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Compile Data Set for Download or QSAR

Found 221 hits Enz. Inhib. hit(s) with Target = 'Ionotropic glutamate receptor kainate 2/5' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50060627
PNG
((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...)
Show SMILES N[C@@H](Cn1cc(I)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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0.240n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50060630
PNG
((S)-2-Amino-3-(6-bromo-3,5-dioxo-4,5-dihydro-3H-[1...)
Show SMILES N[C@@H](Cn1nc(Br)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H7BrN4O4/c7-3-4(12)9-6(15)11(10-3)1-2(8)5(13)14/h2H,1,8H2,(H,13,14)(H,9,12,15)/t2-/m0/s1
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2.90n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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8n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50060636
PNG
((S)-2-Amino-3-(5-bromo-2,4-dioxo-3,4-dihydro-2H-py...)
Show SMILES N[C@@H](Cn1cc(Br)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8BrN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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9.10n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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10n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053058
PNG
((4E,6E)-(R)-7-[4,5-Bis-(1-hydroxy-vinyl)-pyrrolidi...)
Show SMILES C[C@H](C=CC=C(C)C1CNC(C1C(C)=O)C(C)=O)C(C)=O
Show InChI InChI=1S/C17H25NO3/c1-10(12(3)19)7-6-8-11(2)15-9-18-17(14(5)21)16(15)13(4)20/h6-8,10,15-18H,9H2,1-5H3/t10-,15?,16?,17?/m1/s1
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18.3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50060629
PNG
((S)-2-Amino-3-(6-iodo-3,5-dioxo-4,5-dihydro-3H-[1,...)
Show SMILES N[C@@H](Cn1nc(I)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H7IN4O4/c7-3-4(12)9-6(15)11(10-3)1-2(8)5(13)14/h2H,1,8H2,(H,13,14)(H,9,12,15)/t2-/m0/s1
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20n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053067
PNG
((2S,3S,4S)-3-Carboxymethyl-4-(1-phenyl-vinyl)-pyrr...)
Show SMILES OC(=O)C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(=C)c1ccccc1
Show InChI InChI=1S/C15H17NO4/c1-9(10-5-3-2-4-6-10)12-8-16-14(15(19)20)11(12)7-13(17)18/h2-6,11-12,14,16H,1,7-8H2,(H,17,18)(H,19,20)/t11-,12+,14-/m0/s1
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29.8n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50060628
PNG
((S)-2-Amino-3-(6-chloro-3,5-dioxo-4,5-dihydro-3H-[...)
Show SMILES N[C@@H](Cn1nc(Cl)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C6H7ClN4O4/c7-3-4(12)9-6(15)11(10-3)1-2(8)5(13)14/h2H,1,8H2,(H,13,14)(H,9,12,15)/t2-/m0/s1
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31n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053061
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-chloro-phenyl)-...)
Show SMILES OC(=O)C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(=C)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H16ClNO4/c1-8(9-2-4-10(16)5-3-9)12-7-17-14(15(20)21)11(12)6-13(18)19/h2-5,11-12,14,17H,1,6-7H2,(H,18,19)(H,20,21)/t11-,12+,14-/m0/s1
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31.7n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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32n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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32n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053087
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-fluoro-phenyl)-...)
Show SMILES OC(=O)C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(=C)c1ccc(F)cc1
Show InChI InChI=1S/C15H16FNO4/c1-8(9-2-4-10(16)5-3-9)12-7-17-14(15(20)21)11(12)6-13(18)19/h2-5,11-12,14,17H,1,6-7H2,(H,18,19)(H,20,21)/t11-,12+,14-/m0/s1
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38.4n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053088
PNG
((2S,3S,4S)-3-Carboxymethyl-4-(1-p-tolyl-vinyl)-pyr...)
Show SMILES Cc1ccc(cc1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C16H19NO4/c1-9-3-5-11(6-4-9)10(2)13-8-17-15(16(20)21)12(13)7-14(18)19/h3-6,12-13,15,17H,2,7-8H2,1H3,(H,18,19)(H,20,21)/t12-,13+,15-/m0/s1
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41.1n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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48n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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48n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radio...


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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53n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053071
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-fluoro-3-methyl...)
Show SMILES Cc1cc(ccc1F)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C16H18FNO4/c1-8-5-10(3-4-13(8)17)9(2)12-7-18-15(16(21)22)11(12)6-14(19)20/h3-5,11-12,15,18H,2,6-7H2,1H3,(H,19,20)(H,21,22)/t11-,12+,15-/m0/s1
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54.3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50060632
PNG
((S)-2-Amino-3-(5-chloro-2,4-dioxo-3,4-dihydro-2H-p...)
Show SMILES N[C@@H](Cn1cc(Cl)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8ClN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
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57n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053073
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-methoxy-phenyl)...)
Show SMILES COc1ccc(cc1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C16H19NO5/c1-9(10-3-5-11(22-2)6-4-10)13-8-17-15(16(20)21)12(13)7-14(18)19/h3-6,12-13,15,17H,1,7-8H2,2H3,(H,18,19)(H,20,21)/t12-,13+,15-/m0/s1
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57.4n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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59n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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80n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Glutamate receptor (KA2) using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053089
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-ethyl-phenyl)-v...)
Show SMILES CCc1ccc(cc1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C17H21NO4/c1-3-11-4-6-12(7-5-11)10(2)14-9-18-16(17(21)22)13(14)8-15(19)20/h4-7,13-14,16,18H,2-3,8-9H2,1H3,(H,19,20)(H,21,22)/t13-,14+,16-/m0/s1
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82.2n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053075
PNG
((2S,3S,4S)-4-(1-Biphenyl-3-yl-vinyl)-3-carboxymeth...)
Show SMILES OC(=O)C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(=C)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H21NO4/c1-13(18-12-22-20(21(25)26)17(18)11-19(23)24)15-8-5-9-16(10-15)14-6-3-2-4-7-14/h2-10,17-18,20,22H,1,11-12H2,(H,23,24)(H,25,26)/t17-,18+,20-/m0/s1
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90.6n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053063
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(3-methoxy-phenyl)...)
Show SMILES COc1cccc(c1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C16H19NO5/c1-9(10-4-3-5-11(6-10)22-2)13-8-17-15(16(20)21)12(13)7-14(18)19/h3-6,12-13,15,17H,1,7-8H2,2H3,(H,18,19)(H,20,21)/t12-,13+,15-/m0/s1
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93.5n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053080
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(3,4-dimethyl-phen...)
Show SMILES Cc1ccc(cc1C)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C17H21NO4/c1-9-4-5-12(6-10(9)2)11(3)14-8-18-16(17(21)22)13(14)7-15(19)20/h4-6,13-14,16,18H,3,7-8H2,1-2H3,(H,19,20)(H,21,22)/t13-,14+,16-/m0/s1
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108n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053083
PNG
((2S,3S,4S)-3-Carboxymethyl-4-(1-m-tolyl-vinyl)-pyr...)
Show SMILES Cc1cccc(c1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C16H19NO4/c1-9-4-3-5-11(6-9)10(2)13-8-17-15(16(20)21)12(13)7-14(18)19/h3-6,12-13,15,17H,2,7-8H2,1H3,(H,18,19)(H,20,21)/t12-,13+,15-/m0/s1
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123n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053065
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-phenethyloxy-ph...)
Show SMILES OC(=O)C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(=C)c1ccc(OCCc2ccccc2)cc1
Show InChI InChI=1S/C23H25NO5/c1-15(20-14-24-22(23(27)28)19(20)13-21(25)26)17-7-9-18(10-8-17)29-12-11-16-5-3-2-4-6-16/h2-10,19-20,22,24H,1,11-14H2,(H,25,26)(H,27,28)/t19-,20+,22-/m0/s1
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126n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053084
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(3-methyl-4-phenet...)
Show SMILES Cc1cc(ccc1OCCc1ccccc1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H27NO5/c1-15-12-18(8-9-21(15)30-11-10-17-6-4-3-5-7-17)16(2)20-14-25-23(24(28)29)19(20)13-22(26)27/h3-9,12,19-20,23,25H,2,10-11,13-14H2,1H3,(H,26,27)(H,28,29)/t19-,20+,23-/m0/s1
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129n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053076
PNG
((2S,3S,4S)-4-(1-Biphenyl-4-yl-vinyl)-3-carboxymeth...)
