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Found 247 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase MNK1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130704
PNG
(CHEMBL3632744)
Show SMILES CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C18H19FN4O2S/c1-9(2)25-13-7-11(19)5-6-12(13)23-16-14-10(3)15(17(24)20-4)26-18(14)22-8-21-16/h5-9H,1-4H3,(H,20,24)(H,21,22,23)
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106n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130702
PNG
(CHEMBL3632742)
Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12
Show InChI InChI=1S/C17H16FN3O3S/c1-8(2)24-12-6-10(18)4-5-11(12)21-15-13-9(3)14(17(22)23)25-16(13)20-7-19-15/h4-8H,1-3H3,(H,22,23)(H,19,20,21)
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186n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130707
PNG
(CHEMBL3632747)
Show SMILES COCCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C21H25FN4O3S/c1-12(2)29-16-10-14(22)6-7-15(16)26-19-17-13(3)18(30-21(17)25-11-24-19)20(27)23-8-5-9-28-4/h6-7,10-12H,5,8-9H2,1-4H3,(H,23,27)(H,24,25,26)
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320n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130694
PNG
(CHEMBL3416305)
Show SMILES CC(=O)C1=C(O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@@]2(C)C1=O
Show InChI InChI=1/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,19-21H,1-2H3,(H2,17,23)/t16-/s2
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507n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130705
PNG
(CHEMBL3632745)
Show SMILES CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C19H21FN4O2S/c1-5-21-18(25)16-11(4)15-17(22-9-23-19(15)27-16)24-13-7-6-12(20)8-14(13)26-10(2)3/h6-10H,5H2,1-4H3,(H,21,25)(H,22,23,24)
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933n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50298223
PNG
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)
Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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1.01E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130693
PNG
(CGP-57380 | CHEMBL1240885)
Show SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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PubMed
1.01E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130703
PNG
(CHEMBL3632743)
Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12
Show InChI InChI=1S/C17H17FN4O2S/c1-8(2)24-12-6-10(18)4-5-11(12)22-16-13-9(3)14(15(19)23)25-17(13)21-7-20-16/h4-8H,1-3H3,(H2,19,23)(H,20,21,22)
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1.02E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130697
PNG
(CHEMBL3632740)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3)c12)C(O)=O
Show InChI InChI=1S/C14H10FN3O2S/c1-7-10-12(18-9-4-2-8(15)3-5-9)16-6-17-13(10)21-11(7)14(19)20/h2-6H,1H3,(H,19,20)(H,16,17,18)
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1.90E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079470
PNG
(CHEMBL3417199)
Show SMILES COCCn1cc(C)cc(Nc2ncnc3sc(C(O)=O)c(C)c23)c1=O
Show InChI InChI=1S/C17H18N4O4S/c1-9-6-11(16(22)21(7-9)4-5-25-3)20-14-12-10(2)13(17(23)24)26-15(12)19-8-18-14/h6-8H,4-5H2,1-3H3,(H,23,24)(H,18,19,20)
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2.06E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079403
PNG
(CHEMBL3417207)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(=O)n(C)c3)c12)C(O)=O
Show InChI InChI=1S/C14H12N4O3S/c1-7-10-12(17-8-3-4-9(19)18(2)5-8)15-6-16-13(10)22-11(7)14(20)21/h3-6H,1-2H3,(H,20,21)(H,15,16,17)
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2.15E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079405
PNG
(CHEMBL3417205)
Show SMILES COCCn1cc(C)cc(Nc2ncnc3sc(C(N)=O)c(C)c23)c1=O
Show InChI InChI=1S/C17H19N5O3S/c1-9-6-11(17(24)22(7-9)4-5-25-3)21-15-12-10(2)13(14(18)23)26-16(12)20-8-19-15/h6-8H,4-5H2,1-3H3,(H2,18,23)(H,19,20,21)
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2.33E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079402
PNG
(CHEMBL3417208)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(=O)n(C)c3)c12)C(N)=O
Show InChI InChI=1S/C14H13N5O2S/c1-7-10-13(18-8-3-4-9(20)19(2)5-8)16-6-17-14(10)22-11(7)12(15)21/h3-6H,1-2H3,(H2,15,21)(H,16,17,18)
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4.51E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079471
