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Compile Data Set for Download or QSAR

Found 19 hits Enz. Inhib. hit(s) with Target = 'Leukotriene A4 hydrolase' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425166
PNG
(CHEMBL2313573)
Show SMILES CC(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2Cc1coc2cc(Oc3nc4ncccc4s3)ccc12
Show InChI InChI=1S/C24H24N4O3S/c1-14(29)26-16-9-17-4-5-18(10-16)28(17)12-15-13-30-21-11-19(6-7-20(15)21)31-24-27-23-22(32-24)3-2-8-25-23/h2-3,6-8,11,13,16-18H,4-5,9-10,12H2,1H3,(H,26,29)/t16-,17+,18-
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n/an/a 9.80n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425170
PNG
(CHEMBL2313569)
Show SMILES CC(=O)NC1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1
Show InChI InChI=1S/C22H22N4O3S/c1-14(27)24-16-6-9-26(10-7-16)12-15-13-28-19-11-17(4-5-18(15)19)29-22-25-21-20(30-22)3-2-8-23-21/h2-5,8,11,13,16H,6-7,9-10,12H2,1H3,(H,24,27)
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n/an/a 17n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425148
PNG
(CHEMBL2313566)
Show SMILES OC(=O)C1CCN(Cc2coc3cc(Oc4nc5ccccc5s4)ccc23)CC1
Show InChI InChI=1S/C22H20N2O4S/c25-21(26)14-7-9-24(10-8-14)12-15-13-27-19-11-16(5-6-17(15)19)28-22-23-18-3-1-2-4-20(18)29-22/h1-6,11,13-14H,7-10,12H2,(H,25,26)
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n/an/a 19n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425168
PNG
(CHEMBL2313571)
Show SMILES O=C1CCCN1C1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1
Show InChI InChI=1S/C24H24N4O3S/c29-22-4-2-10-28(22)17-7-11-27(12-8-17)14-16-15-30-20-13-18(5-6-19(16)20)31-24-26-23-21(32-24)3-1-9-25-23/h1,3,5-6,9,13,15,17H,2,4,7-8,10-12,14H2
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n/an/a 21n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425151
PNG
(CHEMBL2313563)
Show SMILES C(N1CCCCC1)c1coc2cc(Oc3nc4ncccc4s3)ccc12
Show InChI InChI=1S/C20H19N3O2S/c1-2-9-23(10-3-1)12-14-13-24-17-11-15(6-7-16(14)17)25-20-22-19-18(26-20)5-4-8-21-19/h4-8,11,13H,1-3,9-10,12H2
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n/an/a 21n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425164
PNG
(CHEMBL2313265)
Show SMILES CC(=O)N1C[C@@H]2C[C@H]1CN2Cc1coc2cc(Oc3nc4ncccc4s3)ccc12
Show InChI InChI=1S/C22H20N4O3S/c1-13(27)26-11-15-7-16(26)10-25(15)9-14-12-28-19-8-17(4-5-18(14)19)29-22-24-21-20(30-22)3-2-6-23-21/h2-6,8,12,15-16H,7,9-11H2,1H3/t15-,16-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425157
PNG
(CHEMBL2313272)
Show SMILES CC(=O)N1CC2CC1CN2Cc1coc2cc(Oc3nc4ncccc4s3)ccc12
Show InChI InChI=1S/C22H20N4O3S/c1-13(27)26-11-15-7-16(26)10-25(15)9-14-12-28-19-8-17(4-5-18(14)19)29-22-24-21-20(30-22)3-2-6-23-21/h2-6,8,12,15-16H,7,9-11H2,1H3
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n/an/a 21n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425163
PNG
(CHEMBL2313266)
Show SMILES CC(=O)N1CC2CC1CN2Cc1cc2cc(Oc3nc4ncccc4s3)ccc2o1
Show InChI InChI=1S/C22H20N4O3S/c1-13(27)26-11-15-9-16(26)10-25(15)12-18-8-14-7-17(4-5-19(14)28-18)29-22-24-21-20(30-22)3-2-6-23-21/h2-8,15-16H,9-12H2,1H3
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n/an/a 27n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425149
PNG
(CHEMBL2313565)
Show SMILES C(N1CCOCC1)c1coc2cc(Oc3nc4ncccc4s3)ccc12
Show InChI InChI=1S/C19H17N3O3S/c1-2-17-18(20-5-1)21-19(26-17)25-14-3-4-15-13(12-24-16(15)10-14)11-22-6-8-23-9-7-22/h1-5,10,12H,6-9,11H2
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n/an/a 49n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425167
PNG
(CHEMBL2313572)
Show SMILES CC(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2Cc1coc2cc(Oc3nc4ccccc4s3)ccc12
Show InChI InChI=1S/C25H25N3O3S/c1-15(29)26-17-10-18-6-7-19(11-17)28(18)13-16-14-30-23-12-20(8-9-21(16)23)31-25-27-22-4-2-3-5-24(22)32-25/h2-5,8-9,12,14,17-19H,6-7,10-11,13H2,1H3,(H,26,29)/t17-,18+,19-
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n/an/a 69n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425153
PNG
(CHEMBL2313561)
Show SMILES C(N1CCCCC1)c1cc2cc(Oc3nc4ncccc4s3)ccc2o1
Show InChI InChI=1S/C20H19N3O2S/c1-2-9-23(10-3-1)13-16-12-14-11-15(6-7-17(14)24-16)25-20-22-19-18(26-20)5-4-8-21-19/h4-8,11-12H,1-3,9-10,13H2
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n/an/a 91n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425171
PNG
(CHEMBL2313568)
Show SMILES CC(=O)NC1CCN(Cc2coc3cc(Oc4nc5ccccc5s4)ccc23)CC1
Show InChI InChI=1S/C23H23N3O3S/c1-15(27)24-17-8-10-26(11-9-17)13-16-14-28-21-12-18(6-7-19(16)21)29-23-25-20-4-2-3-5-22(20)30-23/h2-7,12,14,17H,8-11,13H2,1H3,(H,24,27)
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n/an/a 100n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425152
PNG
(CHEMBL2313562)
Show SMILES C(N1CCCCC1)c1cc2ccc(Oc3nc4ncccc4s3)cc2o1
Show InChI InChI=1S/C20H19N3O2S/c1-2-9-23(10-3-1)13-16-11-14-6-7-15(12-17(14)24-16)25-20-22-19-18(26-20)5-4-8-21-19/h4-8,11-12H,1-3,9-10,13H2
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n/an/a 140n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425160
PNG
(CHEMBL2313269)
Show SMILES CC(=O)N1CC2CC1CN2Cc1cc2ccc(Oc3nc4ncccc4s3)cc2o1
Show InChI InChI=1S/C22H20N4O3S/c1-13(27)26-11-15-8-16(26)10-25(15)12-18-7-14-4-5-17(9-19(14)28-18)29-22-24-21-20(30-22)3-2-6-23-21/h2-7,9,15-16H,8,10-12H2,1H3
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n/an/a 210n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425169
PNG
(CHEMBL2313570)
Show SMILES O=C1CCCN1C1CCN(Cc2coc3cc(Oc4nc5ccccc5s4)ccc23)CC1
Show InChI InChI=1S/C25H25N3O3S/c29-24-6-3-11-28(24)18-9-12-27(13-10-18)15-17-16-30-22-14-19(7-8-20(17)22)31-25-26-21-4-1-2-5-23(21)32-25/h1-2,4-5,7-8,14,16,18H,3,6,9-13,15H2
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n/an/a 230n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425165
PNG
(CHEMBL2313264)
Show SMILES CC(=O)N1C[C@@H]2C[C@H]1CN2Cc1coc2cc(Oc3nc4ccccc4s3)ccc12
Show InChI InChI=1S/C23H21N3O3S/c1-14(27)26-12-16-8-17(26)11-25(16)10-15-13-28-21-9-18(6-7-19(15)21)29-23-24-20-4-2-3-5-22(20)30-23/h2-7,9,13,16-17H,8,10-12H2,1H3/t16-,17-/m0/s1
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n/an/a 250n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425147
PNG
(CHEMBL2313567)
Show SMILES OC(=O)C1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1
Show InChI InChI=1S/C21H19N3O4S/c25-20(26)13-5-8-24(9-6-13)11-14-12-27-17-10-15(3-4-16(14)17)28-21-23-19-18(29-21)2-1-7-22-19/h1-4,7,10,12-13H,5-6,8-9,11H2,(H,25,26)
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n/an/a 280n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425154
PNG
(CHEMBL2313560)
Show SMILES C(N1CCCCC1)c1coc2cc(Oc3nc4ccccc4s3)ccc12
Show InChI InChI=1S/C21H20N2O2S/c1-4-10-23(11-5-1)13-15-14-24-19-12-16(8-9-17(15)19)25-21-22-18-6-2-3-7-20(18)26-21/h2-3,6-9,12,14H,1,4-5,10-11,13H2
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n/an/a 420n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Mus musculus)
BDBM50425150
PNG
(CHEMBL2313564)
Show SMILES C(N1CCOCC1)c1coc2cc(Oc3nc4ccccc4s3)ccc12
Show InChI InChI=1S/C20H18N2O3S/c1-2-4-19-17(3-1)21-20(26-19)25-15-5-6-16-14(13-24-18(16)11-15)12-22-7-9-23-10-8-22/h1-6,11,13H,7-10,12H2
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n/an/a 1.12E+3n/an/an/an/an/an/a



Janssen Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...


Bioorg Med Chem Lett 23: 811-5 (2013)

More data for this
Ligand-Target Pair