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Found 12 hits Enz. Inhib. hit(s) with Target = 'Lysosomal acid lipase/cholesteryl ester hydrolase' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50318690
PNG
(4-Piperidinyl-1,2,5-thiadiazolyl-3-morpholine carb...)
Show SMILES O=C(Oc1nsnc1N1CCCCC1)N1CCOCC1
Show InChI InChI=1S/C12H18N4O3S/c17-12(16-6-8-18-9-7-16)19-11-10(13-20-14-11)15-4-2-1-3-5-15/h1-9H2
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n/an/a 68n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human LAL after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50318691
PNG
(4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidin...)
Show SMILES O=C(Oc1nsnc1N1CCCCC1)N1CCCCC1
Show InChI InChI=1S/C13H20N4O2S/c18-13(17-9-5-2-6-10-17)19-12-11(14-20-15-12)16-7-3-1-4-8-16/h1-10H2
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Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human LAL after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50318686
PNG
(4-(Azepan-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4...)
Show SMILES O=C(Oc1nsnc1N1CCCCCC1)N1CCOCC1
Show InChI InChI=1S/C13H20N4O3S/c18-13(17-7-9-19-10-8-17)20-12-11(14-21-15-12)16-5-3-1-2-4-6-16/h1-10H2
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Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human LAL after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50318687
PNG
(4-(Azepan-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1...)
Show SMILES O=C(Oc1nsnc1N1CCCCCC1)N1CCCCC1
Show InChI InChI=1S/C14H22N4O2S/c19-14(18-10-6-3-7-11-18)20-13-12(15-21-16-13)17-8-4-1-2-5-9-17/h1-11H2
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Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human LAL after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50318689
PNG
(4-Morpholino-1,2,5-thiadiazol-3-yl piperidine-1-ca...)
Show SMILES O=C(Oc1nsnc1N1CCOCC1)N1CCCCC1
Show InChI InChI=1S/C12H18N4O3S/c17-12(16-4-2-1-3-5-16)19-11-10(13-20-14-11)15-6-8-18-9-7-15/h1-9H2
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n/an/a 424n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human LAL after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50318692
PNG
(4-(Pyrrolidin-1-yl)-1,2,5-thiadiazol-3-yl morpholi...)
Show SMILES O=C(Oc1nsnc1N1CCCC1)N1CCOCC1
Show InChI InChI=1S/C11H16N4O3S/c16-11(15-5-7-17-8-6-15)18-10-9(12-19-13-10)14-3-1-2-4-14/h1-8H2
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Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human LAL after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50318688
PNG
(3-N-Morpholinocarbamate-4-morpholino-1,2,5-thiadia...)
Show SMILES O=C(Oc1nsnc1N1CCOCC1)N1CCOCC1
Show InChI InChI=1S/C11H16N4O4S/c16-11(15-3-7-18-8-4-15)19-10-9(12-20-13-10)14-1-5-17-6-2-14/h1-8H2
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n/an/a 492n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human LAL after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50318693
PNG
(4-(Pyrrolidin-1-yl)-1,2,5-thiadiazol-3-yl Piperidi...)
Show SMILES O=C(Oc1nsnc1N1CCCC1)N1CCCCC1
Show InChI InChI=1S/C12H18N4O2S/c17-12(16-8-2-1-3-9-16)18-11-10(13-19-14-11)15-6-4-5-7-15/h1-9H2
KEGG

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n/an/a 496n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human LAL after 30 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50287473
PNG
(3,3,4,4,4-Pentafluoro-1-((2S,4aS,8aS)-4a-methyl-de...)
Show SMILES C[C@@]12CCCC[C@H]1C[C@@H](CC(=O)C(F)(F)C(F)(F)F)CC2
Show InChI InChI=1S/C15H21F5O/c1-13-6-3-2-4-11(13)8-10(5-7-13)9-12(21)14(16,17)15(18,19)20/h10-11H,2-9H2,1H3/t10-,11-,13-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of ancreatic cholesterol esterase using using p-nitrophenylacetate or cholesteryl [1-14C]-oleate as substrates


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50287472
PNG
(1-((S)-10,13-Dimethyl-17-octyl-hexadecahydro-cyclo...)
Show SMILES CCCCCCCCC1CC[C@H]2[C@@H]3CCC4C[C@@H](CC(=O)C(F)(F)C(F)(F)F)CCC4(C)[C@H]3CCC12C
Show InChI InChI=1S/C31H49F5O/c1-4-5-6-7-8-9-10-22-12-14-25-24-13-11-23-19-21(20-27(37)30(32,33)31(34,35)36)15-17-29(23,3)26(24)16-18-28(22,25)2/h21-26H,4-20H2,1-3H3/t21-,22?,23?,24-,25-,26-,28?,29?/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of ancreatic cholesterol esterase using using p-nitrophenylacetate or cholesteryl [1-14C]-oleate as substrates


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50287471
PNG
(1-(4-tert-Butyl-cyclohexyl)-3,3,4,4,4-pentafluoro-...)
Show SMILES CC(C)(C)[C@H]1CC[C@H](CC(=O)C(F)(F)C(F)(F)F)CC1
Show InChI InChI=1S/C14H21F5O/c1-12(2,3)10-6-4-9(5-7-10)8-11(20)13(15,16)14(17,18)19/h9-10H,4-8H2,1-3H3/t9-,10-
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of ancreatic cholesterol esterase using using p-nitrophenylacetate or cholesteryl [1-14C]-oleate as substrates


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal acid lipase/cholesteryl ester hydrolase


(Homo sapiens)
BDBM50287474
PNG
(3,3-Difluoro-1-((2S,4aS,8aS)-4a-methyl-decahydro-n...)
Show SMILES CCCCCCCCCCCCC(F)(F)C(=O)C[C@H]1CC[C@]2(C)CCCC[C@H]2C1
Show InChI InChI=1S/C26H46F2O/c1-3-4-5-6-7-8-9-10-11-13-18-26(27,28)24(29)21-22-16-19-25(2)17-14-12-15-23(25)20-22/h22-23H,3-21H2,1-2H3/t22-,23-,25-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of ancreatic cholesterol esterase using using p-nitrophenylacetate or cholesteryl [1-14C]-oleate as substrates


Citation and Details
More data for this
Ligand-Target Pair