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Found 5 hits Enz. Inhib. hit(s) with Target = 'Isoprenylcysteine carboxyl methyltransferase' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isoprenylcysteine carboxyl methyltransferase


(Rattus norvegicus)
BDBM50034278
PNG
(2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienyls...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CSc1ccccc1C(O)=O
Show InChI InChI=1S/C22H30O2S/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H,23,24)/b18-11+,19-15+
KEGG

UniProtKB/SwissProt

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PC sid
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PubMed
2.80E+3n/an/an/an/an/an/an/an/a



Institute for Biological Research

Curated by ChEMBL


Assay Description
Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems


J Med Chem 38: 1267-72 (1995)

More data for this
Ligand-Target Pair
Isoprenylcysteine carboxyl methyltransferase


(Rattus norvegicus)
BDBM50034280
PNG
(2-Chloro-5-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CNc1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C22H30ClNO2/c1-16(2)7-5-8-17(3)9-6-10-18(4)13-14-24-19-11-12-21(23)20(15-19)22(25)26/h7,9,11-13,15,24H,5-6,8,10,14H2,1-4H3,(H,25,26)/b17-9+,18-13+
KEGG

UniProtKB/SwissProt

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PubMed
8.00E+3n/an/an/an/an/an/an/an/a



Institute for Biological Research

Curated by ChEMBL


Assay Description
Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems


J Med Chem 38: 1267-72 (1995)

More data for this
Ligand-Target Pair
Isoprenylcysteine carboxyl methyltransferase


(Rattus norvegicus)
BDBM50034277
PNG
(CHEMBL23289 | Thioacetic acid S-((2E,6E)-3,7,11-tr...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC(C)=O
Show InChI InChI=1S/C17H28OS/c1-14(2)8-6-9-15(3)10-7-11-16(4)12-13-19-17(5)18/h8,10,12H,6-7,9,11,13H2,1-5H3/b15-10+,16-12+
KEGG

UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
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PubMed
8.10E+3n/an/an/an/an/an/an/an/a



Institute for Biological Research

Curated by ChEMBL


Assay Description
Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems


J Med Chem 38: 1267-72 (1995)

More data for this
Ligand-Target Pair
Isoprenylcysteine carboxyl methyltransferase


(Rattus norvegicus)
BDBM50034276
PNG
(2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienyl-...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CSc1ncccc1C(O)=O
Show InChI InChI=1S/C21H29NO2S/c1-16(2)8-5-9-17(3)10-6-11-18(4)13-15-25-20-19(21(23)24)12-7-14-22-20/h7-8,10,12-14H,5-6,9,11,15H2,1-4H3,(H,23,24)/b17-10+,18-13+
KEGG

UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
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PubMed
1.49E+4n/an/an/an/an/an/an/an/a



Institute for Biological Research

Curated by ChEMBL


Assay Description
Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems


J Med Chem 38: 1267-72 (1995)

More data for this
Ligand-Target Pair
Isoprenylcysteine carboxyl methyltransferase


(Rattus norvegicus)
BDBM50034279
PNG
(5-Amino-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CSc1ccc(N)cc1C(O)=O
Show InChI InChI=1S/C22H31NO2S/c1-16(2)7-5-8-17(3)9-6-10-18(4)13-14-26-21-12-11-19(23)15-20(21)22(24)25/h7,9,11-13,15H,5-6,8,10,14,23H2,1-4H3,(H,24,25)/b17-9+,18-13+
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
7.28E+4n/an/an/an/an/an/an/an/a



Institute for Biological Research

Curated by ChEMBL


Assay Description
Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems


J Med Chem 38: 1267-72 (1995)

More data for this
Ligand-Target Pair