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Found 58 hits Enz. Inhib. hit(s) with Target = 'Leukotriene A-4 hydrolase' AND taxid = 10141   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266135
PNG
((R)-3-(4-bromobenzylthio)-2-((S)-3-mercapto-2-meth...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C14H18BrNO3S2/c1-9(6-20)13(17)16-12(14(18)19)8-21-7-10-2-4-11(15)5-3-10/h2-5,9,12,20H,6-8H2,1H3,(H,16,17)(H,18,19)/t9-,12+/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266172
PNG
((R)-3-(4-isopropylbenzylthio)-2-((S)-3-mercapto-2-...)
Show SMILES CC(C)c1ccc(CSC[C@H](NC(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C17H25NO3S2/c1-11(2)14-6-4-13(5-7-14)9-23-10-15(17(20)21)18-16(19)12(3)8-22/h4-7,11-12,15,22H,8-10H2,1-3H3,(H,18,19)(H,20,21)/t12-,15+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272201
PNG
((2S,5S)-5-(4-tert-butylbenzylthio)-1-((S)-3-mercap...)
Show SMILES C[C@H](CS)C(=O)N1[C@H](CC[C@H]1C(O)=O)SCc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C20H29NO3S2/c1-13(11-25)18(22)21-16(19(23)24)9-10-17(21)26-12-14-5-7-15(8-6-14)20(2,3)4/h5-8,13,16-17,25H,9-12H2,1-4H3,(H,23,24)/t13-,16+,17+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272202
PNG
((2S,5S)-5-(4-cyclohexylbenzylthio)-1-((S)-3-mercap...)
Show SMILES C[C@H](CS)C(=O)N1[C@H](CC[C@H]1C(O)=O)SCc1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C22H31NO3S2/c1-15(13-27)21(24)23-19(22(25)26)11-12-20(23)28-14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h7-10,15,17,19-20,27H,2-6,11-14H2,1H3,(H,25,26)/t15-,19+,20+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266244
PNG
((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-(m...)
Show SMILES CSc1ccc(CSC[C@H](NC(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C15H21NO3S3/c1-10(7-20)14(17)16-13(15(18)19)9-22-8-11-3-5-12(21-2)6-4-11/h3-6,10,13,20H,7-9H2,1-2H3,(H,16,17)(H,18,19)/t10-,13+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272142
PNG
((2S,5S)-5-(4-isopropylbenzylthio)-1-((S)-3-mercapt...)
Show SMILES CC(C)c1ccc(CS[C@H]2CC[C@H](N2C(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C19H27NO3S2/c1-12(2)15-6-4-14(5-7-15)11-25-17-9-8-16(19(22)23)20(17)18(21)13(3)10-24/h4-7,12-13,16-17,24H,8-11H2,1-3H3,(H,22,23)/t13-,16+,17+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266247
PNG
((2R)-3-(1-(4-isopropylphenyl)ethylthio)-2-((S)-3-m...)
Show SMILES CC(C)c1ccc(cc1)C(C)SC[C@H](NC(=O)[C@H](C)CS)C(O)=O
Show InChI InChI=1S/C18H27NO3S2/c1-11(2)14-5-7-15(8-6-14)13(4)24-10-16(18(21)22)19-17(20)12(3)9-23/h5-8,11-13,16,23H,9-10H2,1-4H3,(H,19,20)(H,21,22)/t12-,13?,16+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266316
PNG
((R)-3-(2-(4-cyclohexylphenyl)propan-2-ylthio)-2-((...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSC(C)(C)c1ccc(cc1)C1CCCCC1)C(O)=O
Show InChI InChI=1S/C22H33NO3S2/c1-15(13-27)20(24)23-19(21(25)26)14-28-22(2,3)18-11-9-17(10-12-18)16-7-5-4-6-8-16/h9-12,15-16,19,27H,4-8,13-14H2,1-3H3,(H,23,24)(H,25,26)/t15-,19+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266248
PNG
((2R)-3-(1-(4-isopropylphenyl)propylthio)-2-((S)-3-...)
