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Compile Data Set for Download or QSAR

Found 12 hits Enz. Inhib. hit(s) with Target = 'Methyl-CpG-binding protein 2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM158512
PNG
(US9034574, XXII)
Show SMILES Oc1ccc2ccccc2c1C1NN=C(S1)c1ccccc1
Show InChI InChI=1/C18H14N2OS/c21-15-11-10-12-6-4-5-9-14(12)16(15)18-20-19-17(22-18)13-7-2-1-3-8-13/h1-11,18,20-21H
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US Patent
n/an/a 610n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM47368
PNG
(BDBM77674 | US9034574, XXIV)
Show SMILES COc1ccc(NC(=O)Nc2cccc3cccnc23)cc1
Show InChI InChI=1S/C17H15N3O2/c1-22-14-9-7-13(8-10-14)19-17(21)20-15-6-2-4-12-5-3-11-18-16(12)15/h2-11H,1H3,(H2,19,20,21)
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US Patent
n/an/a 2.81E+3n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM47366
PNG
(US9034574, XXIII)
Show SMILES Nc1cccc(c1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H11N3O/c15-12-8-4-7-11(9-12)14-17-16-13(18-14)10-5-2-1-3-6-10/h1-9H,15H2
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US Patent
n/an/a 8.59E+3n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM50264020
PNG
(CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
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US Patent
n/an/a 1.05E+4n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM158508
PNG
(US9034574, XVII)
Show SMILES Oc1ccc(cc1)C1NN=C(S1)c1ccccc1
Show InChI InChI=1/C14H12N2OS/c17-12-8-6-11(7-9-12)14-16-15-13(18-14)10-4-2-1-3-5-10/h1-9,14,16-17H
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n/an/a 1.69E+4n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM158511
PNG
(US9034574, XXI)
Show SMILES Clc1ccc(cc1)C1NN=C(S1)c1ccccc1
Show InChI InChI=1/C14H11ClN2S/c15-12-8-6-11(7-9-12)14-17-16-13(18-14)10-4-2-1-3-5-10/h1-9,14,17H
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n/an/a 3.39E+4n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM158510
PNG
(US9034574, XX)
Show SMILES OC1(CC(=NN1C(=S)c1ccccc1)c1ccccc1)C(F)(F)F
Show InChI InChI=1/C17H13F3N2OS/c18-17(19,20)16(23)11-14(12-7-3-1-4-8-12)21-22(16)15(24)13-9-5-2-6-10-13/h1-10,23H,11H2
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n/an/a>2.00E+5n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM47369
PNG
(US9034574, XXV)
Show SMILES CCOc1ccc(Nc2nc(cs2)-c2ccccn2)cc1
Show InChI InChI=1S/C16H15N3OS/c1-2-20-13-8-6-12(7-9-13)18-16-19-15(11-21-16)14-5-3-4-10-17-14/h3-11H,2H2,1H3,(H,18,19)
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n/an/a>2.00E+5n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM158507
PNG
(US9034574, Add | US9034574, III)
Show SMILES Cn1c2ccccc2n2cc(nc12)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C16H12N4O2/c1-18-14-4-2-3-5-15(14)19-10-13(17-16(18)19)11-6-8-12(9-7-11)20(21)22/h2-10H,1H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM158509
PNG
(US9034574, XVIII)
Show SMILES COc1cc(O)cc(Br)c1\C=N\Nc1nc2ccccc2s1
Show InChI InChI=1S/C15H12BrN3O2S/c1-21-13-7-9(20)6-11(16)10(13)8-17-19-15-18-12-4-2-3-5-14(12)22-15/h2-8,20H,1H3,(H,18,19)/b17-8+
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n/an/a>2.00E+5n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM47365
PNG
(US9034574, X)
Show SMILES COc1ccccc1-c1nc(no1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C15H11N3O4/c1-21-13-8-3-2-7-12(13)15-16-14(17-22-15)10-5-4-6-11(9-10)18(19)20/h2-9H,1H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3


(Homo sapiens)
BDBM158506
PNG
(US9034574, II)
Show SMILES Oc1cccc(Nc2nc(cs2)-c2ccccn2)c1
Show InChI InChI=1S/C14H11N3OS/c18-11-5-3-4-10(8-11)16-14-17-13(9-19-14)12-6-1-2-7-15-12/h1-9,18H,(H,16,17)
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n/an/a>2.00E+5n/an/an/an/an/an/a



The Johns Hopkins University

US Patent


Assay Description
DNA binding assays using recombinant MBDs. To produce recombinant His6-tagged MBD polypeptides from human MBD2 (MBD2-MBD), MBD2-MBD cDNA was amplifie...


US Patent US9034574 (2015)

More data for this
Ligand-Target Pair