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Found 369 hits Enz. Inhib. hit(s) with Target = 'Methionine Aminopeptidase (MAP)' AND taxid = 83333   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170371
PNG
(5-Piperidin-1-ylmethyl-thiazole-4-carboxylic acid ...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CN1CCCCC1
Show InChI InChI=1S/C13H16N4OS2/c18-12(16-13-14-4-7-19-13)11-10(20-9-15-11)8-17-5-2-1-3-6-17/h4,7,9H,1-3,5-6,8H2,(H,14,16,18)
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n/an/a 10n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170370
PNG
(5-[2-Methoxy-2-(4-methoxy-phenyl)-ethyl]-thiazole-...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccc(OC)cc1
Show InChI InChI=1S/C17H17N3O3S2/c1-22-12-5-3-11(4-6-12)13(23-2)9-14-15(19-10-25-14)16(21)20-17-18-7-8-24-17/h3-8,10,13H,9H2,1-2H3,(H,18,20,21)
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n/an/a 23n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169672
PNG
(5-(Cyclopentanecarbonyl-amino)-thiazole-4-carboxyl...)
Show SMILES O=C(Nc1scnc1C(=O)Nc1nccs1)C1CCCC1
Show InChI InChI=1S/C13H14N4O2S2/c18-10(8-3-1-2-4-8)16-12-9(15-7-21-12)11(19)17-13-14-5-6-20-13/h5-8H,1-4H2,(H,16,18)(H,14,17,19)
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n/an/a 24n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170365
PNG
(5-Pyrrolidin-1-ylmethyl-thiazole-4-carboxylic acid...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CN1CCCC1
Show InChI InChI=1S/C12H14N4OS2/c17-11(15-12-13-3-6-18-12)10-9(19-8-14-10)7-16-4-1-2-5-16/h3,6,8H,1-2,4-5,7H2,(H,13,15,17)
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n/an/a 25n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170369
PNG
(5-(2-Ethoxy-3-methyl-butyl)-thiazole-4-carboxylic ...)
Show SMILES CCOC(Cc1scnc1C(=O)Nc1nccs1)C(C)C
Show InChI InChI=1S/C14H19N3O2S2/c1-4-19-10(9(2)3)7-11-12(16-8-21-11)13(18)17-14-15-5-6-20-14/h5-6,8-10H,4,7H2,1-3H3,(H,15,17,18)
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n/an/a 28n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169661
PNG
(5-(2-Benzyloxy-acetylamino)-thiazole-4-carboxylic ...)
Show SMILES O=C(COCc1ccccc1)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C16H14N4O3S2/c21-12(9-23-8-11-4-2-1-3-5-11)19-15-13(18-10-25-15)14(22)20-16-17-6-7-24-16/h1-7,10H,8-9H2,(H,19,21)(H,17,20,22)
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n/an/a 29n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170386
PNG
(CHEMBL366071 | Phenyl-acetic acid 2-[4-(thiazol-2-...)
Show SMILES O=C(Cc1ccccc1)OCCc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C17H15N3O3S2/c21-14(10-12-4-2-1-3-5-12)23-8-6-13-15(19-11-25-13)16(22)20-17-18-7-9-24-17/h1-5,7,9,11H,6,8,10H2,(H,18,20,22)
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n/an/a 33n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170378
PNG
(5-[2-(4-Chloro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H14ClN3O2S2/c1-22-12(10-2-4-11(17)5-3-10)8-13-14(19-9-24-13)15(21)20-16-18-6-7-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 33n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170383
PNG
(5-[2-(2-Fluoro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccccc1F
Show InChI InChI=1S/C16H14FN3O2S2/c1-22-12(10-4-2-3-5-11(10)17)8-13-14(19-9-24-13)15(21)20-16-18-6-7-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 34n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170367
PNG
(5-[2-Methoxy-2-(2-methoxy-phenyl)-ethyl]-thiazole-...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccccc1OC
Show InChI InChI=1S/C17H17N3O3S2/c1-22-12-6-4-3-5-11(12)13(23-2)9-14-15(19-10-25-14)16(21)20-17-18-7-8-24-17/h3-8,10,13H,9H2,1-2H3,(H,18,20,21)
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n/an/a 35n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170388
PNG
(5-((R)-2-Methoxy-2-phenyl-ethyl)-thiazole-4-carbox...)
