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Compile Data Set for Download or QSAR

Found 190 hits Enz. Inhib. hit(s) with Target = 'Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285598
PNG
(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F
Show InChI InChI=1S/C17H14ClFN4O/c1-9-4-5-10(7-11(9)18)16-15(17(24)21-13-8-12(13)19)22-14-3-2-6-20-23(14)16/h2-7,12-13H,8H2,1H3,(H,21,24)/t12-,13+/m0/s1
PDB

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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285534
PNG
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1
Show InChI InChI=1S/C17H12ClFN6O/c1-24-9-11(8-21-24)22-17(26)15-16(10-4-5-12(18)13(19)7-10)25-14(23-15)3-2-6-20-25/h2-9H,1H3,(H,22,26)
PDB

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UniChem
n/an/a 2.35n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285634
PNG
(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)6-8(7-11(13)19)15-14(16(24)21-9-3-4-9)22-12-2-1-5-20-23(12)15/h1-2,5-7,9H,3-4H2,(H,21,24)
PDB

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UniChem
n/an/a 4.69n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285537
PNG
(3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-11-6-3-9(8-12(11)18)15-14(16(23)20-10-4-5-10)21-13-2-1-7-19-22(13)15/h1-3,6-8,10H,4-5H2,(H,20,23)
PDB

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n/an/a 6.84n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285572
PNG
(3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H11ClF2N4O/c17-9-4-3-8(6-10(9)18)15-14(16(24)21-12-7-11(12)19)22-13-2-1-5-20-23(13)15/h1-6,11-12H,7H2,(H,21,24)/t11-,12+/m0/s1
PDB

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n/an/a 11.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285556
PNG
(3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...)
Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H14ClFN4O/c1-2-7-19-16(23)14-15(10-5-6-11(17)12(18)9-10)22-13(21-14)4-3-8-20-22/h3-6,8-9H,2,7H2,1H3,(H,19,23)
PDB

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n/an/a 13.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285568
PNG
(N-cyclopropyl-3-(3-fluoro-4-methylphenyl)imidazo[1...)
Show SMILES Cc1ccc(cc1F)-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15FN4O/c1-10-4-5-11(9-13(10)18)16-15(17(23)20-12-6-7-12)21-14-3-2-8-19-22(14)16/h2-5,8-9,12H,6-7H2,1H3,(H,20,23)
PDB

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UniChem
n/an/a 16.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285540
PNG
(US10077269, Example 13 | azetidin-1-yl[3-(4-chloro...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C16H12ClFN4O/c17-11-5-4-10(9-12(11)18)15-14(16(23)21-7-2-8-21)20-13-3-1-6-19-22(13)15/h1,3-6,9H,2,7-8H2
PDB

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UniChem
n/an/a 17.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285576
PNG
(US10077269, Example 49 | azetidin-1-yl[3-(3-chloro...)
Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C17H15ClN4O/c1-11-5-6-12(10-13(11)18)16-15(17(23)21-8-3-9-21)20-14-4-2-7-19-22(14)16/h2,4-7,10H,3,8-9H2,1H3
PDB

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UniChem
n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285627
PNG
(3-(4-chloro-5-fluoro-2-methylphenyl)-N-(propan-2-y...)
Show SMILES CC(C)NC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1C
Show InChI InChI=1S/C17H16ClFN4O/c1-9(2)21-17(24)15-16(23-14(22-15)5-4-6-20-23)11-8-13(19)12(18)7-10(11)3/h4-9H,1-3H3,(H,21,24)
PDB

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UniChem
n/an/a 20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285563
PNG
(3-(3-chlorophenyl)-N-cyclopropylimidazo[1,2-b]pyri...)
Show SMILES Clc1cccc(c1)-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13ClN4O/c17-11-4-1-3-10(9-11)15-14(16(22)19-12-6-7-12)20-13-5-2-8-18-21(13)15/h1-5,8-9,12H,6-7H2,(H,19,22)
PDB

