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Compile Data Set for Download or QSAR

Found 213 hits Enz. Inhib. hit(s) with Target = 'Microsomal triglyceride transfer protein' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50098322
PNG
(9-(4-{5-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)
Show SMILES Cc1ccc2n(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc34)cnc2c1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C42H34F6N4O2/c1-26-16-21-35-37(36(26)51-38(53)32-13-3-2-10-29(32)27-17-19-28(20-18-27)42(46,47)48)50-25-52(35)23-9-8-22-40(39(54)49-24-41(43,44)45)33-14-6-4-11-30(33)31-12-5-7-15-34(31)40/h2-7,10-21,25H,8-9,22-24H2,1H3,(H,49,54)(H,51,53)
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n/an/a 0.0200n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay


J Med Chem 44: 851-6 (2001)

More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50098321
PNG
(9-(4-{2,5-Dimethyl-4-[(4'-trifluoromethyl-biphenyl...)
Show SMILES Cc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)c(C)ccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C43H36F6N4O2/c1-26-17-22-36-38(37(26)52-39(54)33-14-4-3-11-30(33)28-18-20-29(21-19-28)43(47,48)49)51-27(2)53(36)24-10-9-23-41(40(55)50-25-42(44,45)46)34-15-7-5-12-31(34)32-13-6-8-16-35(32)41/h3-8,11-22H,9-10,23-25H2,1-2H3,(H,50,55)(H,52,54)
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n/an/a 0.0300n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay


J Med Chem 44: 851-6 (2001)

More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50098326
PNG
(9-(4-{2-Isopropyl-4-[(4'-trifluoromethyl-biphenyl-...)
Show SMILES CC(C)c1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C44H38F6N4O2/c1-27(2)39-53-38-36(52-40(55)33-15-4-3-12-30(33)28-20-22-29(23-21-28)44(48,49)50)18-11-19-37(38)54(39)25-10-9-24-42(41(56)51-26-43(45,46)47)34-16-7-5-13-31(34)32-14-6-8-17-35(32)42/h3-8,11-23,27H,9-10,24-26H2,1-2H3,(H,51,56)(H,52,55)
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n/an/a 0.0600n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay


J Med Chem 44: 851-6 (2001)

More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50098324
PNG
(9-(4-{2-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)
Show SMILES Cc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C42H34F6N4O2/c1-26-50-37-35(51-38(53)32-14-3-2-11-29(32)27-19-21-28(22-20-27)42(46,47)48)17-10-18-36(37)52(26)24-9-8-23-40(39(54)49-25-41(43,44)45)33-15-6-4-12-30(33)31-13-5-7-16-34(31)40/h2-7,10-22H,8-9,23-25H2,1H3,(H,49,54)(H,51,53)
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n/an/a 0.150n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay


J Med Chem 44: 851-6 (2001)

More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50098325
PNG
(9-(4-{4-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-...)
Show SMILES FC(F)(F)CNC(=O)C1(CCCCn2cnc3c(NC(=O)c4ccccc4-c4ccc(cc4)C(F)(F)F)cccc23)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C41H32F6N4O2/c42-40(43,44)24-48-38(53)39(32-14-5-3-11-29(32)30-12-4-6-15-33(30)39)22-7-8-23-51-25-49-36-34(16-9-17-35(36)51)50-37(52)31-13-2-1-10-28(31)26-18-20-27(21-19-26)41(45,46)47/h1-6,9-21,25H,7-8,22-24H2,(H,48,53)(H,50,52)
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n/an/a 0.240n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay


J Med Chem 44: 851-6 (2001)