Show SMILES CO[C@H](Cc1scnc1C(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-21-12(11-5-3-2-4-6-11)9-13-14(18-10-23-13)15(20)19-16-17-7-8-22-16/h2-8,10,12H,9H2,1H3,(H,17,19,20)/t12-/m1/s1
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n/an/a 36n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170358
PNG
(5-[2-(3-Fluoro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1cccc(F)c1
Show InChI InChI=1S/C16H14FN3O2S2/c1-22-12(10-3-2-4-11(17)7-10)8-13-14(19-9-24-13)15(21)20-16-18-5-6-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 37n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169669
PNG
(5-(Cyclobutanecarbonyl-amino)-thiazole-4-carboxyli...)
Show SMILES O=C(Nc1scnc1C(=O)Nc1nccs1)C1CCC1
Show InChI InChI=1S/C12H12N4O2S2/c17-9(7-2-1-3-7)15-11-8(14-6-20-11)10(18)16-12-13-4-5-19-12/h4-7H,1-3H2,(H,15,17)(H,13,16,18)
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n/an/a 40n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170364
PNG
(Benzoic acid 2-[4-(thiazol-2-ylcarbamoyl)-thiazol-...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CCOC(=O)c1ccccc1
Show InChI InChI=1S/C16H13N3O3S2/c20-14(19-16-17-7-9-23-16)13-12(24-10-18-13)6-8-22-15(21)11-4-2-1-3-5-11/h1-5,7,9-10H,6,8H2,(H,17,19,20)
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n/an/a 41n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169676
PNG
(5-(Cyclopropanecarbonyl-amino)-thiazole-4-carboxyl...)
Show SMILES O=C(Nc1scnc1C(=O)Nc1nccs1)C1CC1
Show InChI InChI=1S/C11H10N4O2S2/c16-8(6-1-2-6)14-10-7(13-5-19-10)9(17)15-11-12-3-4-18-11/h3-6H,1-2H2,(H,14,16)(H,12,15,17)
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n/an/a 42n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170382
PNG
(5-(2-Methoxy-2-phenyl-ethyl)-thiazole-4-carboxylic...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-21-12(11-5-3-2-4-6-11)9-13-14(18-10-23-13)15(20)19-16-17-7-8-22-16/h2-8,10,12H,9H2,1H3,(H,17,19,20)
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n/an/a 43n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169656
PNG
(5-(2-Methyl-but-3-enoylamino)-thiazole-4-carboxyli...)
Show SMILES CC(C=C)C(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H12N4O2S2/c1-3-7(2)9(17)15-11-8(14-6-20-11)10(18)16-12-13-4-5-19-12/h3-7H,1H2,2H3,(H,15,17)(H,13,16,18)
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n/an/a 44n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170361
PNG
(5-(2-Piperidin-1-yl-ethyl)-thiazole-4-carboxylic a...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CCN1CCCCC1
Show InChI InChI=1S/C14H18N4OS2/c19-13(17-14-15-5-9-20-14)12-11(21-10-16-12)4-8-18-6-2-1-3-7-18/h5,9-10H,1-4,6-8H2,(H,15,17,19)
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n/an/a 45n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169665
PNG
(5-But-3-enoylamino-thiazole-4-carboxylic acid thia...)
