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Found 58 hits Enz. Inhib. hit(s) with Target = 'Lactase-glycosylceramidase' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50182801
PNG
((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350758
PNG
(CHEMBL1818433)
Show SMILES OC[C@H]1CNC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m1/s1
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n/an/a 510n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50292389
PNG
(3-epi-fagomine | 3-epifagomine | CHEMBL456583)
Show SMILES OC[C@H]1NCC[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-6(10)5(9)1-2-7-4/h4-10H,1-3H2/t4-,5+,6-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Tested for competitive inhibition of rat intestinal lactase


J Med Chem 37: 3701-6 (1994)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50031481
PNG
((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...)
Show SMILES OC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50031481
PNG
((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...)
Show SMILES OC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat intestinal lactase


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50242071
PNG
(2,5-Dideoxy-2,5-imino-D-glycero-D-manno-heptitol |...)
Show SMILES OCC(O)[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-6(12)7(13)5(8-3)4(11)2-10/h3-13H,1-2H2/t3-,4?,5-,6-,7-/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat intestinal lactase


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50292389
PNG
(3-epi-fagomine | 3-epifagomine | CHEMBL456583)
Show SMILES OC[C@H]1NCC[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-6(10)5(9)1-2-7-4/h4-10H,1-3H2/t4-,5+,6-/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM18353
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Show SMILES CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
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n/an/a 4.40E+3n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50241865
PNG
(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6+/m1/s1
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n/an/a 7.20E+3n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as p-nitrophenol release by spectrometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50278912
PNG
(CHEMBL524631 | Hyacinthacine B3)
Show SMILES C[C@@H]1C[C@@H](O)[C@@H]2[C@H](O)[C@H](O)[C@@H](CO)N12
Show InChI InChI=1S/C9H17NO4/c1-4-2-6(12)7-9(14)8(13)5(3-11)10(4)7/h4-9,11-14H,2-3H2,1H3/t4-,5-,6-,7-,8-,9+/m1/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as p-nitrophenol release after 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50263043
PNG
(CHEMBL501385 | L-Isofagomine)
Show SMILES OC[C@@H]1CNC[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestine


J Med Chem 37: 3701-6 (1994)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 3.40E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432219
PNG
(CHEMBL2347146)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(Cc3ccc(C(O)=O)c(O)c3)C(=O)c2c1
Show InChI InChI=1S/C23H18N2O7S/c1-13-2-6-16(7-3-13)33(31,32)24-15-5-9-17-19(11-15)22(28)25(21(17)27)12-14-4-8-18(23(29)30)20(26)10-14/h2-11,24,26H,12H2,1H3,(H,29,30)
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n/an/a 4.47E+4n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 4.90E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50031483
PNG
((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-1-methyl-pyrro...)
Show SMILES CN1[C@H](CO)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-4(2-9)6(11)7(12)5(8)3-10/h4-7,9-12H,2-3H2,1H3/t4-,5-,6-,7-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50031482
PNG
((2R,3R,4R,5R)-1-Butyl-2,5-bis-hydroxymethyl-pyrrol...)
Show SMILES CCCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-7(5-12)9(14)10(15)8(11)6-13/h7-10,12-15H,2-6H2,1H3/t7-,8-,9-,10-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50031480
PNG
((2R,3R,4R)-2-Hydroxymethyl-1-methyl-pyrrolidine-3,...)
Show SMILES CN1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C6H13NO3/c1-7-2-5(9)6(10)4(7)3-8/h4-6,8-10H,2-3H2,1H3/t4-,5-,6-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50031484
PNG
((2R,3R,4R)-1-Butyl-2-hydroxymethyl-pyrrolidine-3,4...)
Show SMILES CCCCN1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H19NO3/c1-2-3-4-10-5-8(12)9(13)7(10)6-11/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350761
PNG
(CHEMBL1818321)
Show SMILES OC[C@H]1CNC[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6-/m1/s1
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n/an/a 5.20E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432216
PNG
(CHEMBL2347149)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(CCNc3ccc(O)c(O)c3)C(=O)c2c1
Show InChI InChI=1S/C23H21N3O6S/c1-14-2-6-17(7-3-14)33(31,32)25-16-4-8-18-19(12-16)23(30)26(22(18)29)11-10-24-15-5-9-20(27)21(28)13-15/h2-9,12-13,24-25,27-28H,10-11H2,1H3
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n/an/a 6.66E+4n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50163440
PNG
((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1
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n/an/a 7.20E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as p-nitrophenol release by spectrometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432221
PNG
(CHEMBL2347144)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(Cc3ccc(cc3)C(N)=O)C(=O)c2c1
Show InChI InChI=1S/C23H19N3O5S/c1-14-2-9-18(10-3-14)32(30,31)25-17-8-11-19-20(12-17)23(29)26(22(19)28)13-15-4-6-16(7-5-15)21(24)27/h2-12,25H,13H2,1H3,(H2,24,27)
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n/an/a 8.42E+4n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350759
PNG
(CHEMBL1818434)
Show SMILES OC[C@@H]1CNC[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m0/s1
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n/an/a 9.00E+4n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432214
PNG
(CHEMBL2347151)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(CCOc3ccc(O)cc3)C(=O)c2c1
Show InChI InChI=1S/C23H20N2O6S/c1-15-2-9-19(10-3-15)32(29,30)24-16-4-11-20-21(14-16)23(28)25(22(20)27)12-13-31-18-7-5-17(26)6-8-18/h2-11,14,24,26H,12-13H2,1H3
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n/an/a 1.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432224
PNG
(CHEMBL2347141)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(Cc3ccc(Cl)c(Cl)c3)C(=O)c2c1
Show InChI InChI=1S/C22H16Cl2N2O4S/c1-13-2-6-16(7-3-13)31(29,30)25-15-5-8-17-18(11-15)22(28)26(21(17)27)12-14-4-9-19(23)20(24)10-14/h2-11,25H,12H2,1H3
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n/an/a 1.01E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432215
PNG
(CHEMBL2347150)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(CCOc3cccc(O)c3)C(=O)c2c1
Show InChI InChI=1S/C23H20N2O6S/c1-15-5-8-19(9-6-15)32(29,30)24-16-7-10-20-21(13-16)23(28)25(22(20)27)11-12-31-18-4-2-3-17(26)14-18/h2-10,13-14,24,26H,11-12H2,1H3
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n/an/a 1.11E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350760
PNG
(CHEMBL1818436)
Show SMILES OC[C@@H]1NCC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-6(10)5(9)1-2-7-4/h4-10H,1-3H2/t4-,5+,6-/m0/s1
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n/an/a 1.22E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432225
PNG
(CHEMBL2347140)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(Cc3ccc(Cl)cc3)C(=O)c2c1
Show InChI InChI=1S/C22H17ClN2O4S/c1-14-2-9-18(10-3-14)30(28,29)24-17-8-11-19-20(12-17)22(27)25(21(19)26)13-15-4-6-16(23)7-5-15/h2-12,24H,13H2,1H3
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n/an/a 1.55E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432220
PNG
(CHEMBL2347145)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(Cc3ccc(O)c(O)c3)C(=O)c2c1
Show InChI InChI=1S/C22H18N2O6S/c1-13-2-6-16(7-3-13)31(29,30)23-15-5-8-17-18(11-15)22(28)24(21(17)27)12-14-4-9-19(25)20(26)10-14/h2-11,23,25-26H,12H2,1H3
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n/an/a 1.64E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50333465
PNG
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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n/an/a 1.67E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432213
PNG
(CHEMBL2347152)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(CCOc3ccccc3)C(=O)c2c1
Show InChI InChI=1S/C23H20N2O5S/c1-16-7-10-19(11-8-16)31(28,29)24-17-9-12-20-21(15-17)23(27)25(22(20)26)13-14-30-18-5-3-2-4-6-18/h2-12,15,24H,13-14H2,1H3