More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391864
PNG
(CHEMBL2147287)
Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1
Show InChI InChI=1S/C43H39FN4O3/c1-43(2,3)33-20-16-29(17-21-33)35-12-8-9-13-36(35)41(50)46-38-25-19-31-26-32(18-24-37(31)45-38)40(49)47-39(30-10-6-5-7-11-30)42(51)48(4)27-28-14-22-34(44)23-15-28/h5-26,39H,27H2,1-4H3,(H,47,49)(H,45,46,50)/t39-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391862
PNG
(CHEMBL2147285)
Show SMILES CCCc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C42H37FN4O3/c1-3-9-28-14-18-30(19-15-28)35-12-7-8-13-36(35)41(49)45-38-25-21-32-26-33(20-24-37(32)44-38)40(48)46-39(31-10-5-4-6-11-31)42(50)47(2)27-29-16-22-34(43)23-17-29/h4-8,10-26,39H,3,9,27H2,1-2H3,(H,46,48)(H,44,45,49)/t39-/m0/s1
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n/an/a 0.440n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391861
PNG
(CHEMBL2147284)
Show SMILES CCc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C41H35FN4O3/c1-3-27-13-17-29(18-14-27)34-11-7-8-12-35(34)40(48)44-37-24-20-31-25-32(19-23-36(31)43-37)39(47)45-38(30-9-5-4-6-10-30)41(49)46(2)26-28-15-21-33(42)22-16-28/h4-25,38H,3,26H2,1-2H3,(H,45,47)(H,43,44,48)/t38-/m0/s1
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n/an/a 0.550n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391875
PNG
(CHEMBL2147296)
Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1
Show InChI InChI=1S/C36H34N4O3/c1-36(2,3)27-18-14-23(15-19-27)28-12-8-9-13-29(28)34(42)39-31-21-17-25-22-26(16-20-30(25)38-31)33(41)40-32(35(43)37-4)24-10-6-5-7-11-24/h5-22,32H,1-4H3,(H,37,43)(H,40,41)(H,38,39,42)/t32-/m0/s1
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n/an/a 0.560n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50277189
PNG
((R)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3C[C@H](Cc3c2)NCc2nccs2)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N3OS/c1-17-3-2-4-24(26(17)18-5-8-21(9-6-18)28(29,30)31)27(35)34-22-10-7-19-13-23(15-20(19)14-22)33-16-25-32-11-12-36-25/h2-12,14,23,33H,13,15-16H2,1H3,(H,34,35)/t23-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391863
PNG
(CHEMBL2147286)
Show SMILES CC(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C42H37FN4O3/c1-27(2)29-15-17-30(18-16-29)35-11-7-8-12-36(35)41(49)45-38-24-20-32-25-33(19-23-37(32)44-38)40(48)46-39(31-9-5-4-6-10-31)42(50)47(3)26-28-13-21-34(43)22-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391869
PNG
(CHEMBL2147301)
Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(OC(C)C)cc3)ccc2c1)c1ccccc1
Show InChI InChI=1S/C35H32N4O4/c1-22(2)43-27-17-13-23(14-18-27)28-11-7-8-12-29(28)34(41)38-31-20-16-25-21-26(15-19-30(25)37-31)33(40)39-32(35(42)36-3)24-9-5-4-6-10-24/h4-22,32H,1-3H3,(H,36,42)(H,39,40)(H,37,38,41)/t32-/m0/s1
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n/an/a 0.630n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391863
PNG
(CHEMBL2147286)
Show SMILES CC(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C42H37FN4O3/c1-27(2)29-15-17-30(18-16-29)35-11-7-8-12-36(35)41(49)45-38-24-20-32-25-33(19-23-37(32)44-38)40(48)46-39(31-9-5-4-6-10-31)42(50)47(3)26-28-13-21-34(43)22-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391858
PNG
(CHEMBL2147281)
Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2c1)c1ccccc1
Show InChI InChI=1S/C40H30F4N4O3/c1-48(24-25-11-19-31(41)20-12-25)39(51)36(27-7-3-2-4-8-27)47-37(49)29-15-21-34-28(23-29)16-22-35(45-34)46-38(50)33-10-6-5-9-32(33)26-13-17-30(18-14-26)40(42,43)44/h2-23,36H,24H2,1H3,(H,47,49)(H,45,46,50)/t36-/m0/s1
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n/an/a 0.740n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391867
PNG
(CHEMBL2147290)
Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C42H37FN4O4/c1-27(2)51-34-21-15-29(16-22-34)35-11-7-8-12-36(35)41(49)45-38-24-18-31-25-32(17-23-37(31)44-38)40(48)46-39(30-9-5-4-6-10-30)42(50)47(3)26-28-13-19-33(43)20-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1
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n/an/a 0.770n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50098320
PNG
(9-(4-{4-[(4''-Trifluoromethyl-biphenyl-2-carbonyl)...)
Show SMILES FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
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n/an/a 0.800n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay


J Med Chem 44: 851-6 (2001)

