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Compile Data Set for Download or QSAR

Found 61 hits Enz. Inhib. hit(s) with Target = 'Insulin receptor' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin receptor


(Mus musculus)
BDBM50296348
PNG
(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Show SMILES Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@@H](C1)N1CCC1
Show InChI InChI=1S/C26H27N5O/c27-25-24-23(19-8-4-9-22(12-19)32-16-18-6-2-1-3-7-18)15-31(26(24)29-17-28-25)21-13-20(14-21)30-10-5-11-30/h1-4,6-9,12,15,17,20-21H,5,10-11,13-14,16H2,(H2,27,28,29)/t20-,21-
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n/an/a 140n/an/an/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Insulin receptor kinase in P19 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50384721
PNG
(CHEMBL2037224)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(Nc3ccc4\C(=C\c5ccc[nH]5)C(=O)Nc4c3)c2)c1
Show InChI InChI=1S/C27H20F3N5O2/c28-27(29,30)16-4-1-5-18(12-16)33-26(37)34-20-7-2-6-19(13-20)32-21-9-10-22-23(14-17-8-3-11-31-17)25(36)35-24(22)15-21/h1-15,31-32H,(H,35,36)(H2,33,34,37)/b23-14-
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n/an/a 2.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused INSR in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused INSR in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50384725
PNG
(CHEMBL2037209)
Show SMILES Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C31H23F3N6O2/c1-18-16-40(17-36-18)25-11-19(10-20(12-25)31(32,33)34)29(41)38-23-5-2-4-22(13-23)37-24-7-8-26-27(14-21-6-3-9-35-21)30(42)39-28(26)15-24/h2-17,35,37H,1H3,(H,38,41)(H,39,42)/b27-14-
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n/an/a 5.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused INSR in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50384726
PNG
(CHEMBL2037208)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)17-5-1-4-16(12-17)25(35)33-20-7-2-6-19(13-20)32-21-9-10-22-23(14-18-8-3-11-31-18)26(36)34-24(22)15-21/h1-15,31-32H,(H,33,35)(H,34,36)/b23-14-
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n/an/a 5.80E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused INSR in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50066982
PNG
(5-[1,4-Bis-(4-methoxy-benzyl)-1H-imidazol-2-ylamin...)
Show SMILES COc1ccc(Cc2cn(Cc3ccc(OC)cc3)c(NC3=NC(=O)N(C)C3=O)n2)cc1
Show InChI InChI=1S/C23H23N5O4/c1-27-21(29)20(26-23(27)30)25-22-24-17(12-15-4-8-18(31-2)9-5-15)14-28(22)13-16-6-10-19(32-3)11-7-16/h4-11,14H,12-13H2,1-3H3,(H,24,25,26,30)
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n/an/a 6.70E+3n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor mediated mitogenesis of NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50384727
PNG
(CHEMBL2037226)
Show SMILES Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1Nc1ccc2\C(=C\c3ccc[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
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n/an/a 8.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused INSR in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50066983
PNG
(5-[1-(4-Hydroxy-benzyl)-4-(4-methoxy-benzyl)-1H-im...)
Show SMILES COc1ccc(Cc2cn(Cc3ccc(O)cc3)c(NC3=NC(=O)N(C)C3=O)n2)cc1
Show InChI InChI=1S/C22H21N5O4/c1-26-20(29)19(25-22(26)30)24-21-23-16(11-14-5-9-18(31-2)10-6-14)13-27(21)12-15-3-7-17(28)8-4-15/h3-10,13,28H,11-12H2,1-2H3,(H,23,24,25,30)
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n/an/a 9.80E+3n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor mediated mitogenesis of NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50162996
PNG
(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-[...)
Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3ccc4ccccc4c3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C34H29N5O2/c1-37(2)18-9-19-39-29-15-8-6-13-26(29)32(36-39)31-30(33(40)35-34(31)41)27-21-38(28-14-7-5-12-25(27)28)24-17-16-22-10-3-4-11-23(22)20-24/h3-8,10-17,20-21H,9,18-19H2,1-2H3,(H,35,40,41)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Insulin receptor kinase in P19 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50162990
PNG
(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3cnc4ccccc4c3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C33H28N6O2/c1-37(2)16-9-17-39-28-15-8-5-12-24(28)31(36-39)30-29(32(40)35-33(30)41)25-20-38(27-14-7-4-11-23(25)27)22-18-21-10-3-6-13-26(21)34-19-22/h3-8,10-15,18-20H,9,16-17H2,1-2H3,(H,35,40,41)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Insulin receptor kinase in P19 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50162991
PNG
(3-(1-Benzo[b]thiophen-2-yl-1H-indol-3-yl)-4-[1-(3-...)
Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3csc4ccccc34)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C32H27N5O2S/c1-35(2)16-9-17-37-25-14-7-4-12-22(25)30(34-37)29-28(31(38)33-32(29)39)23-18-36(24-13-6-3-10-20(23)24)26-19-40-27-15-8-5-11-21(26)27/h3-8,10-15,18-19H,9,16-17H2,1-2H3,(H,33,38,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Insulin receptor kinase in P19 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50162993
PNG
(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3cccnc3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C29H26N6O2/c1-33(2)15-8-16-35-24-13-6-4-11-21(24)27(32-35)26-25(28(36)31-29(26)37)22-18-34(19-9-7-14-30-17-19)23-12-5-3-10-20(22)23/h3-7,9-14,17-18H,8,15-16H2,1-2H3,(H,31,36,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Insulin receptor kinase in P19 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50162998
PNG
(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3cccs3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C28H25N5O2S/c1-31(2)14-8-15-33-22-12-6-4-10-19(22)26(30-33)25-24(27(34)29-28(25)35)20-17-32(23-13-7-16-36-23)21-11-5-3-9-18(20)21/h3-7,9-13,16-17H,8,14-15H2,1-2H3,(H,29,34,35)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Insulin receptor kinase in P19 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50162994
PNG
(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-[...)
Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3cccc4ccccc34)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C34H29N5O2/c1-37(2)19-10-20-39-29-17-8-6-15-25(29)32(36-39)31-30(33(40)35-34(31)41)26-21-38(28-16-7-5-14-24(26)28)27-18-9-12-22-11-3-4-13-23(22)27/h3-9,11-18,21H,10,19-20H2,1-2H3,(H,35,40,41)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Insulin receptor kinase in P19 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50384720
PNG
(CHEMBL2037220)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4cc(c[nH]4)C(O)=O)C(=O)Nc3c2)c1
Show InChI InChI=1S/C33H29F3N6O4/c1-41-7-9-42(10-8-41)26-13-19(11-21(14-26)33(34,35)36)30(43)39-23-4-2-3-22(15-23)38-24-5-6-27-28(31(44)40-29(27)17-24)16-25-12-20(18-37-25)32(45)46/h2-6,11-18,37-38H,7-10H2,1H3,(H,39,43)(H,40,44)(H,45,46)/b28-16-
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused INSR in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50271907
PNG
(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Show SMILES Nc1nc(Nc2cccc(Br)c2)c2cc(Cc3ccccc3Cl)[nH]c2n1
Show InChI InChI=1S/C19H15BrClN5/c20-12-5-3-6-13(9-12)23-17-15-10-14(24-18(15)26-19(22)25-17)8-11-4-1-2-7-16(11)21/h1-7,9-10H,8H2,(H4,22,23,24,25,26)
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50271906
PNG
(2-benzyl-N4-(3-bromophenyl)-1H-indole-4,6-diamine ...)
Show SMILES Nc1nc(Nc2cccc(Br)c2)c2cc(Cc3ccccc3)[nH]c2n1
Show InChI InChI=1S/C19H16BrN5/c20-13-7-4-8-14(10-13)22-17-16-11-15(9-12-5-2-1-3-6-12)23-18(16)25-19(21)24-17/h1-8,10-11H,9H2,(H4,21,22,23,24,25)
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50066984
PNG
(4-(5-(4-hydroxybenzyl)-4-(4-methoxybenzyl)-1-methy...)
Show SMILES COc1ccc(Cc2nc(NC3=NC(=O)N(C)C3=O)n(C)c2Cc2ccc(O)cc2)cc1
Show InChI InChI=1S/C23H23N5O4/c1-27-19(13-15-4-8-16(29)9-5-15)18(12-14-6-10-17(32-3)11-7-14)24-22(27)25-20-21(30)28(2)23(31)26-20/h4-11,29H,12-13H2,1-3H3,(H,24,25,26,31)
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n/an/a 2.42E+5n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor mediated mitogenesis of NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253178
PNG
(5-{[(7-{[(7-{[(3-Carboxy-4-chlorophenyl)amino]sulf...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)C(O)=O)cc3c2)ccc1Cl
Show InChI InChI=1S/C35H24Cl2N4O11S2/c36-29-7-3-21(13-27(29)33(44)45)40-53(49,50)23-11-17-9-19(1-5-25(17)31(42)15-23)38-35(48)39-20-2-6-26-18(10-20)12-24(16-32(26)43)54(51,52)41-22-4-8-30(37)28(14-22)34(46)47/h1-16,40-43H,(H,44,45)(H,46,47)(H2,38,39,48)
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n/an/an/an/a 1.80E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253175
PNG
(2-{7-[({7-[(2-carboxyphenyl)sulfamoyl]-5-hydroxyna...)
