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Compile Data Set for Download or QSAR

Found 168 hits Enz. Inhib. hit(s) with Target = 'Intermediate conductance calcium-activated potassium channel protein 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kca 3.1 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4/Voltage-gated potassium channel beta subunit Mink/Voltage-gated potassium channel subunit Kv7.1


(Homo sapiens)
BDBM50099566
PNG
((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccccc1F
Show InChI InChI=1S/C20H15F2NO/c21-16-12-10-15(11-13-16)20(19(23)24,14-6-2-1-3-7-14)17-8-4-5-9-18(17)22/h1-13H,(H2,23,24)
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n/an/a 9n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Selectivity for gardos channel; (Gardos channel vs 2000 nM for the cardiac IKs channel).)


J Med Chem 44: 1627-53 (2001)


Article DOI: 10.1021/jm000484+
BindingDB Entry DOI: 10.7270/Q218376D
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50099566
PNG
((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccccc1F
Show InChI InChI=1S/C20H15F2NO/c21-16-12-10-15(11-13-16)20(19(23)24,14-6-2-1-3-7-14)17-8-4-5-9-18(17)22/h1-13H,(H2,23,24)
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n/an/a 9n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371390
PNG
(CHEMBL272039)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccccc1F
Show InChI InChI=1S/C20H14F3NO/c21-15-9-5-13(6-10-15)20(19(24)25,14-7-11-16(22)12-8-14)17-3-1-2-4-18(17)23/h1-12H,(H2,24,25)
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n/an/a 10n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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n/an/a 12n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371385
PNG
(CHEMBL260736)
Show SMILES NC(=O)C(c1cccc(F)c1)(c1cccc(F)c1)c1cccc(F)c1
Show InChI InChI=1S/C20H14F3NO/c21-16-7-1-4-13(10-16)20(19(24)25,14-5-2-8-17(22)11-14)15-6-3-9-18(23)12-15/h1-12H,(H2,24,25)
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n/an/a 13n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371388
PNG
(CHEMBL270704)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H14F3NO/c21-16-7-1-13(2-8-16)20(19(24)25,14-3-9-17(22)10-4-14)15-5-11-18(23)12-6-15/h1-12H,(H2,24,25)
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n/an/a 14n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371389
PNG
(CHEMBL272040)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C20H15F2NO/c21-17-12-11-16(13-18(17)22)20(19(23)24,14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13H,(H2,23,24)
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n/an/a 14n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371384
PNG
(CHEMBL270071)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1F
Show InChI InChI=1S/C20H16FNO/c21-18-14-8-7-13-17(18)20(19(22)23,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,(H2,22,23)
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n/an/a 15n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371382
PNG
(CHEMBL408700)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1cccc(F)c1)c1cccc(F)c1
Show InChI InChI=1S/C20H14F3NO/c21-16-9-7-13(8-10-16)20(19(24)25,14-3-1-5-17(22)11-14)15-4-2-6-18(23)12-15/h1-12H,(H2,24,25)
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n/an/a 15n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371395
PNG
(CHEMBL273092)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccccc1F)c1ccccc1F
Show InChI InChI=1S/C20H14F3NO/c21-14-11-9-13(10-12-14)20(19(24)25,15-5-1-3-7-17(15)22)16-6-2-4-8-18(16)23/h1-12H,(H2,24,25)
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n/an/a 15n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205030
PNG
(US9556132, 7 | process for preparing 2-(2-{2-[1-(2...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1OCC#N
Show InChI InChI=1S/C21H14FN5O/c22-18-10-4-5-11-19(18)27-21(24-25-26-27)17-9-2-1-7-15(17)16-8-3-6-12-20(16)28-14-13-23/h1-12H,14H2
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n/an/a 16n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205069
PNG
(US9556132, 33 | process for preparing 5-{2-[2-(flu...)
Show SMILES FCc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H14F2N4/c21-13-14-7-1-2-8-15(14)16-9-3-4-10-17(16)20-23-24-25-26(20)19-12-6-5-11-18(19)22/h1-12H,13H2
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n/an/a 17n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371386
PNG
(CHEMBL260953)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1cccc(F)c1
Show InChI InChI=1S/C20H14F3NO/c21-16-8-4-13(5-9-16)20(19(24)25,14-6-10-17(22)11-7-14)15-2-1-3-18(23)12-15/h1-12H,(H2,24,25)
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n/an/a 17n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50279107
PNG
(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
Show InChI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
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n/an/a 20n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.077
BindingDB Entry DOI: 10.7270/Q29K4B38
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50279107
PNG
(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
Show InChI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
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n/an/a 20n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of IK1 (unknown origin)


