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Compile Data Set for Download or QSAR

Found 228 hits Enz. Inhib. hit(s) with Target = 'Imidazoline I1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Imidazoline I1


(RAT)
BDBM50387827
PNG
(CHEMBL2058635)
Show SMILES CC1CCC(N1)=Nc1ccc(I)cc1Cl
Show InChI InChI=1S/C11H12ClIN2/c1-7-2-5-11(14-7)15-10-4-3-8(13)6-9(10)12/h3-4,6-7H,2,5H2,1H3,(H,14,15)
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0.178n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting method


Bioorg Med Chem 24: 3174-83 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50387827
PNG
(CHEMBL2058635)
Show SMILES CC1CCC(N1)=Nc1ccc(I)cc1Cl
Show InChI InChI=1S/C11H12ClIN2/c1-7-2-5-11(14-7)15-10-4-3-8(13)6-9(10)12/h3-4,6-7H,2,5H2,1H3,(H,14,15)
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0.200n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50387827
PNG
(CHEMBL2058635)
Show SMILES CC1CCC(N1)=Nc1ccc(I)cc1Cl
Show InChI InChI=1S/C11H12ClIN2/c1-7-2-5-11(14-7)15-10-4-3-8(13)6-9(10)12/h3-4,6-7H,2,5H2,1H3,(H,14,15)
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0.219n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]paraiodoclonidine from imidazoline I1 receptor in rat PC12 cells after 30 mins by gamma counter


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070374
PNG
(CHEMBL3408293)
Show SMILES Cl.CC1CN\C(C1)=N/c1ccc(Cl)c2CCCc12
Show InChI InChI=1/C14H17ClN2/c1-9-7-14(16-8-9)17-13-6-5-12(15)10-3-2-4-11(10)13/h5-6,9H,2-4,7-8H2,1H3,(H,16,17)
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0.220n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50021809
PNG
((2,6-Dichloro-4-iodo-phenyl)-(4,5-dihydro-1H-imida...)
Show SMILES Clc1cc(I)cc(Cl)c1N=C1NCCN1
Show InChI InChI=1S/C9H8Cl2IN3/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2H2,(H2,13,14,15)
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0.794n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting method


Bioorg Med Chem 24: 3174-83 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50387823
PNG
(CHEMBL2058631)
Show SMILES CC1CNC(N1)=Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C10H11Cl2N3/c1-6-5-13-10(14-6)15-9-7(11)3-2-4-8(9)12/h2-4,6H,5H2,1H3,(H2,13,14,15)
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0.930n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50387823
PNG
(CHEMBL2058631)
Show SMILES CC1CNC(N1)=Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C10H11Cl2N3/c1-6-5-13-10(14-6)15-9-7(11)3-2-4-8(9)12/h2-4,6H,5H2,1H3,(H2,13,14,15)
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0.933n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]paraiodoclonidine from imidazoline I1 receptor in rat PC12 cells after 30 mins by gamma counter


Citation and Details
More data for this
Ligand-Target Pair
Nischarin


(RAT)
BDBM50091345
PNG
(CHEMBL2092861)
Show SMILES C[C@@H](Cc1ccccc1)C1=NCCN1
Show InChI InChI=1/C12H16N2/c1-10(12-13-7-8-14-12)9-11-5-3-2-4-6-11/h2-6,10H,7-9H2,1H3,(H,13,14)/t10-/s2
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1.10n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [125I]-p-iodoclonidin from I1-imidazoline receptor in rat PC12 cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50091345
PNG
(CHEMBL2092861)
Show SMILES C[C@@H](Cc1ccccc1)C1=NCCN1
Show InChI InChI=1/C12H16N2/c1-10(12-13-7-8-14-12)9-11-5-3-2-4-6-11/h2-6,10H,7-9H2,1H3,(H,13,14)/t10-/s2
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1.10n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting method


Bioorg Med Chem 24: 3174-83 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50240366
PNG
(2-(naphthalen-2-yl)-4,5-dihydro-1H-imidazole | 2-N...)
Show SMILES C1CN=C(N1)c1ccc2ccccc2c1
Show InChI InChI=1S/C13H12N2/c1-2-4-11-9-12(6-5-10(11)3-1)13-14-7-8-15-13/h1-6,9H,7-8H2,(H,14,15)
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1.30n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting method


