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Compile Data Set for Download or QSAR

Found 1214 hits Enz. Inhib. hit(s) with Target = 'Kinesin-like protein 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kinesin-like protein 1


(Homo sapiens)
BDBM50427294
PNG
(CHEMBL2325429 | SB-743921)
Show SMILES CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)c1oc2cc(Cl)ccc2c(=O)c1Cc1ccccc1
Show InChI InChI=1S/C31H33ClN2O3/c1-20(2)28(34(17-7-16-33)31(36)23-12-10-21(3)11-13-23)30-26(18-22-8-5-4-6-9-22)29(35)25-15-14-24(32)19-27(25)37-30/h4-6,8-15,19-20,28H,7,16-18,33H2,1-3H3/t28-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50427274
PNG
(CHEMBL2325410)
Show SMILES Cc1ccc(cc1C)C(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2S/c1-17-13-14-21(15-18(17)2)24(19-9-5-3-6-10-19,20-11-7-4-8-12-20)28-16-22(25)23(26)27/h3-15,22H,16,25H2,1-2H3,(H,26,27)/t22-/m0/s1
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1.20n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
kinesin spindle protein


(Homo sapiens)
BDBM36350
PNG
(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C16H12F3NO/c17-16(18,19)13-5-1-10(2-6-13)11-3-7-14-12(9-11)4-8-15(21)20-14/h1-3,5-7,9H,4,8H2,(H,20,21)
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1.70n/an/an/an/an/an/a6.8n/a



GlaxoSmithKline



Assay Description
Cell proliferation assay for wild-type cells


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427278
PNG
(CHEMBL2325414)
Show SMILES N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccc2CCCCc2c1)C(O)=O
Show InChI InChI=1S/C26H27NO2S/c27-24(25(28)29)18-30-26(21-11-3-1-4-12-21,22-13-5-2-6-14-22)23-16-15-19-9-7-8-10-20(19)17-23/h1-6,11-17,24H,7-10,18,27H2,(H,28,29)/t24-/m0/s1
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2.10n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382559
PNG
(ISPINESIB)
Show SMILES CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C30H33ClN4O2/c1-20(2)27(34(17-7-16-32)29(36)23-12-10-21(3)11-13-23)28-33-26-18-24(31)14-15-25(26)30(37)35(28)19-22-8-5-4-6-9-22/h4-6,8-15,18,20,27H,7,16-17,19,32H2,1-3H3/t27-/m1/s1
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2.30n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50382559
PNG
(ISPINESIB)
Show SMILES CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C30H33ClN4O2/c1-20(2)27(34(17-7-16-32)29(36)23-12-10-21(3)11-13-23)28-33-26-18-24(31)14-15-25(26)30(37)35(28)19-22-8-5-4-6-9-22/h4-6,8-15,18,20,27H,7,16-17,19,32H2,1-3H3/t27-/m1/s1
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2.5n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50382584
PNG
(CHEMBL2023001)
Show SMILES Cc1ccc(cc1)C(CC[C@@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-12-14-21(15-13-18)24(17-16-22(25)23(26)27,19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-15,22H,16-17,25H2,1H3,(H,26,27)/t22-/m1/s1
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3.40n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220180
PNG
(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1F)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H10F4N2O2S/c14-11-7-9(3-6-12(11)19-22(18,20)21)8-1-4-10(5-2-8)13(15,16)17/h1-7,19H,(H2,18,20,21)
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3.5n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM23780
PNG
((2R)-2-amino-3-[(naphthalen-2-yldiphenylmethyl)sul...)
Show SMILES N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C26H23NO2S/c27-24(25(28)29)18-30-26(21-11-3-1-4-12-21,22-13-5-2-6-14-22)23-16-15-19-9-7-8-10-20(19)17-23/h1-17,24H,18,27H2,(H,28,29)/t24-/m0/s1
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4.20n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427276
PNG
(CHEMBL2325412)
Show SMILES CCc1cc(ccc1C)C(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H27NO2S/c1-3-19-16-22(15-14-18(19)2)25(20-10-6-4-7-11-20,21-12-8-5-9-13-21)29-17-23(26)24(27)28/h4-16,23H,3,17,26H2,1-2H3,(H,27,28)/t23-/m0/s1
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4.60n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427285
PNG
(CHEMBL2325421)
Show SMILES CCc1cccc(c1)C(SCCN)(c1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C23H25NOS/c1-2-18-8-6-11-20(16-18)23(26-15-14-24,19-9-4-3-5-10-19)21-12-7-13-22(25)17-21/h3-13,16-17,25H,2,14-15,24H2,1H3
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4.80n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50427276
PNG
(CHEMBL2325412)
Show SMILES CCc1cc(ccc1C)C(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H27NO2S/c1-3-19-16-22(15-14-18(19)2)25(20-10-6-4-7-11-20,21-12-8-5-9-13-21)29-17-23(26)24(27)28/h4-16,23H,3,17,26H2,1-2H3,(H,27,28)/t23-/m0/s1
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4.90n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382546
PNG
(CHEMBL2022996)
Show SMILES Cc1cccc(c1)C(CC[C@@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-9-8-14-21(17-18)24(16-15-22(25)23(26)27,19-10-4-2-5-11-19)20-12-6-3-7-13-20/h2-14,17,22H,15-16,25H2,1H3,(H,26,27)/t22-/m1/s1
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5.10n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50382584
PNG
(CHEMBL2023001)
Show SMILES Cc1ccc(cc1)C(CC[C@@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-12-14-21(15-13-18)24(17-16-22(25)23(26)27,19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-15,22H,16-17,25H2,1H3,(H,26,27)/t22-/m1/s1
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5.40n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382589
PNG
(CHEMBL2022982)
Show SMILES CCc1cccc(c1)C(SCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25NS/c1-2-19-10-9-15-22(18-19)23(25-17-16-24,20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-15,18H,2,16-17,24H2,1H3
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5.90n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50220182
PNG
(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O2S/c14-13(15,16)11-5-1-9(2-6-11)10-3-7-12(8-4-10)18-21(17,19)20/h1-8,18H,(H2,17,19,20)
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6.20n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human KSP motor domain by ATPase assay


