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Found 49 hits Enz. Inhib. hit(s) with Target = 'Macrophage-expressed gene 1 protein' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078850
PNG
(CHEBI:4778 | EMBELIN | Embelin)
Show SMILES CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
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n/an/a 210n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078850
PNG
(CHEBI:4778 | EMBELIN | Embelin)
Show SMILES CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
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n/an/a 210n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of human mPGES1


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078852
PNG
(CHEMBL221598)
Show SMILES CCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C14H20O4/c1-2-3-4-5-6-7-8-10-13(17)11(15)9-12(16)14(10)18/h9,15,18H,2-8H2,1H3
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n/an/a 800n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078848
PNG
(CHEBI:8779 | Rapanone)
Show SMILES CCCCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C19H30O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18(22)16(20)14-17(21)19(15)23/h14,20,23H,2-13H2,1H3
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n/an/a 900n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078851
PNG
(CHEMBL3416163)
Show SMILES CCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C16H24O4/c1-2-3-4-5-6-7-8-9-10-12-15(19)13(17)11-14(18)16(12)20/h11,17,20H,2-10H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078847
PNG
(CHEMBL3416165)
Show SMILES CCCCCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(23)17(21)15-18(22)20(16)24/h15,21,24H,2-14H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078867
PNG
(CHEMBL3416348)
Show SMILES CCCCCCCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C21H34O4/c1-4-5-6-7-8-9-10-11-12-13-14-15-17-20(23)19(24-2)16-18(22)21(17)25-3/h16H,4-15H2,1-3H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078882
PNG
(CHEMBL462998)
Show SMILES CCCCCCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C21H34O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-20(24)18(22)16-19(23)21(17)25/h16,22,25H,2-15H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50006805
PNG
(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Show SMILES CC(C)c1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1
Show InChI InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31)
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078849
PNG
(CHEMBL3416164)
Show SMILES CCCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C18H28O4/c1-2-3-4-5-6-7-8-9-10-11-12-14-17(21)15(19)13-16(20)18(14)22/h13,19,22H,2-12H2,1H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078868
PNG
(CHEMBL3416349)
Show SMILES CCCCCCCCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C22H36O4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21(24)20(25-2)17-19(23)22(18)26-3/h17H,4-16H2,1-3H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078866
PNG
(CHEMBL3416347)
Show SMILES CCCCCCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C20H32O4/c1-4-5-6-7-8-9-10-11-12-13-14-16-19(22)18(23-2)15-17(21)20(16)24-3/h15H,4-14H2,1-3H3
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n/an/a 4.70E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078844
PNG
(CHEMBL3416173)
Show SMILES CCCCCCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C19H30O4/c1-3-4-5-6-7-8-9-10-11-12-13-15-18(21)16(20)14-17(23-2)19(15)22/h14,21H,3-13H2,1-2H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078855
PNG
(Sorgoleone-364)
Show SMILES CCCCCCCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C20H32O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-16-19(22)17(21)15-18(24-2)20(16)23/h15,22H,3-14H2,1-2H3
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n/an/a 6.10E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078869
PNG
(CHEMBL3416350)
Show SMILES CCCCCCCCCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C23H38O4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22(25)21(26-2)18-20(24)23(19)27-3/h18H,4-17H2,1-3H3
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n/an/a 7.20E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078845
PNG
(5-O-METHYLEMBELIN | 5-O-Methylembelin | CHEBI:6584...)
