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Compile Data Set for Download or QSAR

Found 926 hits Enz. Inhib. hit(s) with Target = 'JAK1 (aa 837-1142)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.340n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM197717
PNG
(US9216984, 2)
Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.570n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.630n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM197717
PNG
(US9216984, 2)
Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM197717
PNG
(US9216984, 2)
Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM448609
PNG
(4-{3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3- d]pyrimid...)
Show SMILES Fc1cc(NC(=O)N2CCCCC2)cc(F)c1N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25F2N9O/c27-20-10-18(34-25(38)35-8-2-1-3-9-35)11-21(28)23(20)36-14-26(15-36,5-6-29)37-13-17(12-33-37)22-19-4-7-30-24(19)32-16-31-22/h4,7,10-13,16H,1-3,5,8-9,14-15H2,(H,34,38)(H,30,31,32)
PDB

GoogleScholar
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM448610
PNG
(4-{3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3- d]pyrimid...)
Show SMILES FC1C=C(NC(=O)N2CCCCC2)C=CC1(F)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400422
PNG
(US10695337, Example 177 | US9999619, Example 177)
Show SMILES Fc1c(Cl)cccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25ClFN9O/c27-20-2-1-3-21(22(20)28)34-25(38)35-10-5-18(6-11-35)36-14-26(15-36,7-8-29)37-13-17(12-33-37)23-19-4-9-30-24(19)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,34,38)(H,30,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400423
PNG
(US10695337, Example 178 | US9999619, Example 178)
Show SMILES Fc1cc(Cl)ccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25ClFN9O/c27-18-1-2-22(21(28)11-18)34-25(38)35-9-4-19(5-10-35)36-14-26(15-36,6-7-29)37-13-17(12-33-37)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,34,38)(H,30,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400425
PNG
(US10695337, Example 180 | US9999619, Example 180)
Show SMILES COc1ccccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H29N9O2/c1-38-23-5-3-2-4-22(23)33-26(37)34-12-7-20(8-13-34)35-16-27(17-35,9-10-28)36-15-19(14-32-36)24-21-6-11-29-25(21)31-18-30-24/h2-6,11,14-15,18,20H,7-9,12-13,16-17H2,1H3,(H,33,37)(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400426
PNG
(US10695337, Example 181 | US9999619, Example 181)
Show SMILES COc1cccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1
Show InChI InChI=1S/C27H29N9O2/c1-38-22-4-2-3-20(13-22)33-26(37)34-11-6-21(7-12-34)35-16-27(17-35,8-9-28)36-15-19(14-32-36)24-23-5-10-29-25(23)31-18-30-24/h2-5,10,13-15,18,21H,6-8,11-12,16-17H2,1H3,(H,33,37)(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400428
PNG
(US10695337, Example 183 | US9999619, Example 183)
Show SMILES Clc1cccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1
Show InChI InChI=1S/C26H26ClN9O/c27-19-2-1-3-20(12-19)33-25(37)34-10-5-21(6-11-34)35-15-26(16-35,7-8-28)36-14-18(13-32-36)23-22-4-9-29-24(22)31-17-30-23/h1-4,9,12-14,17,21H,5-7,10-11,15-16H2,(H,33,37)(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400429
PNG
(US10695337, Example 184 | US9999619, Example 184)
Show SMILES Clc1ccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)cc1
Show InChI InChI=1S/C26H26ClN9O/c27-19-1-3-20(4-2-19)33-25(37)34-11-6-21(7-12-34)35-15-26(16-35,8-9-28)36-14-18(13-32-36)23-22-5-10-29-24(22)31-17-30-23/h1-5,10,13-14,17,21H,6-8,11-12,15-16H2,(H,33,37)(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM448619
PNG
(4-{3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3- d]pyrimid...)