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382546
PNG
(CHEMBL2022996)
Show SMILES Cc1cccc(c1)C(CC[C@@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-9-8-14-21(17-18)24(16-15-22(25)23(26)27,19-10-4-2-5-11-19)20-12-6-3-7-13-20/h2-14,17,22H,15-16,25H2,1H3,(H,26,27)/t22-/m1/s1
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6.40n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50427262
PNG
(CHEMBL2325432)
Show SMILES CCc1cccc(c1)C(CCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H27N/c1-2-20-11-9-16-23(19-20)24(17-10-18-25,21-12-5-3-6-13-21)22-14-7-4-8-15-22/h3-9,11-16,19H,2,10,17-18,25H2,1H3
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6.40n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427263
PNG
(CHEMBL2325433)
Show SMILES CC(C)c1cccc(c1)C(CCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H29N/c1-20(2)21-11-9-16-24(19-21)25(17-10-18-26,22-12-5-3-6-13-22)23-14-7-4-8-15-23/h3-9,11-16,19-20H,10,17-18,26H2,1-2H3
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6.70n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427286
PNG
(CHEMBL2321913)
Show SMILES Cc1ccc(cc1)C(SCCN)(c1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C22H23NOS/c1-17-10-12-19(13-11-17)22(25-15-14-23,18-6-3-2-4-7-18)20-8-5-9-21(24)16-20/h2-13,16,24H,14-15,23H2,1H3
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6.80n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382546
PNG
(CHEMBL2022996)
Show SMILES Cc1cccc(c1)C(CC[C@@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-9-8-14-21(17-18)24(16-15-22(25)23(26)27,19-10-4-2-5-11-19)20-12-6-3-7-13-20/h2-14,17,22H,15-16,25H2,1H3,(H,26,27)/t22-/m1/s1
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7.10n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50427286
PNG
(CHEMBL2321913)
Show SMILES Cc1ccc(cc1)C(SCCN)(c1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C22H23NOS/c1-17-10-12-19(13-11-17)22(25-15-14-23,18-6-3-2-4-7-18)20-8-5-9-21(24)16-20/h2-13,16,24H,14-15,23H2,1H3
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7.10n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382582
PNG
(CHEMBL2022999)
Show SMILES Cc1ccc(cc1)C(CCC(N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-12-14-21(15-13-18)24(17-16-22(25)23(26)27,19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-15,22H,16-17,25H2,1H3,(H,26,27)
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7.5n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427289
PNG
(CHEMBL2325424)
Show SMILES Cc1ccc(cc1)C(CCC(N)C(O)=O)(c1ccccc1)c1cccc(O)c1
Show InChI InChI=1S/C24H25NO3/c1-17-10-12-19(13-11-17)24(15-14-22(25)23(27)28,18-6-3-2-4-7-18)20-8-5-9-21(26)16-20/h2-13,16,22,26H,14-15,25H2,1H3,(H,27,28)
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7.80n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427277
PNG
(CHEMBL2325413)
Show SMILES CCc1cc(ccc1C)C(SCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H27NS/c1-3-20-18-23(15-14-19(20)2)24(26-17-16-25,21-10-6-4-7-11-21)22-12-8-5-9-13-22/h4-15,18H,3,16-17,25H2,1-2H3
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7.80n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382558
PNG
(CHEMBL2022997)
Show SMILES Cc1cccc(c1)C(CCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25N/c1-19-10-8-15-22(18-19)23(16-9-17-24,20-11-4-2-5-12-20)21-13-6-3-7-14-21/h2-8,10-15,18H,9,16-17,24H2,1H3
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8.80n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382558
PNG
(CHEMBL2022997)
Show SMILES Cc1cccc(c1)C(CCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25N/c1-19-10-8-15-22(18-19)23(16-9-17-24,20-11-4-2-5-12-20)21-13-6-3-7-14-21/h2-8,10-15,18H,9,16-17,24H2,1H3
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8.80n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427265
PNG
(CHEMBL2325435)
Show SMILES COc1ccc(cc1)C(CCC(N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO3/c1-28-21-14-12-20(13-15-21)24(17-16-22(25)23(26)27,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-15,22H,16-17,25H2,1H3,(H,26,27)
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9n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM23823
PNG
((2R)-2-amino-3-{[(4-methoxyphenyl)diphenylmethyl]s...)
Show SMILES COc1ccc(cc1)C(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H23NO3S/c1-27-20-14-12-19(13-15-20)23(17-8-4-2-5-9-17,18-10-6-3-7-11-18)28-16-21(24)22(25)26/h2-15,21H,16,24H2,1H3,(H,25,26)/t21-/m0/s1
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9.10n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382560
PNG
(CHEMBL2023002)
Show SMILES Cc1ccc(cc1)C(CCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25N/c1-19-13-15-22(16-14-19)23(17-8-18-24,20-9-4-2-5-10-20)21-11-6-3-7-12-21/h2-7,9-16H,8,17-18,24H2,1H3
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9.70n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427264
PNG
(CHEMBL2325434)
Show SMILES CCc1ccc(cc1)C(CCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H27N/c1-2-20-14-16-23(17-15-20)24(18-9-19-25,21-10-5-3-6-11-21)22-12-7-4-8-13-22/h3-8,10-17H,2,9,18-19,25H2,1H3
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9.70n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382582
PNG
(CHEMBL2022999)
Show SMILES Cc1ccc(cc1)C(CCC(N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-12-14-21(15-13-18)24(17-16-22(25)23(26)27,19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-15,22H,16-17,25H2,1H3,(H,26,27)
