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Found 2008 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2 (mGluR2)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM85212
PNG
(CAS_5311260 | LY341495 | NSC_5311260)
Show SMILES NC(Cn1cnc2c1[nH]c(=O)[nH]c2=O)(C1CC1C(O)=O)C(O)=O
Show InChI InChI=1S/C12H13N5O6/c13-12(10(21)22,5-1-4(5)9(19)20)2-17-3-14-6-7(17)15-11(23)16-8(6)18/h3-5H,1-2,13H2,(H,19,20)(H,21,22)(H2,15,16,18,23)
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0.0780n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by PDSP Ki Database




J Neurochem 71: 2558-64 (1998)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50034503
PNG
((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...)
Show SMILES N[C@@H](C1[C@H]([C@@H]1C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1
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0.368n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by PDSP Ki Database




J Neurochem 71: 2558-64 (1998)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50004899
PNG
((1R,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Show SMILES N[C@@H]([C@H]1C[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3+,4-/m0/s1
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0.378n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by PDSP Ki Database




J Neurochem 71: 2558-64 (1998)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151448
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3-carboxy-benzyloxy)-6...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(c1)C(O)=O)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C16H16FNO7/c17-15(13(21)22)9-5-10(16(18,11(9)15)14(23)24)25-6-7-2-1-3-8(4-7)12(19)20/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)(H,23,24)/t9-,10-,11+,15-,16+/m1/s1
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1.06n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151486
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-ph...)
Show SMILES C[C@@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H16Cl2FNO5/c1-6(7-2-3-9(17)10(18)4-7)25-11-5-8-12(15(8,19)13(21)22)16(11,20)14(23)24/h2-4,6,8,11-12H,5,20H2,1H3,(H,21,22)(H,23,24)/t6-,8-,11-,12+,15-,16+/m1/s1
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1.45n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151439
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-ph...)
Show SMILES CCC[C@@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H20Cl2FNO5/c1-2-3-12(8-4-5-10(19)11(20)6-8)27-13-7-9-14(17(9,21)15(23)24)18(13,22)16(25)26/h4-6,9,12-14H,2-3,7,22H2,1H3,(H,23,24)(H,25,26)/t9-,12-,13-,14+,17-,18+/m1/s1
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1.48n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151481
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-ph...)
Show SMILES CC[C@@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H18Cl2FNO5/c1-2-11(7-3-4-9(18)10(19)5-7)26-12-6-8-13(16(8,20)14(22)23)17(12,21)15(24)25/h3-5,8,11-13H,2,6,21H2,1H3,(H,22,23)(H,24,25)/t8-,11-,12-,13+,16-,17+/m1/s1
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1.61n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151434
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-((S)-1-naphtha...)
Show SMILES C[C@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H20FNO5/c1-10(12-7-6-11-4-2-3-5-13(11)8-12)27-15-9-14-16(19(14,21)17(23)24)20(15,22)18(25)26/h2-8,10,14-16H,9,22H2,1H3,(H,23,24)(H,25,26)/t10-,14+,15+,16-,19+,20-/m0/s1
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1.79n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151476
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-((R)-1-naphtha...)
Show SMILES C[C@@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H20FNO5/c1-10(12-7-6-11-4-2-3-5-13(11)8-12)27-15-9-14-16(19(14,21)17(23)24)20(15,22)18(25)26/h2-8,10,14-16H,9,22H2,1H3,(H,23,24)(H,25,26)/t10-,14-,15-,16+,19-,20+/m1/s1
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2.01n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151435
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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2.20n/an/an/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Binding affinity to mGLUR2