Show SMILES Cc1cc(ccc1NC(=O)N1CCCCC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H29N9O/c1-19-13-21(5-6-23(19)33-26(37)34-11-3-2-4-12-34)35-16-27(17-35,8-9-28)36-15-20(14-32-36)24-22-7-10-29-25(22)31-18-30-24/h5-7,10,13-15,18H,2-4,8,11-12,16-17H2,1H3,(H,33,37)(H,29,30,31)
PDB

GoogleScholar
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400431
PNG
(US10695337, Example 186 | US9999619, Example 186)
Show SMILES COc1ccc(OC)c(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1
Show InChI InChI=1S/C28H31N9O3/c1-39-21-3-4-24(40-2)23(13-21)34-27(38)35-11-6-20(7-12-35)36-16-28(17-36,8-9-29)37-15-19(14-33-37)25-22-5-10-30-26(22)32-18-31-25/h3-5,10,13-15,18,20H,6-8,11-12,16-17H2,1-2H3,(H,34,38)(H,30,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400432
PNG
(US10695337, Example 187 | US9999619, Example 187)
Show SMILES Cc1cc(F)ccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H28FN9O/c1-18-12-20(28)2-3-23(18)34-26(38)35-10-5-21(6-11-35)36-15-27(16-36,7-8-29)37-14-19(13-33-37)24-22-4-9-30-25(22)32-17-31-24/h2-4,9,12-14,17,21H,5-7,10-11,15-16H2,1H3,(H,34,38)(H,30,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400438
PNG
(US10695337, Example 193 | US9999619, Example 193)
Show SMILES O=C(Nc1nc2ccccc2s1)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H26N10OS/c28-9-8-27(37-14-18(13-32-37)23-20-5-10-29-24(20)31-17-30-23)15-36(16-27)19-6-11-35(12-7-19)26(38)34-25-33-21-3-1-2-4-22(21)39-25/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,29,30,31)(H,33,34,38)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400439
PNG
(US10695337, Example 194 | US9999619, Example 194)
Show SMILES Cn1c(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc2ccccc12
Show InChI InChI=1S/C28H29N11O/c1-36-23-5-3-2-4-22(23)34-26(36)35-27(40)37-12-7-20(8-13-37)38-16-28(17-38,9-10-29)39-15-19(14-33-39)24-21-6-11-30-25(21)32-18-31-24/h2-6,11,14-15,18,20H,7-9,12-13,16-17H2,1H3,(H,30,31,32)(H,34,35,40)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400443
PNG
(US10695337, Example 198 | US9999619, Example 198)
Show SMILES Cc1ncccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H28N10O/c1-18-22(3-2-9-28-18)33-25(37)34-11-5-20(6-12-34)35-15-26(16-35,7-8-27)36-14-19(13-32-36)23-21-4-10-29-24(21)31-17-30-23/h2-4,9-10,13-14,17,20H,5-7,11-12,15-16H2,1H3,(H,33,37)(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400444
PNG
(US10695337, Example 199 | US9999619, Example 199)
Show SMILES Cc1nc(F)ccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H27FN10O/c1-17-21(2-3-22(27)33-17)34-25(38)35-10-5-19(6-11-35)36-14-26(15-36,7-8-28)37-13-18(12-32-37)23-20-4-9-29-24(20)31-16-30-23/h2-4,9,12-13,16,19H,5-7,10-11,14-15H2,1H3,(H,34,38)(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400445
PNG
(US10695337, Example 200 | US9999619, Example 200)
Show SMILES Cc1ccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)n1
Show InChI InChI=1S/C26H27FN10O/c1-17-2-3-21(23(27)33-17)34-25(38)35-10-5-19(6-11-35)36-14-26(15-36,7-8-28)37-13-18(12-32-37)22-20-4-9-29-24(20)31-16-30-22/h2-4,9,12-13,16,19H,5-7,10-11,14-15H2,1H3,(H,34,38)(H,29,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400447
PNG
(US10695337, Example 202 | US9999619, Example 202)
Show SMILES Fc1cccnc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C25H25FN10O/c26-20-2-1-8-28-23(20)33-24(37)34-10-4-18(5-11-34)35-14-25(15-35,6-7-27)36-13-17(12-32-36)21-19-3-9-29-22(19)31-16-30-21/h1-3,8-9,12-13,16,18H,4-6,10-11,14-15H2,(H,28,33,37)(H,29,30,31)
