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Found 174 hits Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor (964-1370)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184383
PNG
(US9150578, I-031)
Show SMILES CN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccc(cc3)-c3cnn(C)c3)n2)CC1
Show InChI InChI=1S/C30H35N11/c1-37-12-14-40(15-13-37)16-17-41-11-10-26(36-41)33-30-31-18-23-8-9-25-27(28(23)34-30)29(39(3)35-25)22-6-4-21(5-7-22)24-19-32-38(2)20-24/h4-7,10-11,18-20H,8-9,12-17H2,1-3H3,(H,31,33,34,36)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184545
PNG
(US9150578, I-172)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C34H39N9O/c1-22(2)42-14-16-43(17-15-42)27-11-13-28(30(18-27)44-5)37-34-35-19-25-10-12-29-31(32(25)38-34)33(41(4)39-29)24-8-6-23(7-9-24)26-20-36-40(3)21-26/h6-9,11,13,18-22H,10,12,14-17H2,1-5H3,(H,35,37,38)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184387
PNG
(US9150578, I-035)
Show SMILES Cn1cc(cn1)-c1cccc(Cc2c-3c(CCc4cnc(Nc5ccn(CCCN6CCCC6)n5)nc-34)nn2C)c1
Show InChI InChI=1S/C31H36N10/c1-38-21-25(20-33-38)23-8-5-7-22(17-23)18-27-29-26(36-39(27)2)10-9-24-19-32-31(35-30(24)29)34-28-11-16-41(37-28)15-6-14-40-12-3-4-13-40/h5,7-8,11,16-17,19-21H,3-4,6,9-10,12-15,18H2,1-2H3,(H,32,34,35,37)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184520
PNG
(US9150578, I-149)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(c4)-c4cnn(C)c4)c3-c2n1)C(=O)NCCCN(C)C
Show InChI InChI=1S/C34H39N9O2/c1-41(2)15-7-14-35-33(44)24-10-12-27(30(18-24)45-5)38-34-36-19-25-11-13-28-31(32(25)39-34)29(43(4)40-28)17-22-8-6-9-23(16-22)26-20-37-42(3)21-26/h6,8-10,12,16,18-21H,7,11,13-15,17H2,1-5H3,(H,35,44)(H,36,38,39)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184544
PNG
(US9150578, I-171)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C36H41N9O2/c1-42-23-27(22-38-42)24-4-6-25(7-5-24)35-33-31(41-43(35)2)10-8-26-21-37-36(40-34(26)33)39-30-11-9-29(20-32(30)46-3)45-16-14-44(15-17-45)28-12-18-47-19-13-28/h4-7,9,11,20-23,28H,8,10,12-19H2,1-3H3,(H,37,39,40)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184548
PNG
(US9150578, I-174)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CCO)CC1
Show InChI InChI=1S/C33H37N9O2/c1-39-21-25(20-35-39)22-4-6-23(7-5-22)32-30-28(38-40(32)2)10-8-24-19-34-33(37-31(24)30)36-27-11-9-26(18-29(27)44-3)42-14-12-41(13-15-42)16-17-43/h4-7,9,11,18-21,43H,8,10,12-17H2,1-3H3,(H,34,36,37)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184480
PNG
(US9150578, I-113)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCN(C)CC3)c2)n1
Show InChI InChI=1S/C31H37N11/c1-4-41-12-11-27(37-41)34-31-32-19-24-9-10-26-28(29(24)35-31)30(39(3)36-26)23-7-5-22(6-8-23)25-20-33-42(21-25)18-17-40-15-13-38(2)14-16-40/h5-8,11-12,19-21H,4,9-10,13-18H2,1-3H3,(H,32,34,35,37)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184486
PNG
(US9150578, I-119)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCC(CC3)N(C)C)c2)n1
Show InChI InChI=1S/C33H41N11/c1-5-43-17-14-29(39-43)36-33-34-20-25-10-11-28-30(31(25)37-33)32(41(4)38-28)24-8-6-23(7-9-24)26-21-35-44(22-26)19-18-42-15-12-27(13-16-42)40(2)3/h6-9,14,17,20-22,27H,5,10-13,15-16,18-19H2,1-4H3,(H,34,36,37,39)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184543
PNG
