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Compile Data Set for Download or QSAR

Found 42 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067181
PNG
(CHEMBL3401726)
Show SMILES Clc1cc(Cl)cc(c1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H9Cl2N3O/c15-9-5-8(6-10(16)7-9)13(20)19-14-17-11-3-1-2-4-12(11)18-14/h1-7H,(H2,17,18,19,20)
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n/an/a 6.40E+3n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067180
PNG
(CHEMBL3401725)
Show SMILES Clc1ccc(cc1Cl)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H9Cl2N3O/c15-9-6-5-8(7-10(9)16)13(20)19-14-17-11-3-1-2-4-12(11)18-14/h1-7H,(H2,17,18,19,20)
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n/an/a 9.80E+3n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067173
PNG
(CHEMBL3401720)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C15H10F3N3O/c16-15(17,18)10-5-3-4-9(8-10)13(22)21-14-19-11-6-1-2-7-12(11)20-14/h1-8H,(H2,19,20,21,22)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067178
PNG
(CHEMBL3401723)
Show SMILES Clc1ccc(Cl)c(c1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H9Cl2N3O/c15-8-5-6-10(16)9(7-8)13(20)19-14-17-11-3-1-2-4-12(11)18-14/h1-7H,(H2,17,18,19,20)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067185
PNG
(CHEMBL1578123)
Show SMILES O=C(Nc1nc2ccccc2[nH]1)C1CCC1
Show InChI InChI=1S/C12H13N3O/c16-11(8-4-3-5-8)15-12-13-9-6-1-2-7-10(9)14-12/h1-2,6-8H,3-5H2,(H2,13,14,15,16)
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM39107
PNG
(MLS000092864 | N-(1H-benzimidazol-2-yl)-4-fluorany...)
Show SMILES Fc1ccc(cc1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H10FN3O/c15-10-7-5-9(6-8-10)13(19)18-14-16-11-3-1-2-4-12(11)17-14/h1-8H,(H2,16,17,18,19)
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067177
PNG
(CHEMBL1402439)
Show SMILES CN(C)c1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C16H16N4O/c1-20(2)12-7-5-6-11(10-12)15(21)19-16-17-13-8-3-4-9-14(13)18-16/h3-10H,1-2H3,(H2,17,18,19,21)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083317
PNG
(CHEMBL3423096)
Show SMILES Fc1cccc(c1)[C@H]1C[C@@H]1C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1/C17H14FN3O/c18-11-5-3-4-10(8-11)12-9-13(12)16(22)21-17-19-14-6-1-2-7-15(14)20-17/h1-8,12-13H,9H2,(H2,19,20,21,22)/t12-,13+/s2
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067183
PNG
(CHEMBL3401728)
Show SMILES O=C(Nc1nc2ccccc2[nH]1)\C=C\c1ccncc1
Show InChI InChI=1S/C15H12N4O/c20-14(6-5-11-7-9-16-10-8-11)19-15-17-12-3-1-2-4-13(12)18-15/h1-10H,(H2,17,18,19,20)/b6-5+
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n/an/a 2.20E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50275235
PNG
(CHEMBL486569 | N-(1H-benzo[d]imidazol-2-yl)-4-chlo...)
Show SMILES Clc1ccc(cc1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H10ClN3O/c15-10-7-5-9(6-8-10)13(19)18-14-16-11-3-1-2-4-12(11)17-14/h1-8H,(H2,16,17,18,19)
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50184701
PNG
(CHEMBL210658 | N-(1H-benzo[d]imidazol-2-yl)-3-nitr...)
Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H10N4O3/c19-13(9-4-3-5-10(8-9)18(20)21)17-14-15-11-6-1-2-7-12(11)16-14/h1-8H,(H2,15,16,17,19)
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n/an/a 2.90E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM53441
PNG
(MLS001000876 | N-(1H-benzimidazol-2-yl)-3-chlorany...)
