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Found 40 hits Enz. Inhib. hit(s) with Target = 'Leukocyte proteinase 3' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukocyte proteinase 3


(Homo sapiens)
BDBM50031630
PNG
(CHEMBL3359765)
Show SMILES CCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1N)C(C)C)C(=O)C[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCCNc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1/C54H71N13O19/c1-6-9-36(60-52(80)40(26-45(73)74)63-48(76)29(5)59-54(82)46(27(2)3)65-49(77)33-10-7-8-11-34(33)55)42(69)22-28(4)47(75)62-39(25-44(71)72)53(81)64-38(23-30-12-15-32(68)16-13-30)51(79)61-37(18-19-43(56)70)50(78)58-21-20-57-35-17-14-31(66(83)84)24-41(35)67(85)86/h7-8,10-17,24,27-29,36-40,46,57,68H,6,9,18-23,25-26,55H2,1-5H3,(H2,56,70)(H,58,78)(H,59,82)(H,60,80)(H,61,79)(H,62,75)(H,63,76)(H,64,81)(H,65,77)(H,71,72)(H,73,74)/t28-,29+,36+,37+,38+,39+,40+,46+/s2
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1.50E+3n/an/an/an/an/an/an/an/a



University of Bergen

Curated by ChEMBL


Assay Description
Inhibition of human PR3 using keto-D-DY-FRET as substrate


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101987
PNG
(CHEMBL3398163)
Show SMILES CC(C)(C)S(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccccc1C=O
Show InChI InChI=1/C17H20N2O4S2/c1-17(2,3)24(21)18-14-8-10-15(11-9-14)25(22,23)19-16-7-5-4-6-13(16)12-20/h4-12,18-19H,1-3H3
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101985
PNG
(CHEMBL3398157)
Show SMILES COC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C(F)(F)F)cc1
Show InChI InChI=1S/C20H18F3NO5/c1-19(2,20(21,22)23)18(27)29-13-10-8-12(9-11-13)16(25)24-15-7-5-4-6-14(15)17(26)28-3/h4-11H,1-3H3,(H,24,25)
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101986
PNG
(CHEMBL3398158)
Show SMILES CCOC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C(F)(F)F)cc1
Show InChI InChI=1S/C21H20F3NO5/c1-4-29-18(27)15-7-5-6-8-16(15)25-17(26)13-9-11-14(12-10-13)30-19(28)20(2,3)21(22,23)24/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101977
PNG
(CHEMBL3398159)
Show SMILES CCCOC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C(F)(F)F)cc1
Show InChI InChI=1S/C22H22F3NO5/c1-4-13-30-19(28)16-7-5-6-8-17(16)26-18(27)14-9-11-15(12-10-14)31-20(29)21(2,3)22(23,24)25/h5-12H,4,13H2,1-3H3,(H,26,27)
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101981
PNG
(CHEMBL3398161)
Show SMILES COC(=O)c1ccccc1NS(=O)(=O)c1ccc(NC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C19H22N2O5S/c1-19(2,3)18(23)20-13-9-11-14(12-10-13)27(24,25)21-16-8-6-5-7-15(16)17(22)26-4/h5-12,21H,1-4H3,(H,20,23)
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101982
PNG
(CHEMBL3398162)
Show SMILES CC(=O)c1ccccc1NS(=O)(=O)c1ccc(NS(=O)C(C)(C)C)cc1
Show InChI InChI=1/C18H22N2O4S2/c1-13(21)16-7-5-6-8-17(16)20-26(23,24)15-11-9-14(10-12-15)19-25(22)18(2,3)4/h5-12,19-20H,1-4H3
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n/an/a>1n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50063047
PNG
(CHEMBL3398148)
Show SMILES C\C(=N\O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C19H22N2O5S/c1-13(20-23)16-7-5-6-8-17(16)21-27(24,25)15-11-9-14(10-12-15)26-18(22)19(2,3)4/h5-12,21,23H,1-4H3/b20-13-
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n/an/a 22n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50063046
PNG
(CHEMBL3398149)
Show SMILES CC\C(=N\O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C20H24N2O5S/c1-5-17(21-24)16-8-6-7-9-18(16)22-28(25,26)15-12-10-14(11-13-15)27-19(23)20(2,3)4/h6-13,22,24H,5H2,1-4H3/b21-17-
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n/an/a 25n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50063053
PNG
(CHEMBL3398164)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCCO
Show InChI InChI=1S/C20H24N2O6S/c1-20(2,3)19(25)28-14-8-10-15(11-9-14)29(26,27)22-17-7-5-4-6-16(17)18(24)21-12-13-23/h4-11,22-23H,12-13H2,1-3H3,(H,21,24)
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n/an/a 31n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50084637
PNG
(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC(O)=O
Show InChI InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
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n/an/a 34n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50063050
PNG
(CHEMBL3398145)
Show SMILES CCCC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C21H25NO5S/c1-5-8-19(23)17-9-6-7-10-18(17)22-28(25,26)16-13-11-15(12-14-16)27-20(24)21(2,3)4/h6-7,9-14,22H,5,8H2,1-4H3