Show SMILES CCCCCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C18H28O4/c1-3-4-5-6-7-8-9-10-11-12-14-17(20)15(19)13-16(22-2)18(14)21/h13,20H,3-12H2,1-2H3
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n/an/a 9.10E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078857
PNG
(CHEMBL3416174)
Show SMILES CCCCCCCCCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C22H36O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21(24)19(23)17-20(26-2)22(18)25/h17,24H,3-16H2,1-2H3
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n/an/a 9.30E+3n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078883
PNG
(CHEMBL3416365)
Show SMILES COC1=CC(=O)C(=O)C(C\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C1OC
Show InChI InChI=1S/C23H32O4/c1-16(2)9-7-10-17(3)11-8-12-18(4)13-14-19-22(25)20(24)15-21(26-5)23(19)27-6/h9,11,13,15H,7-8,10,12,14H2,1-6H3/b17-11+,18-13+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078854
PNG
(CHEMBL3416162)
Show SMILES CCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C10H12O4/c1-2-3-4-6-9(13)7(11)5-8(12)10(6)14/h5,11,14H,2-4H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078853
PNG
(CHEMBL3263323)
Show SMILES CCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C12H16O4/c1-2-3-4-5-6-8-11(15)9(13)7-10(14)12(8)16/h7,13,16H,2-6H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078881
PNG
(CHEMBL3416166)
Show SMILES CCCCCCCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C22H36O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21(25)19(23)17-20(24)22(18)26/h17,23,26H,2-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078880
PNG
(CHEMBL3416167)
Show SMILES CC(C)=CCC\C(C)=C\CC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C16H20O4/c1-10(2)5-4-6-11(3)7-8-12-15(19)13(17)9-14(18)16(12)20/h5,7,9,17,20H,4,6,8H2,1-3H3/b11-7+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078879
PNG
(CHEMBL3416168)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC1=C(O)C(=O)C=C(O)C1=O
Show InChI InChI=1S/C21H28O4/c1-14(2)7-5-8-15(3)9-6-10-16(4)11-12-17-20(24)18(22)13-19(23)21(17)25/h7,9,11,13,22,25H,5-6,8,10,12H2,1-4H3/b15-9+,16-11+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078878
PNG
(CHEMBL3416169)
Show SMILES CCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C11H14O4/c1-3-4-5-7-10(13)8(12)6-9(15-2)11(7)14/h6,13H,3-5H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078877
PNG
(CHEMBL3416170)
Show SMILES CCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C13H18O4/c1-3-4-5-6-7-9-12(15)10(14)8-11(17-2)13(9)16/h8,15H,3-7H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078876
PNG
(CHEMBL3416171)
Show SMILES CCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C15H22O4/c1-3-4-5-6-7-8-9-11-14(17)12(16)10-13(19-2)15(11)18/h10,17H,3-9H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078846
PNG
(CHEMBL3416172)
Show SMILES CCCCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C17H26O4/c1-3-4-5-6-7-8-9-10-11-13-16(19)14(18)12-15(21-2)17(13)20/h12,19H,3-11H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078856
PNG
(CHEMBL2228912)
Show SMILES CCCCCCCCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C21H34O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-17-20(23)18(22)16-19(25-2)21(17)24/h16,23H,3-15H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078858
PNG
(CHEMBL3416175)
Show SMILES CCCCCCCCCCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C23H38O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22(25)20(24)18-21(27-2)23(19)26/h18,25H,3-17H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078859
PNG
(CHEMBL3416176)
Show SMILES COC1=CC(=O)C(O)=C(C\C=C(/C)CCC=C(C)C)C1=O
Show InChI InChI=1S/C17H22O4/c1-11(2)6-5-7-12(3)8-9-13-16(19)14(18)10-15(21-4)17(13)20/h6,8,10,19H,5,7,9H2,1-4H3/b12-8+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078860
PNG
(CHEMBL3416177)
Show SMILES COC1=CC(=O)C(O)=C(C\C=C(/C)CC\C=C(/C)CCC=C(C)C)C1=O
Show InChI InChI=1S/C22H30O4/c1-15(2)8-6-9-16(3)10-7-11-17(4)12-13-18-21(24)19(23)14-20(26-5)22(18)25/h8,10,12,14,24H,6-7,9,11,13H2,1-5H3/b16-10+,17-12+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078884
PNG
(CHEMBL3416364)
Show SMILES COC1=CC(=O)C(=O)C(C\C=C(/C)CCC=C(C)C)=C1OC
Show InChI InChI=1S/C18H24O4/c1-12(2)7-6-8-13(3)9-10-14-17(20)15(19)11-16(21-4)18(14)22-5/h7,9,11H,6,8,10H2,1-5H3/b13-9+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078885
