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Compile Data Set for Download or QSAR

Found 23 hits Enz. Inhib. hit(s) with Target = 'Interleukin-17F' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-17F


(Homo sapiens (human))
BDBM247030
PNG
(5-(1H-pyrazol-4-yl)-1-((1-(pyridin-3-ylsulfonyl)pi...)
Show SMILES O=S(=O)(N1CCC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CC1)c1cccnc1
Show InChI InChI=1S/C22H23N5O2S/c28-30(29,21-2-1-8-23-15-21)27-10-5-17(6-11-27)16-26-9-7-19-12-18(3-4-22(19)26)20-13-24-25-14-20/h1-4,7-9,12-15,17H,5-6,10-11,16H2,(H,24,25)
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n/an/a<1.00E+4n/an/an/an/an/an/a



INNOV17 LLC

US Patent




US Patent US9701663 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261509
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES OCC(=O)c1ccc2N(Cc3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)CCc2c1
Show InChI InChI=1S/C20H17F6NO3/c21-19(22,23)18(30,20(24,25)26)15-4-1-12(2-5-15)10-27-8-7-13-9-14(17(29)11-28)3-6-16(13)27/h1-6,9,28,30H,7-8,10-11H2
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM247032
PNG
(US9701663, 47 | rac.-cis-1-((-5-methyl-1-(phenylsu...)
Show SMILES C[C@@H]1CC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CN1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H24N4O2S/c1-17-11-18(16-27(17)30(28,29)22-5-3-2-4-6-22)15-26-10-9-20-12-19(7-8-23(20)26)21-13-24-25-14-21/h2-10,12-14,17-18H,11,15-16H2,1H3,(H,24,25)/t17-,18?/m1/s1
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INNOV17 LLC

US Patent




US Patent US9701663 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM247033
PNG
(US9701663, 48 | rac.-trans-1-((-5-methyl-1-(phenyl...)
Show SMILES C[C@H]1CC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CN1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H24N4O2S/c1-17-11-18(16-27(17)30(28,29)22-5-3-2-4-6-22)15-26-10-9-20-12-19(7-8-23(20)26)21-13-24-25-14-21/h2-10,12-14,17-18H,11,15-16H2,1H3,(H,24,25)/t17-,18?/m0/s1
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INNOV17 LLC

US Patent




US Patent US9701663 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM247034
PNG
(Synthesis of 1-((1-(methylsulfonyl)piperidin-4-yl)...)
Show SMILES CS(=O)(=O)N1CCC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CC1
Show InChI InChI=1S/C18H22N4O2S/c1-25(23,24)22-8-4-14(5-9-22)13-21-7-6-16-10-15(2-3-18(16)21)17-11-19-20-12-17/h2-3,6-7,10-12,14H,4-5,8-9,13H2,1H3,(H,19,20)
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INNOV17 LLC

US Patent




US Patent US9701663 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM247010
PNG
(1-((1-(phenylsulfonyl)piperidin-4-yl)methyl)-5-(1H...)
Show SMILES O=S(=O)(N1CCC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CC1)c1ccccc1
Show InChI InChI=1S/C23H24N4O2S/c28-30(29,22-4-2-1-3-5-22)27-12-8-18(9-13-27)17-26-11-10-20-14-19(6-7-23(20)26)21-15-24-25-16-21/h1-7,10-11,14-16,18H,8-9,12-13,17H2,(H,24,25)
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INNOV17 LLC

US Patent




US Patent US9701663 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM247023
PNG
(US9701663, 6)
Show SMILES C(C1CC2CCC1N2)n1ccc2cc(ccc12)-c1cnn(c1)C1CCCCO1
Show InChI InChI=1S/C23H28N4O/c1-2-10-28-23(3-1)27-15-19(13-24-27)16-4-7-22-17(11-16)8-9-26(22)14-18-12-20-5-6-21(18)25-20/h4,7-9,11,13,15,18,20-21,23,25H,1-3,5-6,10,12,14H2
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INNOV17 LLC

US Patent




US Patent US9701663 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM247026
PNG
(US9701663, 7)
Show SMILES C(C1CCNCC1)N1CCCc2cc(ccc12)-c1cnn(c1)C1CCCCO1
Show InChI InChI=1S/C23H32N4O/c1-2-13-28-23(5-1)27-17-21(15-25-27)19-6-7-22-20(14-19)4-3-12-26(22)16-18-8-10-24-11-9-18/h6-7,14-15,17-18,23-24H,1-5,8-13,16H2
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INNOV17 LLC

US Patent




US Patent US9701663 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM247027
PNG
(US9701663, 8)
Show SMILES FC(F)(F)CS(=O)(=O)N1CCC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CC1
Show InChI InChI=1S/C19H21F3N4O2S/c20-19(21,22)13-29(27,28)26-7-3-14(4-8-26)12-25-6-5-16-9-15(1-2-18(16)25)17-10-23-24-11-17/h1-2,5-6,9-11,14H,3-4,7-8,12-13H2,(H,23,24)
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INNOV17 LLC

US Patent




US Patent US9701663 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM247028
PNG
(1-((5,5-dimethyl-1-(phenylsulfonyl)pyrrolidin-3-yl...)
Show SMILES CC1(C)CC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CN1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H26N4O2S/c1-24(2)13-18(17-28(24)31(29,30)22-6-4-3-5-7-22)16-27-11-10-20-12-19(8-9-23(20)27)21-14-25-26-15-21/h3-12,14-15,18H,13,16-17H2,1-2H3,(H,25,26)
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INNOV17 LLC

US Patent




US Patent US9701663 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM247029
PNG
(1-((1-(4-chlorophenylsulfonyl)piperidin-4-yl)methy...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CC1
Show InChI InChI=1S/C23H23ClN4O2S/c24-21-2-4-22(5-3-21)31(29,30)28-11-7-17(8-12-28)16-27-10-9-19-13-18(1-6-23(19)27)20-14-25-26-15-20/h1-6,9-10,13-15,17H,7-8,11-12,16H2,(H,25,26)
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INNOV17 LLC

US Patent




US Patent US9701663 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261498
PNG
(Preparation of 2-(4-(bromomethyl)phenyl)-1,1,1,3,3...)
Show SMILES OC(c1ccc(CBr)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C10H7BrF6O/c11-5-6-1-3-7(4-2-6)8(18,9(12,13)14)10(15,16)17/h1-4,18H,5H2
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261499
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES O=COCc1ccc2NCCCc2c1
Show InChI InChI=1S/C11H13NO2/c13-8-14-7-9-3-4-11-10(6-9)2-1-5-12-11/h3-4,6,8,12H,1-2,5,7H2
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261500
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES OC(c1ccc(CN2CCCc3cc(COC=O)ccc23)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H19F6NO3/c22-20(23,24)19(30,21(25,26)27)17-6-3-14(4-7-17)11-28-9-1-2-16-10-15(12-31-13-29)5-8-18(16)28/h3-8,10,13,30H,1-2,9,11-12H2
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261501
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES CN(C)C(=O)c1ccc2N(Cc3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)CCCc2c1
Show InChI InChI=1S/C22H22F6N2O2/c1-29(2)19(31)16-7-10-18-15(12-16)4-3-11-30(18)13-14-5-8-17(9-6-14)20(32,21(23,24)25)22(26,27)28/h5-10,12,32H,3-4,11,13H2,1-2H3
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261502
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES Brc1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C9H8BrNO/c10-7-2-3-8-6(5-7)1-4-9(12)11-8/h2-3,5H,1,4H2,(H,11,12)
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261503
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES OC(c1ccc(CN2C(=O)CCc3cc(COC=O)ccc23)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H17F6NO4/c22-20(23,24)19(31,21(25,26)27)16-5-1-13(2-6-16)10-28-17-7-3-14(11-32-12-29)9-15(17)4-8-18(28)30/h1-3,5-7,9,12,31H,4,8,10-11H2
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261504
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES CN(C)C(=O)c1ccc2N(Cc3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)C(=O)CCc2c1
Show InChI InChI=1S/C22H20F6N2O3/c1-29(2)19(32)15-5-9-17-14(11-15)6-10-18(31)30(17)12-13-3-7-16(8-4-13)20(33,21(23,24)25)22(26,27)28/h3-5,7-9,11,33H,6,10,12H2,1-2H3
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261505
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES Brc1ccc(NC(=O)\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C15H12BrNO/c16-13-7-9-14(10-8-13)17-15(18)11-6-12-4-2-1-3-5-12/h1-11H,(H,17,18)/b11-6+
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261506
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES OC(c1ccc(Cn2c3ccc(COC=O)cc3ccc2=O)cc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H15F6NO4/c22-20(23,24)19(31,21(25,26)27)16-5-1-13(2-6-16)10-28-17-7-3-14(11-32-12-29)9-15(17)4-8-18(28)30/h1-9,12,31H,10-11H2
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261507
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES CN(C)C(=O)c1ccc2n(Cc3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)c(=O)ccc2c1
Show InChI InChI=1S/C22H18F6N2O3/c1-29(2)19(32)15-5-9-17-14(11-15)6-10-18(31)30(17)12-13-3-7-16(8-4-13)20(33,21(23,24)25)22(26,27)28/h3-11,33H,12H2,1-2H3
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM261508
PNG
(Preparation of 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Show SMILES Brc1ccc2NCCc2c1
Show InChI InChI=1S/C8H8BrN/c9-7-1-2-8-6(5-7)3-4-10-8/h1-2,5,10H,3-4H2
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INNOV17 LLC

US Patent


Assay Description
Human CD4+ T cells were differentiated to TH17 cells as described in the presence or absence of various concentrations of compounds in a final concen...


US Patent US9708268 (2017)

More data for this
Ligand-Target Pair
Interleukin-17F


(Homo sapiens (human))
BDBM247031
PNG
(1-((1-(2-fluorophenylsulfonyl)piperidin-4-yl)methy...)
Show SMILES Fc1ccccc1S(=O)(=O)N1CCC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CC1
Show InChI InChI=1S/C23H23FN4O2S/c24-21-3-1-2-4-23(21)31(29,30)28-11-7-17(8-12-28)16-27-10-9-19-13-18(5-6-22(19)27)20-14-25-26-15-20/h1-6,9-10,13-15,17H,7-8,11-12,16H2,(H,25,26)
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INNOV17 LLC

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US Patent US9701663 (2017)

More data for this
Ligand-Target Pair