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Compile Data Set for Download or QSAR

Found 616 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM50437408
PNG
(CHEMBL2408790 | US9023865, 2)
Show SMILES COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1
Show InChI InChI=1S/C26H28FN7O2/c1-16-11-17(8-9-28-16)25-19-13-29-24(12-22(19)32-33-25)31-26(35)30-18-5-4-10-34(14-18)15-20-21(27)6-3-7-23(20)36-2/h3,6-9,11-13,18H,4-5,10,14-15H2,1-2H3,(H,32,33)(H2,29,30,31,35)/t18-/m1/s1
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n/an/a 0.152n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM50437407
PNG
(CHEMBL2408789 | US9023865, 6)
Show SMILES C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccc1
Show InChI InChI=1S/C21H20N6O/c1-13-10-16(8-9-22-13)20-17-12-23-19(11-18(17)26-27-20)25-21(28)24-14(2)15-6-4-3-5-7-15/h3-12,14H,1-2H3,(H,26,27)(H2,23,24,25,28)/t14-/m1/s1
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n/an/a 0.152n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157165
PNG
(US9023865, 11)
Show SMILES C[C@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccc(F)cc1
Show InChI InChI=1/C21H19FN6O/c1-12-9-15(7-8-23-12)20-17-11-24-19(10-18(17)27-28-20)26-21(29)25-13(2)14-3-5-16(22)6-4-14/h3-11,13H,1-2H3,(H,27,28)(H2,24,25,26,29)/t13-/s2
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n/an/a 0.152n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157164
PNG
(US9023865, 10)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NC(CO)c3ccccc3)ncc12
Show InChI InChI=1/C21H20N6O2/c1-13-9-15(7-8-22-13)20-16-11-23-19(10-17(16)26-27-20)25-21(29)24-18(12-28)14-5-3-2-4-6-14/h2-11,18,28H,12H2,1H3,(H,26,27)(H2,23,24,25,29)
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n/an/a 0.215n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM50437406
PNG
(CHEMBL2408788 | US9023865, 9)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3ccccc3)ncc12
Show InChI InChI=1S/C20H18N6O/c1-13-9-15(7-8-21-13)19-16-12-22-18(10-17(16)25-26-19)24-20(27)23-11-14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H,25,26)(H2,22,23,24,27)
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n/an/a 0.222n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157173
PNG
(US9023865, 19)
Show SMILES C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccc(Cl)cc1
Show InChI InChI=1/C21H19ClN6O/c1-12-9-15(7-8-23-12)20-17-11-24-19(10-18(17)27-28-20)26-21(29)25-13(2)14-3-5-16(22)6-4-14/h3-11,13H,1-2H3,(H,27,28)(H2,24,25,26,29)/t13-/s2
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n/an/a 0.296n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203329
PNG
(US9242981, 61)
Show SMILES Cn1c(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)cc2ccccc12
Show InChI InChI=1/C27H31N7O/c1-32-22(15-20-5-2-3-7-25(20)32)17-33-13-4-6-21(16-33)29-27(35)34-14-10-24-23(18-34)26(31-30-24)19-8-11-28-12-9-19/h2-3,5,7-9,11-12,15,21H,4,6,10,13-14,16-18H2,1H3,(H,29,35)(H,30,31)/t21-/s2
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n/an/a 0.300n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157180
