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Compile Data Set for Download or QSAR

Found 1618 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158752
PNG
(US9034866, 227)
Show SMILES CN1CCC(O)(C#Cc2ccc3OCCc4sc(nc4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C19H17N3O4S/c1-22-8-7-19(25,18(22)24)6-4-11-2-3-13-12(10-11)15-14(5-9-26-13)27-17(21-15)16(20)23/h2-3,10,25H,5,7-9H2,1H3,(H2,20,23)
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US Patent
0.0400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158801
PNG
(US9034866, 276)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OCCc4sc(nc4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C19H17N3O4S/c1-22-8-7-19(25,18(22)24)6-4-11-2-3-13-12(10-11)15-14(5-9-26-13)27-17(21-15)16(20)23/h2-3,10,25H,5,7-9H2,1H3,(H2,20,23)/t19-/s2
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US Patent
0.0550n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159087
PNG
(US9034866, 562)
Show SMILES C[C@@H]1COc2ccc(cc2-c2nc(sc12)C(N)=O)C#C[C@]1(O)CCNC1=O
Show InChI InChI=1/C19H17N3O4S/c1-10-9-26-13-3-2-11(4-5-19(25)6-7-21-18(19)24)8-12(13)14-15(10)27-17(22-14)16(20)23/h2-3,8,10,25H,6-7,9H2,1H3,(H2,20,23)(H,21,24)/t10-,19+/s2
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159077
PNG
(US9034866, 552)
Show SMILES C[C@H]1COc2ccc(cc2-c2nc(sc12)C(N)=O)C#C[C@]1(O)CCNC1=O
Show InChI InChI=1/C19H17N3O4S/c1-10-9-26-13-3-2-11(4-5-19(25)6-7-21-18(19)24)8-12(13)14-15(10)27-17(22-14)16(20)23/h2-3,8,10,25H,6-7,9H2,1H3,(H2,20,23)(H,21,24)/t10-,19-/s2
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158931
PNG
(US9034866, 406)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OCC(F)(F)c4sc(nc4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C19H15F2N3O4S/c1-24-7-6-18(27,17(24)26)5-4-10-2-3-12-11(8-10)13-14(19(20,21)9-28-12)29-16(23-13)15(22)25/h2-3,8,27H,6-7,9H2,1H3,(H2,22,25)/t18-/s2
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<0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158883
PNG
(US9034866, 358)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3c(nc(C(N)=O)c3[C@H](O)c3ccnn3C)-c2c1
Show InChI InChI=1/C27H26N6O4/c1-14-10-21(31-37-14)27(2,36)8-6-15-4-5-18-16-12-17(13-16)33-23(24(34)20-7-9-29-32(20)3)22(25(28)35)30-26(33)19(18)11-15/h4-5,7,9-11,16-17,24,34,36H,12-13H2,1-3H3,(H2,28,35)/t16?,17?,24-,27-/s2
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158884
PNG
(US9034866, 359)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3c(nc(C(N)=O)c3[C@@H](O)c3ccnn3C)-c2c1
Show InChI InChI=1/C27H26N6O4/c1-14-10-21(31-37-14)27(2,36)8-6-15-4-5-18-16-12-17(13-16)33-23(24(34)20-7-9-29-32(20)3)22(25(28)35)30-26(33)19(18)11-15/h4-5,7,9-11,16-17,24,34,36H,12-13H2,1-3H3,(H2,28,35)/t16?,17?,24-,27+/s2
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158798
PNG
(US9034866, 273)
Show SMILES CNC(=O)c1c(nc2-c3cc(C#CC4(O)CCCC4)c(F)cc3C3CC(C3)n12)C(N)=O
Show InChI InChI=1S/C23H23FN4O3/c1-26-22(30)19-18(20(25)29)27-21-16-10-12(4-7-23(31)5-2-3-6-23)17(24)11-15(16)13-8-14(9-13)28(19)21/h10-11,13-14,31H,2-3,5-6,8-9H2,1H3,(H2,25,29)(H,26,30)
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0.120n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158775
PNG
(US9034866, 250)
Show SMILES CNC(=O)c1c(nc2-c3cc(ccc3C3CC(C3)n12)C#CC(C)(C)O)C(N)=O
