BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Inward rectifier potassium channel 4' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inward rectifier potassium channel 4


(Homo sapiens)
BDBM50426568
PNG
(CHEMBL2324345)
Show SMILES OC(CN1CCOCC1)Cn1c2ccccc2n(Cc2ccccc2)c1=N
Show InChI InChI=1S/C21H26N4O2/c22-21-24(14-17-6-2-1-3-7-17)19-8-4-5-9-20(19)25(21)16-18(26)15-23-10-12-27-13-11-23/h1-9,18,22,26H,10-16H2
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 2.40E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kir2.3 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Inward rectifier potassium channel 4


(Homo sapiens)
BDBM162872
PNG
(US9056859, 72)
Show SMILES Cc1c2COC(=O)c2ccc1CCN1CCN(CC1)C(=O)Cc1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C23H25N7O3/c1-16-18(3-4-19-20(16)14-33-23(19)32)6-7-28-8-10-29(11-9-28)22(31)12-17-2-5-21(24-13-17)30-15-25-26-27-30/h2-5,13,15H,6-12,14H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kir2.3 (unknown origin)


Bioorg Med Chem Lett 26: 2339-43 (2016)

More data for this
Ligand-Target Pair
Inward rectifier potassium channel 4


(Homo sapiens)
BDBM50442600
PNG
(CHEMBL2441437 | US9056859, 1)
Show SMILES O=C(Cc1ccc(cc1)-n1cnnn1)N1CCN(CCc2ccc3C(=O)OCc3c2)CC1
Show InChI InChI=1S/C23H24N6O3/c30-22(14-17-1-4-20(5-2-17)29-16-24-25-26-29)28-11-9-27(10-12-28)8-7-18-3-6-21-19(13-18)15-32-23(21)31/h1-6,13,16H,7-12,14-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kir2.3 channel (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Inward rectifier potassium channel 4


(Homo sapiens)
BDBM155928
PNG
(US9018211, 52)
Show SMILES COc1cc(ncc1C#N)[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1
Show InChI InChI=1/C24H28N4O5/c1-15-17(3-4-18-19(15)14-33-24(18)31)21(29)12-27-5-7-28(8-6-27)13-22(30)20-9-23(32-2)16(10-25)11-26-20/h3-4,9,11,21-22,29-30H,5-8,12-14H2,1-2H3/t21-,22-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kir2.3 potassium channel (unknown origin)


ACS Med Chem Lett 6: 747-52 (2015)

More data for this
Ligand-Target Pair
Inward rectifier potassium channel 4


(Homo sapiens)
BDBM50391770
PNG
(CHEMBL2146755 | US9073882, 1)
Show SMILES [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)[N+]([O-])=O)CC2)cc1
Show InChI InChI=1S/C20H24N4O4/c25-23(26)19-5-1-17(2-6-19)9-11-21-13-15-22(16-14-21)12-10-18-3-7-20(8-4-18)24(27)28/h1-8H,9-16H2
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human Kir2.3 expressed in CHO cells assessed as inhibition of 86Rb+ efflux


Citation and Details
More data for this
Ligand-Target Pair
Inward rectifier potassium channel 4


(Homo sapiens)
BDBM50391771
PNG
(CHEMBL2146754)
Show SMILES [O-][N+](=O)c1ccc(CCN2CCNCC2)cc1
Show InChI InChI=1S/C12H17N3O2/c16-15(17)12-3-1-11(2-4-12)5-8-14-9-6-13-7-10-14/h1-4,13H,5-10H2
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human Kir2.3 expressed in CHO cells assessed as inhibition of 86Rb+ efflux


Citation and Details
More data for this
Ligand-Target Pair