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Compile Data Set for Download or QSAR

Found 342 hits Enz. Inhib. hit(s) with Target = 'Interleukin-2 (IL-2)' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM50229786
PNG
(5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-P...)
Show SMILES CC(C)CC([NH+]=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(o2)C([O-])=O)c(Cl)c1Cl
Show InChI InChI=1S/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36)
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Article
PubMed
60n/an/an/an/an/an/an/an/a



University of California at San Francisco

Curated by ChEMBL


Assay Description
Binding affinity to IL2 assessed as inhibition of IL2-IL2Ralpha interaction


Nature 450: 1001-1009 (2007)


Article DOI: 10.1038/nature06526
BindingDB Entry DOI: 10.7270/Q24Q7VTV
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM128384
PNG
(US8802721, 1)
Show SMILES Fc1cccc(F)c1NC(=O)c1ccc(s1)-c1cc(ccc1Cl)C(F)(F)F
Show InChI InChI=1S/C18H9ClF5NOS/c19-11-5-4-9(18(22,23)24)8-10(11)14-6-7-15(27-14)17(26)25-16-12(20)2-1-3-13(16)21/h1-8H,(H,25,26)
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n/an/a 3n/an/an/an/an/an/a



Synta Pharmaceuticals Corp.

US Patent


Assay Description
Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...


US Patent US8802721 (2014)


BindingDB Entry DOI: 10.7270/Q2CN72M4
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM128386
PNG
(US8802721, 3)
Show SMILES COC(=O)c1ccc(C)c(c1)-c1ccc(s1)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C20H15F2NO3S/c1-11-6-7-12(20(25)26-2)10-13(11)16-8-9-17(27-16)19(24)23-18-14(21)4-3-5-15(18)22/h3-10H,1-2H3,(H,23,24)
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n/an/a 6.40n/an/an/an/an/an/a



Synta Pharmaceuticals Corp.

US Patent


Assay Description
Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...


US Patent US8802721 (2014)


BindingDB Entry DOI: 10.7270/Q2CN72M4
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM128385
PNG
(US8802721, 2)
Show SMILES Cc1cnccc1NC(=O)c1ccc(s1)-c1cc(ccc1Cl)C(F)(F)F
Show InChI InChI=1S/C18H12ClF3N2OS/c1-10-9-23-7-6-14(10)24-17(25)16-5-4-15(26-16)12-8-11(18(20,21)22)2-3-13(12)19/h2-9H,1H3,(H,23,24,25)
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n/an/a 14n/an/an/an/an/an/a



Synta Pharmaceuticals Corp.

US Patent


Assay Description
Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...


US Patent US8802721 (2014)


BindingDB Entry DOI: 10.7270/Q2CN72M4
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM128388
PNG
(US8802721, 117)
Show SMILES Fc1cccc(F)c1C(=O)Nc1ccc(s1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H10F5NOS/c19-12-5-2-6-13(20)16(12)17(25)24-15-8-7-14(26-15)10-3-1-4-11(9-10)18(21,22)23/h1-9H,(H,24,25)
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n/an/a 16.5n/an/an/an/an/an/a



Synta Pharmaceuticals Corp.

US Patent


Assay Description
Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...


US Patent US8802721 (2014)


BindingDB Entry DOI: 10.7270/Q2CN72M4
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM128387
PNG
(US8802721, 4)
Show SMILES COC(=O)c1ccc(C)c(c1)-c1ccc(s1)C(=O)Nc1ccncc1C
Show InChI InChI=1S/C20H18N2O3S/c1-12-4-5-14(20(24)25-3)10-15(12)17-6-7-18(26-17)19(23)22-16-8-9-21-11-13(16)2/h4-11H,1-3H3,(H,21,22,23)
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n/an/a 58.5n/an/an/an/an/an/a



Synta Pharmaceuticals Corp.

US Patent


Assay Description
Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...