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US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400449
PNG
(US10695337, Example 204 | US9999619, Example 204)
Show SMILES COc1ncccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H28N10O2/c1-38-24-21(3-2-9-29-24)33-25(37)34-11-5-19(6-12-34)35-15-26(16-35,7-8-27)36-14-18(13-32-36)22-20-4-10-28-23(20)31-17-30-22/h2-4,9-10,13-14,17,19H,5-7,11-12,15-16H2,1H3,(H,33,37)(H,28,30,31)
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US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400451
PNG
(US10695337, Example 206 | US9999619, Example 206)
Show SMILES COC(=O)c1ccccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H29N9O3/c1-40-26(38)21-4-2-3-5-23(21)34-27(39)35-12-7-20(8-13-35)36-16-28(17-36,9-10-29)37-15-19(14-33-37)24-22-6-11-30-25(22)32-18-31-24/h2-6,11,14-15,18,20H,7-9,12-13,16-17H2,1H3,(H,34,39)(H,30,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400452
PNG
(US10695337, Example 207 | US9999619, Example 207)
Show SMILES COC(=O)c1cc(F)ccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H28FN9O3/c1-41-26(39)22-12-19(29)2-3-23(22)35-27(40)36-10-5-20(6-11-36)37-15-28(16-37,7-8-30)38-14-18(13-34-38)24-21-4-9-31-25(21)33-17-32-24/h2-4,9,12-14,17,20H,5-7,10-11,15-16H2,1H3,(H,35,40)(H,31,32,33)
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US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400453
PNG
(US10695337, Example 208 | US9999619, Example 208)
Show SMILES COC(=O)c1ccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C28H28FN9O3/c1-41-26(39)18-2-3-23(22(29)12-18)35-27(40)36-10-5-20(6-11-36)37-15-28(16-37,7-8-30)38-14-19(13-34-38)24-21-4-9-31-25(21)33-17-32-24/h2-4,9,12-14,17,20H,5-7,10-11,15-16H2,1H3,(H,35,40)(H,31,32,33)
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US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400454
PNG
(3-[(4-{3-(Cyanomethyl)-3-[4-(7H-pyrrolo[2,3-d]pyri...)
Show SMILES CN(C)c1ccc(CN2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1C#N
Show InChI InChI=1S/C29H31FN10/c1-37(2)25-4-3-20(26(30)24(25)13-32)15-38-11-6-22(7-12-38)39-17-29(18-39,8-9-31)40-16-21(14-36-40)27-23-5-10-33-28(23)35-19-34-27/h3-5,10,14,16,19,22H,6-8,11-12,15,17-18H2,1-2H3,(H,33,34,35)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400455
PNG
(US10695337, Example 210 | US9999619, Example 210)
Show SMILES Clc1cc(Cl)cc(CN2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1
Show InChI InChI=1S/C26H26Cl2N8/c27-20-9-18(10-21(28)11-20)13-34-7-2-22(3-8-34)35-15-26(16-35,4-5-29)36-14-19(12-33-36)24-23-1-6-30-25(23)32-17-31-24/h1,6,9-12,14,17,22H,2-4,7-8,13,15-16H2,(H,30,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400458
PNG
(US10695337, Example 213 | US9999619, Example 213)
Show SMILES Fc1cccc(c1CN1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C27H26F4N8/c28-23-3-1-2-22(27(29,30)31)21(23)14-37-10-5-19(6-11-37)38-15-26(16-38,7-8-32)39-13-18(12-36-39)24-20-4-9-33-25(20)35-17-34-24/h1-4,9,12-13,17,19H,5-7,10-11,14-16H2,(H,33,34,35)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400460
PNG
(US10695337, Example 215 | US9999619, Example 215)
Show SMILES Fc1cc(F)cc(CN2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1