Show InChI InChI=1S/C21H22N4O3/c1-21(2,28)7-6-11-4-5-14-12-9-13(10-12)25-17(20(27)23-3)16(18(22)26)24-19(25)15(14)8-11/h4-5,8,12-13,28H,9-10H2,1-3H3,(H2,22,26)(H,23,27)
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0.120n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158808
PNG
(US9034866, 283)
Show SMILES Cn1c(nc-2c1C1CC(C1)c1cc(F)c(cc-21)C#C[C@@](C)(O)c1ncccn1)C(N)=O
Show InChI InChI=1/C23H20FN5O2/c1-23(31,22-26-6-3-7-27-22)5-4-12-10-16-15(11-17(12)24)13-8-14(9-13)19-18(16)28-21(20(25)30)29(19)2/h3,6-7,10-11,13-14,31H,8-9H2,1-2H3,(H2,25,30)/t13?,14?,23-/s2
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US Patent
0.160n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158904
PNG
(US9034866, 379)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3c(Cc4ccnn4C)c(nc3-c2c1)C(N)=O
Show InChI InChI=1/C27H26N6O3/c1-15-10-23(31-36-15)27(2,35)8-6-16-4-5-20-17-12-19(13-17)33-22(14-18-7-9-29-32(18)3)24(25(28)34)30-26(33)21(20)11-16/h4-5,7,9-11,17,19,35H,12-14H2,1-3H3,(H2,28,34)/t17?,19?,27-/s2
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US Patent
0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens)
BDBM50059194
PNG
(CHEMBL3393337)
Show SMILES N#Cc1ccnc(Nc2cc(cc(OC3CCC3)n2)C2CCN(CC2)C2COC2)c1
Show InChI InChI=1S/C23H27N5O2/c24-13-16-4-7-25-21(10-16)26-22-11-18(12-23(27-22)30-20-2-1-3-20)17-5-8-28(9-6-17)19-14-29-15-19/h4,7,10-12,17,19-20H,1-3,5-6,8-9,14-15H2,(H,25,26,27)
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PubMed
0.200n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of DLK (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158565
PNG
(US9034866, 40)
Show SMILES NC(=O)c1nc-2c(CCOc3cc(F)c(cc-23)C#CC2(O)CCCC2)s1
Show InChI InChI=1S/C19H17FN2O3S/c20-13-10-14-12(9-11(13)3-7-19(24)5-1-2-6-19)16-15(4-8-25-14)26-18(22-16)17(21)23/h9-10,24H,1-2,4-6,8H2,(H2,21,23)
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US Patent
0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158886
PNG
(US9034866, 361)
Show SMILES CNC(=O)c1c(nc2-c3cc(ccc3C3CC(C3)n12)C#CC1(O)CCC1)C(N)=O
Show InChI InChI=1S/C22H22N4O3/c1-24-21(28)18-17(19(23)27)25-20-16-9-12(5-8-22(29)6-2-7-22)3-4-15(16)13-10-14(11-13)26(18)20/h3-4,9,13-14,29H,2,6-7,10-11H2,1H3,(H2,23,27)(H,24,28)
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159164
PNG
(US9034866, 641)
Show SMILES CN1CC[C@@](O)(C#Cc2cc3-c4nc(sc4C(F)(F)COc3cc2F)C(N)=O)C1=O
Show InChI InChI=1/C19H14F3N3O4S/c1-25-5-4-18(28,17(25)27)3-2-9-6-10-12(7-11(9)20)29-8-19(21,22)14-13(10)24-16(30-14)15(23)26/h6-7,28H,4-5,8H2,1H3,(H2,23,26)/t18-/s2
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US Patent
0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158532
PNG
(US9034866, 7)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2OCCc3sc(nc3-c2c1)C(N)=O
Show InChI InChI=1/C20H17N3O4S/c1-11-9-16(23-27-11)20(2,25)7-5-12-3-4-14-13(10-12)17-15(6-8-26-14)28-19(22-17)18(21)24/h3-4,9-10,25H,6,8H2,1-2H3,(H2,21,24)/t20-/s2
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158794
PNG
(US9034866, 269)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1cc2-c3nc([nH]c3C3CC(C3)c2cc1F)C(N)=O
Show InChI InChI=1/C22H19FN4O3/c1-10-5-17(27-30-10)22(2,29)4-3-11-8-15-14(9-16(11)23)12-6-13(7-12)18-19(15)26-21(25-18)20(24)28/h5,8-9,12-13,29H,6-7H2,1-2H3,(H2,24,28)(H,25,26)/t12?,13?,22-/s2