Show SMILES C=CCC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C11H10N4O2S2/c1-2-3-7(16)14-10-8(13-6-19-10)9(17)15-11-12-4-5-18-11/h2,4-6H,1,3H2,(H,14,16)(H,12,15,17)
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n/an/a 54n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170389
PNG
(5-(2-Cyclohexyl-2-methoxy-ethyl)-thiazole-4-carbox...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)C1CCCCC1
Show InChI InChI=1S/C16H21N3O2S2/c1-21-12(11-5-3-2-4-6-11)9-13-14(18-10-23-13)15(20)19-16-17-7-8-22-16/h7-8,10-12H,2-6,9H2,1H3,(H,17,19,20)
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n/an/a 54n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170379
PNG
(5-Morpholin-4-ylmethyl-thiazole-4-carboxylic acid ...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CN1CCOCC1
Show InChI InChI=1S/C12H14N4O2S2/c17-11(15-12-13-1-6-19-12)10-9(20-8-14-10)7-16-2-4-18-5-3-16/h1,6,8H,2-5,7H2,(H,13,15,17)
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n/an/a 55n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170366
PNG
(5-[2-(4-Fluoro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1ccc(F)cc1
Show InChI InChI=1S/C16H14FN3O2S2/c1-22-12(10-2-4-11(17)5-3-10)8-13-14(19-9-24-13)15(21)20-16-18-6-7-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 57n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169660
PNG
(CHEMBL176607 | [4-(Thiazol-2-ylcarbamoyl)-thiazol-...)
Show SMILES CC(C)(C)OC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H14N4O3S2/c1-12(2,3)19-11(18)16-9-7(14-6-21-9)8(17)15-10-13-4-5-20-10/h4-6H,1-3H3,(H,16,18)(H,13,15,17)
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n/an/a 60n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170359
PNG
(5-(Methoxy-phenyl-methyl)-thiazole-4-carboxylic ac...)
Show SMILES COC(c1scnc1C(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C15H13N3O2S2/c1-20-12(10-5-3-2-4-6-10)13-11(17-9-22-13)14(19)18-15-16-7-8-21-15/h2-9,12H,1H3,(H,16,18,19)
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n/an/a 61n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169670
PNG
(5-Phenethyl-thiazole-4-carboxylic acid thiazol-2-y...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CCc1ccccc1
Show InChI InChI=1S/C15H13N3OS2/c19-14(18-15-16-8-9-20-15)13-12(21-10-17-13)7-6-11-4-2-1-3-5-11/h1-5,8-10H,6-7H2,(H,16,18,19)
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n/an/a 65n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170384
PNG
(5-((S)-2-Methoxy-2-phenyl-ethyl)-thiazole-4-carbox...)
Show SMILES CO[C@@H](Cc1scnc1C(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-21-12(11-5-3-2-4-6-11)9-13-14(18-10-23-13)15(20)19-16-17-7-8-22-16/h2-8,10,12H,9H2,1H3,(H,17,19,20)/t12-/m0/s1
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n/an/a 66n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169685
PNG
(CHEMBL360353 | N-[4-(Thiazol-2-ylcarbamoyl)-thiazo...)
Show SMILES CCOC(=O)CC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H12N4O4S2/c1-2-20-8(18)5-7(17)15-11-9(14-6-22-11)10(19)16-12-13-3-4-21-12/h3-4,6H,2,5H2,1H3,(H,15,17)(H,13,16,19)
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n/an/a 66n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170387
PNG
(5-(2-Methoxy-2-methyl-propyl)-thiazole-4-carboxyli...)
Show SMILES COC(C)(C)Cc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H15N3O2S2/c1-12(2,17-3)6-8-9(14-7-19-8)10(16)15-11-13-4-5-18-11/h4-5,7H,6H2,1-3H3,(H,13,15,16)
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n/an/a 69n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169664
PNG
(5-(2-Methoxy-propyl)-thiazole-4-carboxylic acid th...)
Show SMILES COC(C)Cc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C11H13N3O2S2/c1-7(16-2)5-8-9(13-6-18-8)10(15)14-11-12-3-4-17-11/h3-4,6-7H,5H2,1-2H3,(H,12,14,15)
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n/an/a 74n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169664
PNG
(5-(2-Methoxy-propyl)-thiazole-4-carboxylic acid th...)
Show SMILES COC(C)Cc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C11H13N3O2S2/c1-7(16-2)5-8-9(13-6-18-8)10(15)14-11-12-3-4-17-11/h3-4,6-7H,5H2,1-2H3,(H,12,14,15)
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n/an/a 74n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169658
PNG
(5-(2-Fluoro-benzoylamino)-thiazole-4-carboxylic ac...)