More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391865
PNG
(CHEMBL2147291)
Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(OC(C)(C)C)cc3)ccc2c1)c1ccccc1
Show InChI InChI=1S/C43H39FN4O4/c1-43(2,3)52-34-22-16-29(17-23-34)35-12-8-9-13-36(35)41(50)46-38-25-19-31-26-32(18-24-37(31)45-38)40(49)47-39(30-10-6-5-7-11-30)42(51)48(4)27-28-14-20-33(44)21-15-28/h5-26,39H,27H2,1-4H3,(H,47,49)(H,45,46,50)/t39-/m0/s1
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n/an/a 0.830n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50107789
PNG
((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)
Show SMILES COC(=O)N[C@@H]1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1
Show InChI InChI=1S/C26H23F3N2O3/c1-15-4-3-5-22(23(15)16-6-9-19(10-7-16)26(27,28)29)24(32)30-20-11-8-17-12-21(14-18(17)13-20)31-25(33)34-2/h3-11,13,21H,12,14H2,1-2H3,(H,30,32)(H,31,33)/t21-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50098324
PNG
(9-(4-{2-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)
Show SMILES Cc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C42H34F6N4O2/c1-26-50-37-35(51-38(53)32-14-3-2-11-29(32)27-19-21-28(22-20-27)42(46,47)48)17-10-18-36(37)52(26)24-9-8-23-40(39(54)49-25-41(43,44)45)33-15-6-4-12-30(33)31-13-5-7-16-34(31)40/h2-7,10-22H,8-9,23-25H2,1H3,(H,49,54)(H,51,53)
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n/an/a 1n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)


J Med Chem 44: 851-6 (2001)

More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50098321
PNG
(9-(4-{2,5-Dimethyl-4-[(4'-trifluoromethyl-biphenyl...)
Show SMILES Cc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)c(C)ccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C43H36F6N4O2/c1-26-17-22-36-38(37(26)52-39(54)33-14-4-3-11-30(33)28-18-20-29(21-19-28)43(47,48)49)51-27(2)53(36)24-10-9-23-41(40(55)50-25-42(44,45)46)34-15-7-5-12-31(34)32-13-6-8-16-35(32)41/h3-8,11-22H,9-10,23-25H2,1-2H3,(H,50,55)(H,52,54)
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n/an/a 1n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)


J Med Chem 44: 851-6 (2001)

More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391858
PNG
(CHEMBL2147281)
Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2c1)c1ccccc1
Show InChI InChI=1S/C40H30F4N4O3/c1-48(24-25-11-19-31(41)20-12-25)39(51)36(27-7-3-2-4-8-27)47-37(49)29-15-21-34-28(23-29)16-22-35(45-34)46-38(50)33-10-6-5-9-32(33)26-13-17-30(18-14-26)40(42,43)44/h2-23,36H,24H2,1H3,(H,47,49)(H,45,46,50)/t36-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50098322
PNG
(9-(4-{5-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)
Show SMILES Cc1ccc2n(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc34)cnc2c1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C42H34F6N4O2/c1-26-16-21-35-37(36(26)51-38(53)32-13-3-2-10-29(32)27-17-19-28(20-18-27)42(46,47)48)50-25-52(35)23-9-8-22-40(39(54)49-24-41(43,44)45)33-14-6-4-11-30(33)31-12-5-7-15-34(31)40/h2-7,10-21,25H,8-9,22-24H2,1H3,(H,49,54)(H,51,53)
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n/an/a 1n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)


J Med Chem 44: 851-6 (2001)