Bioorg Med Chem 24: 3174-83 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070366
PNG
(CHEMBL3408289)
Show SMILES Cl.CC1CC\C(N1)=N\c1ccc(Cl)c2CCCc12
Show InChI InChI=1/C14H17ClN2/c1-9-5-8-14(16-9)17-13-7-6-12(15)10-3-2-4-11(10)13/h6-7,9H,2-5,8H2,1H3,(H,16,17)
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2.80n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070375
PNG
(CHEMBL3408294)
Show SMILES Cl.CC1CN\C(C1)=N/c1ccc(C)c2CCCc12
Show InChI InChI=1/C15H20N2/c1-10-8-15(16-9-10)17-14-7-6-11(2)12-4-3-5-13(12)14/h6-7,10H,3-5,8-9H2,1-2H3,(H,16,17)
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2.80n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070372
PNG
(CHEMBL3408291)
Show SMILES Cl.CC1CN\C(C1)=N\c1cccc(Cl)c1C
Show InChI InChI=1/C12H15ClN2/c1-8-6-12(14-7-8)15-11-5-3-4-10(13)9(11)2/h3-5,8H,6-7H2,1-2H3,(H,14,15)
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3.20n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Nischarin


(RAT)
BDBM50091347
PNG
(CHEMBL71429)
Show SMILES CC(Cc1ccccc1)C1=NCCN1
Show InChI InChI=1/C12H16N2/c1-10(12-13-7-8-14-12)9-11-5-3-2-4-6-11/h2-6,10H,7-9H2,1H3,(H,13,14)
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5n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [125I]-p-iodoclonidin from I1-imidazoline receptor in rat PC12 cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070329
PNG
(CHEMBL268734)
Show SMILES Cc1ccc(F)c(c1)C1=NCCN1
Show InChI InChI=1S/C10H11FN2/c1-7-2-3-9(11)8(6-7)10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H,12,13)
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5.30n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50019646
PNG
(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Show SMILES CC(Oc1c(Cl)cccc1Cl)C1=NCCN1
Show InChI InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)
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5.60n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting method


Bioorg Med Chem 24: 3174-83 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070361
PNG
(CHEMBL3408298)
Show SMILES CC1CC\C(N1)=N/c1cc(N=[N+]=[N-])c(I)cc1Cl
Show InChI InChI=1/C11H11ClIN5/c1-6-2-3-11(15-6)16-9-5-10(17-18-14)8(13)4-7(9)12/h4-6H,2-3H2,1H3,(H,15,16)
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6n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070330
PNG
(CHEMBL3408297)
Show SMILES NC1=NCC(COc2ccccc2Br)O1
Show InChI InChI=1/C10H11BrN2O2/c11-8-3-1-2-4-9(8)14-6-7-5-13-10(12)15-7/h1-4,7H,5-6H2,(H2,12,13)
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6.40n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50019848
PNG
(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
Show SMILES C1CN=C(N1)C1COc2ccccc2O1
Show InChI InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)
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11n/an/an/an/an/an/an/an/a



University of Bonn

Curated by PDSP Ki Database




J Pharmacol Exp Ther 285: 170-7 (1998)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50262235
PNG
(rilmenidine)
Show SMILES C1CC1C(NC1=[NH+]CCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)/p+1
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11n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]paraiodoclonidine from imidazoline I1 receptor in rat PC12 cells after 30 mins by gamma counter


Citation and Details
More data for this
Ligand-Target Pair
Nischarin


(RAT)
BDBM50091336
PNG
(CHEMBL3582266)
Show SMILES C[C@@H](Cc1ccccc1C)C1=NCCN1
Show InChI InChI=1/C13H18N2/c1-10-5-3-4-6-12(10)9-11(2)13-14-7-8-15-13/h3-6,11H,7-9H2,1-2H3,(H,14,15)/t11-/s2
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13n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [125I]-p-iodoclonidin from I1-imidazoline receptor in rat PC12 cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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13n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting method


Bioorg Med Chem 24: 3174-83 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50016897
PNG
(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Show SMILES Clc1cccc(Cl)c1N=C1NCCN1
Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
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14n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070373
PNG
(CHEMBL3408292)
Show SMILES Cl.CC1CN\C(C1)=N/c1cccc2CCCc12
Show InChI InChI=1/C14H18N2/c1-10-8-14(15-9-10)16-13-7-3-5-11-4-2-6-12(11)13/h3,5,7,10H,2,4,6,8-9H2,1H3,(H,15,16)
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19n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50138500
PNG
(2-((E)-Styryl)-4,5-dihydro-1H-imidazole | 2-styryl...)
Show SMILES C1CN=C(N1)\C=C\c1ccccc1
Show InChI InChI=1S/C11H12N2/c1-2-4-10(5-3-1)6-7-11-12-8-9-13-11/h1-7H,8-9H2,(H,12,13)/b7-6+
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19n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting method