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UniChem
n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285603
PNG
(US10077269, Example 76 | azetidin-1-yl{3-[2-(diflu...)
Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-9-10(4-6-19-12)14-13(15(24)22-7-2-8-22)21-11-3-1-5-20-23(11)14/h1,3-6,9,16H,2,7-8H2
PDB

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UniChem
n/an/a 22.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285574
PNG
(US10077269, Example 47 | azetidin-1-yl[3-(4-chloro...)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)7-9(8-11(13)19)15-14(16(24)22-5-2-6-22)21-12-3-1-4-20-23(12)15/h1,3-4,7-8H,2,5-6H2
PDB

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UniChem
n/an/a 23.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285557
PNG
(3-(4-chlorophenyl)-N-(2-methylcyclopropyl)imidazo[...)
Show SMILES CC1CC1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15ClN4O/c1-10-9-13(10)20-17(23)15-16(11-4-6-12(18)7-5-11)22-14(21-15)3-2-8-19-22/h2-8,10,13H,9H2,1H3,(H,20,23)
PDB

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UniChem
n/an/a 24.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285602
PNG
(N-cyclopropyl-3-[2-(difluoro-methoxy)pyridin-4-yl]...)
Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-8-9(5-7-19-12)14-13(15(24)21-10-3-4-10)22-11-2-1-6-20-23(11)14/h1-2,5-8,10,16H,3-4H2,(H,21,24)
PDB

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UniChem
n/an/a 24.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285616
PNG
(US10077269, Example 86 | azetidin-1-yl[3-(2,2-difl...)
Show SMILES FC1(F)Oc2ccc(cc2O1)-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C17H12F2N4O3/c18-17(19)25-11-5-4-10(9-12(11)26-17)15-14(16(24)22-7-2-8-22)21-13-3-1-6-20-23(13)15/h1,3-6,9H,2,7-8H2
PDB

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UniChem
n/an/a 25n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285595
PNG
(3-(4-chloro-2-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1F
Show InChI InChI=1S/C16H11ClF2N4O/c17-8-3-4-9(10(18)6-8)15-14(16(24)21-12-7-11(12)19)22-13-2-1-5-20-23(13)15/h1-6,11-12H,7H2,(H,21,24)/t11-,12+/m0/s1
PDB

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UniChem
n/an/a 25.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285620
PNG
(3-(4-cyano-3-fluorophenyl)-N-cyclopropylimidazo[1,...)
Show SMILES Fc1cc(ccc1C#N)-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C17H12FN5O/c18-13-8-10(3-4-11(13)9-19)16-15(17(24)21-12-5-6-12)22-14-2-1-7-20-23(14)16/h1-4,7-8,12H,5-6H2,(H,21,24)
PDB

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UniChem
n/an/a 25.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285611
PNG
(3-(4-chloro-3-fluorophenyl)-N-ethylimidazo[1,2-b]p...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C15H12ClFN4O/c1-2-18-15(22)13-14(9-5-6-10(16)11(17)8-9)21-12(20-13)4-3-7-19-21/h3-8H,2H2,1H3,(H,18,22)
PDB

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UniChem
n/an/a 25.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285529
PNG
(3-(4-Chlorophenyl)-N-cyclopropylimidazo[1,2-b]pyri...)
Show SMILES Clc1ccc(cc1)-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13ClN4O/c17-11-5-3-10(4-6-11)15-14(16(22)19-12-7-8-12)20-13-2-1-9-18-21(13)15/h1-6,9,12H,7-8H2,(H,19,22)
PDB

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UniChem
n/an/a 27.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F
Show InChI InChI=1S/C15H11ClF2N4O/c1-2-19-15(23)13-14(22-12(21-13)4-3-5-20-22)8-6-11(18)9(16)7-10(8)17/h3-7H,2H2,1H3,(H,19,23)
PDB

