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Found 13 hits Enz. Inhib. hit(s) with Target = 'L-type amino acid transporter 1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50025839
PNG
(2-Amino-7-[bis-(2-chloro-ethyl)-amino]-1,2,3,4-tet...)
Show SMILES NC1(CCc2ccc(cc2C1)N(CCCl)CCCl)C(O)=O
Show InChI InChI=1S/C15H20Cl2N2O2/c16-5-7-19(8-6-17)13-2-1-11-3-4-15(18,14(20)21)10-12(11)9-13/h1-2,9H,3-8,10,18H2,(H,20,21)
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79n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50025839
PNG
(2-Amino-7-[bis-(2-chloro-ethyl)-amino]-1,2,3,4-tet...)
Show SMILES NC1(CCc2ccc(cc2C1)N(CCCl)CCCl)C(O)=O
Show InChI InChI=1S/C15H20Cl2N2O2/c16-5-7-19(8-6-17)13-2-1-11-3-4-15(18,14(20)21)10-12(11)9-13/h1-2,9H,3-8,10,18H2,(H,20,21)
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200n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Binding affinity to LAT1 in rat brain


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50319696
PNG
((+/-)-2-endo-amino-bis(2-chloroethyl)-7'-aminobenz...)
Show SMILES NC1(CC2CC1c1cc(ccc21)N(CCCl)CCCl)C(O)=O
Show InChI InChI=1S/C16H20Cl2N2O2/c17-3-5-20(6-4-18)11-1-2-12-10-7-14(13(12)8-11)16(19,9-10)15(21)22/h1-2,8,10,14H,3-7,9,19H2,(H,21,22)
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2.10E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50319694
PNG
((+/-)-2-Amino-(bis-2-chloroethyl)-5-aminoindane-2-...)
Show SMILES NC1(Cc2ccc(cc2C1)N(CCCl)CCCl)C(O)=O
Show InChI InChI=1S/C14H18Cl2N2O2/c15-3-5-18(6-4-16)12-2-1-10-8-14(17,13(19)20)9-11(10)7-12/h1-2,7H,3-6,8-9,17H2,(H,19,20)
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5.00E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50025838
PNG
((+/-)-2-Amino-1,2,3,4-tetrahydro-2-naphthoic acid ...)
Show SMILES NC1(CCc2ccccc2C1)C(O)=O
Show InChI InChI=1S/C11H13NO2/c12-11(10(13)14)6-5-8-3-1-2-4-9(8)7-11/h1-4H,5-7,12H2,(H,13,14)
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7.70E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50025836
PNG
((+/-)-2-amino-5-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Show SMILES NC1(CCc2c(C1)cccc2N(CCCl)CCCl)C(O)=O
Show InChI InChI=1S/C15H20Cl2N2O2/c16-6-8-19(9-7-17)13-3-1-2-11-10-15(18,14(20)21)5-4-12(11)13/h1-3H,4-10,18H2,(H,20,21)
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8.50E+3n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50319693
PNG
((+/-)-2-Aminoindane-2-carboxylic acid | CHEMBL1082...)
Show SMILES NC1(Cc2ccccc2C1)C(O)=O
Show InChI InChI=1S/C10H11NO2/c11-10(9(12)13)5-7-3-1-2-4-8(7)6-10/h1-4H,5-6,11H2,(H,12,13)
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1.25E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50025836
PNG
((+/-)-2-amino-5-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Show SMILES NC1(CCc2c(C1)cccc2N(CCCl)CCCl)C(O)=O
Show InChI InChI=1S/C15H20Cl2N2O2/c16-6-8-19(9-7-17)13-3-1-2-11-10-15(18,14(20)21)5-4-12(11)13/h1-3H,4-10,18H2,(H,20,21)
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2.50E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Binding affinity to LAT1 in rat brain


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50319695
PNG
((+/-)-2-Aminobenzo-bicyclo-[2.2.1]heptane-2'-exo-c...)
Show SMILES NC1(CC2CC1c1ccccc21)C(O)=O
Show InChI InChI=1S/C12H13NO2/c13-12(11(14)15)6-7-5-10(12)9-4-2-1-3-8(7)9/h1-4,7,10H,5-6,13H2,(H,14,15)
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2.60E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50025837
PNG
((S)-2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phen...)
Show SMILES N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(O)=O
Show InChI InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
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5.50E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM18073
PNG
((2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523...)
Show SMILES N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
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5.50E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50319691
PNG
((+/-)-2-amino-6-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Show SMILES NC1(CCc2cc(ccc2C1)N(CCCl)CCCl)C(O)=O
Show InChI InChI=1S/C15H20Cl2N2O2/c16-5-7-19(8-6-17)13-2-1-12-10-15(18,14(20)21)4-3-11(12)9-13/h1-2,9H,3-8,10,18H2,(H,20,21)
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6.80E+4n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
L-type amino acid transporter 1


(Rattus norvegicus)
BDBM50319692
PNG
((+/-)-2-amino-8-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Show SMILES NC1(CCc2cccc(N(CCCl)CCCl)c2C1)C(O)=O
Show InChI InChI=1S/C15H20Cl2N2O2/c16-6-8-19(9-7-17)13-3-1-2-11-4-5-15(18,14(20)21)10-12(11)13/h1-3H,4-10,18H2,(H,20,21)
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2.52E+5n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of LAT1-mediated L-[14C]-leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair