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Found 27 hits Enz. Inhib. hit(s) with Target = 'Inhibitor of nuclear factor kappa-B kinase subunit beta' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146936
PNG
(CHEMBL3765499)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(F)cc4)cc3)C2=O)CC1
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n/an/a 500n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50149806
PNG
(2''-Amino-6''-(2-hydroxy-phenyl)-1,2,3,4,5,6-hexah...)
Show SMILES Nc1nc(cc(C2CCCNC2)c1C#N)-c1ccccc1O
Show InChI InChI=1S/C17H18N4O/c18-9-14-13(11-4-3-7-20-10-11)8-15(21-17(14)19)12-5-1-2-6-16(12)22/h1-2,5-6,8,11,20,22H,3-4,7,10H2,(H2,19,21)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390260
PNG
(CHEMBL2070413)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(cc4)C(N)=O)cc3)C2=O)CC1
Show InChI InChI=1S/C31H32N4O4S2/c1-33-16-18-34(19-17-33)15-2-20-38-25-13-7-24(8-14-25)35-30(37)28(41-31(35)40)21-22-3-9-26(10-4-22)39-27-11-5-23(6-12-27)29(32)36/h3-14,21H,2,15-20H2,1H3,(H2,32,36)/b28-21-
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n/an/a 2.00E+3n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390260
PNG
(CHEMBL2070413)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(cc4)C(N)=O)cc3)C2=O)CC1
Show InChI InChI=1S/C31H32N4O4S2/c1-33-16-18-34(19-17-33)15-2-20-38-25-13-7-24(8-14-25)35-30(37)28(41-31(35)40)21-22-3-9-26(10-4-22)39-27-11-5-23(6-12-27)29(32)36/h3-14,21H,2,15-20H2,1H3,(H2,32,36)/b28-21-
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n/an/a 2.00E+3n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146940
PNG
(CHEMBL3765155)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(cc4)[N+]([O-])=O)cc3)C2=O)CC1
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n/an/a 2.00E+3n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146937
PNG
(CHEMBL3764369)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(Cl)cc4)cc3)C2=O)CC1
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n/an/a 3.00E+3n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146939
PNG
(CHEMBL3764955)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(cc4)S(C)(=O)=O)cc3)C2=O)CC1
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n/an/a 4.00E+3n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390261
PNG
(CHEMBL2070414)
Show SMILES CN1CCN(CCCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(cc4)C(N)=O)cc3)C2=O)CC1
Show InChI InChI=1S/C32H34N4O4S2/c1-34-17-19-35(20-18-34)16-2-3-21-39-26-14-8-25(9-15-26)36-31(38)29(42-32(36)41)22-23-4-10-27(11-5-23)40-28-12-6-24(7-13-28)30(33)37/h4-15,22H,2-3,16-21H2,1H3,(H2,33,37)/b29-22-
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n/an/a 4.00E+3n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146931
PNG
(CHEMBL3764354)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(cc4)C#N)cc3)C2=O)CC1
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n/an/a 4.00E+3n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146934
PNG
(CHEMBL3765189)
Show SMILES COc1ccc(Oc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(OCCCN4CCN(C)CC4)cc3)cc2)cc1
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n/an/a 4.00E+3n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390262
PNG
(CHEMBL2070416)
Show SMILES NC(=O)c1ccc(Oc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(OCCCN4CCCC4)cc3)cc2)cc1
Show InChI InChI=1S/C30H29N3O4S2/c31-28(34)22-6-12-26(13-7-22)37-25-10-4-21(5-11-25)20-27-29(35)33(30(38)39-27)23-8-14-24(15-9-23)36-19-3-18-32-16-1-2-17-32/h4-15,20H,1-3,16-19H2,(H2,31,34)/b27-20-
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n/an/a 5.00E+3n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146935
PNG
(CHEMBL3763698)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(C)cc4)cc3)C2=O)CC1
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n/an/a 5.00E+3n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390259
PNG
(CHEMBL2070412)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4cccc(c4)C(N)=O)cc3)C2=O)CC1
Show InChI InChI=1S/C31H32N4O4S2/c1-33-15-17-34(18-16-33)14-3-19-38-25-12-8-24(9-13-25)35-30(37)28(41-31(35)40)20-22-6-10-26(11-7-22)39-27-5-2-4-23(21-27)29(32)36/h2,4-13,20-21H,3,14-19H2,1H3,(H2,32,36)/b28-20-
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n/an/a 5.00E+3n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146941
PNG
(CHEMBL3763572)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(N)cc4)cc3)C2=O)CC1
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n/an/a 6.00E+3n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146938
PNG
(CHEMBL3764998)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(Br)cc4)cc3)C2=O)CC1
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n/an/a 6.00E+3n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390270
PNG
(CHEMBL2070426)
Show SMILES NC(=O)c1cccc(Oc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(OCCCN4CCCC4)cc3)cc2)c1