US Patent US8802721 (2014)


BindingDB Entry DOI: 10.7270/Q2CN72M4
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM128391
PNG
(US8802721, 120)
Show SMILES COC(=O)c1cccc(c1)-c1sc(NC(=O)c2c(F)cccc2F)cc1C
Show InChI InChI=1S/C20H15F2NO3S/c1-11-9-16(23-19(24)17-14(21)7-4-8-15(17)22)27-18(11)12-5-3-6-13(10-12)20(25)26-2/h3-10H,1-2H3,(H,23,24)
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n/an/a 87n/an/an/an/an/an/a



Synta Pharmaceuticals Corp.

US Patent


Assay Description
Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...


US Patent US8802721 (2014)


BindingDB Entry DOI: 10.7270/Q2CN72M4
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM128390
PNG
(US8802721, 119)
Show SMILES Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)s1)-c1ncco1
Show InChI InChI=1S/C21H14F2N2O2S/c1-12-5-6-13(21-24-9-10-27-21)11-14(12)17-7-8-18(28-17)25-20(26)19-15(22)3-2-4-16(19)23/h2-11H,1H3,(H,25,26)
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n/an/a 94.8n/an/an/an/an/an/a



Synta Pharmaceuticals Corp.

US Patent


Assay Description
Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...


US Patent US8802721 (2014)


BindingDB Entry DOI: 10.7270/Q2CN72M4
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM128389
PNG
(US8802721, 118)
Show SMILES COC(=O)c1ccc(C)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)s1
Show InChI InChI=1S/C20H15F2NO3S/c1-11-6-7-12(20(25)26-2)10-13(11)16-8-9-17(27-16)23-19(24)18-14(21)4-3-5-15(18)22/h3-10H,1-2H3,(H,23,24)
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n/an/a 104n/an/an/an/an/an/a



Synta Pharmaceuticals Corp.

US Patent


Assay Description
Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...


US Patent US8802721 (2014)


BindingDB Entry DOI: 10.7270/Q2CN72M4
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM128392
PNG
(US8802721, 121)
Show SMILES Fc1cccc(F)c1C(=O)Nc1ccc(s1)-c1cccc(c1)-c1cnco1
Show InChI InChI=1S/C20H12F2N2O2S/c21-14-5-2-6-15(22)19(14)20(25)24-18-8-7-17(27-18)13-4-1-3-12(9-13)16-10-23-11-26-16/h1-11H,(H,24,25)
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n/an/a 164n/an/an/an/an/an/a



Synta Pharmaceuticals Corp.

US Patent


Assay Description
Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...


US Patent US8802721 (2014)