PNG
(US9023865, 26)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3ccc(Cl)cc3)ncc12
Show InChI InChI=1S/C20H17ClN6O/c1-12-8-14(6-7-22-12)19-16-11-23-18(9-17(16)26-27-19)25-20(28)24-10-13-2-4-15(21)5-3-13/h2-9,11H,10H2,1H3,(H,26,27)(H2,23,24,25,28)
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n/an/a 0.457n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203325
PNG
(US9242981, 57)
Show SMILES O=C(N[C@@H]1CCCN(Cc2csc3ccccc23)C1)N1CCc2[nH]nc(c2C1)-c1ccncc1
Show InChI InChI=1/C26H28N6OS/c33-26(32-13-9-23-22(16-32)25(30-29-23)18-7-10-27-11-8-18)28-20-4-3-12-31(15-20)14-19-17-34-24-6-2-1-5-21(19)24/h1-2,5-8,10-11,17,20H,3-4,9,12-16H2,(H,28,33)(H,29,30)/t20-/s2
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n/an/a 0.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157161
PNG
(US9023865, 5)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCCc3ccccc3)ncc12
Show InChI InChI=1S/C21H20N6O/c1-14-11-16(8-10-22-14)20-17-13-24-19(12-18(17)26-27-20)25-21(28)23-9-7-15-5-3-2-4-6-15/h2-6,8,10-13H,7,9H2,1H3,(H,26,27)(H2,23,24,25,28)
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n/an/a 0.502n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157163
PNG
(US9023865, 8)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3ccc(Cl)c(Cl)c3)ncc12
Show InChI InChI=1S/C20H16Cl2N6O/c1-11-6-13(4-5-23-11)19-14-10-24-18(8-17(14)27-28-19)26-20(29)25-9-12-2-3-15(21)16(22)7-12/h2-8,10H,9H2,1H3,(H,27,28)(H2,24,25,26,29)
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n/an/a 0.516n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157174
PNG
(US9023865, 20)
Show SMILES C[C@@H](NC(=O)Nc1cc2[nH]nc(C3=CCOCC3)c2cn1)c1ccccc1
Show InChI InChI=1/C20H21N5O2/c1-13(14-5-3-2-4-6-14)22-20(26)23-18-11-17-16(12-21-18)19(25-24-17)15-7-9-27-10-8-15/h2-7,11-13H,8-10H2,1H3,(H,24,25)(H2,21,22,23,26)/t13-/s2
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n/an/a 0.537n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154612
PNG
(US8999957, Column 165-167, Compound 1)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NOCC1CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1/C32H35FN6O4/c1-19-14-21(12-13-34-19)30-24-15-22(8-10-27(24)36-37-30)31(40)35-23-9-11-28(32(41)38-43-18-20-6-7-20)39(16-23)17-25-26(33)4-3-5-29(25)42-2/h3-5,8,10,12-15,20,23,28H,6-7,9,11,16-18H2,1-2H3,(H,35,40)(H,36,37)(H,38,41)/t23-,28+/s2
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n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203319
PNG
(US9242981, 48)
Show SMILES Fc1ccccc1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1
Show InChI InChI=1/C24H27FN6O/c25-21-6-2-1-4-18(21)14-30-12-3-5-19(15-30)27-24(32)31-13-9-22-20(16-31)23(29-28-22)17-7-10-26-11-8-17/h1-2,4,6-8,10-11,19H,3,5,9,12-16H2,(H,27,32)(H,28,29)/t19-/s2
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n/an/a 0.650n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM103302
PNG
(SCH772984 | US8546404, 6)
Show SMILES O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1
Show InChI InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