Show SMILES Clc1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H10ClN3O/c15-10-5-3-4-9(8-10)13(19)18-14-16-11-6-1-2-7-12(11)17-14/h1-8H,(H2,16,17,18,19)
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n/an/a 2.90E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083267
PNG
(CHEMBL3423270)
Show SMILES Fc1cccc(c1)[C@H]1C[C@@H]1NC(=O)c1cccc(F)c1
Show InChI InChI=1/C16H13F2NO/c17-12-5-1-3-10(7-12)14-9-15(14)19-16(20)11-4-2-6-13(18)8-11/h1-8,14-15H,9H2,(H,19,20)/t14-,15+/s2
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM95957
PNG
(MLS000680654 | N-(1H-benzimidazol-2-yl)-4-nitro-be...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H10N4O3/c19-13(9-5-7-10(8-6-9)18(20)21)17-14-15-11-3-1-2-4-12(11)16-14/h1-8H,(H2,15,16,17,19)
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n/an/a 3.30E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067179
PNG
(CHEMBL3401724)
Show SMILES FC(F)(F)c1ccc(c(c1)C(=O)Nc1nc2ccccc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C16H9F6N3O/c17-15(18,19)8-5-6-10(16(20,21)22)9(7-8)13(26)25-14-23-11-3-1-2-4-12(11)24-14/h1-7H,(H2,23,24,25,26)
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n/an/a 3.40E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM38984
PNG
(MLS000092863 | N-(1H-benzimidazol-2-yl)-2-fluorany...)
Show SMILES Fc1ccccc1C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H10FN3O/c15-10-6-2-1-5-9(10)13(19)18-14-16-11-7-3-4-8-12(11)17-14/h1-8H,(H2,16,17,18,19)
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n/an/a 3.60E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067184
PNG
(CHEMBL3401729)
Show SMILES O=C(Nc1nc2ccccc2[nH]1)C1CCCCC1
Show InChI InChI=1S/C14H17N3O/c18-13(10-6-2-1-3-7-10)17-14-15-11-8-4-5-9-12(11)16-14/h4-5,8-10H,1-3,6-7H2,(H2,15,16,17,18)
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n/an/a 4.20E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083334
PNG
(CHEMBL3423094)
Show SMILES COc1cc(Br)ccc1NC(=O)[C@H]1C[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C17H15BrFNO2/c1-22-16-8-11(18)5-6-15(16)20-17(21)14-9-13(14)10-3-2-4-12(19)7-10/h2-8,13-14H,9H2,1H3,(H,20,21)/t13-,14+/s2
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n/an/a 4.60E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083318
PNG
(CHEMBL3423095)
Show SMILES Fc1cccc(c1)[C@H]1C[C@@H]1C(=O)Nc1nc2ccccc2s1
Show InChI InChI=1/C17H13FN2OS/c18-11-5-3-4-10(8-11)12-9-13(12)16(21)20-17-19-14-6-1-2-7-15(14)22-17/h1-8,12-13H,9H2,(H,19,20,21)/t12-,13+/s2
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n/an/a 4.60E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067176
PNG
(CHEMBL3401722)
Show SMILES O=C(Nc1nc2ccccc2[nH]1)c1ccncc1
Show InChI InChI=1S/C13H10N4O/c18-12(9-5-7-14-8-6-9)17-13-15-10-3-1-2-4-11(10)16-13/h1-8H,(H2,15,16,17,18)
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n/an/a 4.90E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083316
PNG
(CHEMBL3423097)
Show SMILES Fc1ccc(NC(=O)[C@H]2C[C@@H]2c2cccc(Cl)c2)cc1
Show InChI InChI=1/C16H13ClFNO/c17-11-3-1-2-10(8-11)14-9-15(14)16(20)19-13-6-4-12(18)5-7-13/h1-8,14-15H,9H2,(H,19,20)/t14-,15+/s2
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n/an/a 5.80E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067174
PNG
(CHEMBL3401721)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C15H10F3N3O/c16-15(17,18)10-7-5-9(6-8-10)13(22)21-14-19-11-3-1-2-4-12(11)20-14/h1-8H,(H2,19,20,21,22)
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n/an/a 5.90E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083313
PNG
(CHEMBL3423100)
