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Found 238 hits Enz. Inhib. hit(s) with Target = 'Lysine-specific demethylase 6B' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
jmjd3


(Homo sapiens (Human))
BDBM293691
PNG
(3-({[(4S)-7-(thiophen-3-yl)-3,4-dihydro-2H-1-benzo...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccsc1
Show InChI InChI=1S/C20H18N2O3S/c23-20(24)17-3-6-21-11-18(17)22-10-14-4-7-25-19-9-13(1-2-16(14)19)15-5-8-26-12-15/h1-3,5-6,8-9,11-12,14,22H,4,7,10H2,(H,23,24)/t14-/m1/s1
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n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293686
PNG
(3-({[7-(furan-3-yl)-3,4-dihydro-2H-1-benzopyran-4-...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(ccc12)-c1ccoc1
Show InChI InChI=1S/C20H18N2O4/c23-20(24)17-3-6-21-11-18(17)22-10-14-5-8-26-19-9-13(1-2-16(14)19)15-4-7-25-12-15/h1-4,6-7,9,11-12,14,22H,5,8,10H2,(H,23,24)
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n/an/a<100n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140574
PNG
(CHEMBL3753391)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1cccn1)N1CCc2ccccc2CC1
Show InChI InChI=1S/C20H22N6O2/c27-19(28)6-10-21-20-23-17(14-18(24-20)26-11-3-9-22-26)25-12-7-15-4-1-2-5-16(15)8-13-25/h1-5,9,11,14H,6-8,10,12-13H2,(H,27,28)(H,21,23,24)
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n/an/a 150n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM60875
PNG
(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Show SMILES OC(=O)CCNc1cc(nc(n1)-c1ccccn1)N1CCc2ccccc2CC1
Show InChI InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26)
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n/an/a 150n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM60875
PNG
(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Show SMILES OC(=O)CCNc1cc(nc(n1)-c1ccccn1)N1CCc2ccccc2CC1
Show InChI InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26)
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n/an/a 160n/an/an/an/a7.5n/a



University of Oxford



Assay Description
The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...


Nat Chem Biol 12: 539-45 (2016)