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UniChem
n/an/a 29.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (human))
BDBM285534
PNG
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1
Show InChI InChI=1S/C17H12ClFN6O/c1-24-9-11(8-21-24)22-17(26)15-16(10-4-5-12(18)13(19)7-10)25-14(23-15)3-2-6-20-25/h2-9H,1H3,(H,22,26)
PDB

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UniChem
n/an/a 34.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285562
PNG
(3-(3-chloro-5-fluorophenyl)-N-cyclopropylimidazo[1...)
Show SMILES Fc1cc(Cl)cc(c1)-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-10-6-9(7-11(18)8-10)15-14(16(23)20-12-3-4-12)21-13-2-1-5-19-22(13)15/h1-2,5-8,12H,3-4H2,(H,20,23)
PDB

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UniChem
n/an/a 37n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285573
PNG
(3-(4-chlorophenyl)-N-[(1R,2S)-2-fluorocyclopro-pyl...)
Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12ClFN4O/c17-10-5-3-9(4-6-10)15-14(16(23)20-12-8-11(12)18)21-13-2-1-7-19-22(13)15/h1-7,11-12H,8H2,(H,20,23)/t11-,12+/m0/s1
PDB

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UniChem
n/an/a 39.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285613
PNG
(US10077269, Example 83 | azetidin-1-yl[3-(3,4-dich...)
Show SMILES Clc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C16H12Cl2N4O/c17-11-5-4-10(9-12(11)18)15-14(16(23)21-7-2-8-21)20-13-3-1-6-19-22(13)15/h1,3-6,9H,2,7-8H2
PDB

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n/an/a 40n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285536
PNG
(3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimida...)
Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1Cl
Show InChI InChI=1S/C16H11ClF2N4O/c17-10-7-11(18)9(6-12(10)19)15-14(16(24)21-8-3-4-8)22-13-2-1-5-20-23(13)15/h1-2,5-8H,3-4H2,(H,21,24)
PDB

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UniChem
n/an/a 40.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285622
PNG
(3-(4-cyano-2,5-difluorophenyl)-N-cyclopropylimidaz...)
Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1C#N
Show InChI InChI=1S/C17H11F2N5O/c18-12-7-11(13(19)6-9(12)8-20)16-15(17(25)22-10-3-4-10)23-14-2-1-5-21-24(14)16/h1-2,5-7,10H,3-4H2,(H,22,25)
PDB

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n/an/a 42.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285612
PNG
(3-(4-chloro-3-fluorophenyl)-N-(1H-pyrazol-4-yl)imi...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)Nc1cn[nH]c1
PDB

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n/an/a 43.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285614
PNG
(US10077269, Example 84 | azetidin-1-yl[3-(3-chloro...)
Show SMILES Clc1cccc(c1)-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C16H13ClN4O/c17-12-5-1-4-11(10-12)15-14(16(22)20-8-3-9-20)19-13-6-2-7-18-21(13)15/h1-2,4-7,10H,3,8-9H2
PDB

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n/an/a 44.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285550
PNG
(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Show SMILES Fc1cc(ccc1C#N)-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C17H12FN5O/c18-13-9-11(4-5-12(13)10-19)16-15(17(24)22-7-2-8-22)21-14-3-1-6-20-23(14)16/h1,3-6,9H,2,7-8H2
PDB

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n/an/a 45.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285561
PNG
(3-(3-chloro-5-fluorophenyl)-N-propylimidazo[1,2-b]...)
Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1cc(F)cc(Cl)c1
Show InChI InChI=1S/C16H14ClFN4O/c1-2-5-19-16(23)14-15(10-7-11(17)9-12(18)8-10)22-13(21-14)4-3-6-20-22/h3-4,6-9H,2,5H2,1H3,(H,19,23)
PDB

