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Compile Data Set for Download or QSAR

Found 62 hits Enz. Inhib. hit(s) with Target = 'Intermediate conductance calcium-activated potassium channel protein 4' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kca 3.1 (unknown origin)


J Med Chem 56: 593-624 (2013)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50099566
PNG
((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccccc1F
Show InChI InChI=1S/C20H15F2NO/c21-16-12-10-15(11-13-16)20(19(23)24,14-6-2-1-3-7-14)17-8-4-5-9-18(17)22/h1-13H,(H2,23,24)
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n/an/a 9n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371390
PNG
(CHEMBL272039)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccccc1F
Show InChI InChI=1S/C20H14F3NO/c21-15-9-5-13(6-10-15)20(19(24)25,14-7-11-16(22)12-8-14)17-3-1-2-4-18(17)23/h1-12H,(H2,24,25)
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n/an/a 10n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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n/an/a 12n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371385
PNG
(CHEMBL260736)
Show SMILES NC(=O)C(c1cccc(F)c1)(c1cccc(F)c1)c1cccc(F)c1
Show InChI InChI=1S/C20H14F3NO/c21-16-7-1-4-13(10-16)20(19(24)25,14-5-2-8-17(22)11-14)15-6-3-9-18(23)12-15/h1-12H,(H2,24,25)
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n/an/a 13n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371389
PNG
(CHEMBL272040)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C20H15F2NO/c21-17-12-11-16(13-18(17)22)20(19(23)24,14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13H,(H2,23,24)
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n/an/a 14n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371388
PNG
(CHEMBL270704)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H14F3NO/c21-16-7-1-13(2-8-16)20(19(24)25,14-3-9-17(22)10-4-14)15-5-11-18(23)12-6-15/h1-12H,(H2,24,25)
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n/an/a 14n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371395
PNG
(CHEMBL273092)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccccc1F)c1ccccc1F
Show InChI InChI=1S/C20H14F3NO/c21-14-11-9-13(10-12-14)20(19(24)25,15-5-1-3-7-17(15)22)16-6-2-4-8-18(16)23/h1-12H,(H2,24,25)
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n/an/a 15n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371382
PNG
(CHEMBL408700)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1cccc(F)c1)c1cccc(F)c1
Show InChI InChI=1S/C20H14F3NO/c21-16-9-7-13(8-10-16)20(19(24)25,14-3-1-5-17(22)11-14)15-4-2-6-18(23)12-15/h1-12H,(H2,24,25)
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n/an/a 15n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371384
PNG
(CHEMBL270071)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1F
Show InChI InChI=1S/C20H16FNO/c21-18-14-8-7-13-17(18)20(19(22)23,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,(H2,22,23)
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n/an/a 15n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371386
PNG
(CHEMBL260953)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1cccc(F)c1
Show InChI InChI=1S/C20H14F3NO/c21-16-8-4-13(5-9-16)20(19(24)25,14-6-10-17(22)11-7-14)15-2-1-3-18(23)12-15/h1-12H,(H2,24,25)
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n/an/a 17n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50279107
PNG
(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
Show InChI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
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n/an/a 20n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of IK1 (unknown origin)