BindingDB Entry DOI: 10.7270/Q2CN72M4
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160829
PNG
(US9682976, 1 | US9682976, 102)
Show SMILES CC1(C)C[C@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F
Show InChI InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16+/m0/s1
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160830
PNG
(US9682976, 2)
Show SMILES CC1(C)C[C@@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F
Show InChI InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16-/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160831
PNG
(US9682976, 3)
Show SMILES CC1(C)C[C@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F
Show InChI InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16-/m0/s1
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n/an/an/an/a<1.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160833
PNG
(US9682976, 4)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F
Show InChI InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160834
PNG
(US9682976, 5)
Show SMILES CC1(C)CC(CC2CCCN12)Nc1nc(Nc2cc(F)c3OC(C)(C)c4nnnn4-c3c2)ncc1F
Show InChI InChI=1S/C24H29F2N9O/c1-23(2)11-14(8-15-6-5-7-34(15)23)28-20-17(26)12-27-22(30-20)29-13-9-16(25)19-18(10-13)35-21(31-32-33-35)24(3,4)36-19/h9-10,12,14-15H,5-8,11H2,1-4H3,(H2,27,28,29,30)
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160835
PNG
(US9682976, 6)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(NC3CC4CCCN4C(C)(C)C3)n2)cc1OC(F)F
Show InChI InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160836
PNG
(US9682976, 7)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F
Show InChI InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21+/m0/s1
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n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160837
PNG
(US9682976, 8)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F
Show InChI InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21-/m1/s1
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n/an/an/an/a<1.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160838
PNG
(US9682976, 9)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F
Show InChI InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21-/m0/s1
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160839
PNG
(US9682976, 10)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F
Show InChI InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160840
PNG
(US9682976, 11)
Show SMILES COc1cc(Nc2ncc(F)c(N[C@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C
Show InChI InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160842
PNG
(US9682976, 12)
Show SMILES COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C
Show InChI InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17-/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160843
PNG
(US9682976, 13)
Show SMILES COc1cc(Nc2ncc(F)c(N[C@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C
Show InChI InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17-/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160845
PNG
(US9682976, 14)
Show SMILES COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C
Show InChI InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160847
PNG
(US9682976, 15)
Show SMILES Cc1nnnn1-c1cc(Nc2ncc(F)c(NC3CC4CCCN4C(C)(C)C3)n2)cnc1C
Show InChI InChI=1S/C22H29FN10/c1-13-19(33-14(2)29-30-31-33)9-16(11-24-13)27-21-25-12-18(23)20(28-21)26-15-8-17-6-5-7-32(17)22(3,4)10-15/h9,11-12,15,17H,5-8,10H2,1-4H3,(H2,25,26,27,28)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM160848
PNG
(US9682976, 16)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161048
PNG
(US9682976, 17)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4C[C@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161049
PNG
(US9682976, 18)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16-/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161053
PNG
(US9682976, 19)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16-/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161054
PNG
(US9682976, 20 | US9682976, 21)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161054
PNG
(US9682976, 20 | US9682976, 21)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161068
PNG
(US9682976, 22)
Show SMILES COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O
Show InChI InChI=1S/C23H29F2N9O2/c1-23(2)11-13(8-14-6-5-7-33(14)23)27-20-16(25)12-26-21(29-20)28-17-10-18(19(36-4)9-15(17)24)34-22(35)32(3)30-31-34/h9-10,12-14H,5-8,11H2,1-4H3,(H2,26,27,28,29)/t13-,14+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161069
PNG
(US9682976, 23)
Show SMILES CC(C)Oc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O
Show InChI InChI=1S/C25H33F2N9O2/c1-14(2)38-21-10-17(26)19(11-20(21)36-24(37)34(5)32-33-36)30-23-28-13-18(27)22(31-23)29-15-9-16-7-6-8-35(16)25(3,4)12-15/h10-11,13-16H,6-9,12H2,1-5H3,(H2,28,29,30,31)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161070
PNG
(US9682976, 24)
Show SMILES Fc1cnc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)nc1NC1CCN2CCCC2C1
Show InChI InChI=1S/C22H25F2N9/c23-17-9-16(13-3-4-13)20(33-12-26-30-31-33)10-19(17)28-22-25-11-18(24)21(29-22)27-14-5-7-32-6-1-2-15(32)8-14/h9-15H,1-8H2,(H2,25,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161071
PNG
(US9682976, 25)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4CCN5C(CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16?/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161072