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n/an/a 47n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285615
PNG
(3-(4-chlorophenyl)-N-ethylimidazo[1,2-b]pyridazine...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H13ClN4O/c1-2-17-15(21)13-14(10-5-7-11(16)8-6-10)20-12(19-13)4-3-9-18-20/h3-9H,2H2,1H3,(H,17,21)
PDB

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UniChem
n/an/a 47.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285555
PNG
(3-(3,5-dichlorophenyl)-N-propylimidazo[1,2-b]pyrid...)
Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C16H14Cl2N4O/c1-2-5-19-16(23)14-15(10-7-11(17)9-12(18)8-10)22-13(21-14)4-3-6-20-22/h3-4,6-9H,2,5H2,1H3,(H,19,23)
PDB

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n/an/a 49n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285530
PNG
(Azetidin-1-yl[3-(3,5-difluoro-4-methoxyphenyl)imid...)
Show SMILES COc1c(F)cc(cc1F)-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C17H14F2N4O2/c1-25-16-11(18)8-10(9-12(16)19)15-14(17(24)22-6-3-7-22)21-13-4-2-5-20-23(13)15/h2,4-5,8-9H,3,6-7H2,1H3
PDB

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n/an/a 51.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (human))
BDBM285612
PNG
(3-(4-chloro-3-fluorophenyl)-N-(1H-pyrazol-4-yl)imi...)
Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)Nc1cn[nH]c1
PDB

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n/an/a 56.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285567
PNG
(3-(4-chloro-2-fluorophenyl)-N-cyclopropylimidazo[1...)
Show SMILES Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12ClFN4O/c17-9-3-6-11(12(18)8-9)15-14(16(23)20-10-4-5-10)21-13-2-1-7-19-22(13)15/h1-3,6-8,10H,4-5H2,(H,20,23)
PDB

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n/an/a 58.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285551
PNG
(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)N2CCC2)c(F)cc1C#N
Show InChI InChI=1S/C17H11F2N5O/c18-12-8-11(13(19)7-10(12)9-20)16-15(17(25)23-5-2-6-23)22-14-3-1-4-21-24(14)16/h1,3-4,7-8H,2,5-6H2
PDB

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n/an/a 59.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285535
PNG
(Azetidin-1-yl[3-(pyrazolo[1,5-a]pyridin-6-yl)imida...)
Show SMILES O=C(N1CCC1)c1nc2cccnn2c1-c1ccc2ccnn2c1
Show InChI InChI=1S/C17H14N6O/c24-17(21-9-2-10-21)15-16(23-14(20-15)3-1-7-19-23)12-4-5-13-6-8-18-22(13)11-12/h1,3-8,11H,2,9-10H2
PDB

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n/an/a 64.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285624
PNG
(3-(4-chloro-3-fluorophenyl)-N-methylimidazo[1,2-b]...)
Show SMILES CNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C14H10ClFN4O/c1-17-14(21)12-13(8-4-5-9(15)10(16)7-8)20-11(19-12)3-2-6-18-20/h2-7H,1H3,(H,17,21)
PDB

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n/an/a 65n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285566
PNG
(3-(1,3-benzoxazol-5-yl)-N-cyclopropylimidazo[1,2-b...)
Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ocnc2c1
Show InChI InChI=1S/C17H13N5O2/c23-17(20-11-4-5-11)15-16(22-14(21-15)2-1-7-19-22)10-3-6-13-12(8-10)18-9-24-13/h1-3,6-9,11H,4-5H2,(H,20,23)
PDB

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n/an/a 67.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285549
PNG
(N-cyclopropyl-3-(pyrazolo[1,5-a]pyridin-6-yl)imida...)
Show SMILES O=C(NC1CC1)c1nc2cccnn2c1-c1ccc2ccnn2c1
Show InChI InChI=1S/C17H14N6O/c24-17(20-12-4-5-12)15-16(23-14(21-15)2-1-8-19-23)11-3-6-13-7-9-18-22(13)10-11/h1-3,6-10,12H,4-5H2,(H,20,24)
PDB