Show SMILES Fc1ccccc1C(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H9FN4O2S2/c15-9-4-2-1-3-8(9)11(20)18-13-10(17-7-23-13)12(21)19-14-16-5-6-22-14/h1-7H,(H,18,20)(H,16,19,21)
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n/an/a 76n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169667
PNG
(Acetic acid [4-(thiazol-2-ylcarbamoyl)-thiazol-5-y...)
Show SMILES CC(=O)OCC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C11H10N4O4S2/c1-6(16)19-4-7(17)14-10-8(13-5-21-10)9(18)15-11-12-2-3-20-11/h2-3,5H,4H2,1H3,(H,14,17)(H,12,15,18)
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n/an/a 76n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50180755
PNG
(2-thiazol-4-yl-1H-imidazo[4,5-b]pyridine | CHEMBL1...)
Show SMILES c1nc(cs1)-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C9H6N4S/c1-2-6-8(10-3-1)13-9(12-6)7-4-14-5-11-7/h1-5H,(H,10,12,13)
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n/an/a 78n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of Co2+ loaded MetAP expressed in Escherichia coli


J Med Chem 49: 511-22 (2006)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169671
PNG
(5-Propionylamino-thiazole-4-carboxylic acid thiazo...)
Show SMILES CCC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H10N4O2S2/c1-2-6(15)13-9-7(12-5-18-9)8(16)14-10-11-3-4-17-10/h3-5H,2H2,1H3,(H,13,15)(H,11,14,16)
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n/an/a 81n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169684
PNG
(5-(2-Chloro-4-fluoro-benzyl)-thiazole-4-carboxylic...)
Show SMILES Fc1ccc(Cc2scnc2C(=O)Nc2nccs2)c(Cl)c1
Show InChI InChI=1S/C14H9ClFN3OS2/c15-10-6-9(16)2-1-8(10)5-11-12(18-7-22-11)13(20)19-14-17-3-4-21-14/h1-4,6-7H,5H2,(H,17,19,20)
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n/an/a 82n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169681
PNG
(CHEMBL178736 | N-[4-(Thiazol-2-ylcarbamoyl)-thiazo...)
Show SMILES OC(=O)CC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H8N4O4S2/c15-5(3-6(16)17)13-9-7(12-4-20-9)8(18)14-10-11-1-2-19-10/h1-2,4H,3H2,(H,13,15)(H,16,17)(H,11,14,18)
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n/an/a 88n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169679
PNG
(5-(2-Methoxy-3-methyl-butyl)-thiazole-4-carboxylic...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)C(C)C
Show InChI InChI=1S/C13H17N3O2S2/c1-8(2)9(18-3)6-10-11(15-7-20-10)12(17)16-13-14-4-5-19-13/h4-5,7-9H,6H2,1-3H3,(H,14,16,17)
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n/an/a 89n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169679
PNG
(5-(2-Methoxy-3-methyl-butyl)-thiazole-4-carboxylic...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)C(C)C
Show InChI InChI=1S/C13H17N3O2S2/c1-8(2)9(18-3)6-10-11(15-7-20-10)12(17)16-13-14-4-5-19-13/h4-5,7-9H,6H2,1-3H3,(H,14,16,17)
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n/an/a 89n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170360
PNG
(5-(2-Methoxy-4-methyl-pentyl)-thiazole-4-carboxyli...)
Show SMILES COC(CC(C)C)Cc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H19N3O2S2/c1-9(2)6-10(19-3)7-11-12(16-8-21-11)13(18)17-14-15-4-5-20-14/h4-5,8-10H,6-7H2,1-3H3,(H,15,17,18)
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n/an/a 90n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170376
PNG
(5-(2-Benzyloxy-ethyl)-thiazole-4-carboxylic acid t...)
Show SMILES O=C(Nc1nccs1)c1ncsc1CCOCc1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c20-15(19-16-17-7-9-22-16)14-13(23-11-18-14)6-8-21-10-12-4-2-1-3-5-12/h1-5,7,9,11H,6,8,10H2,(H,17,19,20)
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n/an/a 90n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170374
PNG
(5-[2-(3-Chloro-phenyl)-2-methoxy-ethyl]-thiazole-4...)
