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Found 18 hits Enz. Inhib. hit(s) with Target = 'Low molecular weight phosphotyrosine protein phosphatase' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371120
PNG
(CHEMBL242173)
Show SMILES OC(=O)c1ccc2NC(C3CC=CC3c2c1)c1cccc(Br)c1
Show InChI InChI=1S/C19H16BrNO2/c20-13-4-1-3-11(9-13)18-15-6-2-5-14(15)16-10-12(19(22)23)7-8-17(16)21-18/h1-5,7-10,14-15,18,21H,6H2,(H,22,23)
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9.00E+3n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371127
PNG
(CHEMBL244681)
Show SMILES OC(=O)c1ccc(cc1)-n1cccc1CC1=NC(=O)NC1=O
Show InChI InChI=1S/C15H11N3O4/c19-13-12(16-15(22)17-13)8-11-2-1-7-18(11)10-5-3-9(4-6-10)14(20)21/h1-7H,8H2,(H,20,21)(H,17,19,22)
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1.10E+4n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371125
PNG
(CHEMBL244088)
Show SMILES OC(=O)c1ccc2NC(C3CC=CC3c2c1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H16F3NO2/c21-20(22,23)16-7-2-1-4-14(16)18-13-6-3-5-12(13)15-10-11(19(25)26)8-9-17(15)24-18/h1-5,7-10,12-13,18,24H,6H2,(H,25,26)
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5.00E+4n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371131
PNG
(CHEMBL390874)
Show SMILES OC(=O)Cc1ccc2c(c1)[nH]c1ccc(Br)cc21
Show InChI InChI=1S/C14H10BrNO2/c15-9-2-4-12-11(7-9)10-3-1-8(6-14(17)18)5-13(10)16-12/h1-5,7,16H,6H2,(H,17,18)
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6.00E+4n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371118
PNG
(CHEMBL244693)
Show SMILES CCn1c2ccc(CC(O)=O)cc2c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C18H17NO4/c1-2-19-15-5-3-11(9-17(20)21)7-13(15)14-8-12(10-18(22)23)4-6-16(14)19/h3-8H,2,9-10H2,1H3,(H,20,21)(H,22,23)
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1.70E+5n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371123
PNG
(CHEMBL244090)
Show SMILES OC(=O)c1ccc2[nH]c3CCSCc3c2c1
Show InChI InChI=1S/C12H11NO2S/c14-12(15)7-1-2-10-8(5-7)9-6-16-4-3-11(9)13-10/h1-2,5,13H,3-4,6H2,(H,14,15)
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2.40E+5n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM38435
PNG
(9-ethyl-1-oxo-2,3,4,9-tetrahydro-1H-carbazole-6-ca...)
Show SMILES CCn1c2c(CCCC2=O)c2cc(ccc12)C(O)=O
Show InChI InChI=1S/C15H15NO3/c1-2-16-12-7-6-9(15(18)19)8-11(12)10-4-3-5-13(17)14(10)16/h6-8H,2-5H2,1H3,(H,18,19)
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6.10E+5n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371126
PNG
(CHEMBL438508)
Show SMILES OC(=O)Cc1ccc(cc1)C1C(=S)NC2C=CSC2C1=O
Show InChI InChI=1S/C15H13NO3S2/c17-11(18)7-8-1-3-9(4-2-8)12-13(19)14-10(5-6-21-14)16-15(12)20/h1-6,10,12,14H,7H2,(H,16,20)(H,17,18)
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8.80E+5n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371130
PNG
(CHEMBL390873)
Show SMILES OC(=O)c1ccc(cc1)C1Nc2c(F)cc(F)cc2C2C=CCC12
Show InChI InChI=1S/C19H15F2NO2/c20-12-8-15-13-2-1-3-14(13)17(22-18(15)16(21)9-12)10-4-6-11(7-5-10)19(23)24/h1-2,4-9,13-14,17,22H,3H2,(H,23,24)
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9.10E+5n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371117
PNG
(CHEMBL242146)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccccc1F)c1ccccc1
Show InChI InChI=1S/C19H17FN2O3/c20-15-9-5-4-8-14(15)17-12-16(13-6-2-1-3-7-13)21-22(17)18(23)10-11-19(24)25/h1-9,17H,10-12H2,(H,24,25)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371116
PNG
(CHEMBL242148)
Show SMILES Cn1c2ccc(cc2oc1=O)S(=O)(=O)N1CCC(CC1)C(O)=O
Show InChI InChI=1S/C14H16N2O6S/c1-15-11-3-2-10(8-12(11)22-14(15)19)23(20,21)16-6-4-9(5-7-16)13(17)18/h2-3,8-9H,4-7H2,1H3,(H,17,18)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371129
PNG
(CHEMBL244328)
Show SMILES OC(=O)c1ccc2[nH]c3CCCCc3c2c1
Show InChI InChI=1S/C13H13NO2/c15-13(16)8-5-6-12-10(7-8)9-3-1-2-4-11(9)14-12/h5-7,14H,1-4H2,(H,15,16)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371128
PNG
(CHEMBL390401)
Show SMILES OC(=O)c1ccc2NC(C3CC=CC3c2c1)c1ccccc1
Show InChI InChI=1S/C19H17NO2/c21-19(22)13-9-10-17-16(11-13)14-7-4-8-15(14)18(20-17)12-5-2-1-3-6-12/h1-7,9-11,14-15,18,20H,8H2,(H,21,22)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371124
PNG
(CHEMBL244694)
Show SMILES Cn1c2ccccc2c2ccc(CC(O)=O)cc12
Show InChI InChI=1S/C15H13NO2/c1-16-13-5-3-2-4-11(13)12-7-6-10(8-14(12)16)9-15(17)18/h2-8H,9H2,1H3,(H,17,18)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371121
PNG
(CHEMBL440951)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(c2CCCCc12)C(F)(F)F
Show InChI InChI=1S/C15H13F3N2O2/c16-15(17,18)13-11-3-1-2-4-12(11)20(19-13)10-7-5-9(6-8-10)14(21)22/h5-8H,1-4H2,(H,21,22)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371122
PNG
(CHEMBL242363)
Show SMILES OC(=O)CCC(=O)N1CCc2cc(ccc12)S(=O)(=O)NCc1cccs1
Show InChI InChI=1S/C17H18N2O5S2/c20-16(5-6-17(21)22)19-8-7-12-10-14(3-4-15(12)19)26(23,24)18-11-13-2-1-9-25-13/h1-4,9-10,18H,5-8,11H2,(H,21,22)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371119
PNG
(CHEMBL244696)
Show SMILES OC(=O)c1ccc2NC(C3CC=CC3c2c1)c1cccnc1
Show InChI InChI=1S/C18H16N2O2/c21-18(22)11-6-7-16-15(9-11)13-4-1-5-14(13)17(20-16)12-3-2-8-19-10-12/h1-4,6-10,13-14,17,20H,5H2,(H,21,22)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Citation and Details
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM26658
PNG
(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...)
Show SMILES Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Messina

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney LMW-PTPase using phosphotyrosine substrate


Citation and Details
More data for this
Ligand-Target Pair