Bioorg Med Chem Lett 22: 1958-62 (2012)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151453
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-difluoro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(F)c(F)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14F3NO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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2.27n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151435
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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2.38n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151473
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(naphthalen-2-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc3ccccc3c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H18FNO5/c20-18(16(22)23)13-8-14(19(21,15(13)18)17(24)25)26-9-10-5-6-11-3-1-2-4-12(11)7-10/h1-7,13-15H,8-9,21H2,(H,22,23)(H,24,25)/t13-,14-,15+,18-,19+/m1/s1
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2.53n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151438
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-benzhydryloxy-6-fluoro-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC(c1ccccc1)c1ccccc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H20FNO5/c22-20(18(24)25)14-11-15(21(23,17(14)20)19(26)27)28-16(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,14-17H,11,23H2,(H,24,25)(H,26,27)/t14-,15-,17+,20-,21+/m1/s1
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2.58n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151478
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-[bis-(3,4-dichloro-phen...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC(c1ccc(Cl)c(Cl)c1)c1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H16Cl4FNO5/c22-11-3-1-8(5-13(11)24)16(9-2-4-12(23)14(25)6-9)32-15-7-10-17(20(10,26)18(28)29)21(15,27)19(30)31/h1-6,10,15-17H,7,27H2,(H,28,29)(H,30,31)/t10-,15-,17+,20-,21+/m1/s1
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2.61n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50089890
PNG
(4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxyli...)
Show SMILES N[C@]1(COC2[C@@H](C12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3?,4?,7+/m1/s1
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2.70n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151475
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3-cyano-benzyloxy)-6-f...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(c1)C#N)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C16H15FN2O5/c17-15(13(20)21)10-5-11(16(19,12(10)15)14(22)23)24-7-9-3-1-2-8(4-9)6-18/h1-4,10-12H,5,7,19H2,(H,20,21)(H,22,23)/t10-,11-,12+,15-,16+/m1/s1
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2.94n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151482
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-ph...)
Show SMILES CCC[C@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H20Cl2FNO5/c1-2-3-12(8-4-5-10(19)11(20)6-8)27-13-7-9-14(17(9,21)15(23)24)18(13,22)16(25)26/h4-6,9,12-14H,2-3,7,22H2,1H3,(H,23,24)(H,25,26)/t9-,12+,13-,14+,17-,18+/m1/s1
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3.05n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151445
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-ph...)
Show SMILES CC[C@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H18Cl2FNO5/c1-2-11(7-3-4-9(18)10(19)5-7)26-12-6-8-13(16(8,20)14(22)23)17(12,21)15(24)25/h3-5,8,11-13H,2,6,21H2,1H3,(H,22,23)(H,24,25)/t8-,11+,12-,13+,16-,17+/m1/s1
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3.12n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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3.13n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151447
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(4-chloro-benzyloxy)-6-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)cc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15ClFNO5/c16-8-3-1-7(2-4-8)6-23-10-5-9-11(14(9,17)12(19)20)15(10,18)13(21)22/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)/t9-,10-,11+,14-,15+/m1/s1
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3.17n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151464
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3-chloro-benzyloxy)-6-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15ClFNO5/c16-8-3-1-2-7(4-8)6-23-10-5-9-11(14(9,17)12(19)20)15(10,18)13(21)22/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)/t9-,10-,11+,14-,15+/m1/s1
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3.28n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50094843
PNG
((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Show SMILES N[C@]1(CC(=O)[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1
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3.30n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Tested for binding affinity against Metabotropic glutamate receptor 2 in CHO cells using [3H]-7 as radioligand


J Med Chem 43: 4893-909 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151469
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3-chloro-4-fluoro-benz...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(F)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14ClF2NO5/c16-8-3-6(1-2-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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3.57n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151443
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3,4,5-trichlo...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cc(Cl)c(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H13Cl3FNO5/c16-7-1-5(2-8(17)10(7)18)4-25-9-3-6-11(14(6,19)12(21)22)15(9,20)13(23)24/h1-2,6,9,11H,3-4,20H2,(H,21,22)(H,23,24)/t6-,9-,11+,14-,15+/m1/s1
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3.67n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50279772
PNG
(2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...)
Show SMILES N[C@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20+/m0/s1
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3.72n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Tested for binding affinity against Metabotropic glutamate receptor 2 in CHO cells using [3H]-7 as radioligand


