4-amidinobenzyl)-D-ribito...)
Show SMILES NC(=N)c1ccc(CN2C[C@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C13H19N3O3/c14-13(15)9-3-1-8(2-4-9)5-16-6-11(18)12(19)10(16)7-17/h1-4,10-12,17-19H,5-7H2,(H3,14,15)/t10-,11+,12-/m1/s1
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6.70E+3n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260496
PNG
(1,4-Dideoxy-1,4-imino-N-(4-guanidinobenzyl)-D-ribi...)
Show SMILES NC(N)=Nc1ccc(CN2C[C@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C13H20N4O3/c14-13(15)16-9-3-1-8(2-4-9)5-17-6-11(19)12(20)10(17)7-18/h1-4,10-12,18-20H,5-7H2,(H4,14,15,16)/t10-,11+,12-/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260490
PNG
((1S )-1,4-Dideoxy-1-(2-guanidinoethyl)-1,4-imino-D...)
Show SMILES NC(N)=NCC[C@@H]1N[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C8H18N4O3/c9-8(10)11-2-1-4-6(14)7(15)5(3-13)12-4/h4-7,12-15H,1-3H2,(H4,9,10,11)/t4-,5+,6-,7+/m0/s1
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1.80E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50370996
PNG
(CHEMBL230908)
Show SMILES OC[C@H]1O[C@@H](CCn2cc(nn2)-c2ccccc2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C15H19N3O4/c19-9-13-15(21)14(20)12(22-13)6-7-18-8-11(16-17-18)10-4-2-1-3-5-10/h1-5,8,12-15,19-21H,6-7,9H2/t12-,13+,14-,15+/m0/s1
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2.10E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase


Bioorg Med Chem Lett 17: 2523-6 (2007)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50370998
PNG
(CHEMBL397508)
Show SMILES OC[C@H]1O[C@@H](CCn2cc(nn2)-c2ccccn2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C14H18N4O4/c19-8-12-14(21)13(20)11(22-12)4-6-18-7-10(16-17-18)9-3-1-2-5-15-9/h1-3,5,7,11-14,19-21H,4,6,8H2/t11-,12+,13-,14+/m0/s1
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2.30E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase


Bioorg Med Chem Lett 17: 2523-6 (2007)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50371000
PNG
(CHEMBL231322)
Show SMILES Cc1nnn(CC[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1-c1ccccc1
Show InChI InChI=1S/C16H21N3O4/c1-10-14(11-5-3-2-4-6-11)19(18-17-10)8-7-12-15(21)16(22)13(9-20)23-12/h2-6,12-13,15-16,20-22H,7-9H2,1H3/t12-,13+,15-,16+/m0/s1
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3.20E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase


Bioorg Med Chem Lett 17: 2523-6 (2007)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260492
PNG
(1,4-Dideoxy-(3-guanidinopropyl)-1,4-imino-D-ribito...)
Show SMILES NC(N)=NCCCN1C[C@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H20N4O3/c10-9(11)12-2-1-3-13-4-7(15)8(16)6(13)5-14/h6-8,14-16H,1-5H2,(H4,10,11,12)/t6-,7+,8-/m1/s1
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4.00E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50377915
PNG
(CHEMBL1169558)
Show SMILES OC[C@H]1[C@@H](O)[C@@H](O)CN1Cc1ccccc1
Show InChI InChI=1S/C12H17NO3/c14-8-10-12(16)11(15)7-13(10)6-9-4-2-1-3-5-9/h1-5,10-12,14-16H,6-8H2/t10-,11-,12+/m0/s1
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5.90E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50371001
PNG
(CHEMBL395797)
Show SMILES CCc1nnn(CC[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1CC
Show InChI InChI=1S/C13H23N3O4/c1-3-8-9(4-2)16(15-14-8)6-5-10-12(18)13(19)11(7-17)20-10/h10-13,17-19H,3-7H2,1-2H3/t10-,11+,12-,13+/m0/s1
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6.30E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase


Bioorg Med Chem Lett 17: 2523-6 (2007)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50371002
PNG
(CHEMBL230061)
Show SMILES Cc1c(nnn1C[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)-c1ccccc1
Show InChI InChI=1S/C15H19N3O4/c1-9-13(10-5-3-2-4-6-10)16-17-18(9)7-11-14(20)15(21)12(8-19)22-11/h2-6,11-12,14-15,19-21H,7-8H2,1H3/t11-,12+,14-,15+/m0/s1
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8.70E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase


Bioorg Med Chem Lett 17: 2523-6 (2007)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260491
PNG
(1,4-Dideoxy-(2-guanidinoethyl)-1,4-imino-D-ribitol...)
Show SMILES NC(N)=NCCN1C[C@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C8H18N4O3/c9-8(10)11-1-2-12-3-6(14)7(15)5(12)4-13/h5-7,13-15H,1-4H2,(H4,9,10,11)/t5-,6+,7-/m1/s1
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2.86E+5n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260487
PNG
(1-Guanidino-3,6-anhydro-1,2-dideoxy-Dallo-heptitol...)
Show SMILES NC(N)=NCC[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C8H17N3O4/c9-8(10)11-2-1-4-6(13)7(14)5(3-12)15-4/h4-7,12-14H,1-3H2,(H4,9,10,11)/t4-,5+,6-,7+/m0/s1
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3.09E+5n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50370999
PNG
(CHEMBL231025)
Show SMILES Cc1nnn(C[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1-c1ccccc1
Show InChI InChI=1S/C15H19N3O4/c1-9-13(10-5-3-2-4-6-10)18(17-16-9)7-11-14(20)15(21)12(8-19)22-11/h2-6,11-12,14-15,19-21H,7-8H2,1H3/t11-,12+,14-,15+/m0/s1
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5.20E+5n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase


Bioorg Med Chem Lett 17: 2523-6 (2007)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260486
PNG
(1-Guanidino-2,5-anhydro-1-deoxy-D-allitol | CHEMBL...)
Show SMILES NC(N)=NC[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C7H15N3O4/c8-7(9)10-1-3-5(12)6(13)4(2-11)14-3/h3-6,11-13H,1-2H2,(H4,8,9,10)/t3-,4+,5-,6+/m0/s1
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5.45E+5n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260489
PNG
(1-Guanidino-4,7-anhydro-1,2,3-trideoxy-Dallo-octit...)
Show SMILES NC(N)=NCCC[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C9H19N3O4/c10-9(11)12-3-1-2-5-7(14)8(15)6(4-13)16-5/h5-8,13-15H,1-4H2,(H4,10,11,12)/t5-,6+,7-,8+/m0/s1
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6.77E+5n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50370997
PNG
(CHEMBL425996)
Show SMILES OC[C@H]1O[C@@H](CCn2nncc2-c2ccccc2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C15H19N3O4/c19-9-13-15(21)14(20)12(22-13)6-7-18-11(8-16-17-18)10-4-2-1-3-5-10/h1-5,8,12-15,19-21H,6-7,9H2/t12-,13+,14-,15+/m0/s1
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6.80E+5n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase


Bioorg Med Chem Lett 17: 2523-6 (2007)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260488
PNG
(2-Guanidino-4,7-anhydro-1,2,3-trideoxy-Dallo-octit...)
Show SMILES CC(C[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)N=C(N)N
Show InChI InChI=1S/C9H19N3O4/c1-4(12-9(10)11)2-5-7(14)8(15)6(3-13)16-5/h4-8,13-15H,2-3H2,1H3,(H4,10,11,12)/t4?,5-,6+,7-,8+/m0/s1
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6.85E+5n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260485
PNG
(2,5-Anhydro-1-deoxy-1-(trimethylammonio)-D-allitol...)
Show SMILES C[N+](C)(C)C[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C9H20NO4/c1-10(2,3)4-6-8(12)9(13)7(5-11)14-6/h6-9,11-13H,4-5H2,1-3H3/q+1/t6-,7+,8-,9+/m0/s1
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1.28E+6n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50260480
PNG
((2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-tetr...)
Show SMILES NC(=O)[C@@H]1O[C@H](CO)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H11NO5/c7-6(11)5-4(10)3(9)2(1-8)12-5/h2-5,8-10H,1H2,(H2,7,11)/t2-,3+,4+,5-/m1/s1
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4.50E+6n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50206267
PNG
((2S,3R,4S,5R)-2-(2-azidoethyl)-5-(hydroxymethyl)-t...)
Show SMILES OC[C@H]1O[C@@H](CCN=[N+]=[N-])[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H13N3O4/c8-10-9-2-1-4-6(12)7(13)5(3-11)14-4/h4-7,11-13H,1-3H2/t4-,5+,6-,7+/m0/s1
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5.60E+6n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase


Bioorg Med Chem Lett 17: 2523-6 (2007)

More data for this
Ligand-Target Pair
IAG-nucleoside hydrolase


(Trypanosoma vivax)
BDBM50206267
PNG
((2S,3R,4S,5R)-2-(2-azidoethyl)-5-(hydroxymethyl)-t...)
Show SMILES OC[C@H]1O[C@@H](CCN=[N+]=[N-])[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H13N3O4/c8-10-9-2-1-4-6(12)7(13)5(3-11)14-4/h4-7,11-13H,1-3H2/t4-,5+,6-,7+/m0/s1
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5.64E+6n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6


Eur J Med Chem 43: 315-26 (2008)

More data for this
Ligand-Target Pair