Merck Sharp & Dohme

US Patent


Assay Description
Activated ERK2 activity was determined in the IMAP assay format.


US Patent US8546404 (2013)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203317
PNG
(US9242981, 46)
Show SMILES CN1C[C@@H](NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)[C@@H](C1)c1ccccc1C
Show InChI InChI=1/C24H28N6O/c1-16-5-3-4-6-18(16)19-13-29(2)15-22(19)26-24(31)30-12-9-21-20(14-30)23(28-27-21)17-7-10-25-11-8-17/h3-8,10-11,19,22H,9,12-15H2,1-2H3,(H,26,31)(H,27,28)/t19-,22+/s2
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n/an/a 0.890n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157176
PNG
(US9023865, 22)
Show SMILES CCCc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12
Show InChI InChI=1/C18H21N5O/c1-3-7-15-14-11-19-17(10-16(14)23-22-15)21-18(24)20-12(2)13-8-5-4-6-9-13/h4-6,8-12H,3,7H2,1-2H3,(H,22,23)(H2,19,20,21,24)/t12-/s2
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n/an/a 0.919n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154874
PNG
(US8999957, Table 3, Compound 147)
Show SMILES CNC(=S)NNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1/C30H33FN8O3S/c1-17-13-18(11-12-33-17)27-21-14-19(7-9-24(21)35-36-27)28(40)34-20-8-10-25(29(41)37-38-30(43)32-2)39(15-20)16-22-23(31)5-4-6-26(22)42-3/h4-7,9,11-14,20,25H,8,10,15-16H2,1-3H3,(H,34,40)(H,35,36)(H,37,41)(H2,32,38,43)/t20-,25+/s2
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was a...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154863
PNG
(US8999957, Table 3, Compound 136)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(N)=O)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1/C28H29FN6O3/c1-16-12-17(10-11-31-16)26-20-13-18(6-8-23(20)33-34-26)28(37)32-19-7-9-24(27(30)36)35(14-19)15-21-22(29)4-3-5-25(21)38-2/h3-6,8,10-13,19,24H,7,9,14-15H2,1-2H3,(H2,30,36)(H,32,37)(H,33,34)/t19-,24+/s2
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was a...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154864
PNG
(US8999957, Table 3, Compound 137)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NN)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1/C28H30FN7O3/c1-16-12-17(10-11-31-16)26-20-13-18(6-8-23(20)34-35-26)27(37)32-19-7-9-24(28(38)33-30)36(14-19)15-21-22(29)4-3-5-25(21)39-2/h3-6,8,10-13,19,24H,7,9,14-15,30H2,1-2H3,(H,32,37)(H,33,38)(H,34,35)/t19-,24+/s2
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was a...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154613
PNG
(US8999957, Column 165-167, Compound 2)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(C)(O)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1/C32H35FN6O4/c1-19-13-20(11-12-34-19)29-23-14-21(7-9-26(23)36-37-29)30(40)35-22-8-10-27(31(41)39-17-32(2,42)18-39)38(15-22)16-24-25(33)5-4-6-28(24)43-3/h4-7,9,11-14,22,27,42H,8,10,15-18H2,1-3H3,(H,35,40)(H,36,37)/t22-,27+/s2
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n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154600
PNG
(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Show SMILES Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1
Show InChI InChI=1/C25H24FN5O/c26-22-6-2-1-4-19(22)15-31-13-3-5-20(16-31)28-25(32)18-7-8-23-21(14-18)24(30-29-23)17-9-11-27-12-10-17/h1-2,4,6-12,14,20H,3,5,13,15-16H2,(H,28,32)(H,29,30)/t20-/s2
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n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154600
PNG
(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Show SMILES Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1
Show InChI InChI=1/C25H24FN5O/c26-22-6-2-1-4-19(22)15-31-13-3-5-20(16-31)28-25(32)18-7-8-23-21(14-18)24(30-29-23)17-9-11-27-12-10-17/h1-2,4,6-12,14,20H,3,5,13,15-16H2,(H,28,32)(H,29,30)/t20-/s2
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n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157160
PNG
(US9023865, 4)
Show SMILES COc1cccc(F)c1CN1CCCC(C1)NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1
Show InChI InChI=1/C26H28FN7O2/c1-16-11-17(8-9-28-16)25-19-13-29-24(12-22(19)32-33-25)31-26(35)30-18-5-4-10-34(14-18)15-20-21(27)6-3-7-23(20)36-2/h3,6-9,11-13,18H,4-5,10,14-15H2,1-2H3,(H,32,33)(H2,29,30,31,35)
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n/an/a 1.12n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203308
PNG