Bioorg Med Chem 24: 3174-83 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070364
PNG
(CHEMBL3408285)
Show SMILES Cl.CC1CC\C(N1)=N\c1cccc2CCCc12
Show InChI InChI=1/C14H18N2/c1-10-8-9-14(15-10)16-13-7-3-5-11-4-2-6-12(11)13/h3,5,7,10H,2,4,6,8-9H2,1H3,(H,15,16)
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19n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50027060
PNG
(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Show SMILES C(Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
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21n/an/an/an/an/an/an/an/a



University of Bonn

Curated by PDSP Ki Database




J Pharmacol Exp Ther 285: 170-7 (1998)

More data for this
Ligand-Target Pair
Nischarin


(RAT)
BDBM50091338
PNG
(CHEMBL3582264)
Show SMILES CC(Cc1ccccc1C)C1=NCCN1
Show InChI InChI=1/C13H18N2/c1-10-5-3-4-6-12(10)9-11(2)13-14-7-8-15-13/h3-6,11H,7-9H2,1-2H3,(H,14,15)
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23n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [125I]-p-iodoclonidin from I1-imidazoline receptor in rat PC12 cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070363
PNG
(CHEMBL3408284)
Show SMILES Cl.CC1CC\C(N1)=N/c1cccc(Cl)c1C
Show InChI InChI=1/C12H15ClN2/c1-8-6-7-12(14-8)15-11-5-3-4-10(13)9(11)2/h3-5,8H,6-7H2,1-2H3,(H,14,15)
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27n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50179397
PNG
(CHEMBL1162356)
Show SMILES Clc1cccc2CN(Cc12)NC1=NCCN1
Show InChI InChI=1S/C11H13ClN4/c12-10-3-1-2-8-6-16(7-9(8)10)15-11-13-4-5-14-11/h1-3H,4-7H2,(H2,13,14,15)
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28n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting method


Bioorg Med Chem 24: 3174-83 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM81804
PNG
(4-chloro-2-(2-imidazolin-2-ylamino)isoindoline | B...)
Show SMILES Clc1cccc2CN(Cc12)N=C1NCCN1
Show InChI InChI=1S/C11H13ClN4/c12-10-3-1-2-8-6-16(7-9(8)10)15-11-13-4-5-14-11/h1-3H,4-7H2,(H2,13,14,15)
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29n/an/an/an/an/an/an/an/a



University of Bonn

Curated by PDSP Ki Database




J Pharmacol Exp Ther 285: 170-7 (1998)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334197
PNG
(7-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Show SMILES Clc1cccc2c(N=C3NCCN3)[nH]nc12
Show InChI InChI=1S/C10H10ClN5/c11-7-3-1-2-6-8(7)15-16-9(6)14-10-12-4-5-13-10/h1-3H,4-5H2,(H3,12,13,14,15,16)
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30.8n/an/an/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50164835
PNG
(CHEMBL3800398)
Show SMILES Cl.Fc1ccc2n(CC3=NCCN3)ccc2c1
Show InChI InChI=1S/C12H12FN3.ClH/c13-10-1-2-11-9(7-10)3-6-16(11)8-12-14-4-5-15-12;/h1-3,6-7H,4-5,8H2,(H,14,15);1H
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32n/an/an/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation counting


Eur J Med Chem 115: 406-15 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50001922
PNG
(2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; ...)
Show SMILES C(C1=NCCN1)c1cccc2ccccc12
Show InChI InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
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41n/an/an/an/an/an/an/an/a



University of Bonn

Curated by PDSP Ki Database




J Pharmacol Exp Ther 285: 170-7 (1998)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070368
PNG
(CHEMBL3408290)
Show SMILES Cl.CC1CN\C(C1)=N\c1cccc(C)c1C
Show InChI InChI=1/C13H18N2.ClH/c1-9-7-13(14-8-9)15-12-6-4-5-10(2)11(12)3;/h4-6,9H,7-8H2,1-3H3,(H,14,15);1H
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42n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334195
PNG
(4-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Show SMILES Clc1cccc2n[nH]c(N=C3NCCN3)c12
Show InChI InChI=1S/C10H10ClN5/c11-6-2-1-3-7-8(6)9(16-15-7)14-10-12-4-5-13-10/h1-3H,4-5H2,(H3,12,13,14,15,16)
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45.2n/an/an/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50241196
PNG
((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Show SMILES C[C@@H](c1cnc[nH]1)c1cccc(C)c1C
Show InChI InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m1/s1
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50.1n/an/an/an/an/an/an/an/a



Centre de Recherches de Croissy

Curated by PDSP Ki Database




J Pharmacol Exp Ther 295: 1192-205 (2000)

