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Found 10 hits Enz. Inhib. hit(s) with Target = 'Lanosterol synthase' AND taxid = 4754   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lanosterol synthase


(Pneumocystis carinii)
BDBM50195963
PNG
((4E,8E)-N,N,4,8-tetramethyl-10-(3-phenylpropoxy)de...)
Show SMILES CN(C)CCC\C(C)=C\CC\C(C)=C\COCCCc1ccccc1
Show InChI InChI=1S/C23H37NO/c1-21(13-9-18-24(3)4)11-8-12-22(2)17-20-25-19-10-16-23-14-6-5-7-15-23/h5-7,11,14-15,17H,8-10,12-13,16,18-20H2,1-4H3/b21-11+,22-17+
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 330n/an/an/an/an/an/a



Universit£ degli Studi del Piemonte Orientale A. Avogadro

Curated by ChEMBL


Assay Description
Inhibition of Pneumocystis carinii oxidosqualene cyclase


Citation and Details
More data for this
Ligand-Target Pair
Lanosterol synthase


(Pneumocystis carinii)
BDBM50195962
PNG
((4E,8E)-10-(hexyloxy)-N,N,4,8-tetramethyldeca-4,8-...)
Show SMILES CCCCCCOC\C=C(/C)CC\C=C(/C)CCCN(C)C
Show InChI InChI=1S/C20H39NO/c1-6-7-8-9-17-22-18-15-20(3)13-10-12-19(2)14-11-16-21(4)5/h12,15H,6-11,13-14,16-18H2,1-5H3/b19-12+,20-15+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 360n/an/an/an/an/an/a



Universit£ degli Studi del Piemonte Orientale A. Avogadro

Curated by ChEMBL


Assay Description
Inhibition of Pneumocystis carinii oxidosqualene cyclase


Citation and Details
More data for this
Ligand-Target Pair
Lanosterol synthase


(Pneumocystis carinii)
BDBM50433363
PNG
(CHEMBL2377449)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2=C(CCCN(C)CC=C)CCC[C@]12C
Show InChI InChI=1S/C25H45N/c1-7-18-26(6)19-10-14-22-13-9-17-25(5)23(15-16-24(22)25)21(4)12-8-11-20(2)3/h7,20-21,23H,1,8-19H2,2-6H3/t21-,23-,25-/m1/s1
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 900n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of Pneumocystis carinii lanosterol synthase expressed in Saccharomyces cerevisiae SMY8[pBJ4.21] using [14C]-(3S)-2,3-oxidosqualene as subs...


Citation and Details
More data for this
Ligand-Target Pair
Lanosterol synthase


(Pneumocystis carinii)
BDBM50195965
PNG
(CHEMBL392250 | [(4E,8E)-10-(3-biphenyl-4-yl-propox...)
Show SMILES CN(C)CCC\C(C)=C\CC\C(C)=C\COCCCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H41NO/c1-25(13-9-22-30(3)4)11-8-12-26(2)21-24-31-23-10-14-27-17-19-29(20-18-27)28-15-6-5-7-16-28/h5-7,11,15-21H,8-10,12-14,22-24H2,1-4H3/b25-11+,26-21+
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Universit£ degli Studi del Piemonte Orientale A. Avogadro

Curated by ChEMBL


Assay Description
Inhibition of Pneumocystis carinii oxidosqualene cyclase


Citation and Details
More data for this
Ligand-Target Pair
Lanosterol synthase


(Pneumocystis carinii)
BDBM50371200
PNG
(CHEMBL246795)
Show SMILES CN(C)CCC\C(C)=C\CC\C(C)=C\COCCCc1cccc2ccccc12
Show InChI InChI=1S/C27H39NO/c1-23(13-9-20-28(3)4)11-7-12-24(2)19-22-29-21-10-17-26-16-8-15-25-14-5-6-18-27(25)26/h5-6,8,11,14-16,18-19H,7,9-10,12-13,17,20-22H2,1-4H3/b23-11+,24-19+
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi del Piemonte Orientale A. Avogadro