(US9242981, 37)
Show SMILES O=C(N[C@H]1CNC[C@@H]1c1ccccc1)N1CCc2[nH]nc(c2C1)-c1ccncc1
Show InChI InChI=1/C22H24N6O/c29-22(25-20-13-24-12-17(20)15-4-2-1-3-5-15)28-11-8-19-18(14-28)21(27-26-19)16-6-9-23-10-7-16/h1-7,9-10,17,20,24H,8,11-14H2,(H,25,29)(H,26,27)/t17-,20+/s2
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n/an/a 1.16n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157168
PNG
(US9023865, 14)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3cccnc3)ncc12
Show InChI InChI=1S/C19H17N7O/c1-12-7-14(4-6-21-12)18-15-11-22-17(8-16(15)25-26-18)24-19(27)23-10-13-3-2-5-20-9-13/h2-9,11H,10H2,1H3,(H,25,26)(H2,22,23,24,27)
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n/an/a 1.16n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203328
PNG
(US9242981, 60)
Show SMILES Cn1cc(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)c2ccccc12
Show InChI InChI=1/C27H31N7O/c1-32-15-20(22-6-2-3-7-25(22)32)16-33-13-4-5-21(17-33)29-27(35)34-14-10-24-23(18-34)26(31-30-24)19-8-11-28-12-9-19/h2-3,6-9,11-12,15,21H,4-5,10,13-14,16-18H2,1H3,(H,29,35)(H,30,31)/t21-/s2
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n/an/a 1.24n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154614
PNG
(US8999957, Column 165-167, Compound 3)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NC[C@H]1CC[C@H](O)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1/C34H39FN6O4/c1-20-14-22(12-13-36-20)32-26-16-23(7-10-29(26)39-40-32)33(43)38-24-8-11-30(34(44)37-17-21-6-9-25(42)15-21)41(18-24)19-27-28(35)4-3-5-31(27)45-2/h3-5,7,10,12-14,16,21,24-25,30,42H,6,8-9,11,15,17-19H2,1-2H3,(H,37,44)(H,38,43)(H,39,40)/t21-,24+,25-,30-/s2
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154592
PNG
(US8999957, Column 143, Compound 1)
Show SMILES COc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(C3=CCOCC3)c2c1
Show InChI InChI=1/C26H29FN4O3/c1-33-24-6-2-5-22(27)21(24)16-31-11-3-4-19(15-31)28-26(32)18-7-8-23-20(14-18)25(30-29-23)17-9-12-34-13-10-17/h2,5-9,14,19H,3-4,10-13,15-16H2,1H3,(H,28,32)(H,29,30)/t19-/s2
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154897
PNG
(US8999957, Table 4, Compound 2)
Show SMILES CN1CC(Cc2c(F)cccc2F)CC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nn(C)cc4c3)c2c1
Show InChI InChI=1/C29H28F2N6O/c1-36-14-17(11-22-24(30)4-3-5-25(22)31)10-21(16-36)32-29(38)19-7-9-27-23(13-19)28(34-33-27)18-6-8-26-20(12-18)15-37(2)35-26/h3-9,12-13,15,17,21H,10-11,14,16H2,1-2H3,(H,32,38)(H,33,34)
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n/an/a 1.40n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was a...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154900
PNG
(US8999957, Table 4, Compound 5)
Show SMILES CN1C[C@@H](Cc2c(F)cccc2F)C[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)nn4c3)c2c1
Show InChI InChI=1/C28H27F2N7O/c1-16-31-26-9-7-19(14-37(26)35-16)27-22-12-18(6-8-25(22)33-34-27)28(38)32-20-10-17(13-36(2)15-20)11-21-23(29)4-3-5-24(21)30/h3-9,12,14,17,20H,10-11,13,15H2,1-2H3,(H,32,38)(H,33,34)/t17-,20-/s2
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n/an/a 1.45n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was a...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154617
PNG
(US8999957, Column 165-167, Compound 6)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)NC[C@@H]1CC[C@@H](O)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1/C34H39FN6O4/c1-20-14-22(12-13-36-20)32-26-16-23(7-10-29(26)39-40-32)33(43)38-24-8-11-30(34(44)37-17-21-6-9-25(42)15-21)41(18-24)19-27-28(35)4-3-5-31(27)45-2/h3-5,7,10,12-14,16,21,24-25,30,42H,6,8-9,11,15,17-19H2,1-2H3,(H,37,44)(H,38,43)(H,39,40)/t21-,24-,25-,30+/s2
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n/an/a 1.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203447
PNG
(US9242981, 145)
Show SMILES CN1CC(NC(=O)N2CCc3[nH]nc(c3C2)-c2ccc3OCCc3c2)C(C1)c1ccccc1C
Show InChI InChI=1/C27H31N5O2/c1-17-5-3-4-6-20(17)21-14-31(2)16-24(21)28-27(33)32-11-9-23-22(15-32)26(30-29-23)19-7-8-25-18(13-19)10-12-34-25/h3-8,13,21,24H,9-12,14-16H2,1-2H3,(H,28,33)(H,29,30)
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n/an/a 1.52n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154902
PNG
(US8999957, Table 4, Compound 7)
Show SMILES CN1C[C@H](Cc2c(F)cccc2F)C[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccn4ccnc4c3)c2c1