Show SMILES OC(=O)C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(=C)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H21NO4/c1-13(18-12-22-20(21(25)26)17(18)11-19(23)24)14-7-9-16(10-8-14)15-5-3-2-4-6-15/h2-10,17-18,20,22H,1,11-12H2,(H,23,24)(H,25,26)/t17-,18+,20-/m0/s1
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131n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053068
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-isopropenyl-phe...)
Show SMILES CC(=C)c1ccc(cc1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C18H21NO4/c1-10(2)12-4-6-13(7-5-12)11(3)15-9-19-17(18(22)23)14(15)8-16(20)21/h4-7,14-15,17,19H,1,3,8-9H2,2H3,(H,20,21)(H,22,23)/t14-,15+,17-/m0/s1
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132n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053082
PNG
((2S,3S,4S)-4-[1-(4-Butyl-phenyl)-vinyl]-3-carboxym...)
Show SMILES CCCCc1ccc(cc1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C19H25NO4/c1-3-4-5-13-6-8-14(9-7-13)12(2)16-11-20-18(19(23)24)15(16)10-17(21)22/h6-9,15-16,18,20H,2-5,10-11H2,1H3,(H,21,22)(H,23,24)/t15-,16+,18-/m0/s1
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146n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053064
PNG
((2S,3S,4S)-4-[1-(4-Butoxy-phenyl)-vinyl]-3-carboxy...)
Show SMILES CCCCOc1ccc(cc1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C19H25NO5/c1-3-4-9-25-14-7-5-13(6-8-14)12(2)16-11-20-18(19(23)24)15(16)10-17(21)22/h5-8,15-16,18,20H,2-4,9-11H2,1H3,(H,21,22)(H,23,24)/t15-,16+,18-/m0/s1
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147n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053059
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-propyl-phenyl)-...)
Show SMILES CCCc1ccc(cc1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C18H23NO4/c1-3-4-12-5-7-13(8-6-12)11(2)15-10-19-17(18(22)23)14(15)9-16(20)21/h5-8,14-15,17,19H,2-4,9-10H2,1H3,(H,20,21)(H,22,23)/t14-,15+,17-/m0/s1
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147n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50088229
PNG
(2-Amino-4-prop-2-ynyl-pentanedioic acid | CHEMBL59...)
Show SMILES N[C@@H](C[C@@H](CC#C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h1,5-6H,3-4,9H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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160n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053062
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(3,5-dimethyl-phen...)
Show SMILES Cc1cc(C)cc(c1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C17H21NO4/c1-9-4-10(2)6-12(5-9)11(3)14-8-18-16(17(21)22)13(14)7-15(19)20/h4-6,13-14,16,18H,3,7-8H2,1-2H3,(H,19,20)(H,21,22)/t13-,14+,16-/m0/s1
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169n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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177n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053074
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-phenoxy-phenyl)...)
Show SMILES OC(=O)C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(=C)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H21NO5/c1-13(18-12-22-20(21(25)26)17(18)11-19(23)24)14-7-9-16(10-8-14)27-15-5-3-2-4-6-15/h2-10,17-18,20,22H,1,11-12H2,(H,23,24)(H,25,26)/t17-,18+,20-/m0/s1
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210n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053060
PNG
((2S,3S,4S)-4-[1-(4-tert-Butyl-phenyl)-vinyl]-3-car...)
Show SMILES CC(C)(C)c1ccc(cc1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C19H25NO4/c1-11(12-5-7-13(8-6-12)19(2,3)4)15-10-20-17(18(23)24)14(15)9-16(21)22/h5-8,14-15,17,20H,1,9-10H2,2-4H3,(H,21,22)(H,23,24)/t14-,15+,17-/m0/s1
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263n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053079
PNG
((2S,3S,4S)-4-[1-(3-Butoxy-phenyl)-vinyl]-3-carboxy...)
Show SMILES CCCCOc1cccc(c1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C19H25NO5/c1-3-4-8-25-14-7-5-6-13(9-14)12(2)16-11-20-18(19(23)24)15(16)10-17(21)22/h5-7,9,15-16,18,20H,2-4,8,10-11H2,1H3,(H,21,22)(H,23,24)/t15-,16+,18-/m0/s1
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275n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053070
PNG
((2S,3S,4S)-3-Carboxymethyl-4-{1-[4-(1-methylene-pr...)
