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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Microtubule-associated protein tau' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein tau


(Rattus norvegicus)
BDBM50313696
PNG
(CHEMBL1086427 | N-(6-chloro-7-fluoro-5-phenyl-1H-i...)
Show SMILES CCCC(=O)Nc1n[nH]c2c(F)c(Cl)c(cc12)-c1ccccc1
Show InChI InChI=1S/C17H15ClFN3O/c1-2-6-13(23)20-17-12-9-11(10-7-4-3-5-8-10)14(18)15(19)16(12)21-22-17/h3-5,7-9H,2,6H2,1H3,(H2,20,21,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of Tau phosphorylation in rat cerebral cortex after 120 mins by chemiluminescence assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Rattus norvegicus)
BDBM50313661
PNG
(CHEMBL1095040 | N-(6-chloro-5-phenyl-1H-indazol-3-...)
Show SMILES CCCC(=O)Nc1n[nH]c2cc(Cl)c(cc12)-c1ccccc1
Show InChI InChI=1S/C17H16ClN3O/c1-2-6-16(22)19-17-13-9-12(11-7-4-3-5-8-11)14(18)10-15(13)20-21-17/h3-5,7-10H,2,6H2,1H3,(H2,19,20,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Sanofi-aventis

Curated by ChEMBL


Assay Description
Inhibition of Tau phosphorylation in rat cerebral cortex after 120 mins by chemiluminescence assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Rattus norvegicus)
BDBM50340902
PNG
((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluo...)
Show SMILES Nc1nc(Nc2cccnc2)sc1C(=O)c1ccccc1F
Show InChI InChI=1S/C15H11FN4OS/c16-11-6-2-1-5-10(11)12(21)13-14(17)20-15(22-13)19-9-4-3-7-18-8-9/h1-8H,17H2,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 5.50E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of tau protein phosphorylation at Ser396 in rat brain cells at 0.5 to 50 uM after 4 hrs


Citation and Details
More data for this
Ligand-Target Pair