Show SMILES CCC(SC[C@H](NC(=O)[C@H](C)CS)C(O)=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C19H29NO3S2/c1-5-17(15-8-6-14(7-9-15)12(2)3)25-11-16(19(22)23)20-18(21)13(4)10-24/h6-9,12-13,16-17,24H,5,10-11H2,1-4H3,(H,20,21)(H,22,23)/t13-,16+,17?/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266170
PNG
((R)-3-(4-ethylbenzylthio)-2-((S)-3-mercapto-2-meth...)
Show SMILES CCc1ccc(CSC[C@H](NC(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C16H23NO3S2/c1-3-12-4-6-13(7-5-12)9-22-10-14(16(19)20)17-15(18)11(2)8-21/h4-7,11,14,21H,3,8-10H2,1-2H3,(H,17,18)(H,19,20)/t11-,14+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266174
PNG
((R)-3-(biphenyl-4-ylmethylthio)-2-((S)-3-mercapto-...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C20H23NO3S2/c1-14(11-25)19(22)21-18(20(23)24)13-26-12-15-7-9-17(10-8-15)16-5-3-2-4-6-16/h2-10,14,18,25H,11-13H2,1H3,(H,21,22)(H,23,24)/t14-,18+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266280
PNG
((R)-3-(2-(4-isopropylphenyl)propan-2-ylthio)-2-((S...)
Show SMILES CC(C)c1ccc(cc1)C(C)(C)SC[C@H](NC(=O)[C@H](C)CS)C(O)=O
Show InChI InChI=1S/C19H29NO3S2/c1-12(2)14-6-8-15(9-7-14)19(4,5)25-11-16(18(22)23)20-17(21)13(3)10-24/h6-9,12-13,16,24H,10-11H2,1-5H3,(H,20,21)(H,22,23)/t13-,16+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266279
PNG
((2R)-3-((4-isopropylphenyl)(phenyl)methylthio)-2-(...)
Show SMILES CC(C)c1ccc(cc1)C(SC[C@H](NC(=O)[C@H](C)CS)C(O)=O)c1ccccc1
Show InChI InChI=1S/C23H29NO3S2/c1-15(2)17-9-11-19(12-10-17)21(18-7-5-4-6-8-18)29-14-20(23(26)27)24-22(25)16(3)13-28/h4-12,15-16,20-21,28H,13-14H2,1-3H3,(H,24,25)(H,26,27)/t16-,20+,21?/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272200
PNG
((2S,5S)-5-(4-(methylthio)benzylthio)-1-((S)-3-merc...)
Show SMILES CSc1ccc(CS[C@H]2CC[C@H](N2C(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C17H23NO3S3/c1-11(9-22)16(19)18-14(17(20)21)7-8-15(18)24-10-12-3-5-13(23-2)6-4-12/h3-6,11,14-15,22H,7-10H2,1-2H3,(H,20,21)/t11-,14+,15+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266137
PNG
((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-me...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C15H21NO3S2/c1-10-3-5-12(6-4-10)8-21-9-13(15(18)19)16-14(17)11(2)7-20/h3-6,11,13,20H,7-9H2,1-2H3,(H,16,17)(H,18,19)/t11-,13+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266245
PNG
((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-(m...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)S(C)(=O)=O)C(O)=O
Show InChI InChI=1S/C15H21NO5S3/c1-10(7-22)14(17)16-13(15(18)19)9-23-8-11-3-5-12(6-4-11)24(2,20)21/h3-6,10,13,22H,7-9H2,1-2H3,(H,16,17)(H,18,19)/t10-,13+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266276
PNG
((2R)-3-(1-(4-isopropylphenyl)butylthio)-2-((S)-3-m...)
Show SMILES CCCC(SC[C@H](NC(=O)[C@H](C)CS)C(O)=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C20H31NO3S2/c1-5-6-18(16-9-7-15(8-10-16)13(2)3)26-12-17(20(23)24)21-19(22)14(4)11-25/h7-10,13-14,17-18,25H,5-6,11-12H2,1-4H3,(H,21,22)(H,23,24)/t14-,17+,18?/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266171
PNG
((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-pr...)
