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Found 18 hits Enz. Inhib. hit(s) with Target = 'Low molecular weight phosphotyrosine protein phosphatase' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371120
PNG
(CHEMBL242173)
Show SMILES OC(=O)c1ccc2NC(C3CC=CC3c2c1)c1cccc(Br)c1
Show InChI InChI=1S/C19H16BrNO2/c20-13-4-1-3-11(9-13)18-15-6-2-5-14(15)16-10-12(19(22)23)7-8-17(16)21-18/h1-5,7-10,14-15,18,21H,6H2,(H,22,23)
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9.00E+3n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371127
PNG
(CHEMBL244681)
Show SMILES OC(=O)c1ccc(cc1)-n1cccc1CC1=NC(=O)NC1=O
Show InChI InChI=1S/C15H11N3O4/c19-13-12(16-15(22)17-13)8-11-2-1-7-18(11)10-5-3-9(4-6-10)14(20)21/h1-7H,8H2,(H,20,21)(H,17,19,22)
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1.10E+4n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371125
PNG
(CHEMBL244088)
Show SMILES OC(=O)c1ccc2NC(C3CC=CC3c2c1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H16F3NO2/c21-20(22,23)16-7-2-1-4-14(16)18-13-6-3-5-12(13)15-10-11(19(25)26)8-9-17(15)24-18/h1-5,7-10,12-13,18,24H,6H2,(H,25,26)
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5.00E+4n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371131
PNG
(CHEMBL390874)
Show SMILES OC(=O)Cc1ccc2c(c1)[nH]c1ccc(Br)cc21
Show InChI InChI=1S/C14H10BrNO2/c15-9-2-4-12-11(7-9)10-3-1-8(6-14(17)18)5-13(10)16-12/h1-5,7,16H,6H2,(H,17,18)
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6.00E+4n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371118
PNG
(CHEMBL244693)
Show SMILES CCn1c2ccc(CC(O)=O)cc2c2cc(CC(O)=O)ccc12
Show InChI InChI=1S/C18H17NO4/c1-2-19-15-5-3-11(9-17(20)21)7-13(15)14-8-12(10-18(22)23)4-6-16(14)19/h3-8H,2,9-10H2,1H3,(H,20,21)(H,22,23)
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1.70E+5n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371123
PNG
(CHEMBL244090)
Show SMILES OC(=O)c1ccc2[nH]c3CCSCc3c2c1
Show InChI InChI=1S/C12H11NO2S/c14-12(15)7-1-2-10-8(5-7)9-6-16-4-3-11(9)13-10/h1-2,5,13H,3-4,6H2,(H,14,15)
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2.40E+5n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM38435
PNG
(9-ethyl-1-oxo-2,3,4,9-tetrahydro-1H-carbazole-6-ca...)
Show SMILES CCn1c2c(CCCC2=O)c2cc(ccc12)C(O)=O
Show InChI InChI=1S/C15H15NO3/c1-2-16-12-7-6-9(15(18)19)8-11(12)10-4-3-5-13(17)14(10)16/h6-8H,2-5H2,1H3,(H,18,19)
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6.10E+5n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371126
PNG
(CHEMBL438508)
Show SMILES OC(=O)Cc1ccc(cc1)C1C(=S)NC2C=CSC2C1=O
Show InChI InChI=1S/C15H13NO3S2/c17-11(18)7-8-1-3-9(4-2-8)12-13(19)14-10(5-6-21-14)16-15(12)20/h1-6,10,12,14H,7H2,(H,16,20)(H,17,18)
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8.80E+5n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371130
PNG
(CHEMBL390873)
Show SMILES OC(=O)c1ccc(cc1)C1Nc2c(F)cc(F)cc2C2C=CCC12
Show InChI InChI=1S/C19H15F2NO2/c20-12-8-15-13-2-1-3-14(13)17(22-18(15)16(21)9-12)10-4-6-11(7-5-10)19(23)24/h1-2,4-9,13-14,17,22H,3H2,(H,23,24)
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9.10E+5n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371117
PNG
(CHEMBL242146)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccccc1F)c1ccccc1
Show InChI InChI=1S/C19H17FN2O3/c20-15-9-5-4-8-14(15)17-12-16(13-6-2-1-3-7-13)21-22(17)18(23)10-11-19(24)25/h1-9,17H,10-12H2,(H,24,25)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371116
PNG
(CHEMBL242148)
Show SMILES Cn1c2ccc(cc2oc1=O)S(=O)(=O)N1CCC(CC1)C(O)=O
Show InChI InChI=1S/C14H16N2O6S/c1-15-11-3-2-10(8-12(11)22-14(15)19)23(20,21)16-6-4-9(5-7-16)13(17)18/h2-3,8-9H,4-7H2,1H3,(H,17,18)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371129
PNG
(CHEMBL244328)
Show SMILES OC(=O)c1ccc2[nH]c3CCCCc3c2c1
Show InChI InChI=1S/C13H13NO2/c15-13(16)8-5-6-12-10(7-8)9-3-1-2-4-11(9)14-12/h5-7,14H,1-4H2,(H,15,16)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371128
PNG
(CHEMBL390401)
Show SMILES OC(=O)c1ccc2NC(C3CC=CC3c2c1)c1ccccc1
Show InChI InChI=1S/C19H17NO2/c21-19(22)13-9-10-17-16(11-13)14-7-4-8-15(14)18(20-17)12-5-2-1-3-6-12/h1-7,9-11,14-15,18,20H,8H2,(H,21,22)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371124
PNG
(CHEMBL244694)
Show SMILES Cn1c2ccccc2c2ccc(CC(O)=O)cc12
Show InChI InChI=1S/C15H13NO2/c1-16-13-5-3-2-4-11(13)12-7-6-10(8-14(12)16)9-15(17)18/h2-8H,9H2,1H3,(H,17,18)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371121
PNG
(CHEMBL440951)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(c2CCCCc12)C(F)(F)F
Show InChI InChI=1S/C15H13F3N2O2/c16-15(17,18)13-11-3-1-2-4-12(11)20(19-13)10-7-5-9(6-8-10)14(21)22/h5-8H,1-4H2,(H,21,22)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371122
PNG
(CHEMBL242363)
Show SMILES OC(=O)CCC(=O)N1CCc2cc(ccc12)S(=O)(=O)NCc1cccs1
Show InChI InChI=1S/C17H18N2O5S2/c20-16(5-6-17(21)22)19-8-7-12-10-14(3-4-15(12)19)26(23,24)18-11-13-2-1-9-25-13/h1-4,9-10,18H,5-8,11H2,(H,21,22)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM50371119
PNG
(CHEMBL244696)
Show SMILES OC(=O)c1ccc2NC(C3CC=CC3c2c1)c1cccnc1
Show InChI InChI=1S/C18H16N2O2/c21-18(22)11-6-7-16-15(9-11)13-4-1-5-14(13)17(20-16)12-3-2-8-19-10-12/h1-4,6-10,13-14,17,20H,5H2,(H,21,22)
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>1.00E+6n/an/an/an/an/an/an/an/a



Institute for Research in Biomedicine (IRB)

Curated by ChEMBL


Assay Description
Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells


Eur J Med Chem 42: 1102-8 (2007)

More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase


(Bos taurus)
BDBM26658
PNG
(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...)
Show SMILES Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Messina

Curated by ChEMBL


Assay Description
Inhibition of bovine kidney LMW-PTPase using phosphotyrosine substrate


J Med Chem 55: 2-22 (2012)

More data for this
Ligand-Target Pair