More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184105
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Show SMILES COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1
Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-19-25(39-31(41)27-10-6-5-9-26(27)22-13-15-24(16-14-22)34(35,36)37)17-18-28(29)32(42)40-30(23-7-3-2-4-8-23)33(43)38-20-21-11-12-21/h2-10,13-19,21,30H,11-12,20H2,1H3,(H,38,43)(H,39,41)(H,40,42)/t30-/m0/s1
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n/an/a 1.01n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391876
PNG
(CHEMBL2147292)
Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)CO)ccc2c1)c1ccccc1
Show InChI InChI=1S/C43H39FN4O4/c1-43(2,27-49)33-19-15-29(16-20-33)35-11-7-8-12-36(35)41(51)46-38-24-18-31-25-32(17-23-37(31)45-38)40(50)47-39(30-9-5-4-6-10-30)42(52)48(3)26-28-13-21-34(44)22-14-28/h4-25,39,49H,26-27H2,1-3H3,(H,47,50)(H,45,46,51)/t39-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391873
PNG
(CHEMBL2147297)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C42H37FN4O3/c1-42(2,3)32-19-15-28(16-20-32)34-11-7-8-12-35(34)40(49)46-37-24-18-30-25-31(17-23-36(30)45-37)39(48)47-38(29-9-5-4-6-10-29)41(50)44-26-27-13-21-33(43)22-14-27/h4-25,38H,26H2,1-3H3,(H,44,50)(H,47,48)(H,45,46,49)/t38-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391864
PNG
(CHEMBL2147287)
Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1
Show InChI InChI=1S/C43H39FN4O3/c1-43(2,3)33-20-16-29(17-21-33)35-12-8-9-13-36(35)41(50)46-38-25-19-31-26-32(18-24-37(31)45-38)40(49)47-39(30-10-6-5-7-11-30)42(51)48(4)27-28-14-22-34(44)23-15-28/h5-26,39H,27H2,1-4H3,(H,47,49)(H,45,46,50)/t39-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391868
PNG
(CHEMBL2146489)
Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C41H35FN4O4/c1-26(2)50-33-20-14-28(15-21-33)34-10-6-7-11-35(34)40(48)45-37-23-17-30-24-31(16-22-36(30)44-37)39(47)46-38(29-8-4-3-5-9-29)41(49)43-25-27-12-18-32(42)19-13-27/h3-24,26,38H,25H2,1-2H3,(H,43,49)(H,46,47)(H,44,45,48)/t38-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391857
PNG
(CHEMBL2147280)
Show SMILES Cn1c(cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc12)C(=O)N[C@H](C(N)=O)c1ccccc1
Show InChI InChI=1S/C32H25F3N4O3/c1-39-26-16-15-23(17-21(26)18-27(39)31(42)38-28(29(36)40)20-7-3-2-4-8-20)37-30(41)25-10-6-5-9-24(25)19-11-13-22(14-12-19)32(33,34)35/h2-18,28H,1H3,(H2,36,40)(H,37,41)(H,38,42)/t28-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184109
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...)
Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(C)c1)c1ccccc1
Show InChI InChI=1S/C33H30F3N3O3/c1-3-19-37-32(42)29(23-9-5-4-6-10-23)39-30(40)24-15-18-28(21(2)20-24)38-31(41)27-12-8-7-11-26(27)22-13-16-25(17-14-22)33(34,35)36/h4-18,20,29H,3,19H2,1-2H3,(H,37,42)(H,38,41)(H,39,40)/t29-/m0/s1
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n/an/a 1.64n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184153
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1
Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-19-24(31(41)40-30(23-7-3-2-4-8-23)33(43)38-20-21-11-12-21)15-18-28(29)39-32(42)27-10-6-5-9-26(27)22-13-16-25(17-14-22)34(35,36)37/h2-10,13-19,21,30H,11-12,20H2,1H3,(H,38,43)(H,39,42)(H,40,41)/t30-/m0/s1
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n/an/a 1.68n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184111
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...)
Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-21-24(31(41)39-30(23-9-3-2-4-10-23)33(43)40-19-7-8-20-40)15-18-28(29)38-32(42)27-12-6-5-11-26(27)22-13-16-25(17-14-22)34(35,36)37/h2-6,9-18,21,30H,7-8,19-20H2,1H3,(H,38,42)(H,39,41)/t30-/m0/s1
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n/an/a 1.75n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184165
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Show SMILES Cc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1
Show InChI InChI=1S/C34H30F3N3O3/c1-21-19-25(31(41)40-30(24-7-3-2-4-8-24)33(43)38-20-22-11-12-22)15-18-29(21)39-32(42)28-10-6-5-9-27(28)23-13-16-26(17-14-23)34(35,36)37/h2-10,13-19,22,30H,11-12,20H2,1H3,(H,38,43)(H,39,42)(H,40,41)/t30-/m0/s1
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n/an/a 1.78n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391856
PNG
(CHEMBL2147279)
Show SMILES CNC(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1
Show InChI InChI=1S/C33H27F3N4O3/c1-37-32(43)29(21-8-4-3-5-9-21)39-31(42)28-19-22-18-24(16-17-27(22)40(28)2)38-30(41)26-11-7-6-10-25(26)20-12-14-23(15-13-20)33(34,35)36/h3-19,29H,1-2H3,(H,37,43)(H,38,41)(H,39,42)/t29-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50098323
PNG
(9-(4-{2-Propyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)
Show SMILES CCCc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C44H38F6N4O2/c1-2-12-38-53-39-36(52-40(55)33-16-4-3-13-30(33)28-21-23-29(24-22-28)44(48,49)50)19-11-20-37(39)54(38)26-10-9-25-42(41(56)51-27-43(45,46)47)34-17-7-5-14-31(34)32-15-6-8-18-35(32)42/h3-8,11,13-24H,2,9-10,12,25-27H2,1H3,(H,51,56)(H,52,55)
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n/an/a 2n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)