Show SMILES CCCc1ccc(CSC[C@H](NC(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C17H25NO3S2/c1-3-4-13-5-7-14(8-6-13)10-23-11-15(17(20)21)18-16(19)12(2)9-22/h5-8,12,15,22H,3-4,9-11H2,1-2H3,(H,18,19)(H,20,21)/t12-,15+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266315
PNG
((2R)-3-((4-cyclohexylphenyl)(phenyl)methylthio)-2-...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSC(c1ccccc1)c1ccc(cc1)C1CCCCC1)C(O)=O
Show InChI InChI=1S/C26H33NO3S2/c1-18(16-31)25(28)27-23(26(29)30)17-32-24(21-10-6-3-7-11-21)22-14-12-20(13-15-22)19-8-4-2-5-9-19/h3,6-7,10-15,18-19,23-24,31H,2,4-5,8-9,16-17H2,1H3,(H,27,28)(H,29,30)/t18-,23+,24?/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266211
PNG
((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-ph...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(Oc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C20H23NO4S2/c1-14(11-26)19(22)21-18(20(23)24)13-27-12-15-7-9-17(10-8-15)25-16-5-3-2-4-6-16/h2-10,14,18,26H,11-13H2,1H3,(H,21,22)(H,23,24)/t14-,18+/m1/s1
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Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266138
PNG
((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-(t...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C15H18F3NO3S2/c1-9(6-23)13(20)19-12(14(21)22)8-24-7-10-2-4-11(5-3-10)15(16,17)18/h2-5,9,12,23H,6-8H2,1H3,(H,19,20)(H,21,22)/t9-,12+/m1/s1
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n/an/a 282n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272203
PNG
((2S,5R)-5-(4-isopropylbenzylthio)-1-((S)-3-mercapt...)
Show SMILES CC(C)c1ccc(CS[C@@H]2CC[C@H](N2C(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C19H27NO3S2/c1-12(2)15-6-4-14(5-7-15)11-25-17-9-8-16(19(22)23)20(17)18(21)13(3)10-24/h4-7,12-13,16-17,24H,8-11H2,1-3H3,(H,22,23)/t13-,16+,17-/m1/s1
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n/an/a 290n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266208
PNG
((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-me...)
Show SMILES COc1ccc(CSC[C@H](NC(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C15H21NO4S2/c1-10(7-21)14(17)16-13(15(18)19)9-22-8-11-3-5-12(20-2)6-4-11/h3-6,10,13,21H,7-9H2,1-2H3,(H,16,17)(H,18,19)/t10-,13+/m1/s1
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n/an/a 398n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266079
PNG
((R)-3-(4-(dimethylamino)benzylthio)-2-(2-mercaptoa...)
Show SMILES CN(C)c1ccc(CSC[C@H](NC(=O)CS)C(O)=O)cc1
Show InChI InChI=1S/C14H20N2O3S2/c1-16(2)11-5-3-10(4-6-11)8-21-9-12(14(18)19)15-13(17)7-20/h3-6,12,20H,7-9H2,1-2H3,(H,15,17)(H,18,19)/t12-/m0/s1
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n/an/a 470n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266278
PNG
((2R)-3-(1-(4-isopropylphenyl)pentylthio)-2-((S)-3-...)
Show SMILES CCCCC(SC[C@H](NC(=O)[C@H](C)CS)C(O)=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C21H33NO3S2/c1-5-6-7-19(17-10-8-16(9-11-17)14(2)3)27-13-18(21(24)25)22-20(23)15(4)12-26/h8-11,14-15,18-19,26H,5-7,12-13H2,1-4H3,(H,22,23)(H,24,25)/t15-,18+,19?/m1/s1
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n/an/a 510n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266277
PNG
((2R)-3-(1-(4-isopropylphenyl)-2-methylpropylthio)-...)