Show InChI InChI=1S/C26H26F2N8/c27-20-9-18(10-21(28)11-20)13-34-7-2-22(3-8-34)35-15-26(16-35,4-5-29)36-14-19(12-33-36)24-23-1-6-30-25(23)32-17-31-24/h1,6,9-12,14,17,22H,2-4,7-8,13,15-16H2,(H,30,31,32)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400470
PNG
(US10695337, Example 225 | US9999619, Example 225)
Show SMILES Brc1cc(CN2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)cc(Br)n1
Show InChI InChI=1S/C25H25Br2N9/c26-21-9-17(10-22(27)33-21)12-34-7-2-19(3-8-34)35-14-25(15-35,4-5-28)36-13-18(11-32-36)23-20-1-6-29-24(20)31-16-30-23/h1,6,9-11,13,16,19H,2-4,7-8,12,14-15H2,(H,29,30,31)
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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400472
PNG
(US10695337, Example 227 | US9999619, Example 227)
Show SMILES Fc1cccc(Cl)c1CN1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H26ClFN8/c27-22-2-1-3-23(28)21(22)14-34-10-5-19(6-11-34)35-15-26(16-35,7-8-29)36-13-18(12-33-36)24-20-4-9-30-25(20)32-17-31-24/h1-4,9,12-13,17,19H,5-7,10-11,14-16H2,(H,30,31,32)
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400473
PNG
(US10695337, Example 228 | US9999619, Example 228)
Show SMILES Fc1ccc(Cl)c(F)c1CN1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25ClF2N8/c27-21-1-2-22(28)20(23(21)29)13-35-9-4-18(5-10-35)36-14-26(15-36,6-7-30)37-12-17(11-34-37)24-19-3-8-31-25(19)33-16-32-24/h1-3,8,11-12,16,18H,4-6,9-10,13-15H2,(H,31,32,33)
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400479
PNG
(US10695337, Example 234 | US9999619, Example 234)
Show SMILES N#CCC1(CN(C1)C1CCN(Cc2ccc3OCCOc3c2)CC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H30N8O2/c29-7-6-28(36-16-21(14-33-36)26-23-3-8-30-27(23)32-19-31-26)17-35(18-28)22-4-9-34(10-5-22)15-20-1-2-24-25(13-20)38-12-11-37-24/h1-3,8,13-14,16,19,22H,4-6,9-12,15,17-18H2,(H,30,31,32)
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400481
PNG
(US10695337, Example 236 | US9999619, Example 236)
Show SMILES Fc1c(Cl)ccc(c1CN1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C27H25ClF4N8/c28-22-2-1-21(27(30,31)32)20(23(22)29)13-38-9-4-18(5-10-38)39-14-26(15-39,6-7-33)40-12-17(11-37-40)24-19-3-8-34-25(19)36-16-35-24/h1-3,8,11-12,16,18H,4-6,9-10,13-15H2,(H,34,35,36)
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400483
PNG
(US10695337, Example 238 | US9999619, Example 238)
Show SMILES COc1ccc2nc(Cl)c(CN3CCC(CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)cc2c1
Show InChI InChI=1S/C30H30ClN9O/c1-41-24-2-3-26-20(13-24)12-21(28(31)37-26)15-38-10-5-23(6-11-38)39-17-30(18-39,7-8-32)40-16-22(14-36-40)27-25-4-9-33-29(25)35-19-34-27/h2-4,9,12-14,16,19,23H,5-7,10-11,15,17-18H2,1H3,(H,33,34,35)
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400485
PNG
(3-[(3-{3-(Cyanomethyl)-3-[4-(7H-pyrrolo[2,3-d]pyri...)
Show SMILES CN(C)c1ccc(CN2C3CCC2CC(C3)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1C#N
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400486
PNG
(US10695337, Example 241 | US9999619, Example 241 |...)
Show SMILES Fc1ccc(F)c(CN2C3CCC2CC(C3)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1Cl
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM448676
PNG
(Diastereomers of 3-[(4-{3-(cyanomethyl)-3-[4-(7H-p...)
Show SMILES CC1CC(CCN1Cc1ccc(N(C)C)c(C#N)c1F)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400490
PNG
(US10695337, Example 246 | US9999619, Example 246 |...)