Bioorg Med Chem Lett 19: 2299-304 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.077
BindingDB Entry DOI: 10.7270/Q29K4B38
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371377
PNG
(CHEMBL406683)
Show SMILES NC(c1ccccc1)(c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C19H16ClN/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,21H2
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n/an/a 20n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371387
PNG
(CHEMBL261606)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1F)c1ccccc1F
Show InChI InChI=1S/C20H15F2NO/c21-17-12-6-4-10-15(17)20(19(23)24,14-8-2-1-3-9-14)16-11-5-7-13-18(16)22/h1-13H,(H2,23,24)
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n/an/a 30n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205019
PNG
(US9556132, 4 | process for preparing 1-(2-fluoroph...)
Show SMILES COCCOc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C22H19FN4O2/c1-28-14-15-29-21-13-7-4-9-17(21)16-8-2-3-10-18(16)22-24-25-26-27(22)20-12-6-5-11-19(20)23/h2-13H,14-15H2,1H3
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n/an/a 30n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371383
PNG
(CHEMBL261828)
Show SMILES NC(=O)C(c1ccccc1)(c1cccc(F)c1)c1cccc(F)c1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-4-8-15(12-17)20(19(23)24,14-6-2-1-3-7-14)16-9-5-11-18(22)13-16/h1-13H,(H2,23,24)
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n/an/a 30n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371396
PNG
(CHEMBL270913)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)cc1F
Show InChI InChI=1S/C20H15F2NO/c21-16-11-12-17(18(22)13-16)20(19(23)24,14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13H,(H2,23,24)
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n/an/a 34n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205016
PNG
(US9556132, 3 | process for preparing 5-[2-(2-ethox...)
Show SMILES CCOc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4O/c1-2-27-20-14-8-5-10-16(20)15-9-3-4-11-17(15)21-23-24-25-26(21)19-13-7-6-12-18(19)22/h3-14H,2H2,1H3
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n/an/a 37n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200905
PNG
(US9533999, i-39)
Show SMILES Fc1ccc(CN2c3sccc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-10(9)23-14(16,17)18)6-19-12(20)7-25(21,22)11-3-4-24-13(11)19/h1-5H,6-7H2
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n/an/a 39n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019902
PNG
(CHEMBL3287207)
Show SMILES CC(N1c2sccc2S(=O)(=O)CC1=O)c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C15H11F4NO4S2/c1-8(9-2-3-10(16)11(6-9)24-15(17,18)19)20-13(21)7-26(22,23)12-4-5-25-14(12)20/h2-6,8H,7H2,1H3
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n/an/a 39n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371394
PNG
(CHEMBL258604)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H16FNO/c21-18-13-11-17(12-14-18)20(19(22)23,15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-14H,(H2,22,23)
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n/an/a 40n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019905
PNG
(CHEMBL3287210 | US9533999, ii-4)
Show SMILES CC(N1C(=O)CSc2cccnc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N2OS/c1-10(11-4-2-5-12(8-11)16(17,18)19)21-14(22)9-23-13-6-3-7-20-15(13)21/h2-8,10H,9H2,1H3
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n/an/a 41n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019905
PNG
(CHEMBL3287210 | US9533999, ii-4)
Show SMILES CC(N1C(=O)CSc2cccnc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N2OS/c1-10(11-4-2-5-12(8-11)16(17,18)19)21-14(22)9-23-13-6-3-7-20-15(13)21/h2-8,10H,9H2,1H3
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n/an/a 41n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200937
PNG
(US9533999, ii-5)
Show SMILES FC(F)(F)c1cc(CN2C(=O)CSc3cccnc23)ccc1Cl
Show InChI InChI=1S/C15H10ClF3N2OS/c16-11-4-3-9(6-10(11)15(17,18)19)7-21-13(22)8-23-12-2-1-5-20-14(12)21/h1-6H,7-8H2
