BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 15 hits Enz. Inhib. hit(s) with Target = 'Integrin alpha M/beta-2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50055896
PNG
(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Show SMILES NC(=N)c1ccc(cc1)C1=NOC(CC(=O)NCCC(O)=O)C1
Show InChI InChI=1S/C15H18N4O4/c16-15(17)10-3-1-9(2-4-10)12-7-11(23-19-12)8-13(20)18-6-5-14(21)22/h1-4,11H,5-8H2,(H3,16,17)(H,18,20)(H,21,22)
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of Mac-1 integrin (alphaM-beta2)


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50055896
PNG
(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Show SMILES NC(=N)c1ccc(cc1)C1=NOC(CC(=O)NCCC(O)=O)C1
Show InChI InChI=1S/C15H18N4O4/c16-15(17)10-3-1-9(2-4-10)12-7-11(23-19-12)8-13(20)18-6-5-14(21)22/h1-4,11H,5-8H2,(H3,16,17)(H,18,20)(H,21,22)
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of Mac-1 interaction with ICAM


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50089005
PNG
((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Show SMILES CC(=O)N1CSC[C@@H]1C(=O)N[C@@H](Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)C(O)=O
Show InChI InChI=1S/C22H22Cl2N2O5S/c1-13(27)26-12-32-11-20(26)21(28)25-19(22(29)30)9-14-5-7-15(8-6-14)31-10-16-17(23)3-2-4-18(16)24/h2-8,19-20H,9-12H2,1H3,(H,25,28)(H,29,30)/t19-,20+/m0/s1
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a>4.00E+5n/an/an/an/an/an/a



Celltech Chiroscience

Curated by ChEMBL


Assay Description
Inhibition of alphaM-beta2 mediated cell adhesion


Bioorg Med Chem Lett 10: 997-9 (2000)

More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378540
PNG
(CHEMBL583892)
Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccc(C)cc2Br)C1=O
Show InChI InChI=1S/C19H16BrNO5S/c1-3-25-17(22)10-21-18(23)16(27-19(21)24)9-12-5-7-15(26-12)13-6-4-11(2)8-14(13)20/h4-9H,3,10H2,1-2H3/b16-9-
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.86E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378541
PNG
(CHEMBL570321)
Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccc(Cl)c(c2)C(O)=O)C1=O
Show InChI InChI=1S/C19H14ClNO7S/c1-2-27-16(22)9-21-17(23)15(29-19(21)26)8-11-4-6-14(28-11)10-3-5-13(20)12(7-10)18(24)25/h3-8H,2,9H2,1H3,(H,24,25)/b15-8-
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>5.00E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378542
PNG
(CHEMBL569154)
Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2cc(ccc2Cl)C(O)=O)C1=O
Show InChI InChI=1S/C19H14ClNO7S/c1-2-27-16(22)9-21-17(23)15(29-19(21)26)8-11-4-6-14(28-11)12-7-10(18(24)25)3-5-13(12)20/h3-8H,2,9H2,1H3,(H,24,25)/b15-8-
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 4.09E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378543
PNG
(CHEMBL571876)
Show SMILES Clc1ccc(-c2ccc(\C=C3/SC(=O)N(C3=O)c3ccccc3)o2)c(Cl)c1
Show InChI InChI=1S/C20H11Cl2NO3S/c21-12-6-8-15(16(22)10-12)17-9-7-14(26-17)11-18-19(24)23(20(25)27-18)13-4-2-1-3-5-13/h1-11H/b18-11-
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/an/an/a>5.00E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378544
PNG
(CHEMBL570061)
Show SMILES Clc1ccc(-c2ccc(C=C3SC(=O)N(CC(=O)c4ccccc4)C3=O)o2)c(Cl)c1
Show InChI InChI=1S/C22H13Cl2NO4S/c23-14-6-8-16(17(24)10-14)19-9-7-15(29-19)11-20-21(27)25(22(28)30-20)12-18(26)13-4-2-1-3-5-13/h1-11H,12H2
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3.56E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378545
PNG
(CHEMBL585545)
Show SMILES Cc1ccc(cc1)C(=O)CN1C(=O)SC(=Cc2ccc(o2)-c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C23H16ClNO4S/c1-14-2-4-15(5-3-14)19(26)13-25-22(27)21(30-23(25)28)12-18-10-11-20(29-18)16-6-8-17(24)9-7-16/h2-12H,13H2,1H3
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>5.00E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378546
PNG
(CHEMBL585139)
Show SMILES Cc1cccc(NC(=O)CN2C(=O)S\C(=C/c3ccc(o3)-c3ccccc3)C2=O)c1
Show InChI InChI=1S/C23H18N2O4S/c1-15-6-5-9-17(12-15)24-21(26)14-25-22(27)20(30-23(25)28)13-18-10-11-19(29-18)16-7-3-2-4-8-16/h2-13H,14H2,1H3,(H,24,26)/b20-13-
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.23E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378547
PNG
(CHEMBL569007)
Show SMILES Cc1cccc(NC(=O)CN2C(=S)S\C(=C/c3ccc(Cc4ccco4)o3)C2=O)c1
Show InChI InChI=1S/C22H18N2O4S2/c1-14-4-2-5-15(10-14)23-20(25)13-24-21(26)19(30-22(24)29)12-18-8-7-17(28-18)11-16-6-3-9-27-16/h2-10,12H,11,13H2,1H3,(H,23,25)/b19-12-
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.80E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378539
PNG
(CHEMBL570524)
Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccc(Br)cc2)C1=O
Show InChI InChI=1S/C18H14BrNO5S/c1-2-24-16(21)10-20-17(22)15(26-18(20)23)9-13-7-8-14(25-13)11-3-5-12(19)6-4-11/h3-9H,2,10H2,1H3/b15-9-
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 4.04E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378538
PNG
(CHEMBL570523)
Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccccc2)C1=O
Show InChI InChI=1S/C18H15NO5S/c1-2-23-16(20)11-19-17(21)15(25-18(19)22)10-13-8-9-14(24-13)12-6-4-3-5-7-12/h3-10H,2,11H2,1H3/b15-10-
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.05E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378536
PNG
(CHEMBL572115)
Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)-c2ccc(Cl)cc2Cl)C1=O
Show InChI InChI=1S/C18H13Cl2NO5S/c1-2-25-16(22)9-21-17(23)15(27-18(21)24)8-11-4-6-14(26-11)12-5-3-10(19)7-13(12)20/h3-8H,2,9H2,1H3/b15-8-
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.36E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair
Integrin alpha M/beta-2


(Homo sapiens)
BDBM50378537
PNG
(CHEMBL584543)
Show SMILES CCOC(=O)CN1C(=O)S\C(=C/c2ccc(o2)N2CCCC2)C1=O
Show InChI InChI=1S/C16H18N2O5S/c1-2-22-14(19)10-18-15(20)12(24-16(18)21)9-11-5-6-13(23-11)17-7-3-4-8-17/h5-6,9H,2-4,7-8,10H2,1H3/b12-9-
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.32E+4n/an/an/an/a



Department of Medicine and University of Miami

Curated by ChEMBL


Assay Description
Agonist activity at CD11b/CD18 expressed in K562 cells assessed as increase in cell adhesion to fibrinogen


Citation and Details
More data for this
Ligand-Target Pair