J Med Chem 44: 851-6 (2001)

More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184118
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...)
Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(OC)c1)c1ccccc1
Show InChI InChI=1S/C33H30F3N3O4/c1-3-19-37-32(42)29(22-9-5-4-6-10-22)39-30(40)23-15-18-27(28(20-23)43-2)38-31(41)26-12-8-7-11-25(26)21-13-16-24(17-14-21)33(34,35)36/h4-18,20,29H,3,19H2,1-2H3,(H,37,42)(H,38,41)(H,39,40)/t29-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391867
PNG
(CHEMBL2147290)
Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C42H37FN4O4/c1-27(2)51-34-21-15-29(16-22-34)35-11-7-8-12-36(35)41(49)45-38-24-18-31-25-32(17-23-37(31)44-38)40(48)46-39(30-9-5-4-6-10-30)42(50)47(3)26-28-13-19-33(43)20-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391860
PNG
(CHEMBL2147283)
Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(C)cc3)ccc2c1)c1ccccc1
Show InChI InChI=1S/C40H33FN4O3/c1-26-12-16-28(17-13-26)33-10-6-7-11-34(33)39(47)43-36-23-19-30-24-31(18-22-35(30)42-36)38(46)44-37(29-8-4-3-5-9-29)40(48)45(2)25-27-14-20-32(41)21-15-27/h3-24,37H,25H2,1-2H3,(H,44,46)(H,42,43,47)/t37-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184137
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Show SMILES CCCN(CC)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(OC)c1)c1ccccc1
Show InChI InChI=1S/C35H34F3N3O4/c1-4-21-41(5-2)34(44)31(24-11-7-6-8-12-24)40-32(42)25-17-20-29(30(22-25)45-3)39-33(43)28-14-10-9-13-27(28)23-15-18-26(19-16-23)35(36,37)38/h6-20,22,31H,4-5,21H2,1-3H3,(H,39,43)(H,40,42)/t31-/m0/s1
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n/an/a 2.34n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184127
PNG
(CHEMBL207443 | N-((S)-Phenyl-propylcarbamoyl-methy...)
Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)nc1)c1ccccc1
Show InChI InChI=1S/C31H27F3N4O3/c1-2-18-35-30(41)27(21-8-4-3-5-9-21)38-28(39)22-14-17-26(36-19-22)37-29(40)25-11-7-6-10-24(25)20-12-15-23(16-13-20)31(32,33)34/h3-17,19,27H,2,18H2,1H3,(H,35,41)(H,38,39)(H,36,37,40)/t27-/m0/s1
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n/an/a 2.53n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50204367
PNG
(CHEMBL410414 | dirlotapide)
Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1
Show InChI InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391873
PNG
(CHEMBL2147297)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C42H37FN4O3/c1-42(2,3)32-19-15-28(16-20-32)34-11-7-8-12-35(34)40(49)46-37-24-18-30-25-31(17-23-36(30)45-37)39(48)47-38(29-9-5-4-6-10-29)41(50)44-26-27-13-21-33(43)22-14-27/h4-25,38H,26H2,1-3H3,(H,44,50)(H,47,48)(H,45,46,49)/t38-/m0/s1
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n/an/a 2.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391859
PNG
(CHEMBL2147282)
Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccccc3)ccc2c1)c1ccccc1
Show InChI InChI=1S/C39H31FN4O3/c1-44(25-26-16-20-31(40)21-17-26)39(47)36(28-12-6-3-7-13-28)43-37(45)30-18-22-34-29(24-30)19-23-35(41-34)42-38(46)33-15-9-8-14-32(33)27-10-4-2-5-11-27/h2-24,36H,25H2,1H3,(H,43,45)(H,41,42,46)/t36-/m0/s1
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n/an/a 2.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391878
PNG
(CHEMBL2147289)
Show SMILES CCOc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C41H35FN4O4/c1-3-50-33-21-15-28(16-22-33)34-11-7-8-12-35(34)40(48)44-37-24-18-30-25-31(17-23-36(30)43-37)39(47)45-38(29-9-5-4-6-10-29)41(49)46(2)26-27-13-19-32(42)20-14-27/h4-25,38H,3,26H2,1-2H3,(H,45,47)(H,43,44,48)/t38-/m0/s1
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n/an/a 2.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50204367
PNG
(CHEMBL410414 | dirlotapide)
Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1
Show InChI InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP assessed as inhibition of apoB secretion from human HepG2 cells