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371377
PNG
(CHEMBL406683)
Show SMILES NC(c1ccccc1)(c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C19H16ClN/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,21H2
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n/an/a 20n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50279107
PNG
(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
Show InChI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
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n/an/a 20n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371387
PNG
(CHEMBL261606)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1F)c1ccccc1F
Show InChI InChI=1S/C20H15F2NO/c21-17-12-6-4-10-15(17)20(19(23)24,14-8-2-1-3-9-14)16-11-5-7-13-18(16)22/h1-13H,(H2,23,24)
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n/an/a 30n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371383
PNG
(CHEMBL261828)
Show SMILES NC(=O)C(c1ccccc1)(c1cccc(F)c1)c1cccc(F)c1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-4-8-15(12-17)20(19(23)24,14-6-2-1-3-7-14)16-9-5-11-18(22)13-16/h1-13H,(H2,23,24)
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n/an/a 30n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371396
PNG
(CHEMBL270913)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)cc1F
Show InChI InChI=1S/C20H15F2NO/c21-16-11-12-17(18(22)13-16)20(19(23)24,14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13H,(H2,23,24)
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n/an/a 34n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019902
PNG
(CHEMBL3287207)
Show SMILES CC(N1c2sccc2S(=O)(=O)CC1=O)c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C15H11F4NO4S2/c1-8(9-2-3-10(16)11(6-9)24-15(17,18)19)20-13(21)7-26(22,23)12-4-5-25-14(12)20/h2-6,8H,7H2,1H3
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n/an/a 39n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371394
PNG
(CHEMBL258604)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H16FNO/c21-18-13-11-17(12-14-18)20(19(22)23,15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-14H,(H2,22,23)
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n/an/a 40n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019905
PNG
(CHEMBL3287210)
Show SMILES CC(N1C(=O)CSc2cccnc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N2OS/c1-10(11-4-2-5-12(8-11)16(17,18)19)21-14(22)9-23-13-6-3-7-20-15(13)21/h2-8,10H,9H2,1H3
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n/an/a 41n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019903
PNG
(CHEMBL3287208)
Show SMILES Fc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-11(9)23-14(16,17)18)6-19-10-3-4-24-13(10)25(21,22)7-12(19)20/h1-5H,6-7H2
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n/an/a 48n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019900
PNG
(CHEMBL3287205)
Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3cccnc23)cc1OC(F)(F)F
Show InChI InChI=1S/C15H10F4N2O4S/c16-10-4-3-9(6-11(10)25-15(17,18)19)7-21-13(22)8-26(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2
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n/an/a 49n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019904
PNG
(CHEMBL3287209)
Show SMILES FC(F)(F)Oc1cccc(CN2C(=O)CSc3cccnc23)c1
Show InChI InChI=1S/C15H11F3N2O2S/c16-15(17,18)22-11-4-1-3-10(7-11)8-20-13(21)9-23-12-5-2-6-19-14(12)20/h1-7H,8-9H2
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n/an/a 52n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019907
PNG
(CHEMBL3287212)
Show SMILES CC(N1c2scnc2SCC1=O)c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C14H10F4N2O2S2/c1-7(20-11(21)5-23-12-13(20)24-6-19-12)8-2-3-9(15)10(4-8)22-14(16,17)18/h2-4,6-7H,5H2,1H3
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n/an/a 60n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019906
PNG
(CHEMBL3287211)
Show SMILES OCc1ccc2SCC(=O)N(Cc3ccc(Cl)c(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C16H12ClF3N2O2S/c17-12-3-1-9(5-11(12)16(18,19)20)6-22-14(24)8-25-13-4-2-10(7-23)21-15(13)22/h1-5,23H,6-8H2
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n/an/a 66n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM31774
PNG
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
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n/an/a 70n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of IK1 (unknown origin)


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM31774
PNG
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
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n/an/a 70n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM23786
PNG
(Triphenylmethyl-containing compound, 15 | tripheny...)
Show SMILES NC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H17N/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H,20H2
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n/an/a 70n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019901
PNG
(CHEMBL3287206)
Show SMILES CC(C)c1nc2N(Cc3ccc(F)c(OC(F)(F)F)c3)C(=O)CS(=O)(=O)c2s1
Show InChI InChI=1S/C16H14F4N2O4S2/c1-8(2)14-21-13-15(27-14)28(24,25)7-12(23)22(13)6-9-3-4-10(17)11(5-9)26-16(18,19)20/h3-5,8H,6-7H2,1-2H3
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n/an/a 96n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371380
PNG
(CHEMBL270495)
Show SMILES COC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H18O2/c1-23-20(22)21(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19/h2-16H,1H3
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n/an/a 330n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM31774
PNG
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
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n/an/a 360n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50425111
PNG
(CHEMBL2312926 | Rac-3-((Diphenylphosphoryl)(Phenyl...)
Show SMILES O=P(C(c1ccccc1)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H20NOP/c26-27(22-14-6-2-7-15-22,23-16-8-3-9-17-23)24(20-11-4-1-5-12-20)21-13-10-18-25-19-21/h1-19,24H
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n/an/a 500n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of IK channel (unknown origin)


Bioorg Med Chem Lett 23: 706-10 (2013)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371379
PNG
(CHEMBL270288)
Show SMILES CNC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H19N/c1-21-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19/h2-16,21H,1H3
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n/an/a 550n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50425112
PNG
(3,3''-((Diphenylphosphoryl)Methylene)Dipyridine | ...)
Show SMILES O=P(C(c1cccnc1)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H19N2OP/c26-27(21-11-3-1-4-12-21,22-13-5-2-6-14-22)23(19-9-7-15-24-17-19)20-10-8-16-25-18-20/h1-18,23H
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n/an/a 1.00E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of IK channel (unknown origin)


Bioorg Med Chem Lett 23: 706-10 (2013)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50279105
PNG
(5-(3-chlorobenzoyl)-5H-dibenzo[b,d]azepin-7(6H)-on...)
Show SMILES Clc1cccc(c1)C(=O)N1CC(=O)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C21H14ClNO2/c22-15-7-5-6-14(12-15)21(25)23-13-20(24)18-10-2-1-8-16(18)17-9-3-4-11-19(17)23/h1-12H,13H2
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n/an/a 1.30E+3n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50279065
PNG
(5-(4-chlorophenylsulfonyl)-5H-dibenzo[b,d]azepin-7...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C20H14ClNO3S/c21-14-9-11-15(12-10-14)26(24,25)22-13-20(23)18-7-2-1-5-16(18)17-6-3-4-8-19(17)22/h1-12H,13H2
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n/an/a 1.40E+3n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371392
PNG
(CHEMBL260107)
Show SMILES CCNC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H21N/c1-2-22-21(18-12-6-3-7-13-18,19-14-8-4-9-15-19)20-16-10-5-11-17-20/h3-17,22H,2H2,1H3
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n/an/a 1.75E+3n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50425110
PNG
(CHEMBL2312927)
Show SMILES O=P(C(N1CCCCC1)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25N2OP/c26-27(21-12-4-1-5-13-21,22-14-6-2-7-15-22)23(20-11-10-16-24-19-20)25-17-8-3-9-18-25/h1-2,4-7,10-16,19,23H,3,8-9,17-18H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of IK channel (unknown origin)