J Med Chem 43: 4893-909 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151480
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-[bis-(4-chloro-phenyl)-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H18Cl2FNO5/c22-12-5-1-10(2-6-12)16(11-3-7-13(23)8-4-11)30-15-9-14-17(20(14,24)18(26)27)21(15,25)19(28)29/h1-8,14-17H,9,25H2,(H,26,27)(H,28,29)/t14-,15-,17+,20-,21+/m1/s1
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3.75n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151488
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-pentafluorophe...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1c(F)c(F)c(F)c(F)c1F)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H11F6NO5/c16-6-3(7(17)9(19)10(20)8(6)18)2-27-5-1-4-11(14(4,21)12(23)24)15(5,22)13(25)26/h4-5,11H,1-2,22H2,(H,23,24)(H,25,26)/t4-,5-,11+,14-,15+/m1/s1
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3.77n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151472
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-[bis-(4-fluoro-phenyl)-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC(c1ccc(F)cc1)c1ccc(F)cc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H18F3NO5/c22-12-5-1-10(2-6-12)16(11-3-7-13(23)8-4-11)30-15-9-14-17(20(14,24)18(26)27)21(15,25)19(28)29/h1-8,14-17H,9,25H2,(H,26,27)(H,28,29)/t14-,15-,17+,20-,21+/m1/s1
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3.79n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151451
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(2,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)cc1Cl)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-7-2-1-6(9(17)3-7)5-24-10-4-8-11(14(8,18)12(20)21)15(10,19)13(22)23/h1-3,8,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t8-,10-,11+,14-,15+/m1/s1
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3.89n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50089897
PNG
(4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxyl...)
Show SMILES N[C@]1(CSC2[C@@H](C12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO4S/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3?,4?,7+/m1/s1
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3.90n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151449
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(4-chloro-3-fluoro-benz...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(F)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14ClF2NO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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4.02n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151442
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(biphenyl-2-ylmethoxy)-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccccc1-c1ccccc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H20FNO5/c22-20(18(24)25)15-10-16(21(23,17(15)20)19(26)27)28-11-13-8-4-5-9-14(13)12-6-2-1-3-7-12/h1-9,15-17H,10-11,23H2,(H,24,25)(H,26,27)/t15-,16-,17+,20-,21+/m1/s1
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4.07n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151458
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(2,3-difluoro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(F)c1F)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14F3NO5/c16-8-3-1-2-6(10(8)17)5-24-9-4-7-11(14(7,18)12(20)21)15(9,19)13(22)23/h1-3,7,9,11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,9-,11+,14-,15+/m1/s1
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4.25n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151470
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(2,6-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1c(Cl)cccc1Cl)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-3-9(17)6(8)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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4.30n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151463
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(2,3-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(Cl)c1Cl)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-3-1-2-6(10(8)17)5-24-9-4-7-11(14(7,18)12(20)21)15(9,19)13(22)23/h1-3,7,9,11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,9-,11+,14-,15+/m1/s1
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4.35n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50202406
PNG
((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Show SMILES N[C@]1(CS(=O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO5S/c8-7(6(11)12)1-14(13)4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+,14?/m1/s1
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4.40n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cells


