BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 10 hits Enz. Inhib. hit(s) with Target = 'Kynureninase' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynureninase


(Homo sapiens)
BDBM50069730
PNG
(2-Amino-3-(2-amino-benzenesulfonyl)-propionic acid...)
Show SMILES NC(CS(=O)(=O)c1ccccc1N)C(O)=O
Show InChI InChI=1S/C9H12N2O4S/c10-6-3-1-2-4-8(6)16(14,15)5-7(11)9(12)13/h1-4,7H,5,10-11H2,(H,12,13)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
70n/an/an/an/an/an/an/an/a



Glaxo Wellcome Research and Development

Curated by ChEMBL


Assay Description
Compound was tested for the binding affinity against bacterial kynureninase


Bioorg Med Chem Lett 8: 133-8 (1999)

More data for this
Ligand-Target Pair
Kynureninase


(Homo sapiens)
BDBM50288256
PNG
((R)-2-Amino-3-(2-amino-benzenesulfonyl)-propionic ...)
Show SMILES N[C@H](CS(=O)(=O)c1ccccc1N)C(O)=O
Show InChI InChI=1S/C9H12N2O4S/c10-6-3-1-2-4-8(6)16(14,15)5-7(11)9(12)13/h1-4,7H,5,10-11H2,(H,12,13)/t7-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
70n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence


Citation and Details
More data for this
Ligand-Target Pair
Kynureninase


(Homo sapiens)
BDBM50109155
PNG
(2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric aci...)
Show SMILES NC(CC(O)c1cccc(O)c1)C(O)=O
Show InChI InChI=1S/C10H13NO4/c11-8(10(14)15)5-9(13)6-2-1-3-7(12)4-6/h1-4,8-9,12-13H,5,11H2,(H,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
100n/an/an/an/an/an/an/an/a



University of St Andrews

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound against kynureninase enzyme from human


Bioorg Med Chem Lett 12: 361-3 (2002)

More data for this
Ligand-Target Pair
Kynureninase


(Homo sapiens)
BDBM50109155
PNG
(2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric aci...)
Show SMILES NC(CC(O)c1cccc(O)c1)C(O)=O
Show InChI InChI=1S/C10H13NO4/c11-8(10(14)15)5-9(13)6-2-1-3-7(12)4-6/h1-4,8-9,12-13H,5,11H2,(H,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
100n/an/an/an/an/an/an/an/a



University of Georgia

Curated by ChEMBL


Assay Description
Inhibition of human kynureninase


Citation and Details
More data for this
Ligand-Target Pair
Kynureninase


(Homo sapiens)
BDBM50288255
PNG
(2-ammonio-4-(2-ammoniophenyl)-4-oxo-(2S)-butanoate)
Show SMILES [NH3+][C@@H](CC(=O)c1ccccc1[NH3+])C([O-])=O
Show InChI InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/p+1/t8-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
4.28E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence


Citation and Details
More data for this
Ligand-Target Pair
Kynureninase


(Homo sapiens)
BDBM50288257
PNG
((R)-2-Benzyloxycarbonylamino-3-(methoxy-phenyl-pho...)
Show SMILES COC(=O)[C@H](CP(=O)(OC)c1ccccc1)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C19H22NO6P/c1-24-18(21)17(14-27(23,25-2)16-11-7-4-8-12-16)20-19(22)26-13-15-9-5-3-6-10-15/h3-12,17H,13-14H2,1-2H3,(H,20,22)/t17-,27?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
8.80E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence


Citation and Details
More data for this
Ligand-Target Pair
Kynureninase


(Homo sapiens)
BDBM50109155
PNG
(2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric aci...)
Show SMILES NC(CC(O)c1cccc(O)c1)C(O)=O
Show InChI InChI=1S/C10H13NO4/c11-8(10(14)15)5-9(13)6-2-1-3-7(12)4-6/h1-4,8-9,12-13H,5,11H2,(H,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
1.00E+4n/an/an/an/an/an/an/an/a



University of St Andrews

Curated by ChEMBL


Assay Description
Tested for binding affinity of the compound against kynureninase enzyme from bacterial cells


Bioorg Med Chem Lett 12: 361-3 (2002)

More data for this
Ligand-Target Pair
Kynureninase


(Homo sapiens)
BDBM50288254
PNG
(2-ammonio-4-oxo-4-phenyl-(2S)-butanoate | CHEMBL31...)
Show SMILES [NH3+][C@@H](CC(=O)c1ccccc1)C([O-])=O
Show InChI InChI=1S/C10H11NO3/c11-8(10(13)14)6-9(12)7-4-2-1-3-5-7/h1-5,8H,6,11H2,(H,13,14)/t8-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
2.34E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence


Citation and Details
More data for this
Ligand-Target Pair
Kynureninase


(Homo sapiens)
BDBM50265459
PNG
(3-Hydroxyhippuric acid | CHEMBL447627)
Show SMILES OC(=O)CNC(=O)c1cccc(O)c1
Show InChI InChI=1S/C9H9NO4/c11-7-3-1-2-6(4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
MMDB
PDB
Article
PubMed
6.00E+4n/an/an/an/an/an/an/an/a



University of Georgia

Curated by ChEMBL


Assay Description
Inhibition of human kynureninase


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kynureninase


(Homo sapiens)
BDBM50288258
PNG
((R)-2-Benzyloxycarbonylamino-3-(methoxy-phenyl-pho...)
Show SMILES COP(=O)(C[C@H](NC(=O)OCc1ccccc1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C18H20NO6P/c1-24-26(23,15-10-6-3-7-11-15)13-16(17(20)21)19-18(22)25-12-14-8-4-2-5-9-14/h2-11,16H,12-13H2,1H3,(H,19,22)(H,20,21)/t16-,26?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
8.80E+5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence


Citation and Details
More data for this
Ligand-Target Pair