Show InChI InChI=1S/C30H29N3O4S2/c31-28(34)22-5-3-6-26(20-22)37-25-11-7-21(8-12-25)19-27-29(35)33(30(38)39-27)23-9-13-24(14-10-23)36-18-4-17-32-15-1-2-16-32/h3,5-14,19-20H,1-2,4,15-18H2,(H2,31,34)/b27-19-
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n/an/a 7.00E+3n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390275
PNG
(CHEMBL2070423)
Show SMILES CCN(CC)CCOc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Oc3cccc(c3)C(N)=O)cc2)C1=O
Show InChI InChI=1S/C29H29N3O4S2/c1-3-31(4-2)16-17-35-23-14-10-22(11-15-23)32-28(34)26(38-29(32)37)18-20-8-12-24(13-9-20)36-25-7-5-6-21(19-25)27(30)33/h5-15,18-19H,3-4,16-17H2,1-2H3,(H2,30,33)/b26-18-
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n/an/a 7.00E+3n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390269
PNG
(CHEMBL2070424)
Show SMILES CCN(CC)CCOc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Oc3ccc(cc3)C(N)=O)cc2)C1=O
Show InChI InChI=1S/C29H29N3O4S2/c1-3-31(4-2)17-18-35-23-15-9-22(10-16-23)32-28(34)26(38-29(32)37)19-20-5-11-24(12-6-20)36-25-13-7-21(8-14-25)27(30)33/h5-16,19H,3-4,17-18H2,1-2H3,(H2,30,33)/b26-19-
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n/an/a 8.00E+3n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390267
PNG
(CHEMBL2070433)
Show SMILES CCN(CC)CCCOc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Oc3ccc(cc3)C(N)=O)cc2)C1=O
Show InChI InChI=1S/C30H31N3O4S2/c1-3-32(4-2)18-5-19-36-24-16-10-23(11-17-24)33-29(35)27(39-30(33)38)20-21-6-12-25(13-7-21)37-26-14-8-22(9-15-26)28(31)34/h6-17,20H,3-5,18-19H2,1-2H3,(H2,31,34)/b27-20-
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n/an/a 8.00E+3n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146943
PNG
(CHEMBL3765759)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(NS(C)(=O)=O)cc4)cc3)C2=O)CC1
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n/an/a 8.00E+3n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390266
PNG
(CHEMBL2070432)
Show SMILES CCN(CC)CCCOc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Oc3cccc(c3)C(N)=O)cc2)C1=O
Show InChI InChI=1S/C30H31N3O4S2/c1-3-32(4-2)17-6-18-36-24-15-11-23(12-16-24)33-29(35)27(39-30(33)38)19-21-9-13-25(14-10-21)37-26-8-5-7-22(20-26)28(31)34/h5,7-16,19-20H,3-4,6,17-18H2,1-2H3,(H2,31,34)/b27-19-
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n/an/a 1.00E+4n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390258
PNG
(CHEMBL2070411)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccccc4C(N)=O)cc3)C2=O)CC1
Show InChI InChI=1S/C31H32N4O4S2/c1-33-16-18-34(19-17-33)15-4-20-38-24-13-9-23(10-14-24)35-30(37)28(41-31(35)40)21-22-7-11-25(12-8-22)39-27-6-3-2-5-26(27)29(32)36/h2-3,5-14,21H,4,15-20H2,1H3,(H2,32,36)/b28-21-
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n/an/a 1.20E+4n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390265
PNG
(CHEMBL2070430)
Show SMILES CCN(CC)CCCOc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Oc3ccc(Cl)cc3)cc2)C1=O
Show InChI InChI=1S/C29H29ClN2O3S2/c1-3-31(4-2)18-5-19-34-24-16-10-23(11-17-24)32-28(33)27(37-29(32)36)20-21-6-12-25(13-7-21)35-26-14-8-22(30)9-15-26/h6-17,20H,3-5,18-19H2,1-2H3/b27-20-
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n/an/a 1.30E+4n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146942
PNG
(CHEMBL3763983)
Show SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(NC(C)=O)cc4)cc3)C2=O)CC1
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n/an/a 2.00E+4n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50146930
PNG
(CHEMBL3764641)
Show SMILES CN(C)C(=O)c1ccc(Oc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(OCCCN4CCN(C)CC4)cc3)cc2)cc1
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n/an/a 2.00E+4n/an/an/an/an/an/a



The Catholic University of Korea

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by E...


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390271
PNG
(CHEMBL2070418)
Show SMILES NC(=O)c1cccc(Oc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(OCCCN4CCCCC4)cc3)cc2)c1
Show InChI InChI=1S/C31H31N3O4S2/c32-29(35)23-6-4-7-27(21-23)38-26-12-8-22(9-13-26)20-28-30(36)34(31(39)40-28)24-10-14-25(15-11-24)37-19-5-18-33-16-2-1-3-17-33/h4,6-15,20-21H,1-3,5,16-19H2,(H2,32,35)/b28-20-
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n/an/a 3.00E+4n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Mus musculus)
BDBM50390257
PNG
(CHEMBL2070419)
Show SMILES NC(=O)c1ccc(Oc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(OCCCN4CCCCC4)cc3)cc2)cc1
Show InChI InChI=1S/C31H31N3O4S2/c32-29(35)23-7-13-27(14-8-23)38-26-11-5-22(6-12-26)21-28-30(36)34(31(39)40-28)24-9-15-25(16-10-24)37-20-4-19-33-17-2-1-3-18-33/h5-16,21H,1-4,17-20H2,(H2,32,35)/b28-21-
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n/an/a 3.00E+4n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair