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Compile Data Set for Download or QSAR

Found 45 hits Enz. Inhib. hit(s) with Target = 'Interleukin-2' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-2


(Mus musculus)
BDBM50022815
PNG
((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Show SMILES CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
Show InChI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Sandoz Pharma Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for the immunosuppressive activity in interleukin-2 by interleukin-2 reporter gene assay (IL2-RGA)


J Med Chem 38: 3361-7 (1995)

More data for this
Ligand-Target Pair
Interleukin-2


(Mus musculus)
BDBM50422041
PNG
(GECLOSPORIN)
Show SMILES CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
Show InChI InChI=1S/C63H113N11O12/c1-25-27-29-41(15)53(76)52-57(80)66-44(28-26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27,35-48,50-53,76H,26,28-34H2,1-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b27-25+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Sandoz Pharma Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for the immunosuppressive activity in interleukin-2 by interleukin-2 reporter gene assay (IL2-RGA)


J Med Chem 38: 3361-7 (1995)

More data for this
Ligand-Target Pair
Interleukin-2


(Mus musculus)
BDBM50033061
PNG
(27-Hydroxymethyl-33-(1-hydroxy-2-methyl-hex-4-enyl...)
Show SMILES CCC[C@H]1NC(=O)[C@@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](CO)N(C)C1=O)C(C)C
Show InChI InChI=1S/C64H115N11O13/c1-25-27-29-41(15)53(77)52-57(81)67-44(28-26-2)59(83)73(22)49(34-76)62(86)69(18)46(31-36(5)6)56(80)68-50(39(11)12)63(87)70(19)45(30-35(3)4)55(79)65-42(16)54(78)66-43(17)58(82)71(20)47(32-37(7)8)60(84)72(21)48(33-38(9)10)61(85)74(23)51(40(13)14)64(88)75(52)24/h25,27,35-53,76-77H,26,28-34H2,1-24H3,(H,65,79)(H,66,78)(H,67,81)(H,68,80)/b27-25+/t41-,42-,43+,44-,45-,46-,47-,48-,49+,50-,51-,52-,53-/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Sandoz Pharma Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for the immunosuppressive activity in interleukin-2 by interleukin-2 reporter gene assay (IL2-RGA)


J Med Chem 38: 3361-7 (1995)

More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50229786
PNG
(5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-P...)
Show SMILES CC(C)CC([NH+]=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(o2)C([O-])=O)c(Cl)c1Cl
Show InChI InChI=1S/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36)
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n/an/a 60n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2


(Mus musculus)
BDBM50033058
PNG
(33-(1-Hydroxy-2-methyl-hex-4-enyl)-30-(3-hydroxy-p...)
Show SMILES C\C=C\C[C@@H](C)[C@@H](O)[C@H]1N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@@H](CCCO)NC1=O)C(C)C
Show InChI InChI=1S/C63H113N11O13/c1-24-25-27-41(14)53(77)52-57(81)66-44(28-26-29-75)59(83)68(17)34-49(76)69(18)45(30-35(2)3)56(80)67-50(39(10)11)62(86)70(19)46(31-36(4)5)55(79)64-42(15)54(78)65-43(16)58(82)71(20)47(32-37(6)7)60(84)72(21)48(33-38(8)9)61(85)73(22)51(40(12)13)63(87)74(52)23/h24-25,35-48,50-53,75,77H,26-34H2,1-23H3,(H,64,79)(H,65,78)(H,66,81)(H,67,80)/b25-24+/t41-,42-,43+,44-,45-,46-,47-,48-,50-,51-,52-,53-/m1/s1
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n/an/a 70n/an/an/an/an/an/a



Sandoz Pharma Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for the immunosuppressive activity in interleukin-2 by interleukin-2 reporter gene assay (IL2-RGA)


J Med Chem 38: 3361-7 (1995)

More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147987
PNG
(4-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-meth...)
Show SMILES CC(C)C[C@@H](N=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(cc2)C(O)=O)c(Cl)c1Cl
Show InChI InChI=1S/C32H39Cl2N7O5/c1-18(2)14-24(38-32(35)36)30(43)37-16-27(42)41-12-10-20(11-13-41)25-15-23(39-40(25)3)22-8-9-26(29(34)28(22)33)46-17-19-4-6-21(7-5-19)31(44)45/h4-9,15,18,20,24H,10-14,16-17H2,1-3H3,(H,37,43)(H,44,45)(H4,35,36,38)/t24-/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50148004
PNG
(3-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-meth...)
Show SMILES CC(C)C[C@@H](N=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2cccc(c2)C(O)=O)c(Cl)c1Cl
Show InChI InChI=1S/C32H39Cl2N7O5/c1-18(2)13-24(38-32(35)36)30(43)37-16-27(42)41-11-9-20(10-12-41)25-15-23(39-40(25)3)22-7-8-26(29(34)28(22)33)46-17-19-5-4-6-21(14-19)31(44)45/h4-8,14-15,18,20,24H,9-13,16-17H2,1-3H3,(H,37,43)(H,44,45)(H4,35,36,38)/t24-/m1/s1
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n/an/a 400n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147979
PNG
(CHEMBL106951 | {4-[2,3-Dichloro-4-(5-{1-[2-((R)-2-...)
Show SMILES CC(C)C[C@@H](N=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(CC(O)=O)cc2)c(Cl)c1Cl
Show InChI InChI=1S/C33H41Cl2N7O5/c1-19(2)14-25(39-33(36)37)32(46)38-17-28(43)42-12-10-22(11-13-42)26-16-24(40-41(26)3)23-8-9-27(31(35)30(23)34)47-18-21-6-4-20(5-7-21)15-29(44)45/h4-9,16,19,22,25H,10-15,17-18H2,1-3H3,(H,38,46)(H,44,45)(H4,36,37,39)/t25-/m1/s1
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n/an/a 600n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50148000
PNG
(2-Guanidino-4-methyl-pentanoic acid (2-{4-[5-(2,3-...)
Show SMILES CC(C)C[C@@H](N=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C24H33Cl2N7O2/c1-14(2)11-19(30-24(27)28)23(35)29-13-21(34)33-9-7-15(8-10-33)20-12-18(31-32(20)3)16-5-4-6-17(25)22(16)26/h4-6,12,14-15,19H,7-11,13H2,1-3H3,(H,29,35)(H4,27,28,30)/t19-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50148001
PNG
(2-Guanidino-4-methyl-pentanoic acid (2-{4-[5-(2,3-...)
Show SMILES COc1ccc(-c2cc(C3CCN(CC3)C(=O)CNC(=O)[C@@H](CC(C)C)N=C(N)N)n(C)n2)c(Cl)c1Cl
Show InChI InChI=1S/C25H35Cl2N7O3/c1-14(2)11-18(31-25(28)29)24(36)30-13-21(35)34-9-7-15(8-10-34)19-12-17(32-33(19)3)16-5-6-20(37-4)23(27)22(16)26/h5-6,12,14-15,18H,7-11,13H2,1-4H3,(H,30,36)(H4,28,29,31)/t18-/m1/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147974
PNG
((S)-2-[2-((R)-1-Carbamimidoyl-piperidin-3-yl)-acet...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)C[C@H]1CCCN(C1)C(N)=N
Show InChI InChI=1S/C26H30N4O3/c1-33-25(32)23(29-24(31)17-22-8-5-15-30(18-22)26(27)28)16-21-13-11-20(12-14-21)10-9-19-6-3-2-4-7-19/h2-4,6-7,11-14,22-23H,5,8,15-18H2,1H3,(H3,27,28)(H,29,31)/t22-,23+/m1/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Interleukin-2 receptor alpha


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147970
PNG
(2-Guanidino-4-methyl-pentanoic acid (2-{4-[5-(2,3-...)
Show SMILES CC(C)C[C@@H](N=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(O)c(Cl)c1Cl
Show InChI InChI=1S/C24H33Cl2N7O3/c1-13(2)10-17(30-24(27)28)23(36)29-12-20(35)33-8-6-14(7-9-33)18-11-16(31-32(18)3)15-4-5-19(34)22(26)21(15)25/h4-5,11,13-14,17,34H,6-10,12H2,1-3H3,(H,29,36)(H4,27,28,30)/t17-/m1/s1
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n/an/a 8.10E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147999
PNG
((S)-2-[2-((S)-2-Guanidino-3,3-dimethyl-butyrylamin...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)[C@@H](N=C(N)N)C(C)(C)C
Show InChI InChI=1S/C27H33N5O4/c1-27(2,3)23(32-26(28)29)24(34)30-17-22(33)31-21(25(35)36-4)16-20-14-12-19(13-15-20)11-10-18-8-6-5-7-9-18/h5-9,12-15,21,23H,16-17H2,1-4H3,(H,30,34)(H,31,33)(H4,28,29,32)/t21-,23+/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147973
PNG
(2-(R)-Cyclohexyl-N-(2-{4-[5-(2,4-dichloro-phenyl)-...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C25H33Cl2N7O2/c26-17-6-7-18(19(27)12-17)21-13-20(32-33-21)15-8-10-34(11-9-15)22(35)14-30-24(36)23(31-25(28)29)16-4-2-1-3-5-16/h6-7,12-13,15-16,23H,1-5,8-11,14H2,(H,30,36)(H,32,33)(H4,28,29,31)/t23-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50148008
PNG
((R)-2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C25H33Cl2N7O2/c26-18-8-4-7-17(22(18)27)20-13-19(32-33-20)15-9-11-34(12-10-15)21(35)14-30-24(36)23(31-25(28)29)16-5-2-1-3-6-16/h4,7-8,13,15-16,23H,1-3,5-6,9-12,14H2,(H,30,36)(H,32,33)(H4,28,29,31)/t23-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147985
PNG
((S)-2-[2-((R)-2-Cyclohexyl-2-guanidino-acetylamino...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)[C@H](N=C(N)N)C1CCCCC1
Show InChI InChI=1S/C29H35N5O4/c1-38-28(37)24(18-22-16-14-21(15-17-22)13-12-20-8-4-2-5-9-20)33-25(35)19-32-27(36)26(34-29(30)31)23-10-6-3-7-11-23/h2,4-5,8-9,14-17,23-24,26H,3,6-7,10-11,18-19H2,1H3,(H,32,36)(H,33,35)(H4,30,31,34)/t24-,26+/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147982
PNG
(2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-2-me...)
Show SMILES Cn1nc(cc1C1CCN(CC1)C(=O)CNC(=O)[C@H](N=C(N)N)C1CCCCC1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C26H35Cl2N7O2/c1-34-21(14-20(33-34)18-8-5-9-19(27)23(18)28)16-10-12-35(13-11-16)22(36)15-31-25(37)24(32-26(29)30)17-6-3-2-4-7-17/h5,8-9,14,16-17,24H,2-4,6-7,10-13,15H2,1H3,(H,31,37)(H4,29,30,32)/t24-/m1/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50370390
PNG
(CHEMBL1790808)
Show SMILES CC[C@@H](C)[C@H](N=C(N)N)C(=O)NCC(=O)N[C@@H](Cc1ccc(cc1)C#Cc1ccccc1)C(=O)OC
Show InChI InChI=1S/C27H33N5O4/c1-4-18(2)24(32-27(28)29)25(34)30-17-23(33)31-22(26(35)36-3)16-21-14-12-20(13-15-21)11-10-19-8-6-5-7-9-19/h5-9,12-15,18,22,24H,4,16-17H2,1-3H3,(H,30,34)(H,31,33)(H4,28,29,32)/t18-,22+,24+/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147975
PNG
(CHEMBL107739 | N-(2-{4-[5-(2-Chloro-4-hydroxy-phen...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1ccc(O)cc1Cl