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0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158788
PNG
(US9034866, 263)
Show SMILES CN1CC[C@@](O)(C#Cc2cc3-c4nc(cn4CCOc3cc2F)C(N)=O)C1=O
Show InChI InChI=1/C19H17FN4O4/c1-23-5-4-19(27,18(23)26)3-2-11-8-12-15(9-13(11)20)28-7-6-24-10-14(16(21)25)22-17(12)24/h8-10,27H,4-7H2,1H3,(H2,21,25)/t19-/s2
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0.240n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159182
PNG
(US9034866, 659)
Show SMILES Cc1cnc(o1)[C@@](C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O
Show InChI InChI=1/C22H20N4O3/c1-12-10-24-21(29-12)22(2,28)6-5-13-3-4-16-14-8-15(9-14)26-11-18(19(23)27)25-20(26)17(16)7-13/h3-4,7,10-11,14-15,28H,8-9H2,1-2H3,(H2,23,27)/t14?,15?,22-/s2
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US Patent
0.290n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159183
PNG
(US9034866, 660)
Show SMILES Cc1cnc(o1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O
Show InChI InChI=1/C22H20N4O3/c1-12-10-24-21(29-12)22(2,28)6-5-13-3-4-16-14-8-15(9-14)26-11-18(19(23)27)25-20(26)17(16)7-13/h3-4,7,10-11,14-15,28H,8-9H2,1-2H3,(H2,23,27)/t14?,15?,22-/s2
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0.290n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158967
PNG
(US9034866, 442)
Show SMILES C[C@H]1COc2ccc(cc2-c2nc(sc12)C(N)=O)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1/C20H19N3O4S/c1-11-10-27-14-4-3-12(5-6-20(26)7-8-23(2)19(20)25)9-13(14)15-16(11)28-18(22-15)17(21)24/h3-4,9,11,26H,7-8,10H2,1-2H3,(H2,21,24)/t11-,20-/s2
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0.300n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158936
PNG
(US9034866, 411)
Show SMILES CC(C)(O)C#Cc1cc2-c3nc(C(N)=O)n(C(F)F)c3C3CC(C3)c2cc1F
Show InChI InChI=1S/C20H18F3N3O2/c1-20(2,28)4-3-9-7-13-12(8-14(9)21)10-5-11(6-10)16-15(13)25-18(17(24)27)26(16)19(22)23/h7-8,10-11,19,28H,5-6H2,1-2H3,(H2,24,27)
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0.300n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158966
PNG
(US9034866, 441)
Show SMILES C[C@@H]1COc2ccc(cc2-c2nc(sc12)C(N)=O)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1/C20H19N3O4S/c1-11-10-27-14-4-3-12(5-6-20(26)7-8-23(2)19(20)25)9-13(14)15-16(11)28-18(22-15)17(21)24/h3-4,9,11,26H,7-8,10H2,1-2H3,(H2,21,24)/t11-,20+/s2
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0.300n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159241
PNG
(US9034866, 718)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OCCc4c(C(F)F)c(nn4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C20H18F2N4O4/c1-25-8-7-20(29,19(25)28)6-4-11-2-3-14-13(10-11)26-12(5-9-30-14)15(17(21)22)16(24-26)18(23)27/h2-3,10,17,29H,5,7-9H2,1H3,(H2,23,27)/t20-/s2
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0.300n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158531
PNG
(US9034866, 6)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1cc2-c3nc(cn3CCOc2cc1F)C(N)=O
Show InChI InChI=1/C20H17FN4O4/c1-11-7-17(24-29-11)20(2,27)4-3-12-8-13-16(9-14(12)21)28-6-5-25-10-15(18(22)26)23-19(13)25/h7-10,27H,5-6H2,1-2H3,(H2,22,26)/t20-/s2
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0.300n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158621