PNG
(CHEMBL3417198)
Show SMILES Cc1c(sc2ncnc(Nc3cc(C)cn(C)c3=O)c12)C(O)=O
Show InChI InChI=1S/C15H14N4O3S/c1-7-4-9(14(20)19(3)5-7)18-12-10-8(2)11(15(21)22)23-13(10)17-6-16-12/h4-6H,1-3H3,(H,21,22)(H,16,17,18)
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4.82E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079449
PNG
(CHEMBL3417204)
Show SMILES COCCCNC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C
Show InChI InChI=1S/C19H23N5O3S/c1-11-8-13(19(26)24(3)9-11)23-16-14-12(2)15(28-18(14)22-10-21-16)17(25)20-6-5-7-27-4/h8-10H,5-7H2,1-4H3,(H,20,25)(H,21,22,23)
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PubMed
5.00E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079466
PNG
(CHEMBL3417203)
Show SMILES COCCNC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C
Show InChI InChI=1S/C18H21N5O3S/c1-10-7-12(18(25)23(3)8-10)22-15-13-11(2)14(16(24)19-5-6-26-4)27-17(13)21-9-20-15/h7-9H,5-6H2,1-4H3,(H,19,24)(H,20,21,22)
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5.40E+3n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130706
PNG
(CHEMBL3632746)
Show SMILES COCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C20H23FN4O3S/c1-11(2)28-15-9-13(21)5-6-14(15)25-18-16-12(3)17(19(26)22-7-8-27-4)29-20(16)24-10-23-18/h5-6,9-11H,7-8H2,1-4H3,(H,22,26)(H,23,24,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130698
PNG
(CHEMBL3632741)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3C)c12)C(O)=O
Show InChI InChI=1S/C15H12FN3O2S/c1-7-5-9(16)3-4-10(7)19-13-11-8(2)12(15(20)21)22-14(11)18-6-17-13/h3-6H,1-2H3,(H,20,21)(H,17,18,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM98036
PNG
(US8486953, 19)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C18H18FN3O3S/c1-9(2)25-13-7-11(19)5-6-12(13)22-16-14-10(3)15(18(23)24-4)26-17(14)21-8-20-16/h5-9H,1-4H3,(H,20,21,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130696
PNG
(CHEMBL3632738)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3C)c2c1C
Show InChI InChI=1S/C16H14FN3O2S/c1-8-6-10(17)4-5-11(8)20-14-12-9(2)13(16(21)22-3)23-15(12)19-7-18-14/h4-7H,1-3H3,(H,18,19,20)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50130695
PNG
(CHEMBL3632737)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3)c2c1C
Show InChI InChI=1S/C15H12FN3O2S/c1-8-11-13(19-10-5-3-9(16)4-6-10)17-7-18-14(11)22-12(8)15(20)21-2/h3-7H,1-2H3,(H,17,18,19)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...


Eur J Med Chem 103: 539-50 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079472
PNG
(CHEMBL3417197)
Show SMILES COCCn1cc(C)cc(Nc2ncnc3sc(C(=O)OC)c(C)c23)c1=O
Show InChI InChI=1S/C18H20N4O4S/c1-10-7-12(17(23)22(8-10)5-6-25-3)21-15-13-11(2)14(18(24)26-4)27-16(13)20-9-19-15/h7-9H,5-6H2,1-4H3,(H,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079469
PNG
(CHEMBL3417200)
Show SMILES Cc1c(sc2ncnc(Nc3cc(C)cn(C)c3=O)c12)C(N)=O
Show InChI InChI=1S/C15H15N5O2S/c1-7-4-9(15(22)20(3)5-7)19-13-10-8(2)11(12(16)21)23-14(10)18-6-17-13/h4-6H,1-3H3,(H2,16,21)(H,17,18,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079468
PNG
(CHEMBL3417201)
Show SMILES CNC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C
Show InChI InChI=1S/C16H17N5O2S/c1-8-5-10(16(23)21(4)6-8)20-13-11-9(2)12(14(22)17-3)24-15(11)19-7-18-13/h5-7H,1-4H3,(H,17,22)(H,18,19,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079467
PNG
(CHEMBL3417202)
Show SMILES CCNC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C
Show InChI InChI=1S/C17H19N5O2S/c1-5-18-15(23)13-10(3)12-14(19-8-20-16(12)25-13)21-11-6-9(2)7-22(4)17(11)24/h6-8H,5H2,1-4H3,(H,18,23)(H,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079404
PNG
(CHEMBL3417206)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(=O)n(C)c3)c2c1C
Show InChI InChI=1S/C15H14N4O3S/c1-8-11-13(18-9-4-5-10(20)19(2)6-9)16-7-17-14(11)23-12(8)15(21)22-3/h4-7H,1-3H3,(H,16,17,18)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50079473
PNG
(CHEMBL3417196)
Show SMILES COC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C
Show InChI InChI=1S/C16H16N4O3S/c1-8-5-10(15(21)20(3)6-8)19-13-11-9(2)12(16(22)23-4)24-14(11)18-7-17-13/h5-7H,1-4H3,(H,17,18,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50042936
PNG
(CHEMBL3355000)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c3CCC(Cc3c12)C(=O)NCc1ccccc1