Show SMILES Cn1nccc1S(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H26N10O2S/c1-30-20(3-9-28-30)36(34,35)32-10-4-18(5-11-32)31-14-23(15-31,6-7-24)33-13-17(12-29-33)21-19-2-8-25-22(19)27-16-26-21/h2-3,8-9,12-13,16,18H,4-6,10-11,14-15H2,1H3,(H,25,26,27)
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400491
PNG
(US10695337, Example 247 | US9999619, Example 247)
Show SMILES O=S(=O)(N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)c1ccccc1C#N
Show InChI InChI=1S/C26H25N9O2S/c27-9-8-26(35-15-20(14-32-35)24-22-5-10-29-25(22)31-18-30-24)16-33(17-26)21-6-11-34(12-7-21)38(36,37)23-4-2-1-3-19(23)13-28/h1-5,10,14-15,18,21H,6-8,11-12,16-17H2,(H,29,30,31)
PDB

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Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400494
PNG
(US10695337, Example 250 | US9999619, Example 250)
Show SMILES CN(C)c1ccc(cc1C#N)S(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H30N10O2S/c1-35(2)25-4-3-23(13-20(25)14-30)41(39,40)37-11-6-22(7-12-37)36-17-28(18-36,8-9-29)38-16-21(15-34-38)26-24-5-10-31-27(24)33-19-32-26/h3-5,10,13,15-16,19,22H,6-8,11-12,17-18H2,1-2H3,(H,31,32,33)
PDB

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PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400495
PNG
(US10695337, Example 251 | US9999619, Example 251)
Show SMILES Cn1ccc(n1)S(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H26N10O2S/c1-30-9-5-20(29-30)36(34,35)32-10-3-18(4-11-32)31-14-23(15-31,6-7-24)33-13-17(12-28-33)21-19-2-8-25-22(19)27-16-26-21/h2,5,8-9,12-13,16,18H,3-4,6,10-11,14-15H2,1H3,(H,25,26,27)
PDB

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PC cid
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UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400497
PNG
(US10695337, Example 253 | US9999619, Example 253)
Show SMILES O=S(=O)(C1CCCC1)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H30N8O2S/c25-9-8-24(32-14-18(13-29-32)22-21-5-10-26-23(21)28-17-27-22)15-30(16-24)19-6-11-31(12-7-19)35(33,34)20-3-1-2-4-20/h5,10,13-14,17,19-20H,1-4,6-8,11-12,15-16H2,(H,26,27,28)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM448688
PNG
(US10695337, Example 254 | {1-[1-(methylsulfonyl)pi...)
Show SMILES CC(C#N)C1(CN(C1)C1CCN(CC1)S(C)(=O)=O)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400500
PNG
(US10695337, Example 256 | US9999619, Example 256)
Show SMILES O=S(=O)(C1CC1)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C22H26N8O2S/c23-7-6-22(30-12-16(11-27-30)20-19-3-8-24-21(19)26-15-25-20)13-28(14-22)17-4-9-29(10-5-17)33(31,32)18-1-2-18/h3,8,11-12,15,17-18H,1-2,4-6,9-10,13-14H2,(H,24,25,26)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400502
PNG
(US10695337, Example 258 | US9999619, Example 258)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H26N10O2S/c1-30-12-20(28-16-30)36(34,35)32-8-3-18(4-9-32)31-13-23(14-31,5-6-24)33-11-17(10-29-33)21-19-2-7-25-22(19)27-15-26-21/h2,7,10-12,15-16,18H,3-5,8-9,13-14H2,1H3,(H,25,26,27)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400503
PNG
(US10695337, Example 259 | US9999619, Example 259)
Show SMILES Cc1nc(cn1C)S(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H28N10O2S/c1-17-30-21(13-31(17)2)37(35,36)33-9-4-19(5-10-33)32-14-24(15-32,6-7-25)34-12-18(11-29-34)22-20-3-8-26-23(20)28-16-27-22/h3,8,11-13,16,19H,4-6,9-10,14-15H2,1-2H3,(H,26,27,28)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM400504
PNG
(US10695337, Example 260 | US9999619, Example 260)
Show SMILES Cc1noc(C)c1S(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H27N9O3S/c1-16-22(17(2)36-30-16)37(34,35)32-9-4-19(5-10-32)31-13-24(14-31,6-7-25)33-12-18(11-29-33)21-20-3-8-26-23(20)28-15-27-21/h3,8,11-12,15,19H,4-6,9-10,13-14H2,1-2H3,(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...


US Patent US10695337 (2020)

More data for this
Ligand-Target Pair
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