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Found 722 hits Enz. Inhib. hit(s) with Target = 'MAP kinase signal-integrating kinase 2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130704
PNG
(CHEMBL3632744)
Show SMILES CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C18H19FN4O2S/c1-9(2)25-13-7-11(19)5-6-12(13)23-16-14-10(3)15(17(24)20-4)26-18(14)22-8-21-16/h5-9H,1-4H3,(H,20,24)(H,21,22,23)
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18n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130705
PNG
(CHEMBL3632745)
Show SMILES CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C19H21FN4O2S/c1-5-21-18(25)16-11(4)15-17(22-9-23-19(15)27-16)24-13-7-6-12(20)8-14(13)26-10(2)3/h6-10H,5H2,1-4H3,(H,21,25)(H,22,23,24)
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18n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130706
PNG
(CHEMBL3632746)
Show SMILES COCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C20H23FN4O3S/c1-11(2)28-15-9-13(21)5-6-14(15)25-18-16-12(3)17(19(26)22-7-8-27-4)29-20(16)24-10-23-18/h5-6,9-11H,7-8H2,1-4H3,(H,22,26)(H,23,24,25)
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31n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130702
PNG
(CHEMBL3632742)
Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12
Show InChI InChI=1S/C17H16FN3O3S/c1-8(2)24-12-6-10(18)4-5-11(12)21-15-13-9(3)14(17(22)23)25-16(13)20-7-19-15/h4-8H,1-3H3,(H,22,23)(H,19,20,21)
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68n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130694
PNG
(CHEMBL3416305)
Show SMILES CC(=O)C1=C(O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@@]2(C)C1=O
Show InChI InChI=1/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,19-21H,1-2H3,(H2,17,23)/t16-/s2
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79n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130703
PNG
(CHEMBL3632743)
Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12
Show InChI InChI=1S/C17H17FN4O2S/c1-8(2)24-12-6-10(18)4-5-11(12)22-16-13-9(3)14(15(19)23)25-17(13)21-7-20-16/h4-8H,1-3H3,(H2,19,23)(H,20,21,22)
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110n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130697
PNG
(CHEMBL3632740)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3)c12)C(O)=O
Show InChI InChI=1S/C14H10FN3O2S/c1-7-10-12(18-9-4-2-8(15)3-5-9)16-6-17-13(10)21-11(7)14(19)20/h2-6H,1H3,(H,19,20)(H,16,17,18)
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164n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130707
PNG
(CHEMBL3632747)
Show SMILES COCCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C21H25FN4O3S/c1-12(2)29-16-10-14(22)6-7-15(16)26-19-17-13(3)18(30-21(17)25-11-24-19)20(27)23-8-5-9-28-4/h6-7,10-12H,5,8-9H2,1-4H3,(H,23,27)(H,24,25,26)
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164n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079470
PNG
(CHEMBL3417199)
Show SMILES COCCn1cc(C)cc(Nc2ncnc3sc(C(O)=O)c(C)c23)c1=O
Show InChI InChI=1S/C17H18N4O4S/c1-9-6-11(16(22)21(7-9)4-5-25-3)20-14-12-10(2)13(17(23)24)26-15(12)19-8-18-14/h6-8H,4-5H2,1-3H3,(H,23,24)(H,18,19,20)
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240n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079405
PNG
(CHEMBL3417205)
Show SMILES COCCn1cc(C)cc(Nc2ncnc3sc(C(N)=O)c(C)c23)c1=O
Show InChI InChI=1S/C17H19N5O3S/c1-9-6-11(17(24)22(7-9)4-5-25-3)21-15-12-10(2)13(14(18)23)26-16(12)20-8-19-15/h6-8H,4-5H2,1-3H3,(H2,18,23)(H,19,20,21)
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340n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130693
PNG
(CGP-57380 | CHEMBL1240885)
Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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340n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079471
PNG
(CHEMBL3417198)
Show SMILES Cc1c(sc2ncnc(Nc3cc(C)cn(C)c3=O)c12)C(O)=O
Show InChI InChI=1S/C15H14N4O3S/c1-7-4-9(14(20)19(3)5-7)18-12-10-8(2)11(15(21)22)23-13(10)17-6-16-12/h4-6H,1-3H3,(H,21,22)(H,16,17,18)