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n/an/a 71.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285547
PNG
(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C18H14FN5O/c1-11-8-12(10-20)14(19)9-13(11)17-16(18(25)23-6-3-7-23)22-15-4-2-5-21-24(15)17/h2,4-5,8-9H,3,6-7H2,1H3
PDB

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n/an/a 74.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285632
PNG
(3-(4-chlorophenyl)-N-(cyclo-propylmethyl)imidazo[1...)
Show SMILES Clc1ccc(cc1)-c1c(nc2cccnn12)C(=O)NCC1CC1
Show InChI InChI=1S/C17H15ClN4O/c18-13-7-5-12(6-8-13)16-15(17(23)19-10-11-3-4-11)21-14-2-1-9-20-22(14)16/h1-2,5-9,11H,3-4,10H2,(H,19,23)
PDB

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n/an/a 76n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285621
PNG
(US10077269, Example 91 | azetidin-1-yl[3-(4-chloro...)
Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)N2CCC2)c(F)cc1Cl
Show InChI InChI=1S/C16H11ClF2N4O/c17-10-8-11(18)9(7-12(10)19)15-14(16(24)22-5-2-6-22)21-13-3-1-4-20-23(13)15/h1,3-4,7-8H,2,5-6H2
PDB

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n/an/a 80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285583
PNG
(US10077269, Example 56 | azetidin-1-yl[3-(4-chloro...)
Show SMILES Cc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C17H15ClN4O/c1-11-10-12(18)5-6-13(11)16-15(17(23)21-8-3-9-21)20-14-4-2-7-19-22(14)16/h2,4-7,10H,3,8-9H2,1H3
PDB

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n/an/a 84.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285539
PNG
(3-(4-chloro-2-methyl-phenyl)-N-cyclopropyl-imidazo...)
Show SMILES Cc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C17H15ClN4O/c1-10-9-11(18)4-7-13(10)16-15(17(23)20-12-5-6-12)21-14-3-2-8-19-22(14)16/h2-4,7-9,12H,5-6H2,1H3,(H,20,23)
PDB

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n/an/a 89.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285597
PNG
(3-(4-chloro-2-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)
Show SMILES Cc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F
Show InChI InChI=1S/C17H14ClFN4O/c1-9-7-10(18)4-5-11(9)16-15(17(24)21-13-8-12(13)19)22-14-3-2-6-20-23(14)16/h2-7,12-13H,8H2,1H3,(H,21,24)/t12-,13+/m0/s1
PDB

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n/an/a 90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (human))
BDBM285603
PNG
(US10077269, Example 76 | azetidin-1-yl{3-[2-(diflu...)
Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)N1CCC1
Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-9-10(4-6-19-12)14-13(15(24)22-7-2-8-22)21-11-3-1-5-20-23(11)14/h1,3-6,9,16H,2,7-8H2
PDB

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n/an/a 94.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (human))
BDBM285546
PNG
(3-(4-cyano-5-fluoro-2-methylphenyl)-N-cyclo-propyl...)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C18H14FN5O/c1-10-7-11(9-20)14(19)8-13(10)17-16(18(25)22-12-4-5-12)23-15-3-2-6-21-24(15)17/h2-3,6-8,12H,4-5H2,1H3,(H,22,25)
PDB

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n/an/a 98.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (human))
BDBM285602
PNG
(N-cyclopropyl-3-[2-(difluoro-methoxy)pyridin-4-yl]...)
Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)NC1CC1
Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-8-9(5-7-19-12)14-13(15(24)21-10-3-4-10)22-11-2-1-6-20-23(11)14/h1-2,5-8,10,16H,3-4H2,(H,21,24)
PDB

GoogleScholar
AffyNet 
UniChem
n/an/a 104n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...


US Patent US10077269 (2018)

More data for this
Ligand-Target Pair
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