More data for this
Ligand-Target Pair
Nischarin


(RAT)
BDBM50091341
PNG
(CHEMBL3582261)
Show SMILES CC(Cc1ccccc1-c1ccsc1)C1=NCCN1
Show InChI InChI=1/C16H18N2S/c1-12(16-17-7-8-18-16)10-13-4-2-3-5-15(13)14-6-9-19-11-14/h2-6,9,11-12H,7-8,10H2,1H3,(H,17,18)
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63n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [125I]-p-iodoclonidin from I1-imidazoline receptor in rat PC12 cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070362
PNG
(CHEMBL3408283)
Show SMILES Cl.CC1CC\C(N1)=N/c1cccc(C)c1C
Show InChI InChI=1/C13H18N2/c1-9-5-4-6-12(11(9)3)15-13-8-7-10(2)14-13/h4-6,10H,7-8H2,1-3H3,(H,14,15)
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70n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070365
PNG
(CHEMBL3408286)
Show SMILES Cl.CC1CC\C(N1)=N\c1cccc2CCCCc12
Show InChI InChI=1/C15H20N2/c1-11-9-10-15(16-11)17-14-8-4-6-12-5-2-3-7-13(12)14/h4,6,8,11H,2-3,5,7,9-10H2,1H3,(H,16,17)
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73n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50387825
PNG
(CHEMBL2058633)
Show SMILES Clc1ccccc1N=C1CCCN1
Show InChI InChI=1S/C10H11ClN2/c11-8-4-1-2-5-9(8)13-10-6-3-7-12-10/h1-2,4-5H,3,6-7H2,(H,12,13)
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78n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]paraiodoclonidine from imidazoline I1 receptor in rat PC12 cells after 30 mins by gamma counter


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50050093
PNG
((4-Chloro-6-methoxy-2-methyl-pyrimidin-5-yl)-imida...)
Show SMILES COc1nc(C)nc(Cl)c1N=C1NCCN1
Show InChI InChI=1S/C9H12ClN5O/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9/h3-4H2,1-2H3,(H2,11,12,15)
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78n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50164841
PNG
(CHEMBL3798191)
Show SMILES Cl.Brc1cccc2ccn(CC3=NCCN3)c12
Show InChI InChI=1S/C12H12BrN3.ClH/c13-10-3-1-2-9-4-7-16(12(9)10)8-11-14-5-6-15-11;/h1-4,7H,5-6,8H2,(H,14,15);1H
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79n/an/an/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation counting


Eur J Med Chem 115: 406-15 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM85709
PNG
(S18616)
Show SMILES NC1=NC2(CO1)CCc1ccccc1C2
Show InChI InChI=1S/C12H14N2O/c13-11-14-12(8-15-11)6-5-9-3-1-2-4-10(9)7-12/h1-4H,5-8H2,(H2,13,14)
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79.4n/an/an/an/an/an/an/an/a



Centre de Recherches de Croissy

Curated by PDSP Ki Database




J Pharmacol Exp Ther 295: 1192-205 (2000)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50070328
PNG
(CHEBI:8862 | RILMENIDINE | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
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83n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting


Citation and Details
More data for this
Ligand-Target Pair
Nischarin


(RAT)
BDBM50091342
PNG
(CHEMBL3582260)
Show SMILES C[C@@H](Cc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1/C18H20N2/c1-14(18-19-11-12-20-18)13-16-9-5-6-10-17(16)15-7-3-2-4-8-15/h2-10,14H,11-13H2,1H3,(H,19,20)/t14-/s2
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98n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [125I]-p-iodoclonidin from I1-imidazoline receptor in rat PC12 cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Nischarin


(RAT)
BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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126n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Displacement of [125I]-p-iodoclonidin from I1-imidazoline receptor in rat PC12 cell membranes


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50016897
PNG
(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Show SMILES Clc1cccc(Cl)c1N=C1NCCN1
Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
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126n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting method


Bioorg Med Chem 24: 3174-83 (2016)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50387826
PNG
(CHEMBL2058634)
Show SMILES CC1CCC(N1)=Nc1ccccc1Cl
Show InChI InChI=1S/C11H13ClN2/c1-8-6-7-11(13-8)14-10-5-3-2-4-9(10)12/h2-5,8H,6-7H2,1H3,(H,13,14)
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132n/an/an/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]paraiodoclonidine from imidazoline I1 receptor in rat PC12 cells after 30 mins by gamma counter


Citation and Details
More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334196
PNG
(3-[(Imidazolidin-2-yl)imino]-4-methylindazole hydr...)
Show SMILES Cc1cccc2n[nH]c(N=C3NCCN3)c12
Show InChI InChI=1S/C11H13N5/c1-7-3-2-4-8-9(7)10(16-15-8)14-11-12-5-6-13-11/h2-4H,5-6H2,1H3,(H3,12,13,14,15,16)
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133n/an/an/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
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