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9.80n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427282
PNG
(CHEMBL2325418)
Show SMILES Cc1ccc(cc1C)C(CCC(N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H27NO2/c1-18-13-14-22(17-19(18)2)25(16-15-23(26)24(27)28,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-14,17,23H,15-16,26H2,1-2H3,(H,27,28)
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9.90n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427270
PNG
(CHEMBL2325406)
Show SMILES COc1ccc(c(F)c1)C(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H22FNO3S/c1-28-18-12-13-19(20(24)14-18)23(16-8-4-2-5-9-16,17-10-6-3-7-11-17)29-15-21(25)22(26)27/h2-14,21H,15,25H2,1H3,(H,26,27)/t21-/m0/s1
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10n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427266
PNG
(CHEMBL2325436)
Show SMILES COc1ccc(cc1)C(CCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25NO/c1-25-22-15-13-21(14-16-22)23(17-8-18-24,19-9-4-2-5-10-19)20-11-6-3-7-12-20/h2-7,9-16H,8,17-18,24H2,1H3
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10n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427270
PNG
(CHEMBL2325406)
Show SMILES COc1ccc(c(F)c1)C(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H22FNO3S/c1-28-18-12-13-19(20(24)14-18)23(16-8-4-2-5-9-16,17-10-6-3-7-11-17)29-15-21(25)22(26)27/h2-14,21H,15,25H2,1H3,(H,26,27)/t21-/m0/s1
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10n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382546
PNG
(CHEMBL2022996)
Show SMILES Cc1cccc(c1)C(CC[C@@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-9-8-14-21(17-18)24(16-15-22(25)23(26)27,19-10-4-2-5-11-19)20-12-6-3-7-13-20/h2-14,17,22H,15-16,25H2,1H3,(H,26,27)/t22-/m1/s1
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10.2n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50382590
PNG
(CHEMBL2022983)
Show SMILES CC(C)c1cccc(c1)C(SCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H27NS/c1-19(2)20-10-9-15-23(18-20)24(26-17-16-25,21-11-5-3-6-12-21)22-13-7-4-8-14-22/h3-15,18-19H,16-17,25H2,1-2H3
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10.3n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382581
PNG
(CHEMBL2022998)
Show SMILES NCCCC(c1ccccc1)(c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN/c23-21-14-12-20(13-15-21)22(16-7-17-24,18-8-3-1-4-9-18)19-10-5-2-6-11-19/h1-6,8-15H,7,16-17,24H2
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10.7n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382558
PNG
(CHEMBL2022997)
Show SMILES Cc1cccc(c1)C(CCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25N/c1-19-10-8-15-22(18-19)23(16-9-17-24,20-11-4-2-5-12-20)21-13-6-3-7-14-21/h2-8,10-15,18H,9,16-17,24H2,1H3
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10.8n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427279
PNG
(CHEMBL2325415)
Show SMILES NCCSC(c1ccccc1)(c1ccccc1)c1ccc2CCCCc2c1
Show InChI InChI=1S/C25H27NS/c26-17-18-27-25(22-11-3-1-4-12-22,23-13-5-2-6-14-23)24-16-15-20-9-7-8-10-21(20)19-24/h1-6,11-16,19H,7-10,17-18,26H2
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11n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382548
PNG
(CHEMBL2022995)
Show SMILES Cc1cccc(c1)C(CC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-9-8-14-21(17-18)24(16-15-22(25)23(26)27,19-10-4-2-5-11-19)20-12-6-3-7-13-20/h2-14,17,22H,15-16,25H2,1H3,(H,26,27)/t22-/m0/s1
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11.1n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50427282
PNG
(CHEMBL2325418)
Show SMILES Cc1ccc(cc1C)C(CCC(N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H27NO2/c1-18-13-14-22(17-19(18)2)25(16-15-23(26)24(27)28,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-14,17,23H,15-16,26H2,1-2H3,(H,27,28)
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12n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427271
PNG
(CHEMBL2325407)
Show SMILES COc1ccc(c(F)c1)C(SCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H22FNOS/c1-25-19-12-13-20(21(23)16-19)22(26-15-14-24,17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-13,16H,14-15,24H2,1H3
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12n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50382546
PNG
(CHEMBL2022996)
Show SMILES Cc1cccc(c1)C(CC[C@@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-9-8-14-21(17-18)24(16-15-22(25)23(26)27,19-10-4-2-5-11-19)20-12-6-3-7-13-20/h2-14,17,22H,15-16,25H2,1H3,(H,26,27)/t22-/m1/s1
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12n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50382546
PNG
(CHEMBL2022996)
Show SMILES Cc1cccc(c1)C(CC[C@@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-9-8-14-21(17-18)24(16-15-22(25)23(26)27,19-10-4-2-5-11-19)20-12-6-3-7-13-20/h2-14,17,22H,15-16,25H2,1H3,(H,26,27)/t22-/m1/s1
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12.2n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM50382548
PNG
(CHEMBL2022995)
Show SMILES Cc1cccc(c1)C(CC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO2/c1-18-9-8-14-21(17-18)24(16-15-22(25)23(26)27,19-10-4-2-5-11-19)20-12-6-3-7-13-20/h2-14,17,22H,15-16,25H2,1H3,(H,26,27)/t22-/m0/s1
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12.8n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin-like protein 1