J Med Chem 50: 233-40 (2007)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151459
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-methyl-benz...)
Show SMILES Cc1cccc(CO[C@@H]2C[C@@H]3[C@@H]([C@@]3(F)C(O)=O)[C@]2(N)C(O)=O)c1
Show InChI InChI=1S/C16H18FNO5/c1-8-3-2-4-9(5-8)7-23-11-6-10-12(15(10,17)13(19)20)16(11,18)14(21)22/h2-5,10-12H,6-7,18H2,1H3,(H,19,20)(H,21,22)/t10-,11-,12+,15-,16+/m1/s1
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4.53n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151471
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(2,4-difluoro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(F)cc1F)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14F3NO5/c16-7-2-1-6(9(17)3-7)5-24-10-4-8-11(14(8,18)12(20)21)15(10,19)13(22)23/h1-3,8,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t8-,10-,11+,14-,15+/m1/s1
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4.71n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151465
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3-bromo-benzyloxy)-6-f...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(Br)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15BrFNO5/c16-8-3-1-2-7(4-8)6-23-10-5-9-11(14(9,17)12(19)20)15(10,18)13(21)22/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)/t9-,10-,11+,14-,15+/m1/s1
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4.71n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151468
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(2-chloro-benzyloxy)-6-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccccc1Cl)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15ClFNO5/c16-9-4-2-1-3-7(9)6-23-10-5-8-11(14(8,17)12(19)20)15(10,18)13(21)22/h1-4,8,10-11H,5-6,18H2,(H,19,20)(H,21,22)/t8-,10-,11+,14-,15+/m1/s1
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4.99n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151452
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-propoxy-bicycl...)
Show SMILES CCCO[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O
Show InChI InChI=1S/C11H16FNO5/c1-2-3-18-6-4-5-7(10(5,12)8(14)15)11(6,13)9(16)17/h5-7H,2-4,13H2,1H3,(H,14,15)(H,16,17)/t5-,6-,7+,10-,11+/m1/s1
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5.17n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151483
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(naphthalen-1-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc3ccccc13)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H18FNO5/c20-18(16(22)23)13-8-14(19(21,15(13)18)17(24)25)26-9-11-6-3-5-10-4-1-2-7-12(10)11/h1-7,13-15H,8-9,21H2,(H,22,23)(H,24,25)/t13-,14-,15+,18-,19+/m1/s1
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5.36n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151477
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(4-fluoro-benz...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(F)cc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15F2NO5/c16-8-3-1-7(2-4-8)6-23-10-5-9-11(14(9,17)12(19)20)15(10,18)13(21)22/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)/t9-,10-,11+,14-,15+/m1/s1
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5.55n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151436
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(3,5-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cc(Cl)cc(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-7-1-6(2-8(17)3-7)5-24-10-4-9-11(14(9,18)12(20)21)15(10,19)13(22)23/h1-3,9-11H,4-5,19H2,(H,20,21)(H,22,23)/t9-,10-,11+,14-,15+/m1/s1
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5.61n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151455
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-trifluorome...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(c1)C(F)(F)F)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C16H15F4NO5/c17-14(12(22)23)9-5-10(15(21,11(9)14)13(24)25)26-6-7-2-1-3-8(4-7)16(18,19)20/h1-4,9-11H,5-6,21H2,(H,22,23)(H,24,25)/t9-,10-,11+,14-,15+/m1/s1
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5.72n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151437
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-ph...)
Show SMILES C[C@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H16Cl2FNO5/c1-6(7-2-3-9(17)10(18)4-7)25-11-5-8-12(15(8,19)13(21)22)16(11,20)14(23)24/h2-4,6,8,11-12H,5,20H2,1H3,(H,21,22)(H,23,24)/t6-,8+,11+,12-,15+,16-/m0/s1
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5.81n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151457
PNG
((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-methoxy-ben...)
Show SMILES COc1cccc(CO[C@@H]2C[C@@H]3[C@@H]([C@@]3(F)C(O)=O)[C@]2(N)C(O)=O)c1
Show InChI InChI=1S/C16H18FNO6/c1-23-9-4-2-3-8(5-9)7-24-11-6-10-12(15(10,17)13(19)20)16(11,18)14(21)22/h2-5,10-12H,6-7,18H2,1H3,(H,19,20)(H,21,22)/t10-,11-,12+,15-,16+/m1/s1
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5.92n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151433
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-sec-butoxy-6-fluoro-bic...)
Show SMILES CCC(C)O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O
Show InChI InChI=1S/C12H18FNO5/c1-3-5(2)19-7-4-6-8(11(6,13)9(15)16)12(7,14)10(17)18/h5-8H,3-4,14H2,1-2H3,(H,15,16)(H,17,18)/t5?,6-,7-,8+,11-,12+/m1/s1
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6.68n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50151491
PNG
((1R,2R,3R,5R,6R)-2-Amino-3-(2,6-difluoro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1c(F)cccc1F)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14F3NO5/c16-8-2-1-3-9(17)6(8)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
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7.02n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008


J Med Chem 47: 4570-87 (2004)

More data for this
Ligand-Target Pair
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