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Found 19 hits Enz. Inhib. hit(s) with Target = 'Major prion protein' AND taxid = 9940   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Major prion protein


(Ovis aries)
BDBM50437258
PNG
(CHEMBL2407263)
Show SMILES CC(C)N1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)cc1F
Show InChI InChI=1S/C25H27FN4O/c1-18(2)29-13-15-30(16-14-29)24-11-10-21(17-22(24)26)28-25(31)20-8-6-19(7-9-20)23-5-3-4-12-27-23/h3-12,17-18H,13-16H2,1-2H3,(H,28,31)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437274
PNG
(CHEMBL2407264)
Show SMILES CCOc1cccc(c1)C(=O)Nc1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C20H25N3O2/c1-3-25-19-6-4-5-16(15-19)20(24)21-17-7-9-18(10-8-17)23-13-11-22(2)12-14-23/h4-10,15H,3,11-14H2,1-2H3,(H,21,24)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437260
PNG
(CHEMBL2407261)
Show SMILES CC(C)N1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)cn1
Show InChI InChI=1S/C24H27N5O/c1-18(2)28-13-15-29(16-14-28)23-11-10-21(17-26-23)27-24(30)20-8-6-19(7-9-20)22-5-3-4-12-25-22/h3-12,17-18H,13-16H2,1-2H3,(H,27,30)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437261
PNG
(CHEMBL2407260)
Show SMILES CC(C)N1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)nc1
Show InChI InChI=1S/C24H27N5O/c1-18(2)28-13-15-29(16-14-28)21-10-11-23(26-17-21)27-24(30)20-8-6-19(7-9-20)22-5-3-4-12-25-22/h3-12,17-18H,13-16H2,1-2H3,(H,26,27,30)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437262
PNG
(CHEMBL2407259)
Show SMILES CC(C)N1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H28N4O/c1-19(2)28-15-17-29(18-16-28)23-12-10-22(11-13-23)27-25(30)21-8-6-20(7-9-21)24-5-3-4-14-26-24/h3-14,19H,15-18H2,1-2H3,(H,27,30)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437263
PNG
(CHEMBL2407258)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccncc2)cc1
Show InChI InChI=1S/C24H26N4O/c1-2-27-15-17-28(18-16-27)23-9-7-22(8-10-23)26-24(29)21-5-3-19(4-6-21)20-11-13-25-14-12-20/h3-14H,2,15-18H2,1H3,(H,26,29)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437264
PNG
(CHEMBL2407257)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2cccnc2)cc1
Show InChI InChI=1S/C24H26N4O/c1-2-27-14-16-28(17-15-27)23-11-9-22(10-12-23)26-24(29)20-7-5-19(6-8-20)21-4-3-13-25-18-21/h3-13,18H,2,14-17H2,1H3,(H,26,29)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437265
PNG
(CHEMBL2407256)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)cc1
Show InChI InChI=1S/C24H26N4O/c1-2-27-15-17-28(18-16-27)22-12-10-21(11-13-22)26-24(29)20-8-6-19(7-9-20)23-5-3-4-14-25-23/h3-14H,2,15-18H2,1H3,(H,26,29)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437266
PNG
(CHEMBL2407271)
Show SMILES CC(C)N1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C26H29N3O/c1-20(2)28-16-18-29(19-17-28)25-14-12-24(13-15-25)27-26(30)23-10-8-22(9-11-23)21-6-4-3-5-7-21/h3-15,20H,16-19H2,1-2H3,(H,27,30)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437267
PNG
(CHEMBL2407270)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H27N3O/c1-2-27-16-18-28(19-17-27)24-14-12-23(13-15-24)26-25(29)22-10-8-21(9-11-22)20-6-4-3-5-7-20/h3-15H,2,16-19H2,1H3,(H,26,29)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437268
PNG
(CHEMBL2407269)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C24H25N3O/c1-26-15-17-27(18-16-26)23-13-11-22(12-14-23)25-24(28)21-9-7-20(8-10-21)19-5-3-2-4-6-19/h2-14H,15-18H2,1H3,(H,25,28)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437269
PNG
(CHEMBL2407268)
Show SMILES CC(=O)c1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C21H17NO2/c1-15(23)16-11-13-20(14-12-16)22-21(24)19-9-7-18(8-10-19)17-5-3-2-4-6-17/h2-14H,1H3,(H,22,24)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM75523
PNG
(3-Methoxy-naphthalene-2-carboxylic acid (4-ethoxy-...)
Show SMILES CCOc1ccc(NC(=O)c2cc3ccccc3cc2OC)cc1
Show InChI InChI=1S/C20H19NO3/c1-3-24-17-10-8-16(9-11-17)21-20(22)18-12-14-6-4-5-7-15(14)13-19(18)23-2/h4-13H,3H2,1-2H3,(H,21,22)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM80521
PNG
(3-Hydroxy-2-naphtho-p-phenetidide | 3-hydroxy-N-p-...)
Show SMILES CCOc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1
Show InChI InChI=1S/C19H17NO3/c1-2-23-16-9-7-15(8-10-16)20-19(22)17-11-13-5-3-4-6-14(13)12-18(17)21/h3-12,21H,2H2,1H3,(H,20,22)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437270
PNG
(CHEMBL2407267)
Show SMILES Clc1cccc(NC(=O)c2ccc(NC(=O)c3ccccc3)cc2)c1
Show InChI InChI=1S/C20H15ClN2O2/c21-16-7-4-8-18(13-16)23-20(25)15-9-11-17(12-10-15)22-19(24)14-5-2-1-3-6-14/h1-13H,(H,22,24)(H,23,25)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437271
PNG
(CHEMBL2407266)
Show SMILES CCN(CC)c1ccc(NC(=O)c2ccc(Br)cc2)cc1
Show InChI InChI=1S/C17H19BrN2O/c1-3-20(4-2)16-11-9-15(10-12-16)19-17(21)13-5-7-14(18)8-6-13/h5-12H,3-4H2,1-2H3,(H,19,21)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437272
PNG
(CHEMBL2407265)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1S/C18H20BrN3O/c1-21-9-11-22(12-10-21)17-7-5-16(6-8-17)20-18(23)14-3-2-4-15(19)13-14/h2-8,13H,9-12H2,1H3,(H,20,23)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437273
PNG
(CHEMBL1332508)
Show SMILES COc1cccc(c1)C(=O)Nc1ccc(cc1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C25H27N3O2/c1-30-24-9-5-8-21(18-24)25(29)26-22-10-12-23(13-11-22)28-16-14-27(15-17-28)19-20-6-3-2-4-7-20/h2-13,18H,14-17,19H2,1H3,(H,26,29)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Major prion protein


(Ovis aries)
BDBM50437259
PNG
(CHEMBL2407262)
Show SMILES CC(C)N1CCN(CC1)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)c(F)c1
Show InChI InChI=1S/C25H27FN4O/c1-18(2)29-13-15-30(16-14-29)21-10-11-24(22(26)17-21)28-25(31)20-8-6-19(7-9-20)23-5-3-4-12-27-23/h3-12,17-18H,13-16H2,1-2H3,(H,28,31)
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TBA

Assay Description
Antiprion activity against sheep prion infected in mouse ScN2a-cl3 cells assessed as reduction in PrPSc level after 5 days by ELISA


Citation and Details
More data for this
Ligand-Target Pair