Show SMILES CC(C)C(SC[C@H](NC(=O)[C@H](C)CS)C(O)=O)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C20H31NO3S2/c1-12(2)15-6-8-16(9-7-15)18(13(3)4)26-11-17(20(23)24)21-19(22)14(5)10-25/h6-9,12-14,17-18,25H,10-11H2,1-5H3,(H,21,22)(H,23,24)/t14-,17+,18?/m1/s1
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n/an/a 520n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266213
PNG
((R)-3-(4-cyanobenzylthio)-2-((S)-3-mercapto-2-meth...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C15H18N2O3S2/c1-10(7-21)14(18)17-13(15(19)20)9-22-8-12-4-2-11(6-16)3-5-12/h2-5,10,13,21H,7-9H2,1H3,(H,17,18)(H,19,20)/t10-,13+/m1/s1
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n/an/a 525n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266173
PNG
((R)-3-(4-tert-butylbenzylthio)-2-((S)-3-mercapto-2...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)C(C)(C)C)C(O)=O
Show InChI InChI=1S/C18H27NO3S2/c1-12(9-23)16(20)19-15(17(21)22)11-24-10-13-5-7-14(8-6-13)18(2,3)4/h5-8,12,15,23H,9-11H2,1-4H3,(H,19,20)(H,21,22)/t12-,15+/m1/s1
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n/an/a 603n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266134
PNG
((R)-3-(4-chlorobenzylthio)-2-((S)-3-mercapto-2-met...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C14H18ClNO3S2/c1-9(6-20)13(17)16-12(14(18)19)8-21-7-10-2-4-11(15)5-3-10/h2-5,9,12,20H,6-8H2,1H3,(H,16,17)(H,18,19)/t9-,12+/m1/s1
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n/an/a 617n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266209
PNG
((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-(t...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(OC(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C15H18F3NO4S2/c1-9(6-24)13(20)19-12(14(21)22)8-25-7-10-2-4-11(5-3-10)23-15(16,17)18/h2-5,9,12,24H,6-8H2,1H3,(H,19,20)(H,21,22)/t9-,12+/m1/s1
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n/an/a 646n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272143
PNG
((2S,5S)-5-(4-isopropylphenethylthio)-1-((S)-3-merc...)
Show SMILES CC(C)c1ccc(CCS[C@H]2CC[C@H](N2C(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C20H29NO3S2/c1-13(2)16-6-4-15(5-7-16)10-11-26-18-9-8-17(20(23)24)21(18)19(22)14(3)12-25/h4-7,13-14,17-18,25H,8-12H2,1-3H3,(H,23,24)/t14-,17+,18+/m1/s1
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n/an/a 790n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272199
PNG
((2S,5S)-1-((S)-3-Mercapto-2-methyl-propionyl)-5-(2...)
Show SMILES C[C@H](CS)C(=O)N1[C@H](CC[C@H]1C(O)=O)SCc1ccccc1C
Show InChI InChI=1S/C17H23NO3S2/c1-11-5-3-4-6-13(11)10-23-15-8-7-14(17(20)21)18(15)16(19)12(2)9-22/h3-6,12,14-15,22H,7-10H2,1-2H3,(H,20,21)/t12-,14+,15+/m1/s1
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n/an/a 840n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266212
PNG
((R)-3-(4-(diethylamino)benzylthio)-2-((S)-3-mercap...)
Show SMILES CCN(CC)c1ccc(CSC[C@H](NC(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C18H28N2O3S2/c1-4-20(5-2)15-8-6-14(7-9-15)11-25-12-16(18(22)23)19-17(21)13(3)10-24/h6-9,13,16,24H,4-5,10-12H2,1-3H3,(H,19,21)(H,22,23)/t13-,16+/m1/s1
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n/an/a 891n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272062
PNG
((2S,5S)-1-((S)-3-mercapto-2-methylpropanoyl)-5-(3-...)
Show SMILES C[C@H](CS)C(=O)N1[C@H](CC[C@H]1C(O)=O)SCCCc1ccccc1
Show InChI InChI=1S/C18H25NO3S2/c1-13(12-23)17(20)19-15(18(21)22)9-10-16(19)24-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,13,15-16,23H,5,8-12H2,1H3,(H,21,22)/t13-,15+,16+/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272141
PNG
((2S,5S)-1-((S)-3-mercapto-2-methylpropanoyl)-5-(na...)
