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Found 12 hits Enz. Inhib. hit(s) with Target = 'Lipoxygenase (LOX)' AND taxid = 3847   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM32020
PNG
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Show SMILES CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
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PubMed
n/an/a 9.23E+3n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


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More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM111809
PNG
(2,6-Bis[2-methyl-4(N-ethyl-N-ethylacetonitrile) an...)
Show SMILES CCN(CC)C(C#C)c1ccc(\C=C2/CCC\C(=C/c3ccc(cc3C)C(C#C)N(CC)CC)C2=O)c(C)c1
Show InChI InChI=1S/C36H44N2O/c1-9-34(37(11-3)12-4)30-20-18-28(26(7)22-30)24-32-16-15-17-33(36(32)39)25-29-19-21-31(23-27(29)8)35(10-2)38(13-5)14-6/h1-2,18-25,34-35H,11-17H2,3-8H3/b32-24+,33-25+
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n/an/a 3.00E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


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More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM111813
PNG
((1E,4E)-1,5-Bis[2-methyl-4(N-ethyl-Nethylacetonitr...)
Show SMILES CCN(CC)C(C#N)c1ccc(\C=C\C(=O)\C=C\c2ccc(cc2C)C(C#N)N(CC)CC)c(C)c1
Show InChI InChI=1S/C31H38N4O/c1-7-34(8-2)30(21-32)27-13-11-25(23(5)19-27)15-17-29(36)18-16-26-12-14-28(20-24(26)6)31(22-33)35(9-3)10-4/h11-20,30-31H,7-10H2,1-6H3/b17-15+,18-16+
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n/an/a 4.11E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


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More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM111807
PNG
(2,6-Bis(2,3-dimethoxybenzylidene)cyclohexanone (3))
Show SMILES COc1cccc(\C=C2/CCC\C(=C/c3cccc(OC)c3OC)C2=O)c1OC
Show InChI InChI=1S/C24H26O5/c1-26-20-12-6-10-18(23(20)28-3)14-16-8-5-9-17(22(16)25)15-19-11-7-13-21(27-2)24(19)29-4/h6-7,10-15H,5,8-9H2,1-4H3/b16-14+,17-15+
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n/an/a 4.78E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


Citation and Details
More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM111810
PNG
((1Z,4Z)-1,5-Bis [4-(methylaminoethanol)phenyl]- 1,...)
Show SMILES CNC(CO)c1ccc(\C=C\C(=O)\C=C\c2ccc(cc2)C(CO)NC)cc1
Show InChI InChI=1S/C23H28N2O3/c1-24-22(15-26)19-9-3-17(4-10-19)7-13-21(28)14-8-18-5-11-20(12-6-18)23(16-27)25-2/h3-14,22-27H,15-16H2,1-2H3/b13-7+,14-8+
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n/an/a 5.64E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


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More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM111817
PNG
(2,5-Bis(4-diethylaminobenzylidene)cyclopentanone (...)
Show SMILES CCN(CC)c1ccc(\C=C2/CC\C(=C/c3ccc(cc3)N(CC)CC)C2=O)cc1
Show InChI InChI=1S/C27H34N2O/c1-5-28(6-2)25-15-9-21(10-16-25)19-23-13-14-24(27(23)30)20-22-11-17-26(18-12-22)29(7-3)8-4/h9-12,15-20H,5-8,13-14H2,1-4H3/b23-19+,24-20+
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n/an/a 5.68E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


Citation and Details
More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM29532
PNG
((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...)
Show SMILES COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3
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n/an/a 5.78E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


Citation and Details
More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM111811
PNG
((1Z,4Z)–1-5-Bis[2,3(dimethoxy)phenyl]-1,4- pe...)
Show SMILES COc1cccc(\C=C\C(=O)\C=C\c2cccc(OC)c2OC)c1OC
Show InChI InChI=1S/C21H22O5/c1-23-18-9-5-7-15(20(18)25-3)11-13-17(22)14-12-16-8-6-10-19(24-2)21(16)26-4/h5-14H,1-4H3/b13-11+,14-12+
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n/an/a 6.29E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


Citation and Details
More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM111816
PNG
((2E,5E)‐2,5‐bis[(2,3‐ dimethoxyp...)
Show SMILES COc1cccc(\C=C2/CC\C(=C/c3cccc(OC)c3OC)C2=O)c1OC
Show InChI InChI=1S/C23H24O5/c1-25-19-9-5-7-17(22(19)27-3)13-15-11-12-16(21(15)24)14-18-8-6-10-20(26-2)23(18)28-4/h5-10,13-14H,11-12H2,1-4H3/b15-13+,16-14+
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n/an/a 6.38E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


Citation and Details
More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM111805
PNG
(2,6-Bis[4-(methylaminoethanol)benzylidine] cyclohe...)
Show SMILES CNC(CO)c1ccc(\C=C2/CCC\C(=C/c3ccc(cc3)C(CO)NC)C2=O)cc1
Show InChI InChI=1S/C26H32N2O3/c1-27-24(16-29)20-10-6-18(7-11-20)14-22-4-3-5-23(26(22)31)15-19-8-12-21(13-9-19)25(17-30)28-2/h6-15,24-25,27-30H,3-5,16-17H2,1-2H3/b22-14+,23-15+
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n/an/a 8.24E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


Citation and Details
More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM111814
PNG
(2,5-Bis[4-(methylaminoethanol)benzylidene] cyclope...)
Show SMILES CNC(CO)c1ccc(\C=C2/CC\C(=C/c3ccc(cc3)C(CO)NC)C2=O)cc1
Show InChI InChI=1S/C25H30N2O3/c1-26-23(15-28)19-7-3-17(4-8-19)13-21-11-12-22(25(21)30)14-18-5-9-20(10-6-18)24(16-29)27-2/h3-10,13-14,23-24,26-29H,11-12,15-16H2,1-2H3/b21-13+,22-14+
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n/an/a 8.95E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


Citation and Details
More data for this
Ligand-Target Pair
Lipoxygenase (LOX)


(Glycine max (Soybean))
BDBM111812
PNG
((1E,4E)‐1,5‐bis[4‐(diethylamino)...)
Show SMILES CCN(CC)c1ccc(\C=C\C(=O)\C=C\c2ccc(cc2)N(CC)CC)cc1
Show InChI InChI=1S/C25H32N2O/c1-5-26(6-2)23-15-9-21(10-16-23)13-19-25(28)20-14-22-11-17-24(18-12-22)27(7-3)8-4/h9-20H,5-8H2,1-4H3/b19-13+,20-14+
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n/an/a 9.51E+4n/an/an/an/an/an/a



Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia



Assay Description
The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...


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More data for this
Ligand-Target Pair