(US9150578, I-170)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C33H37N9O/c1-5-41-14-16-42(17-15-41)26-11-13-27(29(18-26)43-4)36-33-34-19-24-10-12-28-30(31(24)37-33)32(40(3)38-28)23-8-6-22(7-9-23)25-20-35-39(2)21-25/h6-9,11,13,18-21H,5,10,12,14-17H2,1-4H3,(H,34,36,37)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184357
PNG
(US9150578, I-005)
Show SMILES CN(C)C(=O)Cn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C27H28N10O/c1-34(2)23(38)16-37-15-21(13-30-37)31-27-28-11-19-9-10-22-24(25(19)32-27)26(36(4)33-22)18-7-5-17(6-8-18)20-12-29-35(3)14-20/h5-8,11-15H,9-10,16H2,1-4H3,(H,28,31,32)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184382
PNG
(US9150578, I-030)
Show SMILES COCCN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccc(cc3)-c3cnn(C)c3)n2)CC1
Show InChI InChI=1S/C32H39N11O/c1-39-22-26(21-34-39)23-4-6-24(7-5-23)31-29-27(37-40(31)2)9-8-25-20-33-32(36-30(25)29)35-28-10-11-43(38-28)17-16-41-12-14-42(15-13-41)18-19-44-3/h4-7,10-11,20-22H,8-9,12-19H2,1-3H3,(H,33,35,36,38)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184440
PNG
(US9150578, I-074)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(CCOC)c5)c4-c3n2)n1
Show InChI InChI=1S/C28H31N9O/c1-4-36-11-10-25(34-36)31-28-29-16-21-8-9-23-26(27(21)32-28)24(35(2)33-23)15-19-6-5-7-20(14-19)22-17-30-37(18-22)12-13-38-3/h5-7,10-11,14,16-18H,4,8-9,12-13,15H2,1-3H3,(H,29,31,32,34)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184485
PNG
(US9150578, I-118)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCNCC3)c2)n1
Show InChI InChI=1S/C30H35N11/c1-3-40-13-10-26(37-40)34-30-32-18-23-8-9-25-27(28(23)35-30)29(38(2)36-25)22-6-4-21(5-7-22)24-19-33-41(20-24)17-16-39-14-11-31-12-15-39/h4-7,10,13,18-20,31H,3,8-9,11-12,14-17H2,1-2H3,(H,32,34,35,37)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184542
PNG
(US9150578, I-169 | US9150578, I-173)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(C)CC1
Show InChI InChI=1S/C32H35N9O/c1-38-13-15-41(16-14-38)25-10-12-26(28(17-25)42-4)35-32-33-18-23-9-11-27-29(30(23)36-32)31(40(3)37-27)22-7-5-21(6-8-22)24-19-34-39(2)20-24/h5-8,10,12,17-20H,9,11,13-16H2,1-4H3,(H,33,35,36)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184482
PNG
(US9150578, I-115)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCNCCOC)c2)n1
Show InChI InChI=1S/C29H34N10O/c1-4-38-14-11-25(36-38)33-29-31-17-22-9-10-24-26(27(22)34-29)28(37(2)35-24)21-7-5-20(6-8-21)23-18-32-39(19-23)15-12-30-13-16-40-3/h5-8,11,14,17-19,30H,4,9-10,12-13,15-16H2,1-3H3,(H,31,33,34,36)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184483
PNG
(US9150578, I-116)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCCC3)c2)n1
Show InChI InChI=1S/C30H34N10/c1-3-39-15-12-26(36-39)33-30-31-18-23-10-11-25-27(28(23)34-30)29(37(2)35-25)22-8-6-21(7-9-22)24-19-32-40(20-24)17-16-38-13-4-5-14-38/h6-9,12,15,18-20H,3-5,10-11,13-14,16-17H2,1-2H3,(H,31,33,34,36)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184373
PNG
(US9150578, I-021)
Show SMILES CC(C)n1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C
Show InChI InChI=1S/C29H34N10/c1-19(2)39-18-23(17-31-39)20-6-8-21(9-7-20)28-26-24(34-37(28)5)11-10-22-16-30-29(33-27(22)26)32-25-12-13-38(35-25)15-14-36(3)4/h6-9,12-13,16-19H,10-11,14-15H2,1-5H3,(H,30,32,33,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184425
PNG
(US9150578, I-059)
Show SMILES COCCn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C
