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Compile Data Set for Download or QSAR

Found 99 hits Enz. Inhib. hit(s) with Target = 'Leucine aminopeptidase' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine aminopeptidase


(Homo sapiens)
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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0.600n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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20n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
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30n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50225458
PNG
((2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17,20,23-25H,11-14H2,(H,21,22)/t17-/m1/s1
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45n/an/an/an/an/an/an/an/a



Wroc£?aw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney cytosolic leucine aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129685
PNG
(2-Amino-4-methyl-pentanal | CHEMBL88476)
Show SMILES CC(C)CC(N)C=O
Show InChI InChI=1S/C6H13NO/c1-5(2)3-6(7)4-8/h4-6H,3,7H2,1-2H3
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60n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129683
PNG
(2-[(1-Amino-3-methyl-butyl)-hydroxy-phosphinoylmet...)
Show SMILES CC(C)CC(CP(O)(O)C(=N)CC(C)C)C(O)=O
Show InChI InChI=1S/C12H26NO4P/c1-8(2)5-10(12(14)15)7-18(16,17)11(13)6-9(3)4/h8-10,13,16-18H,5-7H2,1-4H3,(H,14,15)
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65n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of LAP


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129683
PNG
(2-[(1-Amino-3-methyl-butyl)-hydroxy-phosphinoylmet...)
Show SMILES CC(C)CC(CP(O)(O)C(=N)CC(C)C)C(O)=O
Show InChI InChI=1S/C12H26NO4P/c1-8(2)5-10(12(14)15)7-18(16,17)11(13)6-9(3)4/h8-10,13,16-18H,5-7H2,1-4H3,(H,14,15)
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65n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129684
PNG
(3-[(1-amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Show SMILES OC(=O)C(Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17,20,23-25H,11-14H2,(H,21,22)
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66n/an/an/an/an/an/an/an/a



Wroc£?aw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney cytosolic leucine aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129684
PNG
(3-[(1-amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Show SMILES OC(=O)C(Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17,20,23-25H,11-14H2,(H,21,22)
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66n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129681
PNG
(3-[(1-Amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Show SMILES OC(=O)C(Cc1ccc(O)cc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO5P/c20-18(11-8-14-4-2-1-3-5-14)26(24,25)13-16(19(22)23)12-15-6-9-17(21)10-7-15/h1-7,9-10,16,20-21,24-26H,8,11-13H2,(H,22,23)
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67n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129682
PNG
(2-[(1-Amino-3-phenyl-propyl)-hydroxy-phosphinoylme...)
Show SMILES CC(C)CC(CP(O)(O)C(=N)CCc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H26NO4P/c1-12(2)10-14(16(18)19)11-22(20,21)15(17)9-8-13-6-4-3-5-7-13/h3-7,12,14,17,20-22H,8-11H2,1-2H3,(H,18,19)
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74n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50089610
PNG
((Z)-(S)-5-Amino-7-methyl-4-oxo-oct-2-enoic acid me...)
Show SMILES COC(=O)CCC(=O)C(=N)CC(C)C
Show InChI InChI=1S/C10H17NO3/c1-7(2)6-8(11)9(12)4-5-10(13)14-3/h7,11H,4-6H2,1-3H3
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76n/an/an/an/an/an/an/an/a



The Queen's University of Belfast

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against leucine aminopeptidase


Bioorg Med Chem Lett 10: 1481-2 (2000)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129683
PNG
(2-[(1-Amino-3-methyl-butyl)-hydroxy-phosphinoylmet...)
Show SMILES CC(C)CC(CP(O)(O)C(=N)CC(C)C)C(O)=O
Show InChI InChI=1S/C12H26NO4P/c1-8(2)5-10(12(14)15)7-18(16,17)11(13)6-9(3)4/h8-10,13,16-18H,5-7H2,1-4H3,(H,14,15)
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110n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50027041
PNG
(2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-4-met...)
Show SMILES CC(C)CC(N)C(O)C(=O)NC(CC(C)C)C(O)=O
Show InChI InChI=1S/C13H26N2O4/c1-7(2)5-9(14)11(16)12(17)15-10(13(18)19)6-8(3)4/h7-11,16H,5-6,14H2,1-4H3,(H,15,17)(H,18,19)
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120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...


J Med Chem 27: 417-22 (1984)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
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200n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of Leucine aminopeptidase was determined and the Ki was reported which is = k2/k1


J Med Chem 27: 417-22 (1984)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
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220n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...