Show SMILES OC(=O)c1ccccc1NS(=O)(=O)c1cc(O)c2ccc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(=O)(=O)Nc3ccccc3C(O)=O)cc2c1
Show InChI InChI=1S/C35H26N4O11S2/c40-31-17-23(51(47,48)38-29-7-3-1-5-27(29)33(42)43)15-19-13-21(9-11-25(19)31)36-35(46)37-22-10-12-26-20(14-22)16-24(18-32(26)41)52(49,50)39-30-8-4-2-6-28(30)34(44)45/h1-18,38-41H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 9.30E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253194
PNG
(5-({[7-({2-[(7-{[(3-Carboxy-4-chlorophenyl)amino]s...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NCCNc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)C(O)=O)cc3c2)ccc1Cl
Show InChI InChI=1S/C36H28Cl2N4O8S2/c37-33-11-7-27(19-31(33)35(43)44)41-51(47,48)29-9-3-21-1-5-25(15-23(21)17-29)39-13-14-40-26-6-2-22-4-10-30(18-24(22)16-26)52(49,50)42-28-8-12-34(38)32(20-28)36(45)46/h1-12,15-20,39-42H,13-14H2,(H,43,44)(H,45,46)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253172
PNG
(2-[3-(7-{[(7-{[3-(carboxymethyl)phenyl]sulfamoyl}-...)
Show SMILES OC(=O)Cc1cccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4cccc(CC(O)=O)c4)cc3c2)c1
Show InChI InChI=1S/C37H30N4O11S2/c42-33-19-29(53(49,50)40-27-5-1-3-21(11-27)13-35(44)45)17-23-15-25(7-9-31(23)33)38-37(48)39-26-8-10-32-24(16-26)18-30(20-34(32)43)54(51,52)41-28-6-2-4-22(12-28)14-36(46)47/h1-12,15-20,40-43H,13-14H2,(H,44,45)(H,46,47)(H2,38,39,48)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253195
PNG
(5-({[7-({[(7-{[(3-Carboxy-4-chlorophenyl)amino]sul...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=S)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)C(O)=O)cc3c2)ccc1Cl
Show InChI InChI=1S/C35H24Cl2N4O8S3/c36-31-11-7-25(17-29(31)33(42)43)40-51(46,47)27-9-3-19-1-5-23(13-21(19)15-27)38-35(50)39-24-6-2-20-4-10-28(16-22(20)14-24)52(48,49)41-26-8-12-32(37)30(18-26)34(44)45/h1-18,40-41H,(H,42,43)(H,44,45)(H2,38,39,50)
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n/an/an/an/a 1.62E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253173
PNG
(CHEMBL499172 | disodium 4-{7-[({7-[(4-sulfonatophe...)
Show SMILES [O-]S(=O)(=O)c1ccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(cc4)S([O-])(=O)=O)cc3c2)cc1
Show InChI InChI=1S/C33H26N4O11S4/c38-33(34-27-5-1-21-3-11-31(19-23(21)17-27)49(39,40)36-25-7-13-29(14-8-25)51(43,44)45)35-28-6-2-22-4-12-32(20-24(22)18-28)50(41,42)37-26-9-15-30(16-10-26)52(46,47)48/h1-20,36-37H,(H2,34,35,38)(H,43,44,45)(H,46,47,48)/p-2
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n/an/an/an/a 9.40E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253170
PNG
(1,3-bis({7-[(3-hydroxyphenyl)sulfamoyl]naphthalen-...)
Show SMILES Oc1cccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4cccc(O)c4)cc3c2)c1
Show InChI InChI=1S/C33H26N4O7S2/c38-29-5-1-3-27(19-29)36-45(41,42)31-13-9-21-7-11-25(15-23(21)17-31)34-33(40)35-26-12-8-22-10-14-32(18-24(22)16-26)46(43,44)37-28-4-2-6-30(39)20-28/h1-20,36-39H,(H2,34,35,40)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253192
PNG
(CHEMBL505538 | disodium 3-{N-methyl7-[({7-[methyl(...)
Show SMILES CN(c1cccc(c1)S([O-])(=O)=O)S(=O)(=O)c1ccc2ccc(NC(=O)Nc3ccc4ccc(cc4c3)S(=O)(=O)N(C)c3cccc(c3)S([O-])(=O)=O)cc2c1
Show InChI InChI=1S/C35H30N4O11S4/c1-38(29-5-3-7-33(21-29)53(45,46)47)51(41,42)31-15-11-23-9-13-27(17-25(23)19-31)36-35(40)37-28-14-10-24-12-16-32(20-26(24)18-28)52(43,44)39(2)30-6-4-8-34(22-30)54(48,49)50/h3-22H,1-2H3,(H2,36,37,40)(H,45,46,47)(H,48,49,50)/p-2
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n/an/an/an/a 9.10E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253193
PNG
(5-({[7-(N-{2-[N-(7-{[(3-Carboxy-4-chlorophenyl)ami...)
Show SMILES CC(=O)N(CCN(C(C)=O)c1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O)c1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C40H32Cl2N4O10S2/c1-23(47)45(31-9-3-25-5-11-33(19-27(25)17-31)57(53,54)43-29-7-13-37(41)35(21-29)39(49)50)15-16-46(24(2)48)32-10-4-26-6-12-34(20-28(26)18-32)58(55,56)44-30-8-14-38(42)36(22-30)40(51)52/h3-14,17-22,43-44H,15-16H2,1-2H3,(H,49,50)(H,51,52)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253171
PNG
(1,3-bis({7-[(3-sulfamoylphenyl)sulfamoyl]naphthale...)
Show SMILES NS(=O)(=O)c1cccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4cccc(c4)S(N)(=O)=O)cc3c2)c1
Show InChI InChI=1S/C33H28N6O9S4/c34-49(41,42)29-5-1-3-27(19-29)38-51(45,46)31-13-9-21-7-11-25(15-23(21)17-31)36-33(40)37-26-12-8-22-10-14-32(18-24(22)16-26)52(47,48)39-28-4-2-6-30(20-28)50(35,43)44/h1-20,38-39H,(H2,34,41,42)(H2,35,43,44)(H2,36,37,40)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253168
PNG
(1,3-bis(7-{[3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]sul...)
Show SMILES O=C(Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1cccc(c1)-n1cnnn1)Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1cccc(c1)-n1cnnn1
Show InChI InChI=1S/C35H26N12O5S2/c48-35(38-27-11-7-23-9-13-33(17-25(23)15-27)53(49,50)40-29-3-1-5-31(19-29)46-21-36-42-44-46)39-28-12-8-24-10-14-34(18-26(24)16-28)54(51,52)41-30-4-2-6-32(20-30)47-22-37-43-45-47/h1-22,40-41H,(H2,38,39,48)
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n/an/an/an/a 5.40E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253190
PNG
(3-({7-[(N-{7-[N-(3-Carboxyphenyl)carbamoyl]-2-naph...)
Show SMILES OC(=O)c1cccc(NC(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)C(=O)Nc4cccc(c4)C(O)=O)cc3c2)c1
Show InChI InChI=1S/C37H26N4O7/c42-33(38-29-5-1-3-25(17-29)35(44)45)23-9-7-21-11-13-31(19-27(21)15-23)40-37(48)41-32-14-12-22-8-10-24(16-28(22)20-32)34(43)39-30-6-2-4-26(18-30)36(46)47/h1-20H,(H,38,42)(H,39,43)(H,44,45)(H,46,47)(H2,40,41,48)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253169
PNG
(1,3-bis(5-hydroxy-7-{[3-(hydroxymethyl)phenyl]sulf...)
Show SMILES OCc1cccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4cccc(CO)c4)cc3c2)c1
Show InChI InChI=1S/C35H30N4O9S2/c40-19-21-3-1-5-27(11-21)38-49(45,46)29-15-23-13-25(7-9-31(23)33(42)17-29)36-35(44)37-26-8-10-32-24(14-26)16-30(18-34(32)43)50(47,48)39-28-6-2-4-22(12-28)20-41/h1-18,38-43H,19-20H2,(H2,36,37,44)
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253191
PNG
(CHEMBL442662 | disodium 3-{7-[({7-[(3-sulfonatophe...)