Show SMILES C[C@H](CS)C(=O)N1[C@H](CC[C@H]1C(O)=O)SCc1ccc2ccccc2c1
Show InChI InChI=1S/C20H23NO3S2/c1-13(11-25)19(22)21-17(20(23)24)8-9-18(21)26-12-14-6-7-15-4-2-3-5-16(15)10-14/h2-7,10,13,17-18,25H,8-9,11-12H2,1H3,(H,23,24)/t13-,17+,18+/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266108
PNG
((R)-3-(4-(dimethylamino)benzylthio)-2-((R)-3-merca...)
Show SMILES C[C@@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)N(C)C)C(O)=O
Show InChI InChI=1S/C16H24N2O3S2/c1-11(8-22)15(19)17-14(16(20)21)10-23-9-12-4-6-13(7-5-12)18(2)3/h4-7,11,14,22H,8-10H2,1-3H3,(H,17,19)(H,20,21)/t11-,14-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266210
PNG
((R)-3-(4-ethoxybenzylthio)-2-((S)-3-mercapto-2-met...)
Show SMILES CCOc1ccc(CSC[C@H](NC(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C16H23NO4S2/c1-3-21-13-6-4-12(5-7-13)9-23-10-14(16(19)20)17-15(18)11(2)8-22/h4-7,11,14,22H,3,8-10H2,1-2H3,(H,17,18)(H,19,20)/t11-,14+/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266133
PNG
((R)-3-(4-fluorobenzylthio)-2-((S)-3-mercapto-2-met...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C14H18FNO3S2/c1-9(6-20)13(17)16-12(14(18)19)8-21-7-10-2-4-11(15)5-3-10/h2-5,9,12,20H,6-8H2,1H3,(H,16,17)(H,18,19)/t9-,12+/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266175
PNG
((R)-3-(4-cyclohexylbenzylthio)-2-((S)-3-mercapto-2...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)C1CCCCC1)C(O)=O
Show InChI InChI=1S/C20H29NO3S2/c1-14(11-25)19(22)21-18(20(23)24)13-26-12-15-7-9-17(10-8-15)16-5-3-2-4-6-16/h7-10,14,16,18,25H,2-6,11-13H2,1H3,(H,21,22)(H,23,24)/t14-,18+/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272144
PNG
((2S,5S)-5-(3-(4-isopropylphenyl)propylthio)-1-((S)...)
Show SMILES CC(C)c1ccc(CCCS[C@H]2CC[C@H](N2C(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C21H31NO3S2/c1-14(2)17-8-6-16(7-9-17)5-4-12-27-19-11-10-18(21(24)25)22(19)20(23)15(3)13-26/h6-9,14-15,18-19,26H,4-5,10-13H2,1-3H3,(H,24,25)/t15-,18+,19+/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272060
PNG
((2S,5S)-5-(benzylthio)-1-((S)-3-mercapto-2-methylp...)
Show SMILES C[C@H](CS)C(=O)N1[C@H](CC[C@H]1C(O)=O)SCc1ccccc1
Show InChI InChI=1S/C16H21NO3S2/c1-11(9-21)15(18)17-13(16(19)20)7-8-14(17)22-10-12-5-3-2-4-6-12/h2-6,11,13-14,21H,7-10H2,1H3,(H,19,20)/t11-,13+,14+/m1/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266243
PNG
((R)-2-((S)-3-mercapto-2-methylpropanamido)-3-(4-ni...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C14H18N2O5S2/c1-9(6-22)13(17)15-12(14(18)19)8-23-7-10-2-4-11(5-3-10)16(20)21/h2-5,9,12,22H,6-8H2,1H3,(H,15,17)(H,18,19)/t9-,12+/m1/s1
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n/an/a 4.90E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272061
PNG
((2S,5S)-1-((S)-3-mercapto-2-methylpropanoyl)-5-(ph...)
Show SMILES C[C@H](CS)C(=O)N1[C@H](CC[C@H]1C(O)=O)SCCc1ccccc1
Show InChI InChI=1S/C17H23NO3S2/c1-12(11-22)16(19)18-14(17(20)21)7-8-15(18)23-10-9-13-5-3-2-4-6-13/h2-6,12,14-15,22H,7-11H2,1H3,(H,20,21)/t12-,14+,15+/m1/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266136
PNG
((R)-3-(4-iodobenzylthio)-2-((S)-3-mercapto-2-methy...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(I)cc1)C(O)=O
Show InChI InChI=1S/C14H18INO3S2/c1-9(6-20)13(17)16-12(14(18)19)8-21-7-10-2-4-11(15)5-3-10/h2-5,9,12,20H,6-8H2,1H3,(H,16,17)(H,18,19)/t9-,12+/m1/s1
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n/an/a 7.24E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266109
PNG
((2R)-3-(4-(dimethylamino)benzylthio)-2-(3-mercapto...)
Show SMILES CC(S)CC(=O)N[C@@H](CSCc1ccc(cc1)N(C)C)C(O)=O
Show InChI InChI=1S/C16H24N2O3S2/c1-11(22)8-15(19)17-14(16(20)21)10-23-9-12-4-6-13(7-5-12)18(2)3/h4-7,11,14,22H,8-10H2,1-3H3,(H,17,19)(H,20,21)/t11?,14-/m0/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272099
PNG
((2S,5S)-1-((S)-3-mercapto-2-methylpropanoyl)-5-(na...)
Show SMILES C[C@H](CS)C(=O)N1[C@H](CC[C@H]1C(O)=O)SCc1cccc2ccccc12
Show InChI InChI=1S/C20H23NO3S2/c1-13(11-25)19(22)21-17(20(23)24)9-10-18(21)26-12-15-7-4-6-14-5-2-3-8-16(14)15/h2-8,13,17-18,25H,9-12H2,1H3,(H,23,24)/t13-,17+,18+/m1/s1
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n/an/a 9.20E+3n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266074
PNG
(CHEMBL457317 | S-(4-dimethylamino)benzy-N-[(2S)-3-...)
Show SMILES C[C@H](CS)C(=O)N[C@@H](CSCc1ccc(cc1)N(C)C)C(O)=O
Show InChI InChI=1S/C16H24N2O3S2/c1-11(8-22)15(19)17-14(16(20)21)10-23-9-12-4-6-13(7-5-12)18(2)3/h4-7,11,14,22H,8-10H2,1-3H3,(H,17,19)(H,20,21)/t11-,14+/m1/s1
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n/an/a<1.00E+4n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266106
PNG
((R)-3-(4-(dimethylamino)benzylthio)-2-((R)-2-merca...)
Show SMILES C[C@@H](S)C(=O)N[C@@H](CSCc1ccc(cc1)N(C)C)C(O)=O
Show InChI InChI=1S/C15H22N2O3S2/c1-10(21)14(18)16-13(15(19)20)9-22-8-11-4-6-12(7-5-11)17(2)3/h4-7,10,13,21H,8-9H2,1-3H3,(H,16,18)(H,19,20)/t10-,13+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50266246
PNG
((R)-3-(4-isopropylbenzylthio)-2-((S)-3-mercapto-2-...)
Show SMILES CC(C)c1ccc(CSC(C)(C)[C@H](NC(=O)[C@H](C)CS)C(O)=O)cc1
Show InChI InChI=1S/C19H29NO3S2/c1-12(2)15-8-6-14(7-9-15)11-25-19(4,5)16(18(22)23)20-17(21)13(3)10-24/h6-9,12-13,16,24H,10-11H2,1-5H3,(H,20,21)(H,22,23)/t13-,16-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production


Citation and Details
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Cavia porcellus)
BDBM50272145
PNG
((2S,5S)-1-((S)-3-Mercapto-2-methyl-propionyl)-5-(3...)
Show SMILES C[C@H](CS)C(=O)N1[C@H](CC[C@H]1C(O)=O)SCc1cccc(C)c1
Show InChI InChI=1S/C17H23NO3S2/c1-11-4-3-5-13(8-11)10-23-15-7-6-14(17(20)21)18(15)16(19)12(2)9-22/h3-5,8,12,14-15,22H,6-7,9-10H2,1-2H3,(H,20,21)/t12-,14+,15+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Santen Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of guinea pig lung leukotriene A4 hydrolase


Citation and Details
More data for this
Ligand-Target Pair
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