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Found 149 hits Enz. Inhib. hit(s) with Target = 'KCNQ (Kv7) potassium channel' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50095027
PNG
((2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-eth...)
Show SMILES COc1cccc([C@H](O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC
Show InChI InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1
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PubMed
1.06E+3n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme

Curated by ChEMBL


Assay Description
Binding affinity at Voltage-gated potassium channel


J Med Chem 44: 477-501 (2001)

More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395464
PNG
(CHEMBL2164048)
Show SMILES CC[C@H](C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395501
PNG
(CHEMBL2163658)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1cccc(OC)c1
Show InChI InChI=1S/C21H26N2O2/c1-3-18(16-9-8-10-17(15-16)25-2)21(24)22-19-11-4-5-12-20(19)23-13-6-7-14-23/h4-5,8-12,15,18H,3,6-7,13-14H2,1-2H3,(H,22,24)
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n/an/a 120n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395505
PNG
(CHEMBL2164068)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(F)cc1
Show InChI InChI=1S/C20H23FN2O/c1-2-17(15-9-11-16(21)12-10-15)20(24)22-18-7-3-4-8-19(18)23-13-5-6-14-23/h3-4,7-12,17H,2,5-6,13-14H2,1H3,(H,22,24)
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n/an/a 130n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM84184
PNG
(2-phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamide | 2...)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)
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n/an/a 163n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395508
PNG
(CHEMBL2164062)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C20H22F2N2O/c1-2-15(14-9-10-16(21)17(22)13-14)20(25)23-18-7-3-4-8-19(18)24-11-5-6-12-24/h3-4,7-10,13,15H,2,5-6,11-12H2,1H3,(H,23,25)
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n/an/a 170n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395464
PNG
(CHEMBL2164048)
Show SMILES CC[C@H](C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ4 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395481
PNG
(CHEMBL2163667)
Show SMILES CCC(C(=O)Nc1ccc(cc1)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-2-19(16-8-4-3-5-9-16)20(23)21-17-10-12-18(13-11-17)22-14-6-7-15-22/h3-5,8-13,19H,2,6-7,14-15H2,1H3,(H,21,23)
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n/an/a 210n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395500
PNG
(CHEMBL2163659)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1cccc(Cl)c1
Show InChI InChI=1S/C20H23ClN2O/c1-2-17(15-8-7-9-16(21)14-15)20(24)22-18-10-3-4-11-19(18)23-12-5-6-13-23/h3-4,7-11,14,17H,2,5-6,12-13H2,1H3,(H,22,24)
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n/an/a 240n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395518
PNG
(CHEMBL2164049)
Show SMILES CC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C19H22N2O/c1-15(16-9-3-2-4-10-16)19(22)20-17-11-5-6-12-18(17)21-13-7-8-14-21/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,20,22)
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n/an/a 260n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395498
PNG
(CHEMBL2163662)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClN2O/c1-2-17(15-9-11-16(21)12-10-15)20(24)22-18-7-3-4-8-19(18)23-13-5-6-14-23/h3-4,7-12,17H,2,5-6,13-14H2,1H3,(H,22,24)
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n/an/a 280n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395515
PNG
(CHEMBL2164054)
Show SMILES CCCC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C21H26N2O/c1-2-10-18(17-11-4-3-5-12-17)21(24)22-19-13-6-7-14-20(19)23-15-8-9-16-23/h3-7,11-14,18H,2,8-10,15-16H2,1H3,(H,22,24)
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n/an/a 320n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395506
PNG
(CHEMBL2164066)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1cccc(C)c1
Show InChI InChI=1S/C21H26N2O/c1-3-18(17-10-8-9-16(2)15-17)21(24)22-19-11-4-5-12-20(19)23-13-6-7-14-23/h4-5,8-12,15,18H,3,6-7,13-14H2,1-2H3,(H,22,24)
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n/an/a 330n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395514
PNG
(CHEMBL2164055)
Show SMILES O=C(Nc1ccccc1N1CCCC1)C1CCc2ccccc12
Show InChI InChI=1S/C20H22N2O/c23-20(17-12-11-15-7-1-2-8-16(15)17)21-18-9-3-4-10-19(18)22-13-5-6-14-22/h1-4,7-10,17H,5-6,11-14H2,(H,21,23)
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n/an/a 330n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395507
PNG
(CHEMBL2164064)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1cccc(F)c1
Show InChI InChI=1S/C20H23FN2O/c1-2-17(15-8-7-9-16(21)14-15)20(24)22-18-10-3-4-11-19(18)23-12-5-6-13-23/h3-4,7-11,14,17H,2,5-6,12-13H2,1H3,(H,22,24)
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n/an/a 360n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395499
PNG
(CHEMBL2163661)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(OC)cc1
Show InChI InChI=1S/C21H26N2O2/c1-3-18(16-10-12-17(25-2)13-11-16)21(24)22-19-8-4-5-9-20(19)23-14-6-7-15-23/h4-5,8-13,18H,3,6-7,14-15H2,1-2H3,(H,22,24)
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n/an/a 380n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395502
PNG
(CHEMBL2163657)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N2O/c1-2-17(15-8-7-9-16(14-15)21(22,23)24)20(27)25-18-10-3-4-11-19(18)26-12-5-6-13-26/h3-4,7-11,14,17H,2,5-6,12-13H2,1H3,(H,25,27)
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n/an/a 390n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395497
PNG
(CHEMBL2163664)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1F
Show InChI InChI=1S/C20H23FN2O/c1-2-15(16-9-3-4-10-17(16)21)20(24)22-18-11-5-6-12-19(18)23-13-7-8-14-23/h3-6,9-12,15H,2,7-8,13-14H2,1H3,(H,22,24)
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n/an/a 440n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395504
PNG
(CHEMBL2164069)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H22Cl2N2O/c1-2-15(14-9-10-16(21)17(22)13-14)20(25)23-18-7-3-4-8-19(18)24-11-5-6-12-24/h3-4,7-10,13,15H,2,5-6,11-12H2,1H3,(H,23,25)
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n/an/a 470n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated K channel 7.1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM84166
PNG
(2-phenyl-N-(2-phenylphenyl)butanamide | 2-phenyl-N...)
Show SMILES CCC(C(=O)Nc1ccccc1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H21NO/c1-2-19(17-11-5-3-6-12-17)22(24)23-21-16-10-9-15-20(21)18-13-7-4-8-14-18/h3-16,19H,2H2,1H3,(H,23,24)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395333
PNG
(CHEMBL2164389)
Show SMILES FC(F)(F)Oc1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C24H20F3N3O3/c25-24(26,27)33-18-10-8-16(9-11-18)15-29-22(31)21-19-6-1-2-7-20(19)23(32)30(21)14-12-17-5-3-4-13-28-17/h1-11,13,21H,12,14-15H2,(H,29,31)
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n/an/a 1.60E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395516
PNG
(CHEMBL2164053)
Show SMILES CC(C)CC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C22H28N2O/c1-17(2)16-19(18-10-4-3-5-11-18)22(25)23-20-12-6-7-13-21(20)24-14-8-9-15-24/h3-7,10-13,17,19H,8-9,14-16H2,1-2H3,(H,23,25)