PNG
(CHEMBL3416362)
Show SMILES CCCCCCCCCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C23H38O4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22(25)20(24)18-21(26-2)23(19)27-3/h18H,4-17H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078886
PNG
(CHEMBL3416361)
Show SMILES CCCCCCCCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C22H36O4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21(24)19(23)17-20(25-2)22(18)26-3/h17H,4-16H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078887
PNG
(CHEMBL3416360)
Show SMILES CCCCCCCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C21H34O4/c1-4-5-6-7-8-9-10-11-12-13-14-15-17-20(23)18(22)16-19(24-2)21(17)25-3/h16H,4-15H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078888
PNG
(CHEMBL3416359)
Show SMILES CCCCCCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C20H32O4/c1-4-5-6-7-8-9-10-11-12-13-14-16-19(22)17(21)15-18(23-2)20(16)24-3/h15H,4-14H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078889
PNG
(CHEMBL3416358)
Show SMILES CCCCCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C19H30O4/c1-4-5-6-7-8-9-10-11-12-13-15-18(21)16(20)14-17(22-2)19(15)23-3/h14H,4-13H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078890
PNG
(CHEMBL3416357)
Show SMILES CCCCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C18H28O4/c1-4-5-6-7-8-9-10-11-12-14-17(20)15(19)13-16(21-2)18(14)22-3/h13H,4-12H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078875
PNG
(CHEMBL3416356)
Show SMILES CCCCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C16H24O4/c1-4-5-6-7-8-9-10-12-15(18)13(17)11-14(19-2)16(12)20-3/h11H,4-10H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078874
PNG
(CHEMBL3416355)
Show SMILES CCCCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C14H20O4/c1-4-5-6-7-8-10-13(16)11(15)9-12(17-2)14(10)18-3/h9H,4-8H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078873
PNG
(CHEMBL3416354)
Show SMILES CCCCC1=C(OC)C(OC)=CC(=O)C1=O
Show InChI InChI=1S/C12H16O4/c1-4-5-6-8-11(14)9(13)7-10(15-2)12(8)16-3/h7H,4-6H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078872
PNG
(CHEMBL3416353)
Show SMILES COC1=CC(=O)C(OC)=C(C\C=C(/C)CC\C=C(/C)CCC=C(C)C)C1=O
Show InChI InChI=1S/C23H32O4/c1-16(2)9-7-10-17(3)11-8-12-18(4)13-14-19-22(25)21(26-5)15-20(24)23(19)27-6/h9,11,13,15H,7-8,10,12,14H2,1-6H3/b17-11+,18-13+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078871
PNG
(CHEMBL3416352)
Show SMILES COC1=CC(=O)C(OC)=C(C\C=C(/C)CCC=C(C)C)C1=O
Show InChI InChI=1S/C18H24O4/c1-12(2)7-6-8-13(3)9-10-14-17(20)16(21-4)11-15(19)18(14)22-5/h7,9,11H,6,8,10H2,1-5H3/b13-9+
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078870
PNG
(CHEMBL3416351)
Show SMILES CCCCCCCCCCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C24H40O4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-23(26)22(27-2)19-21(25)24(20)28-3/h19H,4-18H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078865
PNG
(CHEMBL2296071)
Show SMILES CCCCCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C19H30O4/c1-4-5-6-7-8-9-10-11-12-13-15-18(21)17(22-2)14-16(20)19(15)23-3/h14H,4-13H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078864
PNG
(CHEMBL2228913)
Show SMILES CCCCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C18H28O4/c1-4-5-6-7-8-9-10-11-12-14-17(20)16(21-2)13-15(19)18(14)22-3/h13H,4-12H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078863
PNG
(CHEMBL3416180)
Show SMILES CCCCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C16H24O4/c1-4-5-6-7-8-9-10-12-15(18)14(19-2)11-13(17)16(12)20-3/h11H,4-10H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078861
PNG
(CHEMBL3416178)
Show SMILES CCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C12H16O4/c1-4-5-6-8-11(14)10(15-2)7-9(13)12(8)16-3/h7H,4-6H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage-expressed gene 1 protein


(Homo sapiens)
BDBM50078862
PNG
(CHEMBL3416179)
Show SMILES CCCCCCC1=C(OC)C(=O)C=C(OC)C1=O
Show InChI InChI=1S/C14H20O4/c1-4-5-6-7-8-10-13(16)12(17-2)9-11(15)14(10)18-3/h9H,4-8H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Naples

Curated by ChEMBL


Assay Description
Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...


Citation and Details
More data for this
Ligand-Target Pair