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Found 4 hits Enz. Inhib. hit(s) with Target = 'Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (human))
BDBM194487
PNG
(US9200016, 169)
Show SMILES COCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H21F3N2O4/c1-31-12-19-16-9-22(33-3)21(32-2)8-15(16)14(11-29-19)6-13-7-17-18(28-10-13)4-5-20(30)23(17)24(25,26)27/h4-5,7-11,30H,6,12H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 194n/an/an/an/an/an/a



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)

More data for this
Ligand-Target Pair
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (human))
BDBM194480
PNG
(US9200016, 162)
Show SMILES CCCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H23F3N2O3/c1-4-5-19-17-11-23(33-3)22(32-2)10-16(17)15(13-30-19)8-14-9-18-20(29-12-14)6-7-21(31)24(18)25(26,27)28/h6-7,9-13,31H,4-5,8H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 232n/an/an/an/an/an/a



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)

More data for this
Ligand-Target Pair
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (human))
BDBM194411
PNG
(US9200016, 93)
Show SMILES CCc1ncc(Cc2ccc3cccc(NC(=O)C(N)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H24N4O4/c1-4-19-18-12-22(33-3)21(32-2)11-17(18)15(13-27-19)10-16-9-8-14-6-5-7-20(23(14)28-16)29-25(31)24(26)30/h5-9,11-13H,4,10H2,1-3H3,(H2,26,30)(H,29,31)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 398n/an/an/an/an/an/a



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)

More data for this
Ligand-Target Pair
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (human))
BDBM194401
PNG
(US9200016, 83)
Show SMILES CCc1ncc(Cc2ccc3cccc(O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H22N2O3/c1-4-19-18-12-22(28-3)21(27-2)11-17(18)15(13-24-19)10-16-9-8-14-6-5-7-20(26)23(14)25-16/h5-9,11-13,26H,4,10H2,1-3H3
PDB

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 439n/an/an/an/an/an/a



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)

More data for this
Ligand-Target Pair