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n/an/a 46n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200946
PNG
(US9533999, ii-8)
Show SMILES FC(F)(F)S(=O)(=O)c1cc(CN2C(=O)CSc3cccnc23)ccc1Cl
Show InChI InChI=1S/C15H10ClF3N2O3S2/c16-10-4-3-9(6-12(10)26(23,24)15(17,18)19)7-21-13(22)8-25-11-2-1-5-20-14(11)21/h1-6H,7-8H2
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n/an/a 47n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019903
PNG
(CHEMBL3287208 | US9533999, i-40)
Show SMILES Fc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-11(9)23-14(16,17)18)6-19-10-3-4-24-13(10)25(21,22)7-12(19)20/h1-5H,6-7H2
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n/an/a 48n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019903
PNG
(CHEMBL3287208 | US9533999, i-40)
Show SMILES Fc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-11(9)23-14(16,17)18)6-19-10-3-4-24-13(10)25(21,22)7-12(19)20/h1-5H,6-7H2
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n/an/a 48n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019900
PNG
(CHEMBL3287205 | US9533999, i-5)
Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3cccnc23)cc1OC(F)(F)F
Show InChI InChI=1S/C15H10F4N2O4S/c16-10-4-3-9(6-11(10)25-15(17,18)19)7-21-13(22)8-26(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2
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n/an/a 49n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019900
PNG
(CHEMBL3287205 | US9533999, i-5)
Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3cccnc23)cc1OC(F)(F)F
Show InChI InChI=1S/C15H10F4N2O4S/c16-10-4-3-9(6-11(10)25-15(17,18)19)7-21-13(22)8-26(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2
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n/an/a 49n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200942
PNG
(US9533999, ii-7)
Show SMILES FC(F)(F)Sc1cc(CN2C(=O)CSc3cccnc23)ccc1Cl
Show InChI InChI=1S/C15H10ClF3N2OS2/c16-10-4-3-9(6-12(10)24-15(17,18)19)7-21-13(22)8-23-11-2-1-5-20-14(11)21/h1-6H,7-8H2
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n/an/a 52n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019904
PNG
(CHEMBL3287209 | US9533999, ii-1)
Show SMILES FC(F)(F)Oc1cccc(CN2C(=O)CSc3cccnc23)c1
Show InChI InChI=1S/C15H11F3N2O2S/c16-15(17,18)22-11-4-1-3-10(7-11)8-20-13(21)9-23-12-5-2-6-19-14(12)20/h1-7H,8-9H2
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n/an/a 52n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019904
PNG
(CHEMBL3287209 | US9533999, ii-1)
Show SMILES FC(F)(F)Oc1cccc(CN2C(=O)CSc3cccnc23)c1
Show InChI InChI=1S/C15H11F3N2O2S/c16-15(17,18)22-11-4-1-3-10(7-11)8-20-13(21)9-23-12-5-2-6-19-14(12)20/h1-7H,8-9H2
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n/an/a 52n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205066
PNG
(US9556132, 30 | process for preparing (e)-n-[(2-{2...)
Show SMILES O\N=C/c1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H14FN5O/c21-18-11-5-6-12-19(18)26-20(23-24-25-26)17-10-4-3-9-16(17)15-8-2-1-7-14(15)13-22-27/h1-13,27H/b22-13-
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n/an/a 57n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205065
PNG
(US9556132, 29 | process for preparing 1-(2-fluorop...)
Show SMILES COCc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4O/c1-27-14-15-8-2-3-9-16(15)17-10-4-5-11-18(17)21-23-24-25-26(21)20-13-7-6-12-19(20)22/h2-13H,14H2,1H3
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n/an/a 58n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019907
PNG
(CHEMBL3287212)
Show SMILES CC(N1c2scnc2SCC1=O)c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C14H10F4N2O2S2/c1-7(20-11(21)5-23-12-13(20)24-6-19-12)8-2-3-9(15)10(4-8)22-14(16,17)18/h2-4,6-7H,5H2,1H3
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n/an/a 60n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200966
PNG
(US9533999, ii-17)
Show SMILES Fc1ccc(CN2c3scnc3SCC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C13H8F4N2O2S2/c14-8-2-1-7(3-9(8)21-13(15,16)17)4-19-10(20)5-22-11-12(19)23-6-18-11/h1-3,6H,4-5H2
PDB

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n/an/a 60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205077
PNG
(US9556132, 56 | process for preparing 2-{5-[2-(2-m...)
Show SMILES COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1C#N
Show InChI InChI=1S/C21H15N5O/c1-27-20-13-7-5-10-17(20)16-9-3-4-11-18(16)21-23-24-25-26(21)19-12-6-2-8-15(19)14-22/h2-13H,1H3
PDB

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n/an/a 64n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019906
PNG
(CHEMBL3287211 | US9533999, ii-11)
Show SMILES OCc1ccc2SCC(=O)N(Cc3ccc(Cl)c(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C16H12ClF3N2O2S/c17-12-3-1-9(5-11(12)16(18,19)20)6-22-14(24)8-25-13-4-2-10(7-23)21-15(13)22/h1-5,23H,6-8H2
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n/an/a 66n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019906
PNG
(CHEMBL3287211 | US9533999, ii-11)
Show SMILES OCc1ccc2SCC(=O)N(Cc3ccc(Cl)c(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C16H12ClF3N2O2S/c17-12-3-1-9(5-11(12)16(18,19)20)6-22-14(24)8-25-13-4-2-10(7-23)21-15(13)22/h1-5,23H,6-8H2
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n/an/a 66n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200973
PNG
(US9533999, ii-23)
Show SMILES CC(N1c2nc(C)sc2SCC1=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N2OS2/c1-8(10-4-3-5-11(6-10)15(16,17)18)20-12(21)7-22-14-13(20)19-9(2)23-14/h3-6,8H,7H2,1-2H3
PDB

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n/an/a 67n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205079
PNG
(US9556132, 59 | process for preparing 1-[2-(difluo...)
Show SMILES COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1OC(F)F
Show InChI InChI=1S/C21H16F2N4O2/c1-28-18-12-6-4-9-15(18)14-8-2-3-10-16(14)20-24-25-26-27(20)17-11-5-7-13-19(17)29-21(22)23/h2-13,21H,1H3
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n/an/a 69n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM31774
PNG
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
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n/an/a 70n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.077
BindingDB Entry DOI: 10.7270/Q29K4B38
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM31774
PNG
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
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n/an/a 70n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of IK1 (unknown origin)


Bioorg Med Chem Lett 19: 2299-304 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.077
BindingDB Entry DOI: 10.7270/Q29K4B38
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM23786
PNG
(Triphenylmethyl-containing compound, 15 | tripheny...)
Show SMILES NC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H17N/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H,20H2
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n/an/a 70n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
BindingDB Entry DOI: 10.7270/Q23F4QGH
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200904
PNG
(US9533999, i-38)
Show SMILES CC(N1c2sccc2S(=O)(=O)CC1=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H12F3NO3S2/c1-9(10-3-2-4-11(7-10)15(16,17)18)19-13(20)8-24(21,22)12-5-6-23-14(12)19/h2-7,9H,8H2,1H3
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n/an/a 71n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200971
PNG
(US9533999, ii-22)
Show SMILES Cc1nc2N(Cc3cccc(c3)C(F)(F)F)C(=O)CSc2s1
Show InChI InChI=1S/C14H11F3N2OS2/c1-8-18-12-13(22-8)21-7-11(20)19(12)6-9-3-2-4-10(5-9)14(15,16)17/h2-5H,6-7H2,1H3
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n/an/a 73n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)


BindingDB Entry DOI: 10.7270/Q21V5C4S
More data for this
Ligand-Target Pair
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