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n/an/a 36n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50063052
PNG
(CHEMBL3398143)
Show SMILES CC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C19H21NO5S/c1-13(21)16-7-5-6-8-17(16)20-26(23,24)15-11-9-14(10-12-15)25-18(22)19(2,3)4/h5-12,20H,1-4H3
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n/an/a 47n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101988
PNG
(CHEMBL3398153)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1\C=N/O
Show InChI InChI=1S/C18H20N2O5S/c1-18(2,3)17(21)25-14-8-10-15(11-9-14)26(23,24)20-16-7-5-4-6-13(16)12-19-22/h4-12,20,22H,1-3H3/b19-12-
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n/an/a 53n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM166437
PNG
(US9073833, 5)
Show SMILES CO\N=C(/C)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C20H24N2O5S/c1-14(21-26-5)17-8-6-7-9-18(17)22-28(24,25)16-12-10-15(11-13-16)27-19(23)20(2,3)4/h6-13,22H,1-5H3/b21-14+
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n/an/a 61n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50063054
PNG
(CHEMBL3398165)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)OCCO
Show InChI InChI=1S/C20H23NO7S/c1-20(2,3)19(24)28-14-8-10-15(11-9-14)29(25,26)21-17-7-5-4-6-16(17)18(23)27-13-12-22/h4-11,21-22H,12-13H2,1-3H3
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n/an/a 61n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50063051
PNG
(CHEMBL3398144)
Show SMILES CCC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C20H23NO5S/c1-5-18(22)16-8-6-7-9-17(16)21-27(24,25)15-12-10-14(11-13-15)26-19(23)20(2,3)4/h6-13,21H,5H2,1-4H3
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n/an/a 109n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101980
PNG
(CHEMBL3398150)
Show SMILES CCC\C(=N\O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C21H26N2O5S/c1-5-8-18(22-25)17-9-6-7-10-19(17)23-29(26,27)16-13-11-15(12-14-16)28-20(24)21(2,3)4/h6-7,9-14,23,25H,5,8H2,1-4H3/b22-18-
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n/an/a 173n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50063048
PNG
(CHEMBL3398147)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C=O
Show InChI InChI=1S/C18H19NO5S/c1-18(2,3)17(21)24-14-8-10-15(11-9-14)25(22,23)19-16-7-5-4-6-13(16)12-20/h4-12,19H,1-3H3
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n/an/a 205n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101989
PNG
(CHEMBL3398154)
Show SMILES COC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C20H21NO5/c1-20(2,3)19(24)26-14-11-9-13(10-12-14)17(22)21-16-8-6-5-7-15(16)18(23)25-4/h5-12H,1-4H3,(H,21,22)
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n/an/a 205n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50063049
PNG
(CHEMBL3398146)
Show SMILES CCCCC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C22H27NO5S/c1-5-6-11-20(24)18-9-7-8-10-19(18)23-29(26,27)17-14-12-16(13-15-17)28-21(25)22(2,3)4/h7-10,12-15,23H,5-6,11H2,1-4H3
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n/an/a 231n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM166438
PNG
(US9073833, 6)
Show SMILES CO\N=C(\C)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C20H24N2O5S/c1-14(21-26-5)17-8-6-7-9-18(17)22-28(24,25)16-12-10-15(11-13-16)27-19(23)20(2,3)4/h6-13,22H,1-5H3/b21-14-
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n/an/a 237n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101983
PNG
(CHEMBL3398155)
Show SMILES CCOC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C21H23NO5/c1-5-26-19(24)16-8-6-7-9-17(16)22-18(23)14-10-12-15(13-11-14)27-20(25)21(2,3)4/h6-13H,5H2,1-4H3,(H,22,23)
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n/an/a 302n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101984
PNG
(CHEMBL3398156)
Show SMILES CCCOC(=O)c1ccccc1NC(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C22H25NO5/c1-5-14-27-20(25)17-8-6-7-9-18(17)23-19(24)15-10-12-16(13-11-15)28-21(26)22(2,3)4/h6-13H,5,14H2,1-4H3,(H,23,24)
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n/an/a 391n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50101978
PNG
(CHEMBL3398160)
Show SMILES COC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C(F)(F)F)cc1
Show InChI InChI=1S/C19H18F3NO6S/c1-18(2,19(20,21)22)17(25)29-12-8-10-13(11-9-12)30(26,27)23-15-7-5-4-6-14(15)16(24)28-3/h4-11,23H,1-3H3
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n/an/a 494n/an/an/an/an/an/a



