BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 19 hits Enz. Inhib. hit(s) with Target = 'Matrix metalloproteinase-2 (MMP-2)' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199123
PNG
(N-(4-(1-(4,6-bis((4-hydroxyphenyl)amino)-1,3,5-tri...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(Nc2ccc(O)cc2)nc(Nc2ccc(O)cc2)n1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C38H32N8O5S/c1-24-3-21-33(22-4-24)52-51-50-45-29-9-5-25(6-10-29)34-23-35(26-7-19-32(49-2)20-8-26)46(44-34)38-42-36(39-27-11-15-30(47)16-12-27)41-37(43-38)40-28-13-17-31(48)18-14-28/h3-23,45,47-48H,1-2H3,(H2,39,40,41,42,43)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 8.12n/an/an/an/an/an/a



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199124
PNG
(N-(4-(1-(4,6-bis((4-methoxyphenyl)amino)-1,3,5-tri...)
Show SMILES COc1ccc(Nc2nc(Nc3ccc(OC)cc3)nc(n2)-n2nc(cc2-c2ccc(OC)cc2)-c2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)cc1
Show InChI InChI=1S/C40H36N8O5S/c1-26-5-23-35(24-6-26)54-53-52-47-31-11-7-27(8-12-31)36-25-37(28-9-17-32(49-2)18-10-28)48(46-36)40-44-38(41-29-13-19-33(50-3)20-14-29)43-39(45-40)42-30-15-21-34(51-4)22-16-30/h5-25,47H,1-4H3,(H2,41,42,43,44,45)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 18.6n/an/an/an/an/an/a



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199128
PNG
(N-(4-(1-(4,6-dimorpholino-1,3,5-triazin-2-yl)-5-(4...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C34H36N8O5S/c1-24-3-13-29(14-4-24)48-47-46-39-27-9-5-25(6-10-27)30-23-31(26-7-11-28(43-2)12-8-26)42(38-30)34-36-32(40-15-19-44-20-16-40)35-33(37-34)41-17-21-45-22-18-41/h3-14,23,39H,15-22H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 42.3n/an/an/an/an/an/a



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199127
PNG
(N-(4-(1-(4,6-di(piperazin-1-yl)-1,3,5-triazin-2-yl...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(nc(n1)N1CCNCC1)N1CCNCC1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C34H38N10O3S/c1-24-3-13-29(14-4-24)48-47-46-41-27-9-5-25(6-10-27)30-23-31(26-7-11-28(45-2)12-8-26)44(40-30)34-38-32(42-19-15-35-16-20-42)37-33(39-34)43-21-17-36-18-22-43/h3-14,23,35-36,41H,15-22H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 55.3n/an/an/an/an/an/a



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199125
PNG
(N-(4-(1-(4,6-bis(o-tolylamino)-1,3,5-triazin-2-yl)...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(Nc2ccccc2C)nc(Nc2ccccc2C)n1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C40H36N8O3S/c1-26-13-23-33(24-14-26)52-51-50-47-31-19-15-29(16-20-31)36-25-37(30-17-21-32(49-4)22-18-30)48(46-36)40-44-38(41-34-11-7-5-9-27(34)2)43-39(45-40)42-35-12-8-6-10-28(35)3/h5-25,47H,1-4H3,(H2,41,42,43,44,45)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 67.1n/an/an/an/an/an/a



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199126
PNG
(N-(4-(1-(4,6-bis((4-nitrophenyl)amino)-1,3,5-triaz...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(Nc2ccc(cc2)[N+]([O-])=O)nc(Nc2ccc(cc2)[N+]([O-])=O)n1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C38H30N10O7S/c1-24-3-21-33(22-4-24)56-55-54-45-29-9-5-25(6-10-29)34-23-35(26-7-19-32(53-2)20-8-26)46(44-34)38-42-36(39-27-11-15-30(16-12-27)47(49)50)41-37(43-38)40-28-13-17-31(18-14-28)48(51)52/h3-23,45H,1-2H3,(H2,39,40,41,42,43)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 76.6n/an/an/an/an/an/a



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199122
PNG
(N-(4-(1-(4,6-bis(phenylamino)-1,3,5-triazin-2-yl)-...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(Nc2ccccc2)nc(Nc2ccccc2)n1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C38H32N8O3S/c1-26-13-23-33(24-14-26)50-49-48-45-31-19-15-27(16-20-31)34-25-35(28-17-21-32(47-2)22-18-28)46(44-34)38-42-36(39-29-9-5-3-6-10-29)41-37(43-38)40-30-11-7-4-8-12-30/h3-25,45H,1-2H3,(H2,39,40,41,42,43)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 123n/an/an/an/an/an/a



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199121
PNG
(N-(4-(1-(4,6-bis((3-aminopropyl)amino)-1,3,5-triaz...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(NCCCN)nc(NCCCN)n1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C32H38N10O3S/c1-22-5-15-27(16-6-22)46-45-44-41-25-11-7-23(8-12-25)28-21-29(24-9-13-26(43-2)14-10-24)42(40-28)32-38-30(35-19-3-17-33)37-31(39-32)36-20-4-18-34/h5-16,21,41H,3-4,17-20,33-34H2,1-2H3,(H2,35,36,37,38,39)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 189n/an/an/an/an/an/a