Show InChI InChI=1S/C29H34N10O/c1-36(2)13-14-38-12-11-25(35-38)32-29-30-17-22-9-10-24-26(27(22)33-29)28(37(3)34-24)21-7-5-20(6-8-21)23-18-31-39(19-23)15-16-40-4/h5-8,11-12,17-19H,9-10,13-16H2,1-4H3,(H,30,32,33,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184428
PNG
(US9150578, I-062)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN(C)C)c2)n1
Show InChI InChI=1S/C28H32N10/c1-5-37-13-12-24(34-37)31-28-29-16-21-10-11-23-25(26(21)32-28)27(36(4)33-23)20-8-6-19(7-9-20)22-17-30-38(18-22)15-14-35(2)3/h6-9,12-13,16-18H,5,10-11,14-15H2,1-4H3,(H,29,31,32,34)
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US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184481
PNG
(US9150578, I-114)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCN(CCO)CC3)c2)n1
Show InChI InChI=1S/C32H39N11O/c1-3-42-11-10-28(38-42)35-32-33-20-25-8-9-27-29(30(25)36-32)31(39(2)37-27)24-6-4-23(5-7-24)26-21-34-43(22-26)17-16-40-12-14-41(15-13-40)18-19-44/h4-7,10-11,20-22,44H,3,8-9,12-19H2,1-2H3,(H,33,35,36,38)
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n/an/a 0.130n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184484
PNG
(US9150578, I-117)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCN(CCOC)CC3)c2)n1
Show InChI InChI=1S/C33H41N11O/c1-4-43-12-11-29(39-43)36-33-34-21-26-9-10-28-30(31(26)37-33)32(40(2)38-28)25-7-5-24(6-8-25)27-22-35-44(23-27)18-17-41-13-15-42(16-14-41)19-20-45-3/h5-8,11-12,21-23H,4,9-10,13-20H2,1-3H3,(H,34,36,37,39)
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n/an/a 0.130n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184505
PNG
(US9150578, I-134)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NCCN(C)C
Show InChI InChI=1S/C32H35N9O2/c1-39(2)15-14-33-31(42)22-10-12-25(27(16-22)43-5)36-32-34-17-23-11-13-26-28(29(23)37-32)30(41(4)38-26)21-8-6-20(7-9-21)24-18-35-40(3)19-24/h6-10,12,16-19H,11,13-15H2,1-5H3,(H,33,42)(H,34,36,37)
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n/an/a 0.130n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184507
PNG
(US9150578, I-136)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NCCCN(C)C
Show InChI InChI=1S/C33H37N9O2/c1-40(2)16-6-15-34-32(43)23-11-13-26(28(17-23)44-5)37-33-35-18-24-12-14-27-29(30(24)38-33)31(42(4)39-27)22-9-7-21(8-10-22)25-19-36-41(3)20-25/h7-11,13,17-20H,6,12,14-16H2,1-5H3,(H,34,43)(H,35,37,38)
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n/an/a 0.130n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184504
PNG
(US9150578, I-133)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C34H37N9O2/c1-41-15-13-26(14-16-41)37-33(44)23-9-11-27(29(17-23)45-4)38-34-35-18-24-10-12-28-30(31(24)39-34)32(43(3)40-28)22-7-5-21(6-8-22)25-19-36-42(2)20-25/h5-9,11,17-20,26H,10,12-16H2,1-4H3,(H,37,44)(H,35,38,39)
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n/an/a 0.140n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184506
PNG
(US9150578, I-135)
Show SMILES COCCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C36H41N9O3/c1-43-22-27(21-38-43)23-5-7-24(8-6-23)34-32-30(42-44(34)2)12-10-26-20-37-36(41-33(26)32)40-29-11-9-25(19-31(29)48-4)35(46)39-28-13-15-45(16-14-28)17-18-47-3/h5-9,11,19-22,28H,10,12-18H2,1-4H3,(H,39,46)(H,37,40,41)
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n/an/a 0.140n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184521