Chang Gung University

Curated by ChEMBL


Assay Description
Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50031630
PNG
(CHEMBL3359765)
Show SMILES CCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1N)C(C)C)C(=O)C[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCCNc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1/C54H71N13O19/c1-6-9-36(60-52(80)40(26-45(73)74)63-48(76)29(5)59-54(82)46(27(2)3)65-49(77)33-10-7-8-11-34(33)55)42(69)22-28(4)47(75)62-39(25-44(71)72)53(81)64-38(23-30-12-15-32(68)16-13-30)51(79)61-37(18-19-43(56)70)50(78)58-21-20-57-35-17-14-31(66(83)84)24-41(35)67(85)86/h7-8,10-17,24,27-29,36-40,46,57,68H,6,9,18-23,25-26,55H2,1-5H3,(H2,56,70)(H,58,78)(H,59,82)(H,60,80)(H,61,79)(H,62,75)(H,63,76)(H,64,81)(H,65,77)(H,71,72)(H,73,74)/t28-,29+,36+,37+,38+,39+,40+,46+/s2
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n/an/a 530n/an/an/an/an/an/a



University of Bergen

Curated by ChEMBL


Assay Description
Inhibition of human PR3 using keto-D-DY-FRET as substrate after 30 mins by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50384111
PNG
(CHEMBL2029556)
Show SMILES COc1ccc(cc1)C(=O)N1C(=O)OC(C)(C)C1=O
Show InChI InChI=1S/C13H13NO5/c1-13(2)11(16)14(12(17)19-13)10(15)8-4-6-9(18-3)7-5-8/h4-7H,1-3H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Lisbon

Curated by ChEMBL


Assay Description
Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50031630
PNG
(CHEMBL3359765)
Show SMILES CCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1N)C(C)C)C(=O)C[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCCNc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1/C54H71N13O19/c1-6-9-36(60-52(80)40(26-45(73)74)63-48(76)29(5)59-54(82)46(27(2)3)65-49(77)33-10-7-8-11-34(33)55)42(69)22-28(4)47(75)62-39(25-44(71)72)53(81)64-38(23-30-12-15-32(68)16-13-30)51(79)61-37(18-19-43(56)70)50(78)58-21-20-57-35-17-14-31(66(83)84)24-41(35)67(85)86/h7-8,10-17,24,27-29,36-40,46,57,68H,6,9,18-23,25-26,55H2,1-5H3,(H2,56,70)(H,58,78)(H,59,82)(H,60,80)(H,61,79)(H,62,75)(H,63,76)(H,64,81)(H,65,77)(H,71,72)(H,73,74)/t28-,29+,36+,37+,38+,39+,40+,46+/s2
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n/an/a 1.91E+3n/an/an/an/an/an/a



University of Bergen

Curated by ChEMBL


Assay Description
Inhibition of human PR3 using D-DY-FRET as substrate after 30 mins by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50384104
PNG
(CHEMBL2029559)
Show SMILES COc1ccc(cc1)C(=O)n1c(O)c(oc1=O)-c1ccccc1
Show InChI InChI=1S/C17H13NO5/c1-22-13-9-7-12(8-10-13)15(19)18-16(20)14(23-17(18)21)11-5-3-2-4-6-11/h2-10,20H,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Lisbon

Curated by ChEMBL


Assay Description
Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50444297
PNG
(CHEMBL3093815)
Show SMILES CC(C)(C)C(=O)Oc1coc(CSc2nc3ccccc3s2)cc1=O
Show InChI InChI=1S/C18H17NO4S2/c1-18(2,3)16(21)23-14-9-22-11(8-13(14)20)10-24-17-19-12-6-4-5-7-15(12)25-17/h4-9H,10H2,1-3H3
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n/an/a 5.90E+3n/an/an/an/an/an/a



Universidade de Lisboa

Curated by ChEMBL


Assay Description
Inhibition of human proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate measured for 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50031631
PNG
(CHEMBL3359767)
Show SMILES CCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1N)C(C)C)C(=O)C[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)NCCNc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1/C52H77N17O17/c1-6-10-33(62-50(81)37(25-41(55)72)66-45(76)28(5)61-51(82)43(26(2)3)67-46(77)30-11-7-8-12-31(30)53)39(70)23-27(4)44(75)63-36(17-19-42(73)74)49(80)64-34(13-9-20-60-52(56)57)48(79)65-35(16-18-40(54)71)47(78)59-22-21-58-32-15-14-29(68(83)84)24-38(32)69(85)86/h7-8,11-12,14-15,24,26-28,33-37,43,58H,6,9-10,13,16-23,25,53H2,1-5H3,(H2,54,71)(H2,55,72)(H,59,78)(H,61,82)(H,62,81)(H,63,75)(H,64,80)(H,65,79)(H,66,76)(H,67,77)(H,73,74)(H4,56,57,60)/t27-,28+,33+,34+,35+,36+,37+,43+/s2
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n/an/a 1.04E+4n/an/an/an/an/an/a