Curated by ChEMBL


Assay Description
Inhibition of Pneumocystis carinii oxidosqualene cyclase


Citation and Details
More data for this
Ligand-Target Pair
Lanosterol synthase


(Pneumocystis carinii)
BDBM50433360
PNG
(CHEMBL2375380)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2=C(CCC[n+]3ccccc3)CCC[C@]12C
Show InChI InChI=1S/C26H42N/c1-21(2)11-8-12-22(3)24-15-16-25-23(13-9-17-26(24,25)4)14-10-20-27-18-6-5-7-19-27/h5-7,18-19,21-22,24H,8-17,20H2,1-4H3/q+1/t22-,24-,26-/m1/s1
UniProtKB/SwissProt

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AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.10E+4n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of Pneumocystis carinii lanosterol synthase expressed in Saccharomyces cerevisiae SMY8[pBJ4.21] using [14C]-(3S)-2,3-oxidosqualene as subs...


Citation and Details
More data for this
Ligand-Target Pair
Lanosterol synthase


(Pneumocystis carinii)
BDBM50433362
PNG
(CHEMBL2377451)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2=C(CCCN(C)C)CCC[C@]12C
Show InChI InChI=1S/C23H43N/c1-18(2)10-7-11-19(3)21-14-15-22-20(13-9-17-24(5)6)12-8-16-23(21,22)4/h18-19,21H,7-17H2,1-6H3/t19-,21-,23-/m1/s1
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of Pneumocystis carinii lanosterol synthase expressed in Saccharomyces cerevisiae SMY8[pBJ4.21] using [14C]-(3S)-2,3-oxidosqualene as subs...


Citation and Details
More data for this
Ligand-Target Pair
Lanosterol synthase


(Pneumocystis carinii)
BDBM50433364
PNG
(CHEMBL2377453)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2=C(CCC[N+](C)(C)[O-])CCC[C@]12C
Show InChI InChI=1S/C23H43NO/c1-18(2)10-7-11-19(3)21-14-15-22-20(12-8-16-23(21,22)4)13-9-17-24(5,6)25/h18-19,21H,7-17H2,1-6H3/t19-,21-,23-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of Pneumocystis carinii lanosterol synthase expressed in Saccharomyces cerevisiae SMY8[pBJ4.21] using [14C]-(3S)-2,3-oxidosqualene as subs...


Citation and Details
More data for this
Ligand-Target Pair
Lanosterol synthase


(Pneumocystis carinii)
BDBM50433361
PNG
(CHEMBL2377452)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2=C(CCCN3CCCCC3)CCC[C@]12C
Show InChI InChI=1S/C26H47N/c1-21(2)11-8-12-22(3)24-15-16-25-23(13-9-17-26(24,25)4)14-10-20-27-18-6-5-7-19-27/h21-22,24H,5-20H2,1-4H3/t22-,24-,26-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of Pneumocystis carinii lanosterol synthase expressed in Saccharomyces cerevisiae SMY8[pBJ4.21] using [14C]-(3S)-2,3-oxidosqualene as subs...


Citation and Details
More data for this
Ligand-Target Pair
Lanosterol synthase


(Pneumocystis carinii)
BDBM50433365
PNG
(CHEMBL2377450)
Show SMILES CNCCCC1=C2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CCC1
Show InChI InChI=1S/C22H41N/c1-17(2)9-6-10-18(3)20-13-14-21-19(12-8-16-23-5)11-7-15-22(20,21)4/h17-18,20,23H,6-16H2,1-5H3/t18-,20-,22-/m1/s1
UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of Pneumocystis carinii lanosterol synthase expressed in Saccharomyces cerevisiae SMY8[pBJ4.21] using [14C]-(3S)-2,3-oxidosqualene as subs...


Citation and Details
More data for this
Ligand-Target Pair