PNG
(US9034866, 96)
Show SMILES CNC(=O)c1c(nc2-c3cc(ccc3OCCn12)C#C[C@@](C)(O)c1cc(C)on1)C(N)=O
Show InChI InChI=1/C22H21N5O5/c1-12-10-16(26-32-12)22(2,30)7-6-13-4-5-15-14(11-13)20-25-17(19(23)28)18(21(29)24-3)27(20)8-9-31-15/h4-5,10-11,30H,8-9H2,1-3H3,(H2,23,28)(H,24,29)/t22-/s2
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0.300n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158675
PNG
(US9034866, 150)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O
Show InChI InChI=1/C22H20N4O3/c1-12-7-19(25-29-12)22(2,28)6-5-13-3-4-16-14-9-15(10-14)26-11-18(20(23)27)24-21(26)17(16)8-13/h3-4,7-8,11,14-15,28H,9-10H2,1-2H3,(H2,23,27)/t14?,15?,22-/s2
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0.300n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158743
PNG
(US9034866, 218)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1cc2-c3nc(C(N)=O)c(C4CC4)n3C3CC(C3)c2cc1F
Show InChI InChI=1/C25H23FN4O3/c1-12-7-20(29-33-12)25(2,32)6-5-14-10-18-17(11-19(14)26)15-8-16(9-15)30-22(13-3-4-13)21(23(27)31)28-24(18)30/h7,10-11,13,15-16,32H,3-4,8-9H2,1-2H3,(H2,27,31)/t15?,16?,25-/s2
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0.310n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158779
PNG
(US9034866, 254)
Show SMILES CN(C)[C@@H]1COc2cc(F)c(cc2-c2nc(sc12)C(N)=O)C#C[C@@](C)(O)c1cc(C)on1
Show InChI InChI=1/C22H21FN4O4S/c1-11-7-17(26-31-11)22(2,29)6-5-12-8-13-16(9-14(12)23)30-10-15(27(3)4)19-18(13)25-21(32-19)20(24)28/h7-9,15,29H,10H2,1-4H3,(H2,24,28)/t15-,22-/s2
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0.330n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159203
PNG
(US9034866, 680)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OCC(F)(F)c4cc(nn4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C19H16F2N4O4/c1-24-7-6-18(28,17(24)27)5-4-11-2-3-14-13(8-11)25-15(19(20,21)10-29-14)9-12(23-25)16(22)26/h2-3,8-9,28H,6-7,10H2,1H3,(H2,22,26)/t18-/s2
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0.330n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159096
PNG
(US9034866, 571 | US9034866, 684)
Show SMILES NC(=O)c1cc2n(n1)-c1cc(ccc1OCC2(F)F)C#C[C@]1(O)CCNC1=O
Show InChI InChI=1/C18H14F2N4O4/c19-18(20)9-28-13-2-1-10(3-4-17(27)5-6-22-16(17)26)7-12(13)24-14(18)8-11(23-24)15(21)25/h1-2,7-8,27H,5-6,9H2,(H2,21,25)(H,22,26)/t17-/s2
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0.330n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159204
PNG
(US9034866, 681)
Show SMILES CN1CC[C@](O)(C#Cc2ccc3OCC(F)(F)c4cc(nn4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C19H16F2N4O4/c1-24-7-6-18(28,17(24)27)5-4-11-2-3-14-13(8-11)25-15(19(20,21)10-29-14)9-12(23-25)16(22)26/h2-3,8-9,28H,6-7,10H2,1H3,(H2,22,26)/t18-/s2
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0.330n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158782
PNG
(US9034866, 257)
Show SMILES CN(C)[C@H]1COc2cc(F)c(cc2-c2nc(sc12)C(N)=O)C#C[C@@](C)(O)c1cc(C)on1
Show InChI InChI=1/C22H21FN4O4S/c1-11-7-17(26-31-11)22(2,29)6-5-12-8-13-16(9-14(12)23)30-10-15(27(3)4)19-18(13)25-21(32-19)20(24)28/h7-9,15,29H,10H2,1-4H3,(H2,24,28)/t15-,22+/s2
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0.330n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159089
PNG
(US9034866, 564)