Show InChI InChI=1/C28H26F2N6O/c1-35-15-17(12-21-23(29)3-2-4-24(21)30)11-20(16-35)32-28(37)19-5-6-25-22(13-19)27(34-33-25)18-7-9-36-10-8-31-26(36)14-18/h2-10,13-14,17,20H,11-12,15-16H2,1H3,(H,32,37)(H,33,34)/t17-,20-/s2
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n/an/a 1.59n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was a...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154822
PNG
(US8999957, Table 3, Compound 94)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(N)=O)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1
Show InChI InChI=1/C27H27FN6O3/c1-37-24-4-2-3-21(28)20(24)15-34-14-18(6-8-23(34)26(29)35)31-27(36)17-5-7-22-19(13-17)25(33-32-22)16-9-11-30-12-10-16/h2-5,7,9-13,18,23H,6,8,14-15H2,1H3,(H2,29,35)(H,31,36)(H,32,33)/t18-,23+/s2
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n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was a...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203327
PNG
(US9242981, 59)
Show SMILES Cc1ccc(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)s1
Show InChI InChI=1/C23H28N6OS/c1-16-4-5-19(31-16)14-28-11-2-3-18(13-28)25-23(30)29-12-8-21-20(15-29)22(27-26-21)17-6-9-24-10-7-17/h4-7,9-10,18H,2-3,8,11-15H2,1H3,(H,25,30)(H,26,27)/t18-/s2
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n/an/a 1.78n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203448
PNG
(US9242981, 147)
Show SMILES CCn1cc(cn1)-c1n[nH]c2CCN(Cc12)C(=O)NC1CN(C)CC1c1ccccc1C
Show InChI InChI=1/C24H31N7O/c1-4-31-12-17(11-25-31)23-20-14-30(10-9-21(20)27-28-23)24(32)26-22-15-29(3)13-19(22)18-8-6-5-7-16(18)2/h5-8,11-12,19,22H,4,9-10,13-15H2,1-3H3,(H,26,32)(H,27,28)
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n/an/a 1.90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203322
PNG
(US9242981, 54)
Show SMILES Fc1cccc(F)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1
Show InChI InChI=1/C24H26F2N6O/c25-20-4-1-5-21(26)18(20)14-31-11-2-3-17(13-31)28-24(33)32-12-8-22-19(15-32)23(30-29-22)16-6-9-27-10-7-16/h1,4-7,9-10,17H,2-3,8,11-15H2,(H,28,33)(H,29,30)/t17-/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203326
PNG
(US9242981, 58)
Show SMILES Cc1ccsc1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1
Show InChI InChI=1/C23H28N6OS/c1-16-7-12-31-21(16)15-28-10-2-3-18(13-28)25-23(30)29-11-6-20-19(14-29)22(27-26-20)17-4-8-24-9-5-17/h4-5,7-9,12,18H,2-3,6,10-11,13-15H2,1H3,(H,25,30)(H,26,27)/t18-/s2
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n/an/a 1.98n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233415
PNG
(US9351965, 22)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1/C28H29FN4O3/c1-17-13-18(10-12-30-17)26-21-14-19(8-9-24(21)32-33-26)27(34)31-20-5-4-11-28(35,15-20)16-22-23(29)6-3-7-25(22)36-2/h3,6-10,12-14,20,35H,4-5,11,15-16H2,1-2H3,(H,31,34)(H,32,33)/t20-,28-/s2
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n/an/a 2n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203330
PNG
(US9242981, 62)
Show SMILES CC(=O)n1cc(CN2CCC[C@H](C2)NC(=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)c2ccccc12
Show InChI InChI=1/C28H31N7O2/c1-19(36)35-16-21(23-6-2-3-7-26(23)35)15-33-13-4-5-22(17-33)30-28(37)34-14-10-25-24(18-34)27(32-31-25)20-8-11-29-12-9-20/h2-3,6-9,11-12,16,22H,4-5,10,13-15,17-18H2,1H3,(H,30,37)(H,31,32)/t22-/s2
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n/an/a 2.01n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203339
PNG
(US9242981, 71)
Show SMILES Cc1cccc(C)c1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1
Show InChI InChI=1/C26H32N6O/c1-18-5-3-6-19(2)22(18)16-31-13-4-7-21(15-31)28-26(33)32-14-10-24-23(17-32)25(30-29-24)20-8-11-27-12-9-20/h3,5-6,8-9,11-12,21H,4,7,10,13-17H2,1-2H3,(H,28,33)(H,29,30)/t21-/s2
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n/an/a 2.07n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM103295
PNG
(US8546404, 462)
Show SMILES CO[C@]1(CCN(CC(=O)N2CCN(CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C35H35FN8O3/c1-47-35(34(46)39-27-9-12-30-29(21-27)32(41-40-30)24-3-7-26(36)8-4-24)13-16-42(23-35)22-31(45)44-19-17-43(18-20-44)28-10-5-25(6-11-28)33-37-14-2-15-38-33/h2-12,14-15,21H,13,16-20,22-23H2,1H3,(H,39,46)(H,40,41)/t35-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Merck Sharp & Dohme

