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Found 9 hits Enz. Inhib. hit(s) with Target = 'Inosine-5-monophosphate dehydrogenase (IMPDH)' AND taxid = 563041   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine-5-monophosphate dehydrogenase (IMPDH)


(Helicobacter pylori (strain G27))
BDBM81428
PNG
(N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-1,3-ben...)
Show SMILES O=C(Cn1c(nc2ccccc12)-c1ccccn1)Nc1ccc2ccccc2c1
Show InChI InChI=1S/C24H18N4O/c29-23(26-19-13-12-17-7-1-2-8-18(17)15-19)16-28-22-11-4-3-9-20(22)27-24(28)21-10-5-6-14-25-21/h1-15H,16H2,(H,26,29)
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n/an/a 1.10n/an/an/an/a8.025



Brandeis University



Assay Description
Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).


Citation and Details
More data for this
Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH)


(Helicobacter pylori (strain G27))
BDBM81426
PNG
(1H-naphtho[2,3-d]imidazol-2-ylmethyl 4-aminobenzoa...)
Show SMILES Nc1ccc(cc1)C(=O)OCc1nc2cc3ccccc3cc2[nH]1
Show InChI InChI=1S/C19H15N3O2/c20-15-7-5-12(6-8-15)19(23)24-11-18-21-16-9-13-3-1-2-4-14(13)10-17(16)22-18/h1-10H,11,20H2,(H,21,22)
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n/an/a 300n/an/an/an/a8.025



Brandeis University



Assay Description
Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).


Citation and Details
More data for this
Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH)


(Helicobacter pylori (strain G27))
BDBM81423
PNG
(N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-1,3...)
Show SMILES COc1ccc(NC(=O)Cn2c(nc3ccccc23)-c2cscn2)cc1
Show InChI InChI=1S/C19H16N4O2S/c1-25-14-8-6-13(7-9-14)21-18(24)10-23-17-5-3-2-4-15(17)22-19(23)16-11-26-12-20-16/h2-9,11-12H,10H2,1H3,(H,21,24)
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n/an/a 600n/an/an/an/a8.025



Brandeis University



Assay Description
Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).


Citation and Details
More data for this
Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH)


(Helicobacter pylori (strain G27))
BDBM81425
PNG
(l-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl...)
Show SMILES CCn1c(SCC(=O)Nc2ccc(OC)cc2)nc2ccsc2c1=O
Show InChI InChI=1S/C17H17N3O3S2/c1-3-20-16(22)15-13(8-9-24-15)19-17(20)25-10-14(21)18-11-4-6-12(23-2)7-5-11/h4-9H,3,10H2,1-2H3,(H,18,21)
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n/an/a 1.10E+3n/an/an/an/a8.025



Brandeis University



Assay Description
Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).


Citation and Details
More data for this
Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH)


(Helicobacter pylori (strain G27))
BDBM81427
PNG
(3-{1H-naphtho[2,3-d]imidazol-2-yl}propyl 4-aminobe...)
Show SMILES Nc1ccc(cc1)C(=O)OCCCc1nc2cc3ccccc3cc2[nH]1
Show InChI InChI=1S/C21H19N3O2/c22-17-9-7-14(8-10-17)21(25)26-11-3-6-20-23-18-12-15-4-1-2-5-16(15)13-19(18)24-20/h1-2,4-5,7-10,12-13H,3,6,11,22H2,(H,23,24)
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n/an/a 1.20E+3n/an/an/an/a8.025



Brandeis University



Assay Description
Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).


Citation and Details
More data for this
Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH)


(Helicobacter pylori (strain G27))
BDBM81422
PNG
(N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide, ...)
Show SMILES COc1ccc(NC(=O)Cc2cccc3ccccc23)cc1
Show InChI InChI=1S/C19H17NO2/c1-22-17-11-9-16(10-12-17)20-19(21)13-15-7-4-6-14-5-2-3-8-18(14)15/h2-12H,13H2,1H3,(H,20,21)
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n/an/a 1.30E+3n/an/an/an/a8.025



Brandeis University



Assay Description
Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).


Citation and Details
More data for this
Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH)


(Helicobacter pylori (strain G27))
BDBM81328
PNG
(methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carbo...)
Show SMILES COC(=O)c1c(C)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C12H11NO3/c1-7-10(12(15)16-2)8-5-3-4-6-9(8)13-11(7)14/h3-6H,1-2H3,(H,13,14)
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n/an/a 1.50E+3n/an/an/an/a8.025



Brandeis University



Assay Description
Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).


Citation and Details
More data for this
Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH)


(Helicobacter pylori (strain G27))
BDBM50294184
PNG
(CHEMBL561640 | N-(4-chlorophenyl)-2-phenoxypropana...)
Show SMILES CC(Oc1ccccc1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C15H14ClNO2/c1-11(19-14-5-3-2-4-6-14)15(18)17-13-9-7-12(16)8-10-13/h2-11H,1H3,(H,17,18)
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PubMed
n/an/a 2.20E+3n/an/an/an/a8.025



Brandeis University



Assay Description
Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).


Citation and Details
More data for this
Ligand-Target Pair
Inosine-5-monophosphate dehydrogenase (IMPDH)


(Helicobacter pylori (strain G27))
BDBM81424
PNG
(N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrop...)
Show SMILES COc1ccc(NC(=O)Cc2nn(C)c(=O)c3ccccc23)cc1
Show InChI InChI=1S/C18H17N3O3/c1-21-18(23)15-6-4-3-5-14(15)16(20-21)11-17(22)19-12-7-9-13(24-2)10-8-12/h3-10H,11H2,1-2H3,(H,19,22)
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PubMed
n/an/a 3.00E+3n/an/an/an/a8.025



Brandeis University



Assay Description
Inhibition assay using inosine 5'-onophosphate dehydrogenase (IMPD).


Citation and Details
More data for this
Ligand-Target Pair