(Homo sapiens)
BDBM23822
PNG
((2R)-2-amino-3-{[(4-methylphenyl)diphenylmethyl]su...)
Show SMILES Cc1ccc(cc1)C(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H23NO2S/c1-17-12-14-20(15-13-17)23(18-8-4-2-5-9-18,19-10-6-3-7-11-19)27-16-21(24)22(25)26/h2-15,21H,16,24H2,1H3,(H,25,26)/t21-/m0/s1
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13.6n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin-like protein 1


(Homo sapiens)
BDBM50382558
PNG
(CHEMBL2022997)
Show SMILES Cc1cccc(c1)C(CCCN)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25N/c1-19-10-8-15-22(18-19)23(16-9-17-24,20-11-4-2-5-12-20)21-13-6-3-7-14-21/h2-8,10-15,18H,9,16-17,24H2,1H3
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14n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...


Citation and Details
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens)
BDBM50427265
PNG
(CHEMBL2325435)
Show SMILES COc1ccc(cc1)C(CCC(N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25NO3/c1-28-21-14-12-20(13-15-21)24(17-16-22(25)23(26)27,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-15,22H,16-17,25H2,1H3,(H,26,27)
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15n/an/an/an/an/an/an/an/a



The Beatson Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...


Citation and Details
More data for this
Ligand-Target Pair
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