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n/an/a 2.22E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395464
PNG
(CHEMBL2164048)
Show SMILES CC[C@H](C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1
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n/an/a 2.92E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ1 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395503
PNG
(CHEMBL2163655)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1Cl
Show InChI InChI=1S/C20H23ClN2O/c1-2-15(16-9-3-4-10-17(16)21)20(24)22-18-11-5-6-12-19(18)23-13-7-8-14-23/h3-6,9-12,15H,2,7-8,13-14H2,1H3,(H,22,24)
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n/an/a 3.31E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395517
PNG
(CHEMBL2164052)
Show SMILES O=C(Nc1ccccc1N1CCCC1)C(C1CC1)c1ccccc1
Show InChI InChI=1S/C21H24N2O/c24-21(20(17-12-13-17)16-8-2-1-3-9-16)22-18-10-4-5-11-19(18)23-14-6-7-15-23/h1-5,8-11,17,20H,6-7,12-15H2,(H,22,24)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395475
PNG
(CHEMBL2163350)
Show SMILES CCC(C(=O)Nc1ccccc1-n1cccc1)c1ccccc1
Show InChI InChI=1S/C20H20N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-15,17H,2H2,1H3,(H,21,23)
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n/an/a 5.27E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50212239
PNG
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1
Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 channel


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50212239
PNG
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1
Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KCNQ3 channel


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395479
PNG
(CHEMBL2163673)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O2/c1-2-17(16-8-4-3-5-9-16)20(23)21-18-10-6-7-11-19(18)22-12-14-24-15-13-22/h3-11,17H,2,12-15H2,1H3,(H,21,23)
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n/an/a 1.27E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395474
PNG
(CHEMBL2163686)
Show SMILES CCC(C(=O)Nc1ccccc1Cl)c1ccccc1
Show InChI InChI=1S/C16H16ClNO/c1-2-13(12-8-4-3-5-9-12)16(19)18-15-11-7-6-10-14(15)17/h3-11,13H,2H2,1H3,(H,18,19)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395509
PNG
(CHEMBL2164061)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCC1)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C22H28N2O3/c1-4-17(16-11-12-20(26-2)21(15-16)27-3)22(25)23-18-9-5-6-10-19(18)24-13-7-8-14-24/h5-6,9-12,15,17H,4,7-8,13-14H2,1-3H3,(H,23,25)
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n/an/a 2.02E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395482
PNG
(CHEMBL2163665)
Show SMILES CCC(C(=O)Nc1cccc(c1)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-2-19(16-9-4-3-5-10-16)20(23)21-17-11-8-12-18(15-17)22-13-6-7-14-22/h3-5,8-12,15,19H,2,6-7,13-14H2,1H3,(H,21,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395480
PNG
(CHEMBL2163671)
Show SMILES CCC(C(=O)Nc1ccccc1N1CCCCCC1)c1ccccc1
Show InChI InChI=1S/C22H28N2O/c1-2-19(18-12-6-5-7-13-18)22(25)23-20-14-8-9-15-21(20)24-16-10-3-4-11-17-24/h5-9,12-15,19H,2-4,10-11,16-17H2,1H3,(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395478
PNG
(CHEMBL2163675)
Show SMILES CCC(C(=O)Nc1ccccc1N(C)CC)c1ccccc1
Show InChI InChI=1S/C19H24N2O/c1-4-16(15-11-7-6-8-12-15)19(22)20-17-13-9-10-14-18(17)21(3)5-2/h6-14,16H,4-5H2,1-3H3,(H,20,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395477
PNG
(CHEMBL2163679)
Show SMILES CCC(C(=O)Nc1ccccc1-n1c(O)ccc1O)c1ccccc1
Show InChI InChI=1S/C20H20N2O3/c1-2-15(14-8-4-3-5-9-14)20(25)21-16-10-6-7-11-17(16)22-18(23)12-13-19(22)24/h3-13,15,23-24H,2H2,1H3,(H,21,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395476