Show SMILES CCC(=C)c1ccc(cc1)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C19H23NO4/c1-4-11(2)13-5-7-14(8-6-13)12(3)16-10-20-18(19(23)24)15(16)9-17(21)22/h5-8,15-16,18,20H,2-4,9-10H2,1H3,(H,21,22)(H,23,24)/t15-,16+,18-/m0/s1
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288n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50088225
PNG
(CHEMBL58808 | Z-2-Amino-4-(3-phenyl-allyl)-pentane...)
Show SMILES N[C@@H](C[C@@H](C\C=C/c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-12(14(18)19)9-11(13(16)17)8-4-7-10-5-2-1-3-6-10/h1-7,11-12H,8-9,15H2,(H,16,17)(H,18,19)/b7-4-/t11-,12+/m1/s1
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339n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50060631
PNG
((S)-2-Amino-3-(5-nitro-2,4-dioxo-3,4-dihydro-2H-py...)
Show SMILES N[C@@H](Cn1cc([N+]([O-])=O)c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C7H8N4O6/c8-3(6(13)14)1-10-2-4(11(16)17)5(12)9-7(10)15/h2-3H,1,8H2,(H,13,14)(H,9,12,15)/t3-/m0/s1
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393n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50089912
PNG
((2S)-2-amino-4-methylidenepentanedioic acid | 4-me...)
Show SMILES N[C@@H](CC(=C)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c1-3(5(8)9)2-4(7)6(10)11/h4H,1-2,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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450n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50088214
PNG
(2-Amino-4-(2-methyl-3-phenyl-allyl)-pentanedioic a...)
Show SMILES C\C(C[C@H](C[C@H](N)C(O)=O)C(O)=O)=C/c1ccccc1
Show InChI InChI=1S/C15H19NO4/c1-10(7-11-5-3-2-4-6-11)8-12(14(17)18)9-13(16)15(19)20/h2-7,12-13H,8-9,16H2,1H3,(H,17,18)(H,19,20)/b10-7+/t12-,13+/m1/s1
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500n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50088205
PNG
(CHEMBL294683 | E-2-Amino-4-[3-(4-fluoro-phenyl)-al...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(F)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16FNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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559n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50116040
PNG
((7-{3-[3-(4-Nitro-phenyl)-ureidomethyl]-pyrrol-1-y...)
Show SMILES OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)C(F)(F)F)-n1ccc(CNC(=O)Nc2ccc(cc2)[N+]([O-])=O)c1
Show InChI InChI=1S/C23H17F3N6O7/c24-23(25,26)15-7-16-18(31(11-19(33)34)21(36)20(35)29-16)8-17(15)30-6-5-12(10-30)9-27-22(37)28-13-1-3-14(4-2-13)32(38)39/h1-8,10H,9,11H2,(H,29,35)(H,33,34)(H2,27,28,37)
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610n/an/an/an/an/an/an/an/a



Abbott GmbH & Co. KG

Curated by ChEMBL


Assay Description
Binding affinity for human GluR6 expressed in HEK-293 cells using [3]H-kainate


Bioorg Med Chem Lett 12: 2113-6 (2002)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053086
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(3-methyl-4-pentyl...)
Show SMILES CCCCCOc1ccc(cc1C)C(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H29NO5/c1-4-5-6-9-27-18-8-7-15(10-13(18)2)14(3)17-12-22-20(21(25)26)16(17)11-19(23)24/h7-8,10,16-17,20,22H,3-6,9,11-12H2,1-2H3,(H,23,24)(H,25,26)/t16-,17+,20-/m0/s1
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663n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM50053077
PNG
((2S,3S,4S)-3-Carboxymethyl-4-[1-(3-phenethyloxy-ph...)
Show SMILES OC(=O)C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(=C)c1cccc(OCCc2ccccc2)c1
Show InChI InChI=1S/C23H25NO5/c1-15(20-14-24-22(23(27)28)19(20)13-21(25)26)17-8-5-9-18(12-17)29-11-10-16-6-3-2-4-7-16/h2-9,12,19-20,22,24H,1,10-11,13-14H2,(H,25,26)(H,27,28)/t19-,20+,22-/m0/s1
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667n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Homo sapiens)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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701n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
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