Bioorg Med Chem Lett 23: 706-10 (2013)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50279063
PNG
(5-tosyl-5H-dibenzo[b,d]azepin-7(6H)-one | CHEMBL49...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CC(=O)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C21H17NO3S/c1-15-10-12-16(13-11-15)26(24,25)22-14-21(23)19-8-3-2-6-17(19)18-7-4-5-9-20(18)22/h2-13H,14H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50279103
PNG
(5-(thiophen-2-ylsulfonyl)-5H-dibenzo[b,d]azepin-7(...)
Show SMILES O=C1CN(c2ccccc2-c2ccccc12)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C18H13NO3S2/c20-17-12-19(24(21,22)18-10-5-11-23-18)16-9-4-3-7-14(16)13-6-1-2-8-15(13)17/h1-11H,12H2
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n/an/a 2.40E+3n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50425094
PNG
(CHEMBL2312920)
Show SMILES CCCN(c1cccc(c1)C#N)P(=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H21N2OP/c1-2-16-24(20-11-9-10-19(17-20)18-23)26(25,21-12-5-3-6-13-21)22-14-7-4-8-15-22/h3-15,17H,2,16H2,1H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of IK channel (unknown origin)


Bioorg Med Chem Lett 23: 706-10 (2013)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371378
PNG
(CHEMBL259899)
Show SMILES CN(C)C(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H21N/c1-22(2)21(18-12-6-3-7-13-18,19-14-8-4-9-15-19)20-16-10-5-11-17-20/h3-17H,1-2H3
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n/an/a 3.15E+3n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371381
PNG
(CHEMBL271167)
Show SMILES C1CN=C(O1)C(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H19NO/c1-4-10-18(11-5-1)22(21-23-16-17-24-21,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15H,16-17H2
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n/an/a 4.30E+3n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50425108
PNG
(CHEMBL2312929)
Show SMILES Clc1cccc(c1)-c1ncccc1CNP(=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H20ClN2OP/c25-21-11-7-9-19(17-21)24-20(10-8-16-26-24)18-27-29(28,22-12-3-1-4-13-22)23-14-5-2-6-15-23/h1-17H,18H2,(H,27,28)
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n/an/a 4.90E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of IK channel (unknown origin)


Bioorg Med Chem Lett 23: 706-10 (2013)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50425107
PNG
(CHEMBL2312930)
Show SMILES O=P(NCc1cccnc1-c1cccc(c1)C#N)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H20N3OP/c26-18-20-9-7-10-21(17-20)25-22(11-8-16-27-25)19-28-30(29,23-12-3-1-4-13-23)24-14-5-2-6-15-24/h1-17H,19H2,(H,28,29)
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n/an/a 7.70E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of IK channel (unknown origin)


Bioorg Med Chem Lett 23: 706-10 (2013)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50425091
PNG
(CHEMBL2312923)
Show SMILES Fc1ccc(c(NP(=O)(c2ccccc2)c2ccccc2)c1)-n1cccn1
Show InChI InChI=1S/C21H17FN3OP/c22-17-12-13-21(25-15-7-14-23-25)20(16-17)24-27(26,18-8-3-1-4-9-18)19-10-5-2-6-11-19/h1-16H,(H,24,26)
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n/an/a 7.80E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of IK channel (unknown origin)


Bioorg Med Chem Lett 23: 706-10 (2013)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50279106
PNG
(4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | ...)
Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1
Show InChI InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371393
PNG
(CHEMBL271207)
Show SMILES OC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H16O2/c21-19(22)20(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H,(H,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50425101
PNG
(CHEMBL2313226)
Show SMILES O=P(N(Cc1ccccn1)c1cccnc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H20N3OP/c27-28(22-12-3-1-4-13-22,23-14-5-2-6-15-23)26(21-11-9-16-24-18-21)19-20-10-7-8-17-25-20/h1-18H,19H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of IK channel (unknown origin)


Bioorg Med Chem Lett 23: 706-10 (2013)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of gardos channel (unknown origin)


J Med Chem 56: 593-624 (2013)

More data for this
Ligand-Target Pair
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