Show InChI InChI=1/C26H25N7O2/c1-35-22-11-20-17(13-30-33-20)10-21(22)32-25-23-18-9-16(7-8-19(18)31-24(23)28-14-29-25)26(34)27-12-15-5-3-2-4-6-15/h2-6,10-11,13-14,16H,7-9,12H2,1H3,(H,27,34)(H,30,33)(H2,28,29,31,32)
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n/an/a 1n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50042938
PNG
(CHEMBL3355002)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c3CCC(Cc3c12)C(=O)NCCCS(C)(=O)=O
Show InChI InChI=1/C25H31N7O4S/c1-14(2)36-21-11-19-16(12-29-32-19)10-20(21)31-24-22-17-9-15(25(33)26-7-4-8-37(3,34)35)5-6-18(17)30-23(22)27-13-28-24/h10-15H,4-9H2,1-3H3,(H,26,33)(H,29,32)(H2,27,28,30,31)
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n/an/a 1n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50042934
PNG
(CHEMBL3354998)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c3CCCCc3c12
Show InChI InChI=1S/C20H22N6O/c1-11(2)27-17-8-15-12(9-23-26-15)7-16(17)25-20-18-13-5-3-4-6-14(13)24-19(18)21-10-22-20/h7-11H,3-6H2,1-2H3,(H,23,26)(H2,21,22,24,25)
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n/an/a 5n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50042933
PNG
(CHEMBL3354997)
Show SMILES COc1cc(Cl)c(Cl)cc1Nc1ncnc2[nH]c3CCC(Cc3c12)C(=O)NC1CC1
Show InChI InChI=1/C21H21Cl2N5O2/c1-30-17-8-14(23)13(22)7-16(17)28-20-18-12-6-10(21(29)26-11-3-4-11)2-5-15(12)27-19(18)24-9-25-20/h7-11H,2-6H2,1H3,(H,26,29)(H2,24,25,27,28)
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n/an/a 6n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50042935
PNG
(CHEMBL3354999)
Show SMILES CCNC(=O)C1CCc2[nH]c3ncnc(Nc4cc5cn[nH]c5cc4OC)c3c2C1
Show InChI InChI=1/C21H23N7O2/c1-3-22-21(29)11-4-5-14-13(6-11)18-19(26-14)23-10-24-20(18)27-16-7-12-9-25-28-15(12)8-17(16)30-2/h7-11H,3-6H2,1-2H3,(H,22,29)(H,25,28)(H2,23,24,26,27)
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n/an/a 6n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50262685
PNG
(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
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n/an/a 11n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181594
PNG
(US9139577, 4.100)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C22H20F5N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(23)3-4-16(18)31-20-19-15(24)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/s2
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n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181612
PNG
(US9139577, 4.118)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S(C)(C)=O)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C22H22F5N5O3S/c1-11(21(33)30-12(2)22(25,26)27)35-18-7-13(23)5-6-16(18)31-20-19-15(24)8-14(32-36(3,4)34)9-17(19)28-10-29-20/h5-12H,1-4H3,(H,30,33)(H,28,29,31)/t11-,12+/s2
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n/an/a 21n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181400
PNG
(US9139577, 2.008)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1/C23H24FN5O3S/c1-13-8-17(29-33(4,5)30)11-19-22(13)23(26-12-25-19)27-18-7-6-16(24)10-21(18)31-15(3)20-9-14(2)28-32-20/h6-12,15H,1-5H3,(H,25,26,27)/t15-/s2
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n/an/a 25n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181632
PNG
(US9139577, 4.138)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C22H20ClF4N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(24)3-4-16(18)31-20-19-15(23)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/s2
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n/an/a 27n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50329881
PNG
(4-(2-(4-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimid...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1
Show InChI InChI=1S/C21H22N6O2/c1-3-19(29-10-7-26-5-8-28-9-6-26)4-2-16(1)18-11-22-21-20(14-25-27(21)15-18)17-12-23-24-13-17/h1-4,11-15H,5-10H2,(H,23,24)
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n/an/a 27n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181630
PNG
(US9139577, 4.136)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C23H22F5N5O3S/c1-12(22(34)31-13(2)23(26,27)28)36-19-8-14(24)4-5-17(19)32-21-20-16(25)9-15(10-18(20)29-11-30-21)33-37(35)6-3-7-37/h4-5,8-13H,3,6-7H2,1-2H3,(H,31,34)(H,29,30,32)/t12-,13+/s2
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n/an/a 29n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181410
PNG
(US9139577, 2.018)
Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1/C22H24N6O3S/c1-13-9-16(28-32(4,5)29)11-18-20(13)21(25-12-24-18)26-17-7-6-8-23-22(17)30-15(3)19-10-14(2)27-31-19/h6-12,15H,1-5H3,(H,24,25,26)/t15-/s2
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n/an/a 34n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181380
PNG
(US9139577, 1.011)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C22H23F3N4O2S/c1-14-8-16(29-32(30)6-2-3-7-32)10-19-21(14)22(27-13-26-19)28-18-5-4-15(25)9-20(18)31-17(11-23)12-24/h4-5,8-10,13,17H,2-3,6-7,11-12H2,1H3,(H,26,27,28)
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n/an/a 34n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM98040
PNG
(US8486953, 53)
Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12
Show InChI InChI=1S/C22H28FN5O2S/c1-13(2)30-17-11-15(23)7-8-16(17)27-20-18-14(3)19(31-22(18)26-12-25-20)21(29)24-9-6-10-28(4)5/h7-8,11-13H,6,9-10H2,1-5H3,(H,24,29)(H,25,26,27)
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US Patent
n/an/a 35n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181582
PNG
(US9139577, 4.088)
Show SMILES C[C@@H](Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C23H25ClF3N5O3S/c1-12-8-16(32-36(4,5)34)10-18-20(12)21(29-11-28-18)31-17-7-6-15(24)9-19(17)35-13(2)22(33)30-14(3)23(25,26)27/h6-11,13-14H,1-5H3,(H,30,33)(H,28,29,31)/t13-,14+/s2
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n/an/a 36n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181568
PNG
(US9139577, 4.074)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1/C24H25F4N5O3S/c1-14-9-17(33-37(35)7-3-4-8-37)11-19-21(14)22(31-13-30-19)32-18-6-5-16(25)10-20(18)36-15(2)23(34)29-12-24(26,27)28/h5-6,9-11,13,15H,3-4,7-8,12H2,1-2H3,(H,29,34)(H,30,31,32)/t15-/s2
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n/an/a 38n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181649
PNG
(US9139577, 5.008)
Show SMILES CCNC(=O)N1CCS(=O)(CC1)=Nc1cc(C)c2c(Nc3ccc(F)cc3O[C@H](C)c3cc(C)no3)ncnc2c1
Show InChI InChI=1/C28H32FN7O4S/c1-5-30-28(37)36-8-10-41(38,11-9-36)35-21-12-17(2)26-23(15-21)31-16-32-27(26)33-22-7-6-20(29)14-25(22)39-19(4)24-13-18(3)34-40-24/h6-7,12-16,19H,5,8-11H2,1-4H3,(H,30,37)(H,31,32,33)/t19-/s2
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n/an/a 39n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181661
PNG
(US9139577, 7.002 | US9139577, 7.010)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)C(F)(F)F
Show InChI InChI=1/C20H20F4N4O2S/c1-11-7-14(28-31(3,4)29)9-16-18(11)19(26-10-25-16)27-15-6-5-13(21)8-17(15)30-12(2)20(22,23)24/h5-10,12H,1-4H3,(H,25,26,27)/t12-/s2
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n/an/a 40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181439
PNG
(US9139577, 2.048)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)C(F)(F)F
Show InChI InChI=1/C22H22F4N4O2S/c1-13-9-16(30-33(31)7-3-4-8-33)11-18-20(13)21(28-12-27-18)29-17-6-5-15(23)10-19(17)32-14(2)22(24,25)26/h5-6,9-12,14H,3-4,7-8H2,1-2H3,(H,27,28,29)/t14-/s2
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n/an/a 40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM50329879
PNG
(5-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)
Show SMILES O=c1ccc(c[nH]1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C23H23N5O3/c29-22-6-3-18(13-24-22)21-15-26-28-16-19(14-25-23(21)28)17-1-4-20(5-2-17)31-12-9-27-7-10-30-11-8-27/h1-6,13-16H,7-12H2,(H,24,29)
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n/an/a 45n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181401
PNG
(US9139577, 2.009)
Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)c1cc(C)no1
Show InChI InChI=1/C24H26N6O3S/c1-15-11-18(30-34(31)9-4-5-10-34)13-20-22(15)23(27-14-26-20)28-19-7-6-8-25-24(19)32-17(3)21-12-16(2)29-33-21/h6-8,11-14,17H,4-5,9-10H2,1-3H3,(H,26,27,28)/t17-/s2
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n/an/a 49n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM181663
PNG
(US9139577, 7.007 | US9139577, 7.009)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)C#N
Show InChI InChI=1/C20H20FN5O2S/c1-12-7-15(26-29(3,4)27)9-17-19(12)20(24-11-23-17)25-16-6-5-14(21)8-18(16)28-13(2)10-22/h5-9,11,13H,1-4H3,(H,23,24,25)/t13-/s2
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n/an/a 50n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)

More data for this
Ligand-Target Pair
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