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184152
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-[(...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)NCc1ccc(cc1)C(=O)N[C@H](C(=O)NCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C37H30F3N3O3/c38-37(39,40)30-21-19-27(20-22-30)31-13-7-8-14-32(31)35(45)41-24-26-15-17-29(18-16-26)34(44)43-33(28-11-5-2-6-12-28)36(46)42-23-25-9-3-1-4-10-25/h1-22,33H,23-24H2,(H,41,45)(H,42,46)(H,43,44)/t33-/m0/s1
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n/an/a 2.97n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50153193
PNG
(CHEMBL186836 | Trans-9-{4-[5-(2-Benzooxazol-2-yl-b...)
Show SMILES FC(F)(F)CNC(=O)C1(CCCCP2(=O)OCC(CO2)NC(=O)c2ccccc2-c2nc3ccccc3o2)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C37H33F3N3O6P/c38-37(39,40)23-41-35(45)36(29-15-5-3-11-25(29)26-12-4-6-16-30(26)36)19-9-10-20-50(46)47-21-24(22-48-50)42-33(44)27-13-1-2-14-28(27)34-43-31-17-7-8-18-32(31)49-34/h1-8,11-18,24H,9-10,19-23H2,(H,41,45)(H,42,44)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human Microsomal triglyceride transfer protein


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50391879
PNG
(CHEMBL2147288)
Show SMILES COc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C40H33FN4O4/c1-45(25-26-12-18-31(41)19-13-26)40(48)37(28-8-4-3-5-9-28)44-38(46)30-16-22-35-29(24-30)17-23-36(42-35)43-39(47)34-11-7-6-10-33(34)27-14-20-32(49-2)21-15-27/h3-24,37H,25H2,1-2H3,(H,44,46)(H,42,43,47)/t37-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184138
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...)
Show SMILES Cc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C34H30F3N3O3/c1-22-21-25(31(41)39-30(24-9-3-2-4-10-24)33(43)40-19-7-8-20-40)15-18-29(22)38-32(42)28-12-6-5-11-27(28)23-13-16-26(17-14-23)34(35,36)37/h2-6,9-18,21,30H,7-8,19-20H2,1H3,(H,38,42)(H,39,41)/t30-/m0/s1
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n/an/a 3.37n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50107786
PNG
((R)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-di...)
Show SMILES Cc1cccc(C(=O)Nc2ccc3C[C@H](Cc3c2)NCc2ccccn2)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C30H26F3N3O/c1-19-5-4-7-27(28(19)20-8-11-23(12-9-20)30(31,32)33)29(37)36-24-13-10-21-15-26(17-22(21)16-24)35-18-25-6-2-3-14-34-25/h2-14,16,26,35H,15,17-18H2,1H3,(H,36,37)/t26-/m1/s1
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n/an/a 3.5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein


(Homo sapiens)
BDBM50184147
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {4-[...)
Show SMILES Cc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C37H30F3N3O3/c1-24-22-28(34(44)43-33(27-12-6-3-7-13-27)36(46)41-23-25-10-4-2-5-11-25)18-21-32(24)42-35(45)31-15-9-8-14-30(31)26-16-19-29(20-17-26)37(38,39)40/h2-22,33H,23H2,1H3,(H,41,46)(H,42,45)(H,43,44)/t33-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Citation and Details
More data for this
Ligand-Target Pair
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