Show SMILES Clc1cccc(c1)[C@H]1C[C@@H]1C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1/C17H14ClN3O/c18-11-5-3-4-10(8-11)12-9-13(12)16(22)21-17-19-14-6-1-2-7-15(14)20-17/h1-8,12-13H,9H2,(H2,19,20,21,22)/t12-,13+/s2
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n/an/a 6.70E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083315
PNG
(CHEMBL3423098)
Show SMILES Clc1cccc(c1)[C@H]1C[C@@H]1C(=O)Nc1ccccc1Cl
Show InChI InChI=1/C16H13Cl2NO/c17-11-5-3-4-10(8-11)12-9-13(12)16(20)19-15-7-2-1-6-14(15)18/h1-8,12-13H,9H2,(H,19,20)/t12-,13+/s2
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n/an/a 7.10E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067170
PNG
(CHEMBL3401716)
Show SMILES FC(F)(F)c1ccccc1C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C15H10F3N3O/c16-15(17,18)10-6-2-1-5-9(10)13(22)21-14-19-11-7-3-4-8-12(11)20-14/h1-8H,(H2,19,20,21,22)
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n/an/a 8.80E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067175
PNG
(CHEMBL1604245)
Show SMILES COc1ccc(cc1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C15H13N3O2/c1-20-11-8-6-10(7-9-11)14(19)18-15-16-12-4-2-3-5-13(12)17-15/h2-9H,1H3,(H2,16,17,18,19)
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067169
PNG
(CHEMBL3401715)
Show SMILES Clc1ccccc1C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H10ClN3O/c15-10-6-2-1-5-9(10)13(19)18-14-16-11-7-3-4-8-12(11)17-14/h1-8H,(H2,16,17,18,19)
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n/an/a 1.10E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM48291
PNG
(MLS000566231 | N-(1H-benzimidazol-2-yl)-3-methoxy-...)
Show SMILES COc1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C15H13N3O2/c1-20-11-6-4-5-10(9-11)14(19)18-15-16-12-7-2-3-8-13(12)17-15/h2-9H,1H3,(H2,16,17,18,19)
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n/an/a 1.20E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083265
PNG
(CHEMBL3423272)
Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)N[C@H]1C[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C16H13FN2O3/c17-12-5-1-3-10(7-12)14-9-15(14)18-16(20)11-4-2-6-13(8-11)19(21)22/h1-8,14-15H,9H2,(H,18,20)/t14-,15+/s2
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n/an/a 1.30E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50156074
PNG
(1,2-bis(3-fluorobenzylidene)hydrazine | CHEMBL3718...)
Show SMILES Fc1cccc(\C=N\N=C\c2cccc(F)c2)c1
Show InChI InChI=1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+
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n/an/a 1.36E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50156074
PNG
(1,2-bis(3-fluorobenzylidene)hydrazine | CHEMBL3718...)
Show SMILES Fc1cccc(\C=N\N=C\c2cccc(F)c2)c1
Show InChI InChI=1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+
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n/an/a 1.36E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067182
PNG
(CHEMBL3401727)
Show SMILES COc1cc(ccc1S(N)(=O)=O)C(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C15H14N4O4S/c1-23-12-8-9(6-7-13(12)24(16,21)22)14(20)19-15-17-10-4-2-3-5-11(10)18-15/h2-8H,1H3,(H2,16,21,22)(H2,17,18,19,20)
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n/an/a 1.50E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083353
PNG
(CHEMBL3423092)
Show SMILES Fc1ccc(NC(=O)[C@H]2C[C@@H]2c2cccc(F)c2)cc1
Show InChI InChI=1/C16H13F2NO/c17-11-4-6-13(7-5-11)19-16(20)15-9-14(15)10-2-1-3-12(18)8-10/h1-8,14-15H,9H2,(H,19,20)/t14-,15+/s2
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n/an/a 1.60E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM48290
PNG
(MLS000566310 | N-(1H-benzimidazol-2-yl)benzamide |...)