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n/an/a 1.70E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432227
PNG
(CHEMBL2347138)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(Cc3ccc(F)cc3)C(=O)c2c1
Show InChI InChI=1S/C22H17FN2O4S/c1-14-2-9-18(10-3-14)30(28,29)24-17-8-11-19-20(12-17)22(27)25(21(19)26)13-15-4-6-16(23)7-5-15/h2-12,24H,13H2,1H3
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n/an/a 1.72E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432223
PNG
(CHEMBL2347142)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(CCNc3ccccc3)C(=O)c2c1
Show InChI InChI=1S/C23H21N3O4S/c1-16-7-10-19(11-8-16)31(29,30)25-18-9-12-20-21(15-18)23(28)26(22(20)27)14-13-24-17-5-3-2-4-6-17/h2-12,15,24-25H,13-14H2,1H3
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n/an/a 1.77E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432226
PNG
(CHEMBL2347139)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(Cc3ccccc3F)C(=O)c2c1
Show InChI InChI=1S/C22H17FN2O4S/c1-14-6-9-17(10-7-14)30(28,29)24-16-8-11-18-19(12-16)22(27)25(21(18)26)13-15-4-2-3-5-20(15)23/h2-12,24H,13H2,1H3
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n/an/a 1.80E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432222
PNG
(CHEMBL2347143)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(Cc3ccc(cc3)C#N)C(=O)c2c1
Show InChI InChI=1S/C23H17N3O4S/c1-15-2-9-19(10-3-15)31(29,30)25-18-8-11-20-21(12-18)23(28)26(22(20)27)14-17-6-4-16(13-24)5-7-17/h2-12,25H,14H2,1H3
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n/an/a 1.99E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432211
PNG
(CHEMBL2347154)
Show SMILES [O-][N+](=O)c1ccc2C(=O)N(CCNc3ccccc3)C(=O)c2c1
Show InChI InChI=1S/C16H13N3O4/c20-15-13-7-6-12(19(22)23)10-14(13)16(21)18(15)9-8-17-11-4-2-1-3-5-11/h1-7,10,17H,8-9H2
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n/an/a>2.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432210
PNG
(CHEMBL2347155)
Show SMILES Nc1ccc2C(=O)N(CCNc3ccccc3)C(=O)c2c1
Show InChI InChI=1S/C16H15N3O2/c17-11-6-7-13-14(10-11)16(21)19(15(13)20)9-8-18-12-4-2-1-3-5-12/h1-7,10,18H,8-9,17H2
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n/an/a>2.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432212
PNG
(CHEMBL2347153)
Show SMILES O=C1N(CCNc2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C16H14N2O2/c19-15-13-8-4-5-9-14(13)16(20)18(15)11-10-17-12-6-2-1-3-7-12/h1-9,17H,10-11H2
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n/an/a>2.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432232
PNG
(CHEMBL2347156)
Show SMILES CN1C(=O)c2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2C1=O
Show InChI InChI=1S/C16H14N2O4S/c1-10-3-6-12(7-4-10)23(21,22)17-11-5-8-13-14(9-11)16(20)18(2)15(13)19/h3-9,17H,1-2H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432231
PNG
(CHEMBL2347134)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(CCBr)C(=O)c2c1
Show InChI InChI=1S/C17H15BrN2O4S/c1-11-2-5-13(6-3-11)25(23,24)19-12-4-7-14-15(10-12)17(22)20(9-8-18)16(14)21/h2-7,10,19H,8-9H2,1H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432230
PNG
(CHEMBL2347135)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(CCCBr)C(=O)c2c1
Show InChI InChI=1S/C18H17BrN2O4S/c1-12-3-6-14(7-4-12)26(24,25)20-13-5-8-15-16(11-13)18(23)21(17(15)22)10-2-9-19/h3-8,11,20H,2,9-10H2,1H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432229
PNG
(CHEMBL2347136)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(CCCCBr)C(=O)c2c1
Show InChI InChI=1S/C19H19BrN2O4S/c1-13-4-7-15(8-5-13)27(25,26)21-14-6-9-16-17(12-14)19(24)22(18(16)23)11-3-2-10-20/h4-9,12,21H,2-3,10-11H2,1H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432228
PNG
(CHEMBL2347137)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(Cc3ccccc3)C(=O)c2c1
Show InChI InChI=1S/C22H18N2O4S/c1-15-7-10-18(11-8-15)29(27,28)23-17-9-12-19-20(13-17)22(26)24(21(19)25)14-16-5-3-2-4-6-16/h2-13,23H,14H2,1H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432218
PNG
(CHEMBL2347147)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(N3CCOCC3)C(=O)c2c1
Show InChI InChI=1S/C19H19N3O5S/c1-13-2-5-15(6-3-13)28(25,26)20-14-4-7-16-17(12-14)19(24)22(18(16)23)21-8-10-27-11-9-21/h2-7,12,20H,8-11H2,1H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50432217
PNG
(CHEMBL2347148)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc2C(=O)N(N3CCCCC3)C(=O)c2c1
Show InChI InChI=1S/C20H21N3O4S/c1-14-5-8-16(9-6-14)28(26,27)21-15-7-10-17-18(13-15)20(25)23(19(17)24)22-11-3-2-4-12-22/h5-10,13,21H,2-4,11-12H2,1H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50350756
PNG
(CHEMBL1818323)
Show SMILES OC[C@H]1CNC[C@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6+/m1/s1
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n/an/a 2.11E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM18361
PNG
((2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidi...)
Show SMILES CCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-6-8(13)10(15)9(14)7(5-12)11-6/h6-15H,2-5H2,1H3/t6-,7-,8+,9-,10-/m1/s1
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Article
PubMed
n/an/a 2.30E+5n/an/an/an/an/an/a



University of Toyama

Curated by ChEMBL


Assay Description
Inhibition of rat intestinal lactase using lactose as substrate


Citation and Details
More data for this
Ligand-Target Pair
Lactase-glycosylceramidase


(Rattus norvegicus)
BDBM50031485
PNG
((2R,3R,4R)-2-Hydroxymethyl-pyrrolidine-3,4-diol | ...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5-/m1/s1
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PubMed
n/an/a 2.60E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)

More data for this
Ligand-Target Pair
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