Article DOI: 10.1038/nchembio.2087
BindingDB Entry DOI: 10.7270/Q27P8X6K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140567
PNG
(CHEMBL3752893)
Show SMILES OC(=O)CCNc1nc(cc(n1)-c1nccs1)N1CCc2ccccc2CC1
Show InChI InChI=1S/C20H21N5O2S/c26-18(27)5-8-22-20-23-16(19-21-9-12-28-19)13-17(24-20)25-10-6-14-3-1-2-4-15(14)7-11-25/h1-4,9,12-13H,5-8,10-11H2,(H,26,27)(H,22,23,24)
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n/an/a 200n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140345
PNG
(CHEMBL3752179)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1ccnn1)N1CCc2ccccc2CC1
Show InChI InChI=1S/C19H21N7O2/c27-18(28)5-8-20-19-22-16(13-17(23-19)26-12-9-21-24-26)25-10-6-14-3-1-2-4-15(14)7-11-25/h1-4,9,12-13H,5-8,10-11H2,(H,27,28)(H,20,22,23)
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n/an/a 210n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140680
PNG
(CHEMBL3753740)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1nccn1)N1CCc2ccccc2CC1
Show InChI InChI=1S/C19H21N7O2/c27-18(28)5-8-20-19-23-16(13-17(24-19)26-21-9-10-22-26)25-11-6-14-3-1-2-4-15(14)7-12-25/h1-4,9-10,13H,5-8,11-12H2,(H,27,28)(H,20,23,24)
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n/an/a 270n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140678
PNG
(CHEMBL3752769)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1cccn1)N1CCc2ccccc2C1
Show InChI InChI=1S/C19H20N6O2/c26-18(27)6-9-20-19-22-16(12-17(23-19)25-10-3-8-21-25)24-11-7-14-4-1-2-5-15(14)13-24/h1-5,8,10,12H,6-7,9,11,13H2,(H,26,27)(H,20,22,23)
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n/an/a 490n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293697
PNG
(3-({[(4S)-7-(2-chlorophenyl)-3,4-dihydro-2H-1-benz...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccccc1Cl
Show InChI InChI=1S/C22H19ClN2O3/c23-19-4-2-1-3-16(19)14-5-6-17-15(8-10-28-21(17)11-14)12-25-20-13-24-9-7-18(20)22(26)27/h1-7,9,11,13,15,25H,8,10,12H2,(H,26,27)/t15-/m1/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM270499
PNG
(3-{[((1R)-6-{methyl[4-(methylethyl)phenyl]amino}-1...)
Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@H](CNc3cnccc3C(O)=O)NCCc2c1
Show InChI InChI=1S/C26H30N4O2/c1-17(2)18-4-6-20(7-5-18)30(3)21-8-9-22-19(14-21)10-13-28-25(22)16-29-24-15-27-12-11-23(24)26(31)32/h4-9,11-12,14-15,17,25,28-29H,10,13,16H2,1-3H3,(H,31,32)/t25-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10059687 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293710
PNG
(3-({[(4S)-7-[(3-fluorophenyl)sulfanyl]-3,4-dihydro...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(Sc3cccc(F)c3)ccc12
Show InChI InChI=1S/C22H19FN2O3S/c23-15-2-1-3-16(10-15)29-17-4-5-18-14(7-9-28-21(18)11-17)12-25-20-13-24-8-6-19(20)22(26)27/h1-6,8,10-11,13-14,25H,7,9,12H2,(H,26,27)/t14-/m1/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293712
PNG
(3-({[(4S)-7-[(4-fluorophenyl)sulfanyl]-3,4-dihydro...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(Sc3ccc(F)cc3)ccc12
Show InChI InChI=1S/C22H19FN2O3S/c23-15-1-3-16(4-2-15)29-17-5-6-18-14(8-10-28-21(18)11-17)12-25-20-13-24-9-7-19(20)22(26)27/h1-7,9,11,13-14,25H,8,10,12H2,(H,26,27)/t14-/m1/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM270498
PNG
(3-{[((1S)-6-{methyl[4-(methylethyl)phenyl]amino}-1...)
Show SMILES CC(C)c1ccc(cc1)N(C)c1ccc2[C@@H](CNc3cnccc3C(O)=O)NCCc2c1
Show InChI InChI=1S/C26H30N4O2/c1-17(2)18-4-6-20(7-5-18)30(3)21-8-9-22-19(14-21)10-13-28-25(22)16-29-24-15-27-12-11-23(24)26(31)32/h4-9,11-12,14-15,17,25,28-29H,10,13,16H2,1-3H3,(H,31,32)/t25-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10059687 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293683
PNG
(3-{[(2-phenyl-5,6,7,8-tetrahydroquinolin-5- | US10...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2nc(ccc12)-c1ccccc1
Show InChI InChI=1S/C22H21N3O2/c26-22(27)18-11-12-23-14-21(18)24-13-16-7-4-8-20-17(16)9-10-19(25-20)15-5-2-1-3-6-15/h1-3,5-6,9-12,14,16,24H,4,7-8,13H2,(H,26,27)
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293687
PNG
(3-({[(4S)-7-(3-methylphenyl)-3,4-dihydro-2H-1-benz...)
Show SMILES Cc1cccc(c1)-c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C23H22N2O3/c1-15-3-2-4-16(11-15)17-5-6-19-18(8-10-28-22(19)12-17)13-25-21-14-24-9-7-20(21)23(26)27/h2-7,9,11-12,14,18,25H,8,10,13H2,1H3,(H,26,27)/t18-/m1/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293689
PNG
(3-({[(4S)-7-(4-methylphenyl)-3,4-dihydro-2H-1-benz...)
Show SMILES Cc1ccc(cc1)-c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C23H22N2O3/c1-15-2-4-16(5-3-15)17-6-7-19-18(9-11-28-22(19)12-17)13-25-21-14-24-10-8-20(21)23(26)27/h2-8,10,12,14,18,25H,9,11,13H2,1H3,(H,26,27)/t18-/m1/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293757
PNG
(3-({[(1R)-6-methoxy-5-methyl-1,2,3,4-tetrahydronap...)
Show SMILES COc1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1C
Show InChI InChI=1S/C19H22N2O3/c1-12-14-5-3-4-13(15(14)6-7-18(12)24-2)10-21-17-11-20-9-8-16(17)19(22)23/h6-9,11,13,21H,3-5,10H2,1-2H3,(H,22,23)/t13-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293676
PNG
(3-({[(4R)-7-[methyl(phenyl)amino]-3,4-dihydro-2H-1...)
Show SMILES CN(c1ccccc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C23H23N3O3/c1-26(17-5-3-2-4-6-17)18-7-8-19-16(10-12-29-22(19)13-18)14-25-21-15-24-11-9-20(21)23(27)28/h2-9,11,13,15-16,25H,10,12,14H2,1H3,(H,27,28)/t16-/m0/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
jmjd3


(Homo sapiens (Human))
BDBM293694
PNG
(3-({[(4S)-7-(2-methylthiophen-3-yl)-3,4-dihydro-2H...)
Show SMILES Cc1sccc1-c1ccc2[C@@H](CNc3cnccc3C(O)=O)CCOc2c1
Show InChI InChI=1S/C21H20N2O3S/c1-13-16(6-9-27-13)14-2-3-17-15(5-8-26-20(17)10-14)11-23-19-12-22-7-4-18(19)21(24)25/h2-4,6-7,9-10,12,15,23H,5,8,11H2,1H3,(H,24,25)/t15-/m1/s1
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com...


US Patent US10106534 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140576
PNG
(CHEMBL3752835)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1cccn1)N1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN7O2/c21-15-2-4-16(5-3-15)26-10-12-27(13-11-26)17-14-18(28-9-1-7-23-28)25-20(24-17)22-8-6-19(29)30/h1-5,7,9,14H,6,8,10-13H2,(H,29,30)(H,22,24,25)
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n/an/a 550n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140570
PNG
(CHEMBL3752143)
Show SMILES OC(=O)CCNc1nc(cc(n1)-c1nccs1)N1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C20H21FN6O2S/c21-14-1-3-15(4-2-14)26-8-10-27(11-9-26)17-13-16(19-22-7-12-30-19)24-20(25-17)23-6-5-18(28)29/h1-4,7,12-13H,5-6,8-11H2,(H,28,29)(H,23,24,25)
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n/an/a 600n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50153324
PNG
(CHEMBL3774408)
Show SMILES OC(=O)c1ccncc1NCCCCc1ccccc1
Show InChI InChI=1S/C16H18N2O2/c19-16(20)14-9-11-17-12-15(14)18-10-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,9,11-12,18H,4-5,8,10H2,(H,19,20)
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n/an/a 631n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of human KDM6B catalytic domain using H3(20 to 36 residues)K27Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire...


J Med Chem 59: 1357-69 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01537
BindingDB Entry DOI: 10.7270/Q2542QFT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM26106
PNG
(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Show SMILES OC(=O)CNC(=O)C(O)=O
Show InChI InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
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n/an/a 680n/an/an/an/a7.5n/a



University of Oxford



Assay Description
The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...


Nat Chem Biol 12: 539-45 (2016)


Article DOI: 10.1038/nchembio.2087
BindingDB Entry DOI: 10.7270/Q27P8X6K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140677
PNG
(CHEMBL3752551)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1cccn1)N1CCN(CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H21Cl2N7O2/c21-15-3-2-14(12-16(15)22)27-8-10-28(11-9-27)17-13-18(29-7-1-5-24-29)26-20(25-17)23-6-4-19(30)31/h1-3,5,7,12-13H,4,6,8-11H2,(H,30,31)(H,23,25,26)
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n/an/a 740n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140575
PNG
(CHEMBL3753449)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1cccn1)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H24N6O2/c28-20(29)7-11-22-21-24-18(15-19(25-21)27-12-4-10-23-27)26-13-8-17(9-14-26)16-5-2-1-3-6-16/h1-6,10,12,15,17H,7-9,11,13-14H2,(H,28,29)(H,22,24,25)
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n/an/a 750n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50153350
PNG
(CHEMBL3774399)
Show SMILES OC(=O)c1ccncc1NCCCc1ccccc1
Show InChI InChI=1S/C15H16N2O2/c18-15(19)13-8-10-16-11-14(13)17-9-4-7-12-5-2-1-3-6-12/h1-3,5-6,8,10-11,17H,4,7,9H2,(H,18,19)
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n/an/a 794n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of human KDM6B catalytic domain using H3(20 to 36 residues)K27Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire...


J Med Chem 59: 1357-69 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01537
BindingDB Entry DOI: 10.7270/Q2542QFT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140571
PNG
(CHEMBL3752294)
Show SMILES OC(=O)CCNc1nc(cc(n1)-c1nccs1)N1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C19H21N7O2S/c27-17(28)4-6-22-19-23-14(18-21-7-12-29-18)13-16(24-19)26-10-8-25(9-11-26)15-3-1-2-5-20-15/h1-3,5,7,12-13H,4,6,8-11H2,(H,27,28)(H,22,23,24)
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n/an/a 900n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140573
PNG
(CHEMBL3752343)
Show SMILES OC(=O)CCNc1nc(cc(n1)-c1nccs1)N1CCN(CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H20Cl2N6O2S/c21-14-2-1-13(11-15(14)22)27-6-8-28(9-7-27)17-12-16(19-23-5-10-31-19)25-20(26-17)24-4-3-18(29)30/h1-2,5,10-12H,3-4,6-9H2,(H,29,30)(H,24,25,26)
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n/an/a 940n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140572
PNG
(CHEMBL3753199)
Show SMILES OC(=O)CCNc1nc(cc(n1)-c1nccs1)N1CCc2ccccc2C1
Show InChI InChI=1S/C19H19N5O2S/c25-17(26)5-7-21-19-22-15(18-20-8-10-27-18)11-16(23-19)24-9-6-13-3-1-2-4-14(13)12-24/h1-4,8,10-11H,5-7,9,12H2,(H,25,26)(H,21,22,23)
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n/an/a 990n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM191598
PNG
(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Show SMILES CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O
Show InChI InChI=1S/C15H24N4O3/c1-4-19(8-7-18(2)3)14(20)11-16-10-13-9-12(15(21)22)5-6-17-13/h5-6,9,16H,4,7-8,10-11H2,1-3H3,(H,21,22)
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal FLAG-tagged KDM6B (1043 residues) expressed in baculovirus infected sf9 cells using H3K27me3 as substrate preincubated...


J Med Chem 59: 1308-29 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01758
BindingDB Entry DOI: 10.7270/Q2MP5559
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50153181
PNG
(CHEMBL3774692)
Show SMILES Nc1nc(cs1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C9H7N3O2S/c10-9-12-7(4-15-9)6-3-5(8(13)14)1-2-11-6/h1-4H,(H2,10,12)(H,13,14)
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n/an/a 1.00E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM6B (unknown origin) using biotin-H3K27me3 (21 to 44 residues) as substrate preincubated for 15 mins followed by substrate addition m...


J Med Chem 59: 1388-409 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01635
BindingDB Entry DOI: 10.7270/Q2W097TR
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM191598
PNG
(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Show SMILES CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O
Show InChI InChI=1S/C15H24N4O3/c1-4-19(8-7-18(2)3)14(20)11-16-10-13-9-12(15(21)22)5-6-17-13/h5-6,9,16H,4,7-8,10-11H2,1-3H3,(H,21,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Oxford





Cell Chem Biol 24: 371-380 (2017)


Article DOI: 10.1016/j.chembiol.2017.02.006
BindingDB Entry DOI: 10.7270/Q23N2288
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140577
PNG
(CHEMBL3753326)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1cccn1)N1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C19H22N8O2/c28-18(29)5-8-21-19-23-16(14-17(24-19)27-9-3-7-22-27)26-12-10-25(11-13-26)15-4-1-2-6-20-15/h1-4,6-7,9,14H,5,8,10-13H2,(H,28,29)(H,21,23,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50129197
PNG
(4-(Hydroxyamino)-4-oxobutanoic acid | CHEMBL51979 ...)
Show SMILES ONC(=O)CCC(O)=O
Show InChI InChI=1S/C4H7NO4/c6-3(5-9)1-2-4(7)8/h9H,1-2H2,(H,5,6)(H,7,8)
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human KDM6B catalytic domain expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assay


J Med Chem 55: 6639-43 (2012)


Article DOI: 10.1021/jm300677j
BindingDB Entry DOI: 10.7270/Q2JH3N9S
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140568
PNG
(CHEMBL3754078)
Show SMILES OC(=O)CCNc1nc(cc(n1)-c1nccs1)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H23N5O2S/c27-19(28)6-9-23-21-24-17(20-22-10-13-29-20)14-18(25-21)26-11-7-16(8-12-26)15-4-2-1-3-5-15/h1-5,10,13-14,16H,6-9,11-12H2,(H,27,28)(H,23,24,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140684
PNG
(CHEMBL3753893)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1nccn1)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C20H23N7O2/c28-19(29)6-9-21-20-24-17(14-18(25-20)27-22-10-11-23-27)26-12-7-16(8-13-26)15-4-2-1-3-5-15/h1-5,10-11,14,16H,6-9,12-13H2,(H,28,29)(H,21,24,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50153341
PNG
(CHEMBL3774845)
Show SMILES OC(=O)c1ccncc1NC(=O)CCCc1ccccc1
Show InChI InChI=1S/C16H16N2O3/c19-15(8-4-7-12-5-2-1-3-6-12)18-14-11-17-10-9-13(14)16(20)21/h1-3,5-6,9-11H,4,7-8H2,(H,18,19)(H,20,21)
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n/an/a 1.26E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of human KDM6B catalytic domain using H3(20 to 36 residues)K27Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire...


J Med Chem 59: 1357-69 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01537
BindingDB Entry DOI: 10.7270/Q2542QFT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140682
PNG
(CHEMBL3752967)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1nccn1)N1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C18H21N9O2/c28-17(29)4-6-20-18-23-15(13-16(24-18)27-21-7-8-22-27)26-11-9-25(10-12-26)14-3-1-2-5-19-14/h1-3,5,7-8,13H,4,6,9-12H2,(H,28,29)(H,20,23,24)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140683
PNG
(CHEMBL3752156)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1nccn1)N1CCN(CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H20Cl2N8O2/c20-14-2-1-13(11-15(14)21)27-7-9-28(10-8-27)16-12-17(29-23-5-6-24-29)26-19(25-16)22-4-3-18(30)31/h1-2,5-6,11-12H,3-4,7-10H2,(H,30,31)(H,22,25,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140347
PNG
(CHEMBL3753356)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1ccnn1)N1CCc2ccccc2C1
Show InChI InChI=1S/C18H19N7O2/c26-17(27)5-7-19-18-21-15(11-16(22-18)25-10-8-20-23-25)24-9-6-13-3-1-2-4-14(13)12-24/h1-4,8,10-11H,5-7,9,12H2,(H,26,27)(H,19,21,22)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM191598
PNG
(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Show SMILES CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O
Show InChI InChI=1S/C15H24N4O3/c1-4-19(8-7-18(2)3)14(20)11-16-10-13-9-12(15(21)22)5-6-17-13/h5-6,9,16H,4,7-8,10-11H2,1-3H3,(H,21,22)
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n/an/a 1.40E+3n/an/an/an/a7.5n/a



University of Oxford



Assay Description
The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...


Nat Chem Biol 12: 539-45 (2016)


Article DOI: 10.1038/nchembio.2087
BindingDB Entry DOI: 10.7270/Q27P8X6K
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140681
PNG
(CHEMBL3753787)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1nccn1)N1CCc2ccccc2C1
Show InChI InChI=1S/C18H19N7O2/c26-17(27)5-7-19-18-22-15(11-16(23-18)25-20-8-9-21-25)24-10-6-13-3-1-2-4-14(13)12-24/h1-4,8-9,11H,5-7,10,12H2,(H,26,27)(H,19,22,23)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50153347
PNG
(CHEMBL3775952)
Show SMILES CC(C)CNc1cnccc1C(O)=O
Show InChI InChI=1S/C10H14N2O2/c1-7(2)5-12-9-6-11-4-3-8(9)10(13)14/h3-4,6-7,12H,5H2,1-2H3,(H,13,14)
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n/an/a 2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of human KDM6B catalytic domain using H3(20 to 36 residues)K27Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire...