PNG
(CHEMBL2163680)
Show SMILES CCC(C(=O)Nc1ccccc1-n1ccnc1)c1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-2-16(15-8-4-3-5-9-15)19(23)21-17-10-6-7-11-18(17)22-13-12-20-14-22/h3-14,16H,2H2,1H3,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50050539
PNG
(CHEMBL3187891)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C20H17N3O2/c1-14-4-2-5-16(12-14)20(25)23-18-7-3-6-17(13-18)22-19(24)15-8-10-21-11-9-15/h2-13H,1H3,(H,22,24)(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395513
PNG
(CHEMBL2164056)
Show SMILES O=C(Nc1ccccc1N1CCCC1)C1(CC1)c1ccccc1
Show InChI InChI=1S/C20H22N2O/c23-19(20(12-13-20)16-8-2-1-3-9-16)21-17-10-4-5-11-18(17)22-14-6-7-15-22/h1-5,8-11H,6-7,12-15H2,(H,21,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395512
PNG
(CHEMBL2164057)
Show SMILES CC(C)(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c1-20(2,16-10-4-3-5-11-16)19(23)21-17-12-6-7-13-18(17)22-14-8-9-15-22/h3-7,10-13H,8-9,14-15H2,1-2H3,(H,21,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395510
PNG
(CHEMBL2164060)
Show SMILES CCC(C(=O)N(C)c1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C21H26N2O/c1-3-18(17-11-5-4-6-12-17)21(24)22(2)19-13-7-8-14-20(19)23-15-9-10-16-23/h4-8,11-14,18H,3,9-10,15-16H2,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395511
PNG
(CHEMBL2164058)
Show SMILES O=C(Nc1ccccc1N1CCCC1)C1CCOc2ccccc12
Show InChI InChI=1S/C20H22N2O2/c23-20(16-11-14-24-19-10-4-1-7-15(16)19)21-17-8-2-3-9-18(17)22-12-5-6-13-22/h1-4,7-10,16H,5-6,11-14H2,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50050534
PNG
(CHEMBL3183773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50050530
PNG
(CHEMBL3188857)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50050157
PNG
(CHEMBL1310568)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-7-5-10-17(13-15)21(25)23-19-12-6-11-18(14-19)22-20(24)16-8-3-2-4-9-16/h2-14H,1H3,(H,22,24)(H,23,25)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50312125
PNG
(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395399
PNG
(CHEMBL2165063)
Show SMILES COc1ccc2ncc(=O)n(CCN3CCC(CC3)NCc3ccc4OCC(=O)Nc4n3)c2c1
Show InChI InChI=1S/C24H28N6O4/c1-33-18-3-4-19-20(12-18)30(23(32)14-26-19)11-10-29-8-6-16(7-9-29)25-13-17-2-5-21-24(27-17)28-22(31)15-34-21/h2-5,12,14,16,25H,6-11,13,15H2,1H3,(H,27,28,31)
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n/an/a 3.50E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of potassium channel IKs (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50023589
PNG
(CHEMBL3355573)
Show SMILES N[C@@H](Cn1c2cc(F)ccc2ncc1=O)[C@H]1CC[C@@H](CC1)NCc1ncc2OCC(=O)Nc2n1
Show InChI InChI=1/C23H26FN7O3/c24-14-3-6-17-18(7-14)31(22(33)10-27-17)11-16(25)13-1-4-15(5-2-13)26-9-20-28-8-19-23(29-20)30-21(32)12-34-19/h3,6-8,10,13,15-16,26H,1-2,4-5,9,11-12,25H2,(H,28,29,30,32)/t13-,15-,16-/s2
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n/an/a>3.33E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of potassium channel IKs (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50023582
PNG
(CHEMBL3355575)
Show SMILES COc1cnc2ccc(=O)n(C[C@H](N)[C@H]3CC[C@@H](CC3)NCc3ccc4OCC(=O)Nc4n3)c2c1
Show InChI InChI=1/C25H30N6O4/c1-34-18-10-21-20(28-12-18)7-9-24(33)31(21)13-19(26)15-2-4-16(5-3-15)27-11-17-6-8-22-25(29-17)30-23(32)14-35-22/h6-10,12,15-16,19,27H,2-5,11,13-14,26H2,1H3,(H,29,30,32)/t15-,16-,19-/s2
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n/an/a>3.33E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of potassium channel IKs (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
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