Show SMILES C[C@H]1COc2ccc(cc2-n2nc(C(N)=O)c(c12)C(F)(F)F)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1/C21H19F3N4O4/c1-11-10-32-14-4-3-12(5-6-20(31)7-8-27(2)19(20)30)9-13(14)28-17(11)15(21(22,23)24)16(26-28)18(25)29/h3-4,9,11,31H,7-8,10H2,1-2H3,(H2,25,29)/t11-,20-/s2
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0.390n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159082
PNG
(US9034866, 557)
Show SMILES C[C@@H]1COc2ccc(cc2-n2nc(C(N)=O)c(c12)C(F)(F)F)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1/C21H19F3N4O4/c1-11-10-32-14-4-3-12(5-6-20(31)7-8-27(2)19(20)30)9-13(14)28-17(11)15(21(22,23)24)16(26-28)18(25)29/h3-4,9,11,31H,7-8,10H2,1-2H3,(H2,25,29)/t11-,20+/s2
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0.390n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158610
PNG
(US9034866, 85)
Show SMILES CC(C)(O)C#Cc1cc2-c3nc(C(N)=O)c(C(=O)NCC#N)n3CCOc2cc1F
Show InChI InChI=1S/C20H18FN5O4/c1-20(2,29)4-3-11-9-12-14(10-13(11)21)30-8-7-26-16(19(28)24-6-5-22)15(17(23)27)25-18(12)26/h9-10,29H,6-8H2,1-2H3,(H2,23,27)(H,24,28)
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0.400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159044
PNG
(US9034866, 519)
Show SMILES C[C@H]1COc2ccc(cc2-n2nc(cc12)C(N)=O)C#C[C@](C)(O)c1cc(C)on1
Show InChI InChI=1/C21H20N4O4/c1-12-11-28-18-5-4-14(6-7-21(3,27)19-8-13(2)29-24-19)9-17(18)25-16(12)10-15(23-25)20(22)26/h4-5,8-10,12,27H,11H2,1-3H3,(H2,22,26)/t12-,21-/s2
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0.400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158697
PNG
(US9034866, 172)
Show SMILES CC(C)(O)C#Cc1cc2-c3nc(C(N)=O)c(-c4nc(n[nH]4)-c4cccnc4)n3CCOc2cc1F
Show InChI InChI=1S/C24H20FN7O3/c1-24(2,34)6-5-13-10-15-17(11-16(13)25)35-9-8-32-19(18(20(26)33)28-23(15)32)22-29-21(30-31-22)14-4-3-7-27-12-14/h3-4,7,10-12,34H,8-9H2,1-2H3,(H2,26,33)(H,29,30,31)
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0.400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159171
PNG
(US9034866, 648)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OC[C@@H](O)c4sc(nc4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C19H17N3O5S/c1-22-7-6-19(26,18(22)25)5-4-10-2-3-13-11(8-10)14-15(12(23)9-27-13)28-17(21-14)16(20)24/h2-3,8,12,23,26H,6-7,9H2,1H3,(H2,20,24)/t12-,19+/s2
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0.400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159170
PNG
(US9034866, 647)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OC[C@H](O)c4sc(nc4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C19H17N3O5S/c1-22-7-6-19(26,18(22)25)5-4-10-2-3-13-11(8-10)14-15(12(23)9-27-13)28-17(21-14)16(20)24/h2-3,8,12,23,26H,6-7,9H2,1H3,(H2,20,24)/t12-,19-/s2
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0.400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158893
PNG
(US9034866, 368)
Show SMILES CNC(=O)c1c(nc2-c3cc(C#CC4(O)CCC4)c(F)cc3C3CC(C3)n12)C(N)=O
Show InChI InChI=1S/C22H21FN4O3/c1-25-21(29)18-17(19(24)28)26-20-15-9-11(3-6-22(30)4-2-5-22)16(23)10-14(15)12-7-13(8-12)27(18)20/h9-10,12-13,30H,2,4-5,7-8H2,1H3,(H2,24,28)(H,25,29)
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0.400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159242
PNG