Show SMILES [O-]S(=O)(=O)c1cccc(NC(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)C(=O)Nc4cccc(c4)S([O-])(=O)=O)cc3c2)c1
Show InChI InChI=1S/C35H26N4O9S2/c40-33(36-27-3-1-5-31(19-27)49(43,44)45)23-9-7-21-11-13-29(17-25(21)15-23)38-35(42)39-30-14-12-22-8-10-24(16-26(22)18-30)34(41)37-28-4-2-6-32(20-28)50(46,47)48/h1-20H,(H,36,40)(H,37,41)(H2,38,39,42)(H,43,44,45)(H,46,47,48)/p-2
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n/an/an/an/a>2.00E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253188
PNG
(CHEMBL453256 | sodium 7-[({7-[(3-carboxy-4-hydroxy...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S([O-])(=O)=O)cc3c2)ccc1O
Show InChI InChI=1S/C28H21N3O9S2/c32-26-10-7-22(15-25(26)27(33)34)31-41(36,37)23-8-3-16-1-5-20(11-18(16)13-23)29-28(35)30-21-6-2-17-4-9-24(42(38,39)40)14-19(17)12-21/h1-15,31-32H,(H,33,34)(H2,29,30,35)(H,38,39,40)/p-1
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Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253166
PNG
(3-{7-[({7-[(3-carboxyphenyl)sulfamoyl]naphthalen-2...)
Show SMILES OC(=O)c1cccc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4cccc(c4)C(O)=O)cc3c2)c1
Show InChI InChI=1S/C35H26N4O9S2/c40-33(41)23-3-1-5-29(15-23)38-49(45,46)31-13-9-21-7-11-27(17-25(21)19-31)36-35(44)37-28-12-8-22-10-14-32(20-26(22)18-28)50(47,48)39-30-6-2-4-24(16-30)34(42)43/h1-20,38-39H,(H,40,41)(H,42,43)(H2,36,37,44)
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n/an/an/an/a 2.40E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253189
PNG
(5-[({7-[3-(7-{[(3-Carboxy-4-chlorophenyl)amino]sul...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(cc3c2)N2CCN(C2=O)c2ccc3ccc(cc3c2)S(=O)(=O)Nc2ccc(Cl)c(c2)C(O)=O)ccc1Cl
Show InChI InChI=1S/C37H26Cl2N4O9S2/c38-33-11-5-25(19-31(33)35(44)45)40-53(49,50)29-9-3-21-1-7-27(15-23(21)17-29)42-13-14-43(37(42)48)28-8-2-22-4-10-30(18-24(22)16-28)54(51,52)41-26-6-12-34(39)32(20-26)36(46)47/h1-12,15-20,40-41H,13-14H2,(H,44,45)(H,46,47)
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n/an/an/an/a 5.60E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253167
PNG
(1,3-bis(5-hydroxy-7-{[3-(1H-1,2,3,4-tetrazol-1-yl)...)
Show SMILES Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(=O)(=O)Nc3cccc(c3)-n3cnnn3)ccc12)S(=O)(=O)Nc1cccc(c1)-n1cnnn1
Show InChI InChI=1S/C35H26N12O7S2/c48-33-17-29(55(51,52)40-25-3-1-5-27(15-25)46-19-36-42-44-46)13-21-11-23(7-9-31(21)33)38-35(50)39-24-8-10-32-22(12-24)14-30(18-34(32)49)56(53,54)41-26-4-2-6-28(16-26)47-20-37-43-45-47/h1-20,40-41,48-49H,(H2,38,39,50)
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n/an/an/an/a 7.30E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253165
PNG
(3-{7-[({7-[(3-carboxyphenyl)sulfamoyl]-5-hydroxyna...)
Show SMILES OC(=O)c1cccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4cccc(c4)C(O)=O)cc3c2)c1
Show InChI InChI=1S/C35H26N4O11S2/c40-31-17-27(51(47,48)38-25-5-1-3-19(11-25)33(42)43)15-21-13-23(7-9-29(21)31)36-35(46)37-24-8-10-30-22(14-24)16-28(18-32(30)41)52(49,50)39-26-6-2-4-20(12-26)34(44)45/h1-18,38-41H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 4.30E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253185
PNG
(2-Chloro-5-{[(7-{[(7-{[(4-chloro-3-sulfophenyl)ami...)
Show SMILES [O-]S(=O)(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)S([O-])(=O)=O)cc3c2)ccc1Cl
Show InChI InChI=1S/C33H24Cl2N4O11S4/c34-29-11-7-25(17-31(29)53(45,46)47)38-51(41,42)27-9-3-19-1-5-23(13-21(19)15-27)36-33(40)37-24-6-2-20-4-10-28(16-22(20)14-24)52(43,44)39-26-8-12-30(35)32(18-26)54(48,49)50/h1-18,38-39H,(H2,36,37,40)(H,45,46,47)(H,48,49,50)/p-2
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n/an/an/an/a 6.00E+3n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253163
PNG
(1,3-bis({7-[(3-cyanophenyl)sulfamoyl]naphthalen-2-...)
Show SMILES O=C(Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1cccc(c1)C#N)Nc1ccc2ccc(cc2c1)S(=O)(=O)Nc1cccc(c1)C#N
Show InChI InChI=1S/C35H24N6O5S2/c36-21-23-3-1-5-31(15-23)40-47(43,44)33-13-9-25-7-11-29(17-27(25)19-33)38-35(42)39-30-12-8-26-10-14-34(20-28(26)18-30)48(45,46)41-32-6-2-4-24(16-32)22-37/h1-20,40-41H,(H2,38,39,42)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253164
PNG
(1,3-bis(5-hydroxy-7-{[3-(trifluoromethyl)phenyl]su...)
Show SMILES Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(=O)(=O)Nc3cccc(c3)C(F)(F)F)ccc12)S(=O)(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C35H24F6N4O7S2/c36-34(37,38)21-3-1-5-25(15-21)44-53(49,50)27-13-19-11-23(7-9-29(19)31(46)17-27)42-33(48)43-24-8-10-30-20(12-24)14-28(18-32(30)47)54(51,52)45-26-6-2-4-22(16-26)35(39,40)41/h1-18,44-47H,(H2,42,43,48)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253174
PNG
(4-{7-[({7-[(4-carboxyphenyl)sulfamoyl]-5-hydroxyna...)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4ccc(cc4)C(O)=O)cc3c2)cc1
Show InChI InChI=1S/C35H26N4O11S2/c40-31-17-27(51(47,48)38-23-5-1-19(2-6-23)33(42)43)15-21-13-25(9-11-29(21)31)36-35(46)37-26-10-12-30-22(14-26)16-28(18-32(30)41)52(49,50)39-24-7-3-20(4-8-24)34(44)45/h1-18,38-41H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 1.03E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253199
PNG
(5-{[(7-{[N-(7-{[(3-Carboxy-4-chlorophenyl)amino]su...)
Show SMILES CN(C(=O)N(C)c1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O)c1ccc2ccc(cc2c1)S(=O)(=O)Nc1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C37H28Cl2N4O9S2/c1-42(27-9-3-21-5-11-29(17-23(21)15-27)53(49,50)40-25-7-13-33(38)31(19-25)35(44)45)37(48)43(2)28-10-4-22-6-12-30(18-24(22)16-28)54(51,52)41-26-8-14-34(39)32(20-26)36(46)47/h3-20,40-41H,1-2H3,(H,44,45)(H,46,47)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253177
PNG
(2-{7-[({7-[(2-carboxyphenyl)sulfamoyl]naphthalen-2...)