J Med Chem 27: 417-22 (1984)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129679
PNG
((1-Amino-3-methyl-butyl)-phosphonic acid | 1-amino...)
Show SMILES CC(C)CC(N)P(O)(O)=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)
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230n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of leucine aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50316047
PNG
(1-amino-2-methylbutylphosphonic acid monophenylest...)
Show SMILES CC(C)CC(N)P(O)(=O)Oc1ccccc1
Show InChI InChI=1S/C11H18NO3P/c1-9(2)8-11(12)16(13,14)15-10-6-4-3-5-7-10/h3-7,9,11H,8,12H2,1-2H3,(H,13,14)
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230n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of leucine aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50024594
PNG
((R)-1-Ammonium-3-methyl-butane-1-phosphonic acid a...)
Show SMILES CC(C)C[C@H]([NH3+])P(O)([O-])=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)/t5-/m1/s1
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230n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Leucine aminopeptidase isolated from porcine kidney.


J Med Chem 30: 1603-9 (1987)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129679
PNG
((1-Amino-3-methyl-butyl)-phosphonic acid | 1-amino...)
Show SMILES CC(C)CC(N)P(O)(O)=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)
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230n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50234656
PNG
((R)-3-[((R)-1-amino-3-phenyl-propyl)-hydroxy-phosp...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17,20,23-25H,11-14H2,(H,21,22)/t17-/m0/s1
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271n/an/an/an/an/an/an/an/a



Wroc£?aw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney cytosolic leucine aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022747
PNG
(2-(3-Amino-2-hydroxy-4-phenyl-thiobutyrylamino)-4-...)
Show SMILES CC(C)C[C@H](NC(=S)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O3S/c1-10(2)8-13(16(20)21)18-15(22)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,22)(H,20,21)/t12-,13+,14+/m1/s1
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330n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129677
PNG
(3-[(1-Amino-3-methyl-butyl)-hydroxy-phosphinoyl]-p...)
Show SMILES CC(C)CC(=N)P(O)(O)CCC(O)=O
Show InChI InChI=1S/C8H18NO4P/c1-6(2)5-7(9)14(12,13)4-3-8(10)11/h6,9,12-14H,3-5H2,1-2H3,(H,10,11)
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330n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50316048
PNG
(1-amino-2-phenylethylphosphonic acid monophenyl es...)
Show SMILES NC(Cc1ccccc1)P(O)(=O)Oc1ccccc1
Show InChI InChI=1S/C14H16NO3P/c15-14(11-12-7-3-1-4-8-12)19(16,17)18-13-9-5-2-6-10-13/h1-10,14H,11,15H2,(H,16,17)
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420n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of leucine aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50024596
PNG
((R)-1-Ammonium-2-phenyl-ethanephosphonic acid anio...)
Show SMILES [NH3+][C@@H](Cc1ccccc1)P(O)([O-])=O
Show InChI InChI=1S/C8H12NO3P/c9-8(13(10,11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,9H2,(H2,10,11,12)/t8-/m1/s1
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420n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Leucine aminopeptidase isolated from porcine kidney.


J Med Chem 30: 1603-9 (1987)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50024592
PNG
((S)-1-Ammonium-2-phenyl-ethanephosphonic acid anio...)
Show SMILES [NH3+][C@H](Cc1ccccc1)P(O)([O-])=O
Show InChI InChI=1S/C8H12NO3P/c9-8(13(10,11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,9H2,(H2,10,11,12)/t8-/m0/s1
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420n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of leucine aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50024590
PNG
(1-Ammonium-octane-1-phosphonic acid anion | CHEMBL...)
Show SMILES CCCCCCCC([NH3+])P(O)([O-])=O
Show InChI InChI=1S/C8H20NO3P/c1-2-3-4-5-6-7-8(9)13(10,11)12/h8H,2-7,9H2,1H3,(H2,10,11,12)
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470n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of Leucine aminopeptidase isolated from porcine kidney; Inhibitor exhibits slow-binding behavior(k on <=1000Me-1Se...


J Med Chem 30: 1603-9 (1987)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50027043
PNG
(3-Amino-2-hydroxy-N-(3-methyl-butyl)-4-phenyl-buty...)
Show SMILES CC(C)CCNC(=O)[C@H](O)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C15H24N2O2/c1-11(2)8-9-17-15(19)14(18)13(16)10-12-6-4-3-5-7-12/h3-7,11,13-14,18H,8-10,16H2,1-2H3,(H,17,19)/t13-,14+/m0/s1
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500n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase from porcine kidney and the inhibition constant was determined after preincubatin...