(US9034866, 719)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OCC(F)(F)c4c(Cl)c(nn4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C19H15ClF2N4O4/c1-25-7-6-18(29,17(25)28)5-4-10-2-3-12-11(8-10)26-15(19(21,22)9-30-12)13(20)14(24-26)16(23)27/h2-3,8,29H,6-7,9H2,1H3,(H2,23,27)/t18-/s2
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0.400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159038
PNG
(US9034866, 513)
Show SMILES C[C@@H]1COc2ccc(cc2-n2nc(cc12)C(N)=O)C#C[C@](C)(O)c1cc(C)on1
Show InChI InChI=1/C21H20N4O4/c1-12-11-28-18-5-4-14(6-7-21(3,27)19-8-13(2)29-24-19)9-17(18)25-16(12)10-15(23-25)20(22)26/h4-5,8-10,12,27H,11H2,1-3H3,(H2,22,26)/t12-,21+/s2
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0.400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158906
PNG
(US9034866, 381)
Show SMILES CN1CC[C@@](O)(C#Cc2cc3-c4nc(C(N)=O)n(C)c4C4CC(C4)c3cc2F)C1=O
Show InChI InChI=1/C22H21FN4O3/c1-26-6-5-22(30,21(26)29)4-3-11-9-15-14(10-16(11)23)12-7-13(8-12)18-17(15)25-20(19(24)28)27(18)2/h9-10,12-13,30H,5-8H2,1-2H3,(H2,24,28)/t12?,13?,22-/s2
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158907
PNG
(US9034866, 382)
Show SMILES CN1CC[C@](O)(C#Cc2cc3-c4nc(C(N)=O)n(C)c4C4CC(C4)c3cc2F)C1=O
Show InChI InChI=1/C22H21FN4O3/c1-26-6-5-22(30,21(26)29)4-3-11-9-15-14(10-16(11)23)12-7-13(8-12)18-17(15)25-20(19(24)28)27(18)2/h9-10,12-13,30H,5-8H2,1-2H3,(H2,24,28)/t12?,13?,22-/s2
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM159240
PNG
(US9034866, 717)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc3OCC4(CCC4)c4cc(nn4-c3c2)C(N)=O)C1=O
Show InChI InChI=1/C22H22N4O4/c1-25-10-9-22(29,20(25)28)8-5-14-3-4-17-16(11-14)26-18(12-15(24-26)19(23)27)21(13-30-17)6-2-7-21/h3-4,11-12,29H,2,6-7,9-10,13H2,1H3,(H2,23,27)/t22-/s2
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158724
PNG
(US9034866, 199)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3c(nc(C(N)=O)c3C(F)(F)F)-c2c1
Show InChI InChI=1/C23H19F3N4O3/c1-11-7-17(29-33-11)22(2,32)6-5-12-3-4-15-13-9-14(10-13)30-19(23(24,25)26)18(20(27)31)28-21(30)16(15)8-12/h3-4,7-8,13-14,32H,9-10H2,1-2H3,(H2,27,31)/t13?,14?,22-/s2
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158944
PNG
(US9034866, 419)
Show SMILES CNC(=O)c1c(nc2-c3cc(ccc3OCCn12)C#C[C@]1(O)CCN(C)C1=O)C(N)=O
Show InChI InChI=1/C21H21N5O5/c1-23-19(28)16-15(17(22)27)24-18-13-11-12(3-4-14(13)31-10-9-26(16)18)5-6-21(30)7-8-25(2)20(21)29/h3-4,11,30H,7-10H2,1-2H3,(H2,22,27)(H,23,28)/t21-/s2
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158773
PNG
(US9034866, 248)
Show SMILES CC(C)(O)C#Cc1cc2-c3nc(C(N)=O)c(n3C3CC(C3)c2cc1F)C(C)(C)O
Show InChI InChI=1S/C22H24FN3O3/c1-21(2,28)6-5-11-9-15-14(10-16(11)23)12-7-13(8-12)26-18(22(3,4)29)17(19(24)27)25-20(15)26/h9-10,12-13,28-29H,7-8H2,1-4H3,(H2,24,27)
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
NF-kappa-beta-inducing kinase (NF-kB)


(Homo sapiens (Human))
BDBM158806
PNG
(US9034866, 281)
Show SMILES Cc1nc(no1)[C@](C)(O)C#Cc1cc2-c3nc(C(N)=O)n(C)c3C3CC(C3)c2cc1F
Show InChI InChI=1/C22H20FN5O3/c1-10-25-21(27-31-10)22(2,30)5-4-11-8-15-14(9-16(11)23)12-6-13(7-12)18-17(15)26-20(19(24)29)28(18)3/h8-9,12-13,30H,6-7H2,1-3H3,(H2,24,29)/t12?,13?,22-/s2
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...


US Patent US9034866 (2015)

More data for this
Ligand-Target Pair
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