US Patent


Assay Description
Activated ERK2 activity was determined in the IMAP assay format.


US Patent US8546404 (2013)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233416
PNG
(US9351965, 23)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
Show InChI InChI=1/C29H28FN5O3/c1-38-25-6-2-5-23(30)22(25)16-29(37)11-3-4-20(15-29)32-28(36)18-7-9-24-21(14-18)27(34-33-24)19-8-10-26-31-12-13-35(26)17-19/h2,5-10,12-14,17,20,37H,3-4,11,15-16H2,1H3,(H,32,36)(H,33,34)/t20-,29-/s2
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n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157177
PNG
(US9023865, 23)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc(NC(N)=O)ncc12
Show InChI InChI=1S/C13H12N6O/c1-7-4-8(2-3-15-7)12-9-6-16-11(17-13(14)20)5-10(9)18-19-12/h2-6H,1H3,(H,18,19)(H3,14,16,17,20)
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n/an/a 2.22n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM157175
PNG
(US9023865, 21)
Show SMILES COCCCc1n[nH]c2cc(NC(=O)N[C@H](C)c3ccccc3)ncc12
Show InChI InChI=1/C19H23N5O2/c1-13(14-7-4-3-5-8-14)21-19(25)22-18-11-17-15(12-20-18)16(23-24-17)9-6-10-26-2/h3-5,7-8,11-13H,6,9-10H2,1-2H3,(H,23,24)(H2,20,21,22,25)/t13-/s2
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n/an/a 2.23n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9023865 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM203337
PNG
(US9242981, 69)
Show SMILES Clc1ccccc1CN1CCC[C@H](C1)NC(=O)N1CCc2[nH]nc(c2C1)-c1ccncc1
Show InChI InChI=1/C24H27ClN6O/c25-21-6-2-1-4-18(21)14-30-12-3-5-19(15-30)27-24(32)31-13-9-22-20(16-31)23(29-28-22)17-7-10-26-11-8-17/h1-2,4,6-8,10-11,19H,3,5,9,12-16H2,(H,27,32)(H,28,29)/t19-/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was added to 14 &#...


US Patent US9242981 (2016)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154811
PNG
(BDBM154818 | US8999957, Table 3, Compound 83)
Show SMILES CNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1
Show InChI InChI=1/C28H29FN6O3/c1-30-28(37)24-9-7-19(15-35(24)16-21-22(29)4-3-5-25(21)38-2)32-27(36)18-6-8-23-20(14-18)26(34-33-23)17-10-12-31-13-11-17/h3-6,8,10-14,19,24H,7,9,15-16H2,1-2H3,(H,30,37)(H,32,36)(H,33,34)/t19-,24+/s2
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n/an/a 2.41n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25 compound was a...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM154616
PNG
(US8999957, Column 165-167, Compound 5)
Show SMILES COc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N(C)C1CC1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
Show InChI InChI=1/C32H35FN6O3/c1-19-15-20(13-14-34-19)30-24-16-21(7-11-27(24)36-37-30)31(40)35-22-8-12-28(32(41)38(2)23-9-10-23)39(17-22)18-25-26(33)5-4-6-29(25)42-3/h4-7,11,13-16,22-23,28H,8-10,12,17-18H2,1-3H3,(H,35,40)(H,36,37)/t22-,28+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp...


US Patent US8999957 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM103292
PNG
(US8546404, 1729 | US8546404, 469)
Show SMILES CO[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)C3CC3)c2c1
Show InChI InChI=1S/C38H38N8O3/c1-49-38(37(48)42-30-9-10-32-31(22-30)35(44-43-32)29-11-17-39-33(21-29)27-5-6-27)14-20-45(24-38)23-34(47)46-18-12-26(13-19-46)25-3-7-28(8-4-25)36-40-15-2-16-41-36/h2-4,7-12,15-17,21-22,27H,5-6,13-14,18-20,23-24H2,1H3,(H,42,48)(H,43,44)/t38-/m0/s1
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Merck Sharp & Dohme

US Patent


Assay Description
Activated ERK2 activity was determined in the IMAP assay format.


US Patent US8546404 (2013)

More data for this
Ligand-Target Pair
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