J Med Chem 27: 417-22 (1984)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50008431
PNG
(3-Amino-2-hydroxy-N-(3-methyl-butyl)-4-phenyl-buty...)
Show SMILES CC(C)CCNC(=O)[C@@H](O)[C@H](N)Cc1ccccc1
Show InChI InChI=1S/C15H24N2O2/c1-11(2)8-9-17-15(19)14(18)13(16)10-12-6-4-3-5-7-12/h3-7,11,13-14,18H,8-10,16H2,1-2H3,(H,17,19)/t13-,14+/m1/s1
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510n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022751
PNG
(2-(3-Amino-2-mercapto-4-phenyl-butyrylamino)-4-met...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](S)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O3S/c1-10(2)8-13(16(20)21)18-15(19)14(22)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,22H,8-9,17H2,1-2H3,(H,18,19)(H,20,21)/t12-,13+,14+/m1/s1
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550n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50027042
PNG
(3-Amino-2-hydroxy-5-methyl-hexanoic acid {2-methyl...)
Show SMILES CC(C)CCNC(=O)C(NC(=O)C(NC(=O)C(O)C(N)CC(C)C)C(C)C)C(C)C
Show InChI InChI=1S/C22H44N4O4/c1-12(2)9-10-24-20(28)17(14(5)6)25-21(29)18(15(7)8)26-22(30)19(27)16(23)11-13(3)4/h12-19,27H,9-11,23H2,1-8H3,(H,24,28)(H,25,29)(H,26,30)
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890n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and in...


J Med Chem 27: 417-22 (1984)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50225458
PNG
((2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17,20,23-25H,11-14H2,(H,21,22)/t17-/m1/s1
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988n/an/an/an/an/an/an/an/a



Wroc£?aw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney cytosolic leucine aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50024601
PNG
(1-Ammonium-hexane-1-phosphonic acid anion | 1-amin...)
Show SMILES CCCCCC([NH3+])P(O)([O-])=O
Show InChI InChI=1S/C6H16NO3P/c1-2-3-4-5-6(7)11(8,9)10/h6H,2-5,7H2,1H3,(H2,8,9,10)
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1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Leucine aminopeptidase isolated from porcine kidney.


J Med Chem 30: 1603-9 (1987)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022751
PNG
(2-(3-Amino-2-mercapto-4-phenyl-butyrylamino)-4-met...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](S)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O3S/c1-10(2)8-13(16(20)21)18-15(19)14(22)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,22H,8-9,17H2,1-2H3,(H,18,19)(H,20,21)/t12-,13+,14+/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50024602
PNG
(1-Ammonium-2-methyl-propane-1-phosphonic acid anio...)
Show SMILES CC(C)C([NH3+])P(O)([O-])=O
Show InChI InChI=1S/C4H12NO3P/c1-3(2)4(5)9(6,7)8/h3-4H,5H2,1-2H3,(H2,6,7,8)
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1.20E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of Leucine aminopeptidase isolated from porcine kidney; Inhibitor exhibits slow-binding behavior(k on <=1000Me-1Se...


J Med Chem 30: 1603-9 (1987)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50027046
PNG
(2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-3-...)
Show SMILES CC(C)CC(N)C(O)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(O)=O
Show InChI InChI=1S/C16H29N3O7/c1-7(2)5-9(17)13(22)15(24)19-12(8(3)4)14(23)18-10(16(25)26)6-11(20)21/h7-10,12-13,22H,5-6,17H2,1-4H3,(H,18,23)(H,19,24)(H,20,21)(H,25,26)
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1.24E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...


J Med Chem 27: 417-22 (1984)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50024604
PNG
(1-Ammonium-propane-1-phosphonic acid anion | 1-ami...)
Show SMILES CCC([NH3+])P(O)([O-])=O
Show InChI InChI=1S/C3H10NO3P/c1-2-3(4)8(5,6)7/h3H,2,4H2,1H3,(H2,5,6,7)
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3.60E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of Leucine aminopeptidase isolated from porcine kidney; Inhibitor exhibits slow-binding behavior(k on <=1000Me-1Se...


J Med Chem 30: 1603-9 (1987)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022742
PNG
(3-Amino-2-hydroxy-N-(3-methyl-butyl)-4-phenyl-thio...)
Show SMILES CC(C)CCNC(=S)[C@@H](O)[C@H](N)Cc1ccccc1
Show InChI InChI=1S/C15H24N2OS/c1-11(2)8-9-17-15(19)14(18)13(16)10-12-6-4-3-5-7-12/h3-7,11,13-14,18H,8-10,16H2,1-2H3,(H,17,19)/t13-,14+/m1/s1
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4.40E+3n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50129680
PNG
(CHEMBL423870 | {[hydroxy(1-hydroxy-3-methylbutyl)p...)
Show SMILES CC(C)CC(O)P([O-])(=O)NCC([O-])=O
Show InChI InChI=1S/C7H16NO5P/c1-5(2)3-7(11)14(12,13)8-4-6(9)10/h5,7,11H,3-4H2,1-2H3,(H,9,10)(H2,8,12,13)/p-2
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4.88E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50234656
PNG
((R)-3-[((R)-1-amino-3-phenyl-propyl)-hydroxy-phosp...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17,20,23-25H,11-14H2,(H,21,22)/t17-/m0/s1
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8.80E+3n/an/an/an/an/an/an/an/a



Wroc£?aw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney cytosolic leucine aminopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50024592
PNG
((S)-1-Ammonium-2-phenyl-ethanephosphonic acid anio...)
Show SMILES [NH3+][C@H](Cc1ccccc1)P(O)([O-])=O
Show InChI InChI=1S/C8H12NO3P/c9-8(13(10,11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,9H2,(H2,10,11,12)/t8-/m0/s1
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1.54E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Leucine aminopeptidase isolated from porcine kidney.