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199120
PNG
(N-(4-(1-(4,6-bis(ethylamino)-1,3,5-triazin-2-yl)-5...)
Show SMILES CCNc1nc(NCC)nc(n1)-n1nc(cc1-c1ccc(OC)cc1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C30H32N8O3S/c1-5-31-28-33-29(32-6-2)35-30(34-28)38-27(22-11-15-24(39-4)16-12-22)19-26(36-38)21-9-13-23(14-10-21)37-40-41-42-25-17-7-20(3)8-18-25/h7-19,37H,5-6H2,1-4H3,(H2,31,32,33,34,35)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 332n/an/an/an/an/an/a



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199119
PNG
(N-(4-(1-(4,6-bis(methylamino)-1,3,5-triazin-2-yl)-...)
Show SMILES CNc1nc(NC)nc(n1)-n1nc(cc1-c1ccc(OC)cc1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C28H28N8O3S/c1-18-5-15-23(16-6-18)40-39-38-35-21-11-7-19(8-12-21)24-17-25(20-9-13-22(37-4)14-10-20)36(34-24)28-32-26(29-2)31-27(30-3)33-28/h5-17,35H,1-4H3,(H2,29,30,31,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 666n/an/an/an/an/an/a



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM50310832
PNG
(CHEMBL1080779 | Clinopodic acid C)
Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc2O[C@H]([C@H](Oc2c1)C(O)=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C27H22O12/c28-16-5-1-14(9-18(16)30)11-22(26(33)34)37-23(32)8-3-13-2-7-20-21(10-13)39-25(27(35)36)24(38-20)15-4-6-17(29)19(31)12-15/h1-10,12,22,24-25,28-31H,11H2,(H,33,34)(H,35,36)/b8-3+/t22-,24+,25+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.26E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM50250808
PNG
(CHEMBL518243 | lithospermic acid)
Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c2O[C@@H]([C@@H](C(O)=O)c12)c1ccc(O)c(O)c1
Show InChI InChI=1S/C27H22O12/c28-15-5-1-12(9-18(15)31)10-20(26(34)35)38-21(33)8-4-13-2-7-17(30)25-22(13)23(27(36)37)24(39-25)14-3-6-16(29)19(32)11-14/h1-9,11,20,23-24,28-32H,10H2,(H,34,35)(H,36,37)/b8-4+/t20-,23+,24-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1.02E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM50133496
PNG
((2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydr...)
Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 2.72E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM50310828
PNG
(CHEMBL1079356 | clinopodic acid F)
Show SMILES COc1cc(C[C@@H](OC(=O)\C=C\c2ccc3O[C@@H]([C@@H](Oc3c2)C(O)=O)c2ccc(O)c(O)c2)C(O)=O)ccc1O
Show InChI InChI=1S/C28H24O12/c1-37-21-11-15(2-6-18(21)30)12-23(27(33)34)38-24(32)9-4-14-3-8-20-22(10-14)40-26(28(35)36)25(39-20)16-5-7-17(29)19(31)13-16/h2-11,13,23,25-26,29-31H,12H2,1H3,(H,33,34)(H,35,36)/b9-4+/t23-,25-,26-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM50310827
PNG
(CHEMBL1079357 | clinopodic acid H)
Show SMILES COc1cc(C[C@@H](OC(=O)\C=C\c2ccc(O)c3O[C@@H]([C@@H](C(O)=O)c23)c2ccc(O)c(OC)c2)C(O)=O)ccc1O
Show InChI InChI=1S/C29H26O12/c1-38-20-11-14(3-7-17(20)30)12-22(28(34)35)40-23(33)10-6-15-4-9-19(32)27-24(15)25(29(36)37)26(41-27)16-5-8-18(31)21(13-16)39-2/h3-11,13,22,25-26,30-32H,12H2,1-2H3,(H,34,35)(H,36,37)/b10-6+/t22-,25+,26-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM50310830
PNG
(CHEMBL1080778 | Clinopodic acid B)
Show SMILES COc1cc(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)C(O)=O)ccc1O
Show InChI InChI=1S/C19H18O8/c1-26-16-9-12(3-6-14(16)21)10-17(19(24)25)27-18(23)7-4-11-2-5-13(20)15(22)8-11/h2-9,17,20-22H,10H2,1H3,(H,24,25)/b7-4+/t17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM50310831
PNG
(CHEMBL1079231 | Clinopodic acid A)
Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)cc1
Show InChI InChI=1S/C18H16O7/c19-13-5-1-11(2-6-13)4-8-17(22)25-16(18(23)24)10-12-3-7-14(20)15(21)9-12/h1-9,16,19-21H,10H2,(H,23,24)/b8-4+/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM50210054
PNG
((R,E)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropa...)
Show SMILES COC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C19H18O8/c1-26-19(25)17(10-12-3-6-14(21)16(23)9-12)27-18(24)7-4-11-2-5-13(20)15(22)8-11/h2-9,17,20-23H,10H2,1H3/b7-4+/t17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM50310829
PNG
(CHEMBL1081512 | clinopodic acid E)
Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc2O[C@@H]([C@@H](Oc2c1)C(O)=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C27H22O12/c28-16-5-1-14(9-18(16)30)11-22(26(33)34)37-23(32)8-3-13-2-7-20-21(10-13)39-25(27(35)36)24(38-20)15-4-6-17(29)19(31)12-15/h1-10,12,22,24-25,28-31H,11H2,(H,33,34)(H,35,36)/b8-3+/t22-,24-,25-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins


Citation and Details
More data for this
Ligand-Target Pair