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350n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130698
PNG
(CHEMBL3632741)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3C)c12)C(O)=O
Show InChI InChI=1S/C15H12FN3O2S/c1-7-5-9(16)3-4-10(7)19-13-11-8(2)12(15(20)21)22-14(11)18-6-17-13/h3-6H,1-2H3,(H,20,21)(H,17,18,19)
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500n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50298223
PNG
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)
Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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880n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079403
PNG
(CHEMBL3417207)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(=O)n(C)c3)c12)C(O)=O
Show InChI InChI=1S/C14H12N4O3S/c1-7-10-12(17-8-3-4-9(19)18(2)5-8)15-6-16-13(10)22-11(7)14(20)21/h3-6H,1-2H3,(H,20,21)(H,15,16,17)
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900n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079402
PNG
(CHEMBL3417208)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(=O)n(C)c3)c12)C(N)=O
Show InChI InChI=1S/C14H13N5O2S/c1-7-10-13(18-8-3-4-9(20)19(2)5-8)16-6-17-14(10)22-11(7)12(15)21/h3-6H,1-2H3,(H2,15,21)(H,16,17,18)
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1.60E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079449
PNG
(CHEMBL3417204)
Show SMILES COCCCNC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C
Show InChI InChI=1S/C19H23N5O3S/c1-11-8-13(19(26)24(3)9-11)23-16-14-12(2)15(28-18(14)22-10-21-16)17(25)20-6-5-7-27-4/h8-10H,5-7H2,1-4H3,(H,20,25)(H,21,22,23)
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2.63E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079466
PNG
(CHEMBL3417203)
Show SMILES COCCNC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C
Show InChI InChI=1S/C18H21N5O3S/c1-10-7-12(18(25)23(3)8-10)22-15-13-11(2)14(16(24)19-5-6-26-4)27-17(13)21-9-20-15/h7-9H,5-6H2,1-4H3,(H,19,24)(H,20,21,22)
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3.17E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM98036
PNG
(US8486953, 19)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C18H18FN3O3S/c1-9(2)25-13-7-11(19)5-6-12(13)22-16-14-10(3)15(18(23)24-4)26-17(14)21-8-20-16/h5-9H,1-4H3,(H,20,21,22)
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4.05E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079467
PNG
(CHEMBL3417202)
Show SMILES CCNC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C
Show InChI InChI=1S/C17H19N5O2S/c1-5-18-15(23)13-10(3)12-14(19-8-20-16(12)25-13)21-11-6-9(2)7-22(4)17(11)24/h6-8H,5H2,1-4H3,(H,18,23)(H,19,20,21)
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5.99E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079468
PNG
(CHEMBL3417201)
Show SMILES CNC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C
Show InChI InChI=1S/C16H17N5O2S/c1-8-5-10(16(23)21(4)6-8)20-13-11-9(2)12(14(22)17-3)24-15(11)19-7-18-13/h5-7H,1-4H3,(H,17,22)(H,18,19,20)
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9.05E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>9.35E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of MNK2


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079472
PNG
(CHEMBL3417197)
Show SMILES COCCn1cc(C)cc(Nc2ncnc3sc(C(=O)OC)c(C)c23)c1=O
Show InChI InChI=1S/C18H20N4O4S/c1-10-7-12(17(23)22(8-10)5-6-25-3)21-15-13-11(2)14(18(24)26-4)27-16(13)20-9-19-15/h7-9H,5-6H2,1-4H3,(H,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130695
PNG
(CHEMBL3632737)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3)c2c1C
Show InChI InChI=1S/C15H12FN3O2S/c1-8-11-13(19-10-5-3-9(16)4-6-10)17-7-18-14(11)22-12(8)15(20)21-2/h3-7H,1-2H3,(H,17,18,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079404
PNG
(CHEMBL3417206)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(=O)n(C)c3)c2c1C
Show InChI InChI=1S/C15H14N4O3S/c1-8-11-13(18-9-4-5-10(20)19(2)6-9)16-7-17-14(11)23-12(8)15(21)22-3/h4-7H,1-3H3,(H,16,17,18)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079469
PNG
(CHEMBL3417200)
Show SMILES Cc1c(sc2ncnc(Nc3cc(C)cn(C)c3=O)c12)C(N)=O
Show InChI InChI=1S/C15H15N5O2S/c1-7-4-9(15(22)20(3)5-7)19-13-10-8(2)11(12(16)21)23-14(10)18-6-17-13/h4-6H,1-3H3,(H2,16,21)(H,17,18,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50079473
PNG
(CHEMBL3417196)
Show SMILES COC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C
Show InChI InChI=1S/C16H16N4O3S/c1-8-5-10(15(21)20(3)6-8)19-13-11-9(2)12(16(22)23-4)24-14(11)18-7-17-13/h5-7H,1-4H3,(H,17,18,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM50130696
PNG
(CHEMBL3632738)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3C)c2c1C
Show InChI InChI=1S/C16H14FN3O2S/c1-8-6-10(17)4-5-11(8)20-14-12-9(2)13(16(21)22-3)23-15(12)19-7-18-14/h4-7H,1-3H3,(H,18,19,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181521
PNG
(US9139577, 4.027)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)C(=O)NCC#C
Show InChI InChI=1/C25H26FN5O3S/c1-4-9-27-25(32)17(3)34-22-13-18(26)7-8-20(22)30-24-23-16(2)12-19(14-21(23)28-15-29-24)31-35(33)10-5-6-11-35/h1,7-8,12-15,17H,5-6,9-11H2,2-3H3,(H,27,32)(H,28,29,30)/t17-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181530
PNG
(US9139577, 4.036)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)C(=O)NCC(F)F
Show InChI InChI=1/C22H24F3N5O3S/c1-12-7-15(30-34(3,4)32)9-17-20(12)21(28-11-27-17)29-16-6-5-14(23)8-18(16)33-13(2)22(31)26-10-19(24)25/h5-9,11,13,19H,10H2,1-4H3,(H,26,31)(H,27,28,29)/t13-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181533
PNG
(US9139577, 4.039)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)C(=O)NCC#N
Show InChI InChI=1/C22H23FN6O3S/c1-13-9-16(29-33(3,4)31)11-18-20(13)21(27-12-26-18)28-17-6-5-15(23)10-19(17)32-14(2)22(30)25-8-7-24/h5-6,9-12,14H,8H2,1-4H3,(H,25,30)(H,26,27,28)/t14-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181536
PNG
(US9139577, 4.042)
Show SMILES CC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1
Show InChI InChI=1/C25H30FN5O3S/c1-15(2)29-25(32)17(4)34-22-12-18(26)7-8-20(22)30-24-23-16(3)11-19(13-21(23)27-14-28-24)31-35(33)9-5-6-10-35/h7-8,11-15,17H,5-6,9-10H2,1-4H3,(H,29,32)(H,27,28,30)/t17-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181432
PNG
(US9139577, 2.041)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1/C24H22F7N5O3S/c1-12-8-15(36-40(38)6-3-7-40)10-17-19(12)20(33-11-32-17)34-16-5-4-14(25)9-18(16)39-13(2)21(37)35-22(23(26,27)28)24(29,30)31/h4-5,8-11,13,22H,3,6-7H2,1-2H3,(H,35,37)(H,32,33,34)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181435
PNG
(US9139577, 2.044)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC(C)(C)C1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C25H27F4N5O3S/c1-14-7-17(34-38(36)11-24(3,4)12-38)9-19-21(14)22(32-13-31-19)33-18-6-5-16(26)8-20(18)37-15(2)23(35)30-10-25(27,28)29/h5-9,13,15H,10-12H2,1-4H3,(H,30,35)(H,31,32,33)/t15-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181436
PNG
(US9139577, 2.045)
Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC2(COC2)C1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C26H27ClF3N5O4S/c1-14-6-18(35-40(37)11-25(12-40)9-38-10-25)8-20-22(14)23(32-13-31-20)34-19-5-4-17(27)7-21(19)39-15(2)24(36)33-16(3)26(28,29)30/h4-8,13,15-16H,9-12H2,1-3H3,(H,33,36)(H,31,32,34)/t15-,16+/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181444
PNG
(US9139577, 3.005)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OCC#N)c12)N=S(C)(C)=O
Show InChI InChI=1S/C19H18FN5O2S/c1-12-8-14(25-28(2,3)26)10-16-18(12)19(23-11-22-16)24-15-5-4-13(20)9-17(15)27-7-6-21/h4-5,8-11H,7H2,1-3H3,(H,22,23,24)
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181445
PNG
(US9139577, 3.006)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OCC3CCCCO3)c12)N=S(C)(C)=O
Show InChI InChI=1/C23H27FN4O3S/c1-15-10-17(28-32(2,3)29)12-20-22(15)23(26-14-25-20)27-19-8-7-16(24)11-21(19)31-13-18-6-4-5-9-30-18/h7-8,10-12,14,18H,4-6,9,13H2,1-3H3,(H,25,26,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181457
PNG
(US9139577, 3.018)
Show SMILES C[C@H](CN)Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O
Show InChI InChI=1/C20H24FN5O2S/c1-12-7-15(26-29(3,4)27)9-17-19(12)20(24-11-23-17)25-16-6-5-14(21)8-18(16)28-13(2)10-22/h5-9,11,13H,10,22H2,1-4H3,(H,23,24,25)/t13-/s2
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181478
PNG
(US9139577, 3.039)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OCc3ccon3)c12)N=S(C)(C)=O
Show InChI InChI=1S/C21H20FN5O3S/c1-13-8-16(27-31(2,3)28)10-18-20(13)21(24-12-23-18)25-17-5-4-14(22)9-19(17)29-11-15-6-7-30-26-15/h4-10,12H,11H2,1-3H3,(H,23,24,25)
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181486
PNG
(US9139577, 3.047)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C23H22F5N5O3S/c1-13(22(34)29-11-23(26,27)28)36-19-8-14(24)4-5-17(19)32-21-20-16(25)9-15(10-18(20)30-12-31-21)33-37(35)6-2-3-7-37/h4-5,8-10,12-13H,2-3,6-7,11H2,1H3,(H,29,34)(H,30,31,32)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181493
PNG
(US9139577, 3.054)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)C(=O)NC(C(F)(F)F)C(F)(F)F
Show InChI InChI=1/C23H22F7N5O3S/c1-11-7-14(35-39(3,4)37)9-16-18(11)19(32-10-31-16)33-15-6-5-13(24)8-17(15)38-12(2)20(36)34-21(22(25,26)27)23(28,29)30/h5-10,12,21H,1-4H3,(H,34,36)(H,31,32,33)/t12-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181665
PNG
(US9139577, 7.001)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCN(C)CC1)c1cc(C)no1
Show InChI InChI=1/C26H29FN6O3S/c1-16-11-20(32-37(34)9-7-33(4)8-10-37)14-22-25(16)26(29-15-28-22)30-21-6-5-19(27)13-24(21)35-18(3)23-12-17(2)31-36-23/h5-6,11-15,18H,7-10H2,1-4H3,(H,28,29,30)/t18-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181372
PNG
(US9139577, 1.003)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)C(F)(F)F
Show InChI InChI=1/C19H17ClF4N4O2S/c1-10(19(22,23)24)30-16-6-11(21)4-5-14(16)27-18-17-13(20)7-12(28-31(2,3)29)8-15(17)25-9-26-18/h4-10H,1-3H3,(H,25,26,27)/t10-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181385
PNG
(US9139577, 1.016)
Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1/C21H21ClN6O3S/c1-12-8-18(31-27-12)13(2)30-21-16(6-5-7-23-21)26-20-19-15(22)9-14(28-32(3,4)29)10-17(19)24-11-25-20/h5-11,13H,1-4H3,(H,24,25,26)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181388
PNG
(US9139577, 1.019)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1/C22H21ClFN5O3S/c1-12-7-19(32-28-12)13(2)31-20-8-14(24)5-6-17(20)27-22-21-16(23)9-15(29-33(3,4)30)10-18(21)25-11-26-22/h5-11,13H,1-4H3,(H,25,26,27)/t13-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181390
PNG
(US9139577, 1.021)
Show SMILES FCC(CF)Oc1cc(F)ccc1Nc1ncnc2cc(cc(c12)C(F)(F)F)N=S1(=O)CCOCC1
Show InChI InChI=1S/C22H20F6N4O3S/c23-10-15(11-24)35-19-7-13(25)1-2-17(19)31-21-20-16(22(26,27)28)8-14(9-18(20)29-12-30-21)32-36(33)5-3-34-4-6-36/h1-2,7-9,12,15H,3-6,10-11H2,(H,29,30,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181397
PNG
(US9139577, 2.005)
Show SMILES Cc1cc(cc2ncnc(Nc3cccnc3OCC3CCOC3)c12)N=S1(=O)CCCC1
Show InChI InChI=1/C23H27N5O3S/c1-16-11-18(28-32(29)9-2-3-10-32)12-20-21(16)22(26-15-25-20)27-19-5-4-7-24-23(19)31-14-17-6-8-30-13-17/h4-5,7,11-12,15,17H,2-3,6,8-10,13-14H2,1H3,(H,25,26,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181400
PNG
(US9139577, 2.008)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1/C23H24FN5O3S/c1-13-8-17(29-33(4,5)30)11-19-22(13)23(26-12-25-19)27-18-7-6-16(24)10-21(18)31-15(3)20-9-14(2)28-32-20/h6-12,15H,1-5H3,(H,25,26,27)/t15-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181401
PNG
(US9139577, 2.009)
Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)c1cc(C)no1
Show InChI InChI=1/C24H26N6O3S/c1-15-11-18(30-34(31)9-4-5-10-34)13-20-22(15)23(27-14-26-20)28-19-7-6-8-25-24(19)32-17(3)21-12-16(2)29-33-21/h6-8,11-14,17H,4-5,9-10H2,1-3H3,(H,26,27,28)/t17-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 2


(Homo sapiens (Human))
BDBM181408
PNG
(US9139577, 2.016)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCNCC1)c1cc(C)no1
Show InChI InChI=1/C25H27FN6O3S/c1-15-10-19(32-36(33)8-6-27-7-9-36)13-21-24(15)25(29-14-28-21)30-20-5-4-18(26)12-23(20)34-17(3)22-11-16(2)31-35-22/h4-5,10-14,17,27H,6-9H2,1-3H3,(H,28,29,30)/t17-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
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