J Med Chem 30: 1603-9 (1987)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50046325
PNG
((S)-2-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyryla...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-,14-/m0/s1
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1.70E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...


J Med Chem 27: 417-22 (1984)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50017478
PNG
(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Show SMILES CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
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2.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Effect of inhibitor structure on the slow binding inhibition of Leucine aminopeptidase was determined and Ki* was reported which is obtained by the e...


J Med Chem 27: 417-22 (1984)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50367209
PNG
(BESTATIN HYDROCHLORIDE | Ubenimex)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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2.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...


J Med Chem 27: 417-22 (1984)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022754
PNG
(3-Amino-2-mercapto-N-(3-methyl-butyl)-4-phenyl-but...)
Show SMILES CC(C)CCNC(=O)[C@H](S)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C15H24N2OS/c1-11(2)8-9-17-15(18)14(19)13(16)10-12-6-4-3-5-7-12/h3-7,11,13-14,19H,8-10,16H2,1-2H3,(H,17,18)/t13-,14+/m0/s1
PDB
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KEGG

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2.60E+4n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50105577
PNG
(CHEMBL3597446)
Show SMILES NC1CCc2cccc(-c3cccc(c3)[N+]([O-])=O)c2CC1=O
Show InChI InChI=1/C17H16N2O3.ClH/c18-16-8-7-11-3-2-6-14(15(11)10-17(16)20)12-4-1-5-13(9-12)19(21)22;/h1-6,9,16H,7-8,10,18H2;1H
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KEGG

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3.00E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of cytosolic leucine aminopeptidase (unknown origin)


Bioorg Med Chem 23: 3192-207 (2015)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50022750
PNG
(3-Amino-2-hydroxy-4-phenyl-butyric acid methyl est...)
Show SMILES COC(=O)C(O)[C@H](N)Cc1ccccc1
Show InChI InChI=1S/C11H15NO3/c1-15-11(14)10(13)9(12)7-8-5-3-2-4-6-8/h2-6,9-10,13H,7,12H2,1H3/t9-,10?/m1/s1
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3.30E+4n/an/an/an/an/an/an/an/a



University of Wisconsin

Curated by ChEMBL


Assay Description
Inhibitory activity against Leucine aminopeptidase


J Med Chem 31: 2193-9 (1988)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50105576
PNG
(CHEMBL3597445)
Show SMILES NC1CCc2cccc(-c3ccc(cc3)C#N)c2CC1=O
Show InChI InChI=1/C18H16N2O.ClH/c19-11-12-4-6-14(7-5-12)15-3-1-2-13-8-9-17(20)18(21)10-16(13)15;/h1-7,17H,8-10,20H2;1H
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3.50E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of cytosolic leucine aminopeptidase (unknown origin)


Bioorg Med Chem 23: 3192-207 (2015)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50024608
PNG
(1-[amino({[(1S)-1-carboxylate anion-3-methylbutyl]...)
Show SMILES CC(C)CC([NH3+])P(N)(=O)C(=O)N[C@@H](CC(C)C)C([O-])=O
Show InChI InChI=1S/C12H26N3O4P/c1-7(2)5-9(11(16)17)15-12(18)20(14,19)10(13)6-8(3)4/h7-10H,5-6,13H2,1-4H3,(H2,14,19)(H,15,18)(H,16,17)/t9-,10?,20?/m0/s1
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4.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Leucine aminopeptidase isolated from porcine kidney.


J Med Chem 30: 1603-9 (1987)

More data for this
Ligand-Target Pair
Leucine aminopeptidase


(Homo sapiens)
BDBM50024599
PNG
((1-Ammonium-2-phenyl-ethyl)-phosphonic acid monome...)
Show SMILES COP([O-])(=O)C([NH3+])Cc1ccccc1
Show InChI InChI=1S/C9H14NO3P/c1-13-14(11,12)9(10)7-8-5-3-2-4-6-8/h2-6,9H,7,10H2,1H3,(H,11,12)
PDB
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4.30E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Leucine aminopeptidase isolated from porcine kidney.


J Med Chem 30: 1603-9 (1987)

More data for this
Ligand-Target Pair
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