Show InChI InChI=1S/C25H34ClN7O3/c26-19-12-17(34)6-7-18(19)21-13-20(31-32-21)15-8-10-33(11-9-15)22(35)14-29-24(36)23(30-25(27)28)16-4-2-1-3-5-16/h6-7,12-13,15-16,23,34H,1-5,8-11,14H2,(H,29,36)(H,31,32)(H4,27,28,30)/t23-/m1/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147984
PNG
(2-Guanidino-4-methyl-pentanoic acid (2-{4-[5-(4-be...)
Show SMILES CC(C)C[C@@H](N=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccccc2)c(Cl)c1Cl
Show InChI InChI=1S/C31H39Cl2N7O3/c1-19(2)15-24(37-31(34)35)30(42)36-17-27(41)40-13-11-21(12-14-40)25-16-23(38-39(25)3)22-9-10-26(29(33)28(22)32)43-18-20-7-5-4-6-8-20/h4-10,16,19,21,24H,11-15,17-18H2,1-3H3,(H,36,42)(H4,34,35,37)/t24-/m1/s1
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n/an/a 3.50E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50148006
PNG
((S)-2-[2-((R)-3-Cyclohexyl-2-guanidino-propionylam...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CC1CCCCC1)N=C(N)N
Show InChI InChI=1S/C30H37N5O4/c1-39-29(38)26(19-24-16-14-22(15-17-24)13-12-21-8-4-2-5-9-21)34-27(36)20-33-28(37)25(35-30(31)32)18-23-10-6-3-7-11-23/h2,4-5,8-9,14-17,23,25-26H,3,6-7,10-11,18-20H2,1H3,(H,33,37)(H,34,36)(H4,31,32,35)/t25-,26+/m1/s1
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n/an/a 3.70E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50148003
PNG
(4-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-meth...)
Show SMILES COC(=O)c1ccc(COc2ccc(-c3cc(C4CCN(CC4)C(=O)CNC(=O)[C@@H](CC(C)C)N=C(N)N)n(C)n3)c(Cl)c2Cl)cc1
Show InChI InChI=1S/C33H41Cl2N7O5/c1-19(2)15-25(39-33(36)37)31(44)38-17-28(43)42-13-11-21(12-14-42)26-16-24(40-41(26)3)23-9-10-27(30(35)29(23)34)47-18-20-5-7-22(8-6-20)32(45)46-4/h5-10,16,19,21,25H,11-15,17-18H2,1-4H3,(H,38,44)(H4,36,37,39)/t25-/m1/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147989
PNG
(CHEMBL106262 | N-(2-{4-[5-(2-Chloro-phenyl)-2H-pyr...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1ccccc1Cl
Show InChI InChI=1S/C25H34ClN7O2/c26-19-9-5-4-8-18(19)21-14-20(31-32-21)16-10-12-33(13-11-16)22(34)15-29-24(35)23(30-25(27)28)17-6-2-1-3-7-17/h4-5,8-9,14,16-17,23H,1-3,6-7,10-13,15H2,(H,29,35)(H,31,32)(H4,27,28,30)/t23-/m1/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147997
PNG
(2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-1-me...)
Show SMILES Cn1nc(cc1-c1cccc(Cl)c1Cl)C1CCN(CC1)C(=O)CNC(=O)[C@H](N=C(N)N)C1CCCCC1
Show InChI InChI=1S/C26H35Cl2N7O2/c1-34-21(18-8-5-9-19(27)23(18)28)14-20(33-34)16-10-12-35(13-11-16)22(36)15-31-25(37)24(32-26(29)30)17-6-3-2-4-7-17/h5,8-9,14,16-17,24H,2-4,6-7,10-13,15H2,1H3,(H,31,37)(H4,29,30,32)/t24-/m1/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147998
PNG
(2-(R)-Cyclohexyl-2-guanidino-N-{2-oxo-2-[4-(5-o-to...)
Show SMILES Cc1ccccc1-c1cc([nH]n1)C1CCN(CC1)C(=O)CNC(=O)[C@H](N=C(N)N)C1CCCCC1
Show InChI InChI=1S/C26H37N7O2/c1-17-7-5-6-10-20(17)22-15-21(31-32-22)18-11-13-33(14-12-18)23(34)16-29-25(35)24(30-26(27)28)19-8-3-2-4-9-19/h5-7,10,15,18-19,24H,2-4,8-9,11-14,16H2,1H3,(H,29,35)(H,31,32)(H4,27,28,30)/t24-/m1/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50148002
PNG
(CHEMBL107685 | N-(2-{4-[5-(2-Chloro-4-methoxy-phen...)
Show SMILES COc1ccc(-c2cc([nH]n2)C2CCN(CC2)C(=O)CNC(=O)[C@H](N=C(N)N)C2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C26H36ClN7O3/c1-37-18-7-8-19(20(27)13-18)22-14-21(32-33-22)16-9-11-34(12-10-16)23(35)15-30-25(36)24(31-26(28)29)17-5-3-2-4-6-17/h7-8,13-14,16-17,24H,2-6,9-12,15H2,1H3,(H,30,36)(H,32,33)(H4,28,29,31)/t24-/m1/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147995
PNG
((S)-2-[2-((S)-2-Guanidino-3-methyl-butyrylamino)-a...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)[C@@H](N=C(N)N)C(C)C
Show InChI InChI=1S/C26H31N5O4/c1-17(2)23(31-26(27)28)24(33)29-16-22(32)30-21(25(34)35-3)15-20-13-11-19(12-14-20)10-9-18-7-5-4-6-8-18/h4-8,11-14,17,21,23H,15-16H2,1-3H3,(H,29,33)(H,30,32)(H4,27,28,31)/t21-,23-/m0/s1
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n/an/a 8.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147992
PNG
(2-(R)-Cyclohexyl-N-(2-{4-[5-(3,4-dichloro-phenyl)-...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C25H33Cl2N7O2/c26-18-7-6-17(12-19(18)27)21-13-20(32-33-21)15-8-10-34(11-9-15)22(35)14-30-24(36)23(31-25(28)29)16-4-2-1-3-5-16/h6-7,12-13,15-16,23H,1-5,8-11,14H2,(H,30,36)(H,32,33)(H4,28,29,31)/t23-/m1/s1
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n/an/a 1.10E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147976
PNG
(2-(R)-Cyclohexyl-2-guanidino-N-{2-oxo-2-[4-(5-phen...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1ccccc1
Show InChI InChI=1S/C25H35N7O2/c26-25(27)29-23(19-9-5-2-6-10-19)24(34)28-16-22(33)32-13-11-18(12-14-32)21-15-20(30-31-21)17-7-3-1-4-8-17/h1,3-4,7-8,15,18-19,23H,2,5-6,9-14,16H2,(H,28,34)(H,30,31)(H4,26,27,29)/t23-/m1/s1
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n/an/a 1.20E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147972
PNG
(2-(R)-Cyclohexyl-N-(2-{4-[5-(2,3-dimethyl-phenyl)-...)
Show SMILES Cc1cccc(-c2cc([nH]n2)C2CCN(CC2)C(=O)CNC(=O)[C@H](N=C(N)N)C2CCCCC2)c1C
Show InChI InChI=1S/C27H39N7O2/c1-17-7-6-10-21(18(17)2)23-15-22(32-33-23)19-11-13-34(14-12-19)24(35)16-30-26(36)25(31-27(28)29)20-8-4-3-5-9-20/h6-7,10,15,19-20,25H,3-5,8-9,11-14,16H2,1-2H3,(H,30,36)(H,32,33)(H4,28,29,31)/t25-/m1/s1
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n/an/a 1.30E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147994
PNG
(CHEMBL420283 | N-(2-{4-[5-(3-Chloro-phenyl)-2H-pyr...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1cccc(Cl)c1
Show InChI InChI=1S/C25H34ClN7O2/c26-19-8-4-7-18(13-19)21-14-20(31-32-21)16-9-11-33(12-10-16)22(34)15-29-24(35)23(30-25(27)28)17-5-2-1-3-6-17/h4,7-8,13-14,16-17,23H,1-3,5-6,9-12,15H2,(H,29,35)(H,31,32)(H4,27,28,30)/t23-/m1/s1
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n/an/a 1.30E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147990
PNG
(2-(R)-Cyclohexyl-2-guanidino-N-{2-oxo-2-[4-(5-m-to...)
Show SMILES Cc1cccc(c1)-c1cc([nH]n1)C1CCN(CC1)C(=O)CNC(=O)[C@H](N=C(N)N)C1CCCCC1
Show InChI InChI=1S/C26H37N7O2/c1-17-6-5-9-20(14-17)22-15-21(31-32-22)18-10-12-33(13-11-18)23(34)16-29-25(35)24(30-26(27)28)19-7-3-2-4-8-19/h5-6,9,14-15,18-19,24H,2-4,7-8,10-13,16H2,1H3,(H,29,35)(H,31,32)(H4,27,28,30)/t24-/m1/s1
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n/an/a 1.50E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147993
PNG
(2-Cyclohexyl-N-{2-[4-(2',4'-dichloro-biphenyl-3-yl...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cccc(c1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C28H35Cl2N5O2/c29-22-9-10-23(24(30)16-22)21-8-4-7-20(15-21)18-11-13-35(14-12-18)25(36)17-33-27(37)26(34-28(31)32)19-5-2-1-3-6-19/h4,7-10,15-16,18-19,26H,1-3,5-6,11-14,17H2,(H,33,37)(H4,31,32,34)/t26-/m1/s1
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n/an/a 1.50E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147991
PNG
((S)-2-[2-((S)-2-Guanidino-propionylamino)-acetylam...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)[C@H](C)N=C(N)N
Show InChI InChI=1S/C24H27N5O4/c1-16(28-24(25)26)22(31)27-15-21(30)29-20(23(32)33-2)14-19-12-10-18(11-13-19)9-8-17-6-4-3-5-7-17/h3-7,10-13,16,20H,14-15H2,1-2H3,(H,27,31)(H,29,30)(H4,25,26,28)/t16-,20-/m0/s1
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n/an/a 2.80E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147983
PNG
(2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-4-me...)
Show SMILES Cc1c([nH]nc1-c1cccc(Cl)c1Cl)C1CCN(CC1)C(=O)CNC(=O)[C@H](N=C(N)N)C1CCCCC1
Show InChI InChI=1S/C26H35Cl2N7O2/c1-15-22(33-34-23(15)18-8-5-9-19(27)21(18)28)17-10-12-35(13-11-17)20(36)14-31-25(37)24(32-26(29)30)16-6-3-2-4-7-16/h5,8-9,16-17,24H,2-4,6-7,10-14H2,1H3,(H,31,37)(H,33,34)(H4,29,30,32)/t24-/m1/s1
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n/an/a 4.00E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147977
PNG
(2-Cyclohexyl-N-(2-{4-[3-(2,4-dichloro-phenyl)-[1,2...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1nc(no1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H31Cl2N7O3/c25-16-6-7-17(18(26)12-16)21-31-23(36-32-21)15-8-10-33(11-9-15)19(34)13-29-22(35)20(30-24(27)28)14-4-2-1-3-5-14/h6-7,12,14-15,20H,1-5,8-11,13H2,(H,29,35)(H4,27,28,30)/t20-/m1/s1
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n/an/a 5.00E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147980
PNG
((S)-2-{2-[(1-Carbamimidoyl-pyrrolidine-2-carbonyl)...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(N)=N
Show InChI InChI=1S/C26H29N5O4/c1-35-25(34)21(30-23(32)17-29-24(33)22-8-5-15-31(22)26(27)28)16-20-13-11-19(12-14-20)10-9-18-6-3-2-4-7-18/h2-4,6-7,11-14,21-22H,5,8,15-17H2,1H3,(H3,27,28)(H,29,33)(H,30,32)/t21-,22-/m0/s1
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n/an/a 7.20E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147996
PNG
(2-[(S)-2-(4-Carbamoyl-2-guanidino-butyrylamino)-ac...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CCC(N)=O)N=C(N)N
Show InChI InChI=1S/C26H30N6O5/c1-37-25(36)21(15-19-11-9-18(10-12-19)8-7-17-5-3-2-4-6-17)31-23(34)16-30-24(35)20(32-26(28)29)13-14-22(27)33/h2-6,9-12,20-21H,13-16H2,1H3,(H2,27,33)(H,30,35)(H,31,34)(H4,28,29,32)/t20-,21+/m1/s1
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n/an/a 9.00E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147971
PNG
((S)-2-{2-[(1-Carbamimidoyl-pyrrolidine-2-carbonyl)...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)[C@H]1CCCN1C(N)=N
Show InChI InChI=1S/C26H29N5O4/c1-35-25(34)21(30-23(32)17-29-24(33)22-8-5-15-31(22)26(27)28)16-20-13-11-19(12-14-20)10-9-18-6-3-2-4-7-18/h2-4,6-7,11-14,21-22H,5,8,15-17H2,1H3,(H3,27,28)(H,29,33)(H,30,32)/t21-,22+/m0/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50148005