PNG
(US9150578, I-150)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(c4)-c4cnn(C)c4)c3-c2n1)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C35H39N9O2/c1-42-22-27(21-38-42)24-8-6-7-23(17-24)18-30-32-29(41-43(30)2)12-10-26-20-37-35(40-33(26)32)39-28-11-9-25(19-31(28)46-3)34(45)36-13-16-44-14-4-5-15-44/h6-9,11,17,19-22H,4-5,10,12-16,18H2,1-3H3,(H,36,45)(H,37,39,40)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184532
PNG
(US9150578, I-161)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C35H39N9O2/c1-41-16-14-27(15-17-41)43(3)34(45)24-10-12-28(30(18-24)46-5)38-35-36-19-25-11-13-29-31(32(25)39-35)33(44(4)40-29)23-8-6-22(7-9-23)26-20-37-42(2)21-26/h6-10,12,18-21,27H,11,13-17H2,1-5H3,(H,36,38,39)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184427
PNG
(US9150578, I-061)
Show SMILES CCCn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C
Show InChI InChI=1S/C29H34N10/c1-5-13-39-19-23(18-31-39)20-6-8-21(9-7-20)28-26-24(34-37(28)4)11-10-22-17-30-29(33-27(22)26)32-25-12-14-38(35-25)16-15-36(2)3/h6-9,12,14,17-19H,5,10-11,13,15-16H2,1-4H3,(H,30,32,33,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184519
PNG
(US9150578, I-148)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)c(OC)c1
Show InChI InChI=1S/C30H30N8O2/c1-31-29(39)20-8-10-23(26(14-20)40-4)34-30-32-15-21-9-11-24-27(28(21)35-30)25(38(3)36-24)13-18-6-5-7-19(12-18)22-16-33-37(2)17-22/h5-8,10,12,14-17H,9,11,13H2,1-4H3,(H,31,39)(H,32,34,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184526
PNG
(US9150578, I-155)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)N(C)CCN(C)C
Show InChI InChI=1S/C33H37N9O2/c1-39(2)15-16-40(3)32(43)23-11-13-26(28(17-23)44-6)36-33-34-18-24-12-14-27-29(30(24)37-33)31(42(5)38-27)22-9-7-21(8-10-22)25-19-35-41(4)20-25/h7-11,13,17-20H,12,14-16H2,1-6H3,(H,34,36,37)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184356
PNG
(US9150578, I-004)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCCO)n4)nc-23)nn1C
Show InChI InChI=1S/C26H27N9O/c1-33-16-20(15-28-33)17-4-6-18(7-5-17)25-23-21(31-34(25)2)9-8-19-14-27-26(30-24(19)23)29-22-10-12-35(32-22)11-3-13-36/h4-7,10,12,14-16,36H,3,8-9,11,13H2,1-2H3,(H,27,29,30,32)
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n/an/a 0.160n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184367
PNG
(US9150578, I-015)
Show SMILES CN(C)CCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)n1
Show InChI InChI=1S/C28H32N10/c1-35(2)12-13-38-11-10-25(34-38)31-28-29-16-21-8-9-23-26(27(21)32-28)24(37(4)33-23)15-19-6-5-7-20(14-19)22-17-30-36(3)18-22/h5-7,10-11,14,16-18H,8-9,12-13,15H2,1-4H3,(H,29,31,32,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184376
PNG
(US9150578, I-024)
Show SMILES CCn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C25H25N9/c1-4-34-15-20(13-28-34)29-25-26-11-18-9-10-21-22(23(18)30-25)24(33(3)31-21)17-7-5-16(6-8-17)19-12-27-32(2)14-19/h5-8,11-15H,4,9-10H2,1-3H3,(H,26,29,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184429
PNG
(US9150578, I-063)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(c2)C2CCNCC2)n1
Show InChI InChI=1S/C29H32N10/c1-3-38-15-12-25(36-38)33-29-31-16-21-8-9-24-26(27(21)34-29)28(37(2)35-24)20-6-4-19(5-7-20)22-17-32-39(18-22)23-10-13-30-14-11-23/h4-7,12,15-18,23,30H,3,8-11,13-14H2,1-2H3,(H,31,33,34,36)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184447