Show SMILES O=C(Nc1nc2ccccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C14H11N3O/c18-13(10-6-2-1-3-7-10)17-14-15-11-8-4-5-9-12(11)16-14/h1-9H,(H2,15,16,17,18)
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n/an/a 1.60E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067172
PNG
(CHEMBL3401719)
Show SMILES Clc1cccc(c1)C(=O)Sc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H9ClN2OS/c15-10-5-3-4-9(8-10)13(18)19-14-16-11-6-1-2-7-12(11)17-14/h1-8H,(H,16,17)
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n/an/a 1.60E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083263
PNG
(CHEMBL3423274)
Show SMILES Fc1cccc(c1)[C@H]1C[C@@H]1NC(=O)c1ccccn1
Show InChI InChI=1/C15H13FN2O/c16-11-5-3-4-10(8-11)12-9-14(12)18-15(19)13-6-1-2-7-17-13/h1-8,12,14H,9H2,(H,18,19)/t12-,14+/s2
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n/an/a 1.70E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083352
PNG
(CHEMBL3423093)
Show SMILES Fc1cccc(c1)[C@H]1C[C@@H]1C(=O)Nc1ccccc1Cl
Show InChI InChI=1/C16H13ClFNO/c17-14-6-1-2-7-15(14)19-16(20)13-9-12(13)10-4-3-5-11(18)8-10/h1-8,12-13H,9H2,(H,19,20)/t12-,13+/s2
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n/an/a 1.80E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083266
PNG
(CHEMBL3423271)
Show SMILES Fc1cccc(c1)[C@H]1C[C@@H]1NC(=O)c1cccc(Cl)c1
Show InChI InChI=1/C16H13ClFNO/c17-12-5-1-4-11(7-12)16(20)19-15-9-14(15)10-3-2-6-13(18)8-10/h1-8,14-15H,9H2,(H,19,20)/t14-,15+/s2
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n/an/a 2.00E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083264
PNG
(CHEMBL3423273)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)N[C@H]1C[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C16H13FN2O3/c17-12-3-1-2-11(8-12)14-9-15(14)18-16(20)10-4-6-13(7-5-10)19(21)22/h1-8,14-15H,9H2,(H,18,20)/t14-,15+/s2
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n/an/a 2.00E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50067171
PNG
(CHEMBL3401718)
Show SMILES CN(C(=O)c1cccc(Cl)c1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C15H12ClN3O/c1-19(14(20)10-5-4-6-11(16)9-10)15-17-12-7-2-3-8-13(12)18-15/h2-9H,1H3,(H,17,18)
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n/an/a 2.10E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083354
PNG
(CHEMBL3423091)
Show SMILES Fc1cccc(c1)[C@H]1C[C@@H]1C(=O)Nc1ccccc1F
Show InChI InChI=1/C16H13F2NO/c17-11-5-3-4-10(8-11)12-9-13(12)16(20)19-15-7-2-1-6-14(15)18/h1-8,12-13H,9H2,(H,19,20)/t12-,13+/s2
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n/an/a 2.10E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Mus musculus)
BDBM50083314
PNG
(CHEMBL3423099)
Show SMILES COc1cc(Br)ccc1NC(=O)[C@H]1C[C@@H]1c1cccc(Cl)c1
Show InChI InChI=1/C17H15BrClNO2/c1-22-16-8-11(18)5-6-15(16)20-17(21)14-9-13(14)10-3-2-4-12(19)7-10/h2-8,13-14H,9H2,1H3,(H,20,21)/t13-,14+/s2
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n/an/a 2.30E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...


Citation and Details
More data for this
Ligand-Target Pair