PNG
((S)-2-{2-[2-(N-Methyl-guanidino)-acetylamino]-acet...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)CN(C)C(N)=N
Show InChI InChI=1S/C24H27N5O4/c1-29(24(25)26)16-22(31)27-15-21(30)28-20(23(32)33-2)14-19-12-10-18(11-13-19)9-8-17-6-4-3-5-7-17/h3-7,10-13,20H,14-16H2,1-2H3,(H3,25,26)(H,27,31)(H,28,30)/t20-/m0/s1
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n/an/a 1.20E+6n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147978
PNG
((S)-2-[2-((R)-2-Guanidino-3-methyl-butyrylamino)-a...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)[C@H](N=C(N)N)C(C)C
Show InChI InChI=1S/C26H31N5O4/c1-17(2)23(31-26(27)28)24(33)29-16-22(32)30-21(25(34)35-3)15-20-13-11-19(12-14-20)10-9-18-7-5-4-6-8-18/h4-8,11-14,17,21,23H,15-16H2,1-3H3,(H,29,33)(H,30,32)(H4,27,28,31)/t21-,23+/m0/s1
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n/an/a>2.00E+6n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147988
PNG
((S)-2-[2-(2-Guanidino-acetylamino)-acetylamino]-3-...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)CNC(N)=N
Show InChI InChI=1S/C23H25N5O4/c1-32-22(31)19(28-21(30)15-26-20(29)14-27-23(24)25)13-18-11-9-17(10-12-18)8-7-16-5-3-2-4-6-16/h2-6,9-12,19H,13-15H2,1H3,(H,26,29)(H,28,30)(H4,24,25,27)/t19-/m0/s1
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n/an/a>2.00E+6n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse interleukin-2 alpha receptor by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50148007
PNG
((S)-2-(2-Methoxy-acetylamino)-3-(4-phenylethynyl-p...)
Show SMILES COCC(=O)N[C@@H](Cc1ccc(cc1)C#Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H19NO4/c1-25-14-19(22)21-18(20(23)24)13-17-11-9-16(10-12-17)8-7-15-5-3-2-4-6-15/h2-6,9-12,18H,13-14H2,1H3,(H,21,22)(H,23,24)/t18-/m0/s1
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n/an/a 2.20E+6n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Interleukin-2 receptor alpha


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50229786
PNG
(5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-P...)
Show SMILES CC(C)CC([NH+]=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(o2)C([O-])=O)c(Cl)c1Cl
Show InChI InChI=1S/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36)
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n/an/an/an/a 3n/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Effective concentration required against phosphorylation of Mammary gland factor/STAT5


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Mus musculus)
BDBM50147974
PNG
((S)-2-[2-((R)-1-Carbamimidoyl-piperidin-3-yl)-acet...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)C[C@H]1CCCN(C1)C(N)=N
Show InChI InChI=1S/C26H30N4O3/c1-33-25(32)23(29-24(31)17-22-8-5-15-30(18-22)26(27)28)16-21-13-11-20(12-14-21)10-9-19-6-3-2-4-7-19/h2-4,6-7,11-14,22-23H,5,8,15-18H2,1H3,(H3,27,28)(H,29,31)/t22-,23+/m1/s1
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n/an/an/an/a 1.00E+5n/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Effective concentration required against phosphorylation of Mammary gland factor/STAT5


Citation and Details
More data for this
Ligand-Target Pair