PNG
(US9682976, 26)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4CCN5C(CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16?/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161073
PNG
(US9682976, 27 | US9682976, 29)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CCN5CCCC5C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C23H27F2N9O/c1-32-23(35)34(31-30-32)20-11-19(17(24)10-16(20)13-4-5-13)28-22-26-12-18(25)21(29-22)27-14-6-8-33-7-2-3-15(33)9-14/h10-15H,2-9H2,1H3,(H2,26,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161074
PNG
(US9682976, 28)
Show SMILES Cc1nnnn1-c1cc(Nc2ncc(F)c(NC3CCN4CCCC4C3)n2)c(F)cc1C1CC1
Show InChI InChI=1S/C23H27F2N9/c1-13-30-31-32-34(13)21-11-20(18(24)10-17(21)14-4-5-14)28-23-26-12-19(25)22(29-23)27-15-6-8-33-7-2-3-16(33)9-15/h10-12,14-16H,2-9H2,1H3,(H2,26,27,28,29)
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161073
PNG
(US9682976, 27 | US9682976, 29)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CCN5CCCC5C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C23H27F2N9O/c1-32-23(35)34(31-30-32)20-11-19(17(24)10-16(20)13-4-5-13)28-22-26-12-18(25)21(29-22)27-14-6-8-33-7-2-3-15(33)9-14/h10-15H,2-9H2,1H3,(H2,26,27,28,29)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161076
PNG
(US9682976, 30)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCC(C)(C)N5C(=O)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H29F2N9O2/c1-25(2)7-6-15-8-14(9-21(37)35(15)25)29-22-18(27)12-28-23(31-22)30-19-11-20(36-24(38)34(3)32-33-36)16(10-17(19)26)13-4-5-13/h10-15H,4-9H2,1-3H3,(H2,28,29,30,31)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161077
PNG
(US9682976, 31)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCC(=O)N5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H29F2N9O2/c1-25(2)11-14(8-15-6-7-21(37)35(15)25)29-22-18(27)12-28-23(31-22)30-19-10-20(36-24(38)34(3)32-33-36)16(9-17(19)26)13-4-5-13/h9-10,12-15H,4-8,11H2,1-3H3,(H2,28,29,30,31)/t14-,15+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161078
PNG
(US9682976, 32)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4C[C@@H]5CCC(=O)N5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H29F2N9O2/c1-25(2)11-14(8-15-6-7-21(37)35(15)25)29-22-18(27)12-28-23(31-22)30-19-10-20(36-24(38)34(3)32-33-36)16(9-17(19)26)13-4-5-13/h9-10,12-15H,4-8,11H2,1-3H3,(H2,28,29,30,31)/t14-,15-/m0/s1
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n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161079
PNG
(US9682976, 33)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@H]5CCC(=O)N5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H29F2N9O2/c1-25(2)11-14(8-15-6-7-21(37)35(15)25)29-22-18(27)12-28-23(31-22)30-19-10-20(36-24(38)34(3)32-33-36)16(9-17(19)26)13-4-5-13/h9-10,12-15H,4-8,11H2,1-3H3,(H2,28,29,30,31)/t14-,15-/m1/s1
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n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161080
PNG
(US9682976, 34)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4CCN5[C@H](CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16-/m1/s1
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n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161081
PNG
(US9682976, 35)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4CCN5[C@H](CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m0/s1
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n/an/an/an/a<1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161082
PNG
(US9682976, 36)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4CCN5[C@@H](CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161083
PNG
(US9682976, 37)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4CCN5[C@@H](CCC5(C)C)C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)8-6-16-10-15(7-9-35(16)25)29-22-19(27)13-28-23(31-22)30-20-12-21(36-24(37)34(3)32-33-36)17(11-18(20)26)14-4-5-14/h11-16H,4-10H2,1-3H3,(H2,28,29,30,31)/t15-,16-/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161084
PNG
(US9682976, 38)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4CC5CCCN5C(C)(C)C4)n3)ccc2OC2COC2)c1=O
Show InChI InChI=1S/C25H32FN9O3/c1-25(2)11-16(9-17-5-4-8-34(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-21(38-18-13-37-14-18)20(10-15)35-24(36)33(3)31-32-35/h6-7,10,12,16-18H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)/t16-,17?/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161086
PNG
(US9682976, 39)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4CC5CCCN5C(C)(C)C4)n3)ccc2OC2COC2)c1=O
Show InChI InChI=1S/C25H32FN9O3/c1-25(2)11-16(9-17-5-4-8-34(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-21(38-18-13-37-14-18)20(10-15)35-24(36)33(3)31-32-35/h6-7,10,12,16-18H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)/t16-,17?/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2 (IL-2)


(Homo sapiens (Human))
BDBM161100
PNG
(US9682976, 40)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)ccc2OC2COC2)c1=O
Show InChI InChI=1S/C25H32FN9O3/c1-25(2)11-16(9-17-5-4-8-34(17)25)28-22-19(26)12-27-23(30-22)29-15-6-7-21(38-18-13-37-14-18)20(10-15)35-24(36)33(3)31-32-35/h6-7,10,12,16-18H,4-5,8-9,11,13-14H2,1-3H3,(H2,27,28,29,30)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...


US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
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