J Med Chem 59: 1357-69 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01537
BindingDB Entry DOI: 10.7270/Q2542QFT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140569
PNG
(CHEMBL3752995)
Show SMILES COc1ccccc1N1CCN(CC1)c1cc(nc(NCCC(O)=O)n1)-c1nccs1
Show InChI InChI=1S/C21H24N6O3S/c1-30-17-5-3-2-4-16(17)26-9-11-27(12-10-26)18-14-15(20-22-8-13-31-20)24-21(25-18)23-7-6-19(28)29/h2-5,8,13-14H,6-7,9-12H2,1H3,(H,28,29)(H,23,24,25)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140346
PNG
(CHEMBL3752006)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1ccnn1)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C20H23N7O2/c28-19(29)6-9-21-20-23-17(14-18(24-20)27-13-10-22-25-27)26-11-7-16(8-12-26)15-4-2-1-3-5-15/h1-5,10,13-14,16H,6-9,11-12H2,(H,28,29)(H,21,23,24)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50140349
PNG
(CHEMBL3754555)
Show SMILES OC(=O)CCNc1nc(cc(n1)-n1cc2ccccc2n1)N1CCc2ccccc2CC1
Show InChI InChI=1S/C24H24N6O2/c31-23(32)9-12-25-24-26-21(29-13-10-17-5-1-2-6-18(17)11-14-29)15-22(27-24)30-16-19-7-3-4-8-20(19)28-30/h1-8,15-16H,9-14H2,(H,31,32)(H,25,26,27)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of JMJD3 (unknown origin) using biotinylated H3K27me3 peptide as substrate after 1 hr by AlphaLISA assay


Bioorg Med Chem Lett 26: 721-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.006
BindingDB Entry DOI: 10.7270/Q2P55QC2
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50158857
PNG
(CHEMBL3787547)
Show SMILES CCN(CC)CCCCNCc1cc(C=O)ccn1
Show InChI InChI=1S/C15H25N3O/c1-3-18(4-2)10-6-5-8-16-12-15-11-14(13-19)7-9-17-15/h7,9,11,13,16H,3-6,8,10,12H2,1-2H3
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n/an/a>2.50E+3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal FLAG-tagged KDM6B (1043 residues) expressed in baculovirus infected sf9 cells using H3K27me3 as substrate preincubated...


J Med Chem 59: 1308-29 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01758
BindingDB Entry DOI: 10.7270/Q2MP5559
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50158858
PNG
(CHEMBL3786409)
Show SMILES CCN(CCN(C)C)C(=O)CNCc1cc(CNC(=O)C(F)(F)F)ccn1
Show InChI InChI=1S/C17H26F3N5O2/c1-4-25(8-7-24(2)3)15(26)12-21-11-14-9-13(5-6-22-14)10-23-16(27)17(18,19)20/h5-6,9,21H,4,7-8,10-12H2,1-3H3,(H,23,27)
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n/an/a>2.50E+3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal FLAG-tagged KDM6B (1043 residues) expressed in baculovirus infected sf9 cells using H3K27me3 as substrate preincubated...


J Med Chem 59: 1308-29 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01758
BindingDB Entry DOI: 10.7270/Q2MP5559
More data for this
Ligand-Target Pair
Lysine-specific demethylase 6B


(Homo sapiens (Human))
BDBM50153323
PNG
(CHEMBL3775276)
Show SMILES OC(=O)c1ccncc1NCCc1ccccc1
Show InChI InChI=1S/C14H14N2O2/c17-14(18)12-7-8-15-10-13(12)16-9-6-11-4-2-1-3-5-11/h1-5,7-8,10,16H,6,9H2,(H,17,18)
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n/an/a 2.51E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of human KDM6B catalytic domain using H3(20 to 36 residues)K27Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire...


J Med Chem 59: 1357-69 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01537
BindingDB Entry DOI: 10.7270/Q2542QFT
More data for this
Ligand-Target Pair
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