Show SMILES COC(Cc1scnc1C(=O)Nc1nccs1)c1cccc(Cl)c1
Show InChI InChI=1S/C16H14ClN3O2S2/c1-22-12(10-3-2-4-11(17)7-10)8-13-14(19-9-24-13)15(21)20-16-18-5-6-23-16/h2-7,9,12H,8H2,1H3,(H,18,20,21)
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n/an/a 90n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169677
PNG
(5-(2-Methoxy-acetylamino)-thiazole-4-carboxylic ac...)
Show SMILES COCC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H10N4O3S2/c1-17-4-6(15)13-9-7(12-5-19-9)8(16)14-10-11-2-3-18-10/h2-3,5H,4H2,1H3,(H,13,15)(H,11,14,16)
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n/an/a 92n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170373
PNG
(5-Methoxymethyl-thiazole-4-carboxylic acid thiazol...)
Show SMILES COCc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C9H9N3O2S2/c1-14-4-6-7(11-5-16-6)8(13)12-9-10-2-3-15-9/h2-3,5H,4H2,1H3,(H,10,12,13)
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n/an/a 97n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50170381
PNG
(5-(2-Methoxy-hexyl)-thiazole-4-carboxylic acid thi...)
Show SMILES CCCCC(Cc1scnc1C(=O)Nc1nccs1)OC
Show InChI InChI=1S/C14H19N3O2S2/c1-3-4-5-10(19-2)8-11-12(16-9-21-11)13(18)17-14-15-6-7-20-14/h6-7,9-10H,3-5,8H2,1-2H3,(H,15,17,18)
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n/an/a 100n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169683
PNG
(5-Isobutyl-thiazole-4-carboxylic acid thiazol-2-yl...)
Show SMILES CC(C)Cc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C11H13N3OS2/c1-7(2)5-8-9(13-6-17-8)10(15)14-11-12-3-4-16-11/h3-4,6-7H,5H2,1-2H3,(H,12,14,15)
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n/an/a 100n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50180731
PNG
(2-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridine | 2-pyr...)
Show SMILES c1ccc(nc1)-c1nc2ncccc2[nH]1
Show InChI InChI=1S/C11H8N4/c1-2-6-12-8(4-1)11-14-9-5-3-7-13-10(9)15-11/h1-7H,(H,13,14,15)
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n/an/a 105n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of Co2+ loaded MetAP expressed in Escherichia coli


J Med Chem 49: 511-22 (2006)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169662
PNG
(CHEMBL175540 | Thiazole-4-carboxylic acid thiazol-...)
Show SMILES O=C(Nc1nccs1)c1cscn1
Show InChI InChI=1S/C7H5N3OS2/c11-6(5-3-12-4-9-5)10-7-8-1-2-13-7/h1-4H,(H,8,10,11)
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n/an/a 110n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169662
PNG
(CHEMBL175540 | Thiazole-4-carboxylic acid thiazol-...)
Show SMILES O=C(Nc1nccs1)c1cscn1
Show InChI InChI=1S/C7H5N3OS2/c11-6(5-3-12-4-9-5)10-7-8-1-2-13-7/h1-4H,(H,8,10,11)
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n/an/a 110n/an/an/an/an/an/a



Shanghai Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against EcMetAP1 enzyme activity


Bioorg Med Chem Lett 15: 4130-5 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169673
PNG
(5-(2-Morpholin-4-yl-acetylamino)-thiazole-4-carbox...)
Show SMILES O=C(CN1CCOCC1)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C13H15N5O3S2/c19-9(7-18-2-4-21-5-3-18)16-12-10(15-8-23-12)11(20)17-13-14-1-6-22-13/h1,6,8H,2-5,7H2,(H,16,19)(H,14,17,20)
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n/an/a 110n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169686
PNG
(5-(4-Fluoro-benzoylamino)-thiazole-4-carboxylic ac...)
Show SMILES Fc1ccc(cc1)C(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H9FN4O2S2/c15-9-3-1-8(2-4-9)11(20)18-13-10(17-7-23-13)12(21)19-14-16-5-6-22-14/h1-7H,(H,18,20)(H,16,19,21)
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n/an/a 110n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)

More data for this
Ligand-Target Pair
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