Show SMILES OC(=O)c1ccccc1NS(=O)(=O)c1ccc2ccc(NC(=O)Nc3ccc4ccc(cc4c3)S(=O)(=O)Nc3ccccc3C(O)=O)cc2c1
Show InChI InChI=1S/C35H26N4O9S2/c40-33(41)29-5-1-3-7-31(29)38-49(45,46)27-15-11-21-9-13-25(17-23(21)19-27)36-35(44)37-26-14-10-22-12-16-28(20-24(22)18-26)50(47,48)39-32-8-4-2-6-30(32)34(42)43/h1-20,38-39H,(H,40,41)(H,42,43)(H2,36,37,44)
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n/an/an/an/a 4.10E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253180
PNG
(5-{[(7-{[(7-{[(3-Carboxy-4-hydroxyphenyl)amino]sul...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4ccc(O)c(c4)C(O)=O)cc3c2)ccc1O
Show InChI InChI=1S/C35H26N4O13S2/c40-29-7-3-21(13-27(29)33(44)45)38-53(49,50)23-11-17-9-19(1-5-25(17)31(42)15-23)36-35(48)37-20-2-6-26-18(10-20)12-24(16-32(26)43)54(51,52)39-22-4-8-30(41)28(14-22)34(46)47/h1-16,38-43H,(H,44,45)(H,46,47)(H2,36,37,48)
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n/an/an/an/a 4.30E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253179
PNG
(5-{[(7-{[(7-{[(3-Carboxy-4-chlorophenyl)amino]sulf...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(Cl)c(c4)C(O)=O)cc3c2)ccc1Cl
Show InChI InChI=1S/C35H24Cl2N4O9S2/c36-31-11-7-25(17-29(31)33(42)43)40-51(47,48)27-9-3-19-1-5-23(13-21(19)15-27)38-35(46)39-24-6-2-20-4-10-28(16-22(20)14-24)52(49,50)41-26-8-12-32(37)30(18-26)34(44)45/h1-18,40-41H,(H,42,43)(H,44,45)(H2,38,39,46)
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n/an/an/an/a 1.60E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253182
PNG
(5-{7-[({7-[(3-carboxy-4-nitrophenyl)sulfamoyl]naph...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(c(c4)C(O)=O)[N+]([O-])=O)cc3c2)ccc1[N+]([O-])=O
Show InChI InChI=1S/C35H24N6O13S2/c42-33(43)29-17-25(7-11-31(29)40(47)48)38-55(51,52)27-9-3-19-1-5-23(13-21(19)15-27)36-35(46)37-24-6-2-20-4-10-28(16-22(20)14-24)56(53,54)39-26-8-12-32(41(49)50)30(18-26)34(44)45/h1-18,38-39H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 4.00E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253159
PNG
(3-{[(4-Hydroxy-7-{[(5-hydroxy-7-{[(3-sulfophenyl)a...)
Show SMILES Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(=O)(=O)Nc3cccc(c3)S([O-])(=O)=O)ccc12)S(=O)(=O)Nc1cccc(c1)S([O-])(=O)=O
Show InChI InChI=1S/C33H26N4O13S4/c38-31-17-27(51(41,42)36-23-3-1-5-25(15-23)53(45,46)47)13-19-11-21(7-9-29(19)31)34-33(40)35-22-8-10-30-20(12-22)14-28(18-32(30)39)52(43,44)37-24-4-2-6-26(16-24)54(48,49)50/h1-18,36-39H,(H2,34,35,40)(H,45,46,47)(H,48,49,50)/p-2
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n/an/an/an/a 2.60E+4n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253181
PNG
(2-Hydroxy-5-{[(7-{[(7-sulfo(2-naphthyl))amino]carb...)
Show SMILES OC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=O)Nc4ccc5ccc(cc5c4)S(=O)(=O)Nc4ccc(O)c(c4)C(O)=O)cc3c2)ccc1O
Show InChI InChI=1S/C35H26N4O11S2/c40-31-11-7-25(17-29(31)33(42)43)38-51(47,48)27-9-3-19-1-5-23(13-21(19)15-27)36-35(46)37-24-6-2-20-4-10-28(16-22(20)14-24)52(49,50)39-26-8-12-32(41)30(18-26)34(44)45/h1-18,38-41H,(H,42,43)(H,44,45)(H2,36,37,46)
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n/an/an/an/a 9.00E+3n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
Insulin receptor


(Mus musculus)
BDBM50253184
PNG
(3-{7-[({7-[(3-carboxy-2-chlorophenyl)sulfamoyl]-5-...)
Show SMILES OC(=O)c1cccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(cc5c4)S(=O)(=O)Nc4cccc(C(O)=O)c4Cl)cc3c2)c1Cl
Show InChI InChI=1S/C35H24Cl2N4O11S2/c36-31-25(33(44)45)3-1-5-27(31)40-53(49,50)21-13-17-11-19(7-9-23(17)29(42)15-21)38-35(48)39-20-8-10-24-18(12-20)14-22(16-30(24)43)54(51,52)41-28-6-2-4-26(32(28)37)34(46)47/h1-16,40-43H,(H,44,45)(H,46,47)(H2,38,39,48)
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n/an/an/an/a 1.21E+5n/an/an/an/a



Telik, Inc.

Curated by ChEMBL


Assay Description
Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulin


Citation and Details
More data for this
Ligand-Target Pair
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