University of Bergen

Curated by ChEMBL


Assay Description
Inhibition of human PR3 using D-DY-FRET as substrate after 30 mins by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50384108
PNG
(CHEMBL2029554)
Show SMILES CC1(C)OC(=O)N(Cc2ccccc2)C1=O
Show InChI InChI=1S/C12H13NO3/c1-12(2)10(14)13(11(15)16-12)8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3
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n/an/a 1.28E+4n/an/an/an/an/an/a



University of Lisbon

Curated by ChEMBL


Assay Description
Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50384112
PNG
(CHEMBL2029557)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(=O)OC(C)(C)C1=O
Show InChI InChI=1S/C12H13NO5S/c1-8-4-6-9(7-5-8)19(16,17)13-10(14)12(2,3)18-11(13)15/h4-7H,1-3H3
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n/an/a 1.45E+4n/an/an/an/an/an/a



University of Lisbon

Curated by ChEMBL


Assay Description
Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50171289
PNG
(Benzenemethanesulfonyl fluoride | CHEMBL190503 | P...)
Show SMILES FS(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
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n/an/a 1.92E+4n/an/an/an/an/an/a



University of Bergen

Curated by ChEMBL


Assay Description
Inhibition of human PR3 using D-DY-FRET as substrate after 30 mins by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50444296
PNG
(CHEMBL3093814)
Show SMILES CC(C)(C)C(=O)Oc1coc(CSc2nc3cc(ccc3o2)C(O)=O)cc1=O
Show InChI InChI=1S/C19H17NO7S/c1-19(2,3)17(24)26-15-8-25-11(7-13(15)21)9-28-18-20-12-6-10(16(22)23)4-5-14(12)27-18/h4-8H,9H2,1-3H3,(H,22,23)
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n/an/a 4.75E+4n/an/an/an/an/an/a



Universidade de Lisboa

Curated by ChEMBL


Assay Description
Inhibition of human proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate measured for 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50270040
PNG
((S)-1-((1R,2R)-1-cyano-2-phenylcyclopropylamino)-1...)
Show SMILES [NH3+][C@@H](Cc1cccs1)C(=O)N[C@@]1(C[C@@H]1c1ccccc1)C#N
Show InChI InChI=1S/C17H17N3OS/c18-11-17(10-14(17)12-5-2-1-3-6-12)20-16(21)15(19)9-13-7-4-8-22-13/h1-8,14-15H,9-10,19H2,(H,20,21)/p+1/t14-,15+,17+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of proteinase-3 in human U937 cells


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50270029
PNG
(2-Amino-N-[(S)-3-diazo-1-(4-iodo-benzyl)-2-oxo-pro...)
Show SMILES NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)[CH-][N+]#N
Show InChI InChI=1S/C12H13IN4O2/c13-9-3-1-8(2-4-9)5-10(11(18)7-16-15)17-12(19)6-14/h1-4,7,10H,5-6,14H2,(H,17,19)/t10-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of proteinase-3 in human U937 cells


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50310690
PNG
(CHEMBL1078411 | Cis-(S)-2-amino-N-((1R,2R)-1-cyano...)
Show SMILES N[C@@H](Cc1cccs1)C(=O)N[C@@]1(C[C@@H]1c1ccccc1)C#N
Show InChI InChI=1S/C17H17N3OS/c18-11-17(10-14(17)12-5-2-1-3-6-12)20-16(21)15(19)9-13-7-4-8-22-13/h1-8,14-15H,9-10,19H2,(H,20,21)/t14-,15+,17+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Frosst Canada& Co.

Curated by ChEMBL


Assay Description
Inhibition of human Proteinase-3


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50444295
PNG
(CHEMBL3093806)
Show SMILES CC(C)(C)C(=O)Oc1cn(c(CSc2nc3cc(ccc3o2)C(O)=O)cc1=O)-c1ccccc1
Show InChI InChI=1S/C25H22N2O6S/c1-25(2,3)23(31)32-21-13-27(16-7-5-4-6-8-16)17(12-19(21)28)14-34-24-26-18-11-15(22(29)30)9-10-20(18)33-24/h4-13H,14H2,1-3H3,(H,29,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidade de Lisboa

Curated by ChEMBL


Assay Description
Inhibition of human proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate measured for 30 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Leukocyte proteinase 3


(Homo sapiens)
BDBM50084637
PNG
(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC(O)=O
Show InChI InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidade de Lisboa

Curated by ChEMBL


Assay Description
Inhibition of human proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate measured for 30 mins by spectrophotometry


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Ligand-Target Pair