PNG
(US9150578, I-081)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCO)c2)n1
Show InChI InChI=1S/C26H27N9O/c1-3-34-11-10-22(32-34)29-26-27-14-19-8-9-21-23(24(19)30-26)25(33(2)31-21)18-6-4-17(5-7-18)20-15-28-35(16-20)12-13-36/h4-7,10-11,14-16,36H,3,8-9,12-13H2,1-2H3,(H,27,29,30,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184500
PNG
(US9150578, I-129)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C33H35N9O2/c1-39-13-15-42(16-14-39)32(43)23-9-11-26(28(17-23)44-4)36-33-34-18-24-10-12-27-29(30(24)37-33)31(41(3)38-27)22-7-5-21(6-8-22)25-19-35-40(2)20-25/h5-9,11,17-20H,10,12-16H2,1-4H3,(H,34,36,37)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184518
PNG
(US9150578, I-147)
Show SMILES COCCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)c(OC)c1
Show InChI InChI=1S/C37H43N9O3/c1-44-23-28(22-39-44)25-7-5-6-24(18-25)19-32-34-31(43-45(32)2)11-9-27-21-38-37(42-35(27)34)41-30-10-8-26(20-33(30)49-4)36(47)40-29-12-14-46(15-13-29)16-17-48-3/h5-8,10,18,20-23,29H,9,11-17,19H2,1-4H3,(H,40,47)(H,38,41,42)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184530
PNG
(US9150578, I-159)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NCC1CCN(C)CC1
Show InChI InChI=1S/C35H39N9O2/c1-42-15-13-22(14-16-42)18-36-34(45)25-9-11-28(30(17-25)46-4)39-35-37-19-26-10-12-29-31(32(26)40-35)33(44(3)41-29)24-7-5-23(6-8-24)27-20-38-43(2)21-27/h5-9,11,17,19-22H,10,12-16,18H2,1-4H3,(H,36,45)(H,37,39,40)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184549
PNG
(US9150578, I-175)
Show SMILES COCCN1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C31H36N10O/c1-38-19-24(17-33-38)21-4-6-22(7-5-21)30-28-27(37-39(30)2)9-8-23-16-32-31(36-29(23)28)35-25-18-34-41(20-25)26-10-12-40(13-11-26)14-15-42-3/h4-7,16-20,26H,8-15H2,1-3H3,(H,32,35,36)
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n/an/a 0.160n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184374
PNG
(US9150578, I-022)
Show SMILES CC(C)n1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4cnn(c4)C4CCN(CC4)C(C)=O)nc-23)nn1C
Show InChI InChI=1S/C32H36N10O/c1-20(2)41-18-25(16-34-41)22-5-7-23(8-6-22)31-29-28(38-39(31)4)10-9-24-15-33-32(37-30(24)29)36-26-17-35-42(19-26)27-11-13-40(14-12-27)21(3)43/h5-8,15-20,27H,9-14H2,1-4H3,(H,33,36,37)
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n/an/a 0.170n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184381
PNG
(US9150578, I-029)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN5CCOCC5)n4)nc-23)nn1C
Show InChI InChI=1S/C29H32N10O/c1-36-19-23(18-31-36)20-3-5-21(6-4-20)28-26-24(34-37(28)2)8-7-22-17-30-29(33-27(22)26)32-25-9-10-39(35-25)12-11-38-13-15-40-16-14-38/h3-6,9-10,17-19H,7-8,11-16H2,1-2H3,(H,30,32,33,35)
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n/an/a 0.170n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184386
PNG
(US9150578, I-034)
Show SMILES CN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(Cc6cccc(c6)-c6cnn(C)c6)c5-c4n3)n2)CC1
Show InChI InChI=1S/C31H37N11/c1-38-11-13-41(14-12-38)15-16-42-10-9-28(37-42)34-31-32-19-24-7-8-26-29(30(24)35-31)27(40(3)36-26)18-22-5-4-6-23(17-22)25-20-33-39(2)21-25/h4-6,9-10,17,19-21H,7-8,11-16,18H2,1-3H3,(H,32,34,35,37)
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n/an/a 0.170n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184502
PNG
(US9150578, I-131)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)N(C)C
Show InChI InChI=1S/C30H30N8O2/c1-36(2)29(39)20-10-12-23(25(14-20)40-5)33-30-31-15-21-11-13-24-26(27(21)34-30)28(38(4)35-24)19-8-6-18(7-9-19)22-16-32-37(3)17-22/h6-10,12,14-17H,11,13H2,1-5H3,(H,31,33,34)
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n/an/a 0.170n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184517
PNG
(US9150578, I-146)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(c4)-c4cnn(C)c4)c3-c2n1)C(=O)NCCN(C)C
Show InChI InChI=1S/C33H37N9O2/c1-40(2)14-13-34-32(43)23-9-11-26(29(17-23)44-5)37-33-35-18-24-10-12-27-30(31(24)38-33)28(42(4)39-27)16-21-7-6-8-22(15-21)25-19-36-41(3)20-25/h6-9,11,15,17-20H,10,12-14,16H2,1-5H3,(H,34,43)(H,35,37,38)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184424
PNG
(US9150578, I-058)
Show SMILES CCn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C
Show InChI InChI=1S/C28H32N10/c1-5-37-18-22(17-30-37)19-6-8-20(9-7-19)27-25-23(33-36(27)4)11-10-21-16-29-28(32-26(21)25)31-24-12-13-38(34-24)15-14-35(2)3/h6-9,12-13,16-18H,5,10-11,14-15H2,1-4H3,(H,29,31,32,34)
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n/an/a 0.180n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184501
PNG
(US9150578, I-130)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C29H28N8O2/c1-30-28(38)19-9-11-22(24(13-19)39-4)33-29-31-14-20-10-12-23-25(26(20)34-29)27(37(3)35-23)18-7-5-17(6-8-18)21-15-32-36(2)16-21/h5-9,11,13-16H,10,12H2,1-4H3,(H,30,38)(H,31,33,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184420
PNG
(US9150578, I-054)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(c2)C(C)C)n1
Show InChI InChI=1S/C28H31N9O/c1-18(2)37-17-22(16-30-37)19-5-7-20(8-6-19)27-25-23(33-35(27)3)10-9-21-15-29-28(32-26(21)25)31-24-11-12-36(34-24)13-14-38-4/h5-8,11-12,15-18H,9-10,13-14H2,1-4H3,(H,29,31,32,34)
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n/an/a 0.190n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184535
PNG
(US9150578, I-164)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NC1CN(C)C1
Show InChI InChI=1S/C32H33N9O2/c1-39-17-24(18-39)35-31(42)21-9-11-25(27(13-21)43-4)36-32-33-14-22-10-12-26-28(29(22)37-32)30(41(3)38-26)20-7-5-19(6-8-20)23-15-34-40(2)16-23/h5-9,11,13-16,24H,10,12,17-18H2,1-4H3,(H,35,42)(H,33,36,37)
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n/an/a 0.190n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184451
PNG
(US9150578, I-085)
Show SMILES CN(C)CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCO)c2)n1
Show InChI InChI=1S/C28H32N10O/c1-35(2)12-13-37-11-10-24(34-37)31-28-29-16-21-8-9-23-25(26(21)32-28)27(36(3)33-23)20-6-4-19(5-7-20)22-17-30-38(18-22)14-15-39/h4-7,10-11,16-18,39H,8-9,12-15H2,1-3H3,(H,29,31,32,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184516
PNG
(US9150578, I-145)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(c4)-c4cnn(C)c4)c3-c2n1)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C35H39N9O2/c1-42-14-12-27(13-15-42)38-34(45)24-8-10-28(31(18-24)46-4)39-35-36-19-25-9-11-29-32(33(25)40-35)30(44(3)41-29)17-22-6-5-7-23(16-22)26-20-37-43(2)21-26/h5-8,10,16,18-21,27H,9,11-15,17H2,1-4H3,(H,38,45)(H,36,39,40)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)

More data for this
Ligand-Target Pair
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