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Found 2539 hits Enz. Inhib. hit(s) with Target = 'Monoamine oxidase B (MAO-B)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50430726
PNG
(CHEMBL2333930)
Show SMILES C[C@H](Cc1ccc(OCCCCCCCCNc2c3CCCCc3nc3cc(Cl)ccc23)cc1)N(C)CC#C
Show InChI InChI=1S/C34H44ClN3O/c1-4-22-38(3)26(2)24-27-15-18-29(19-16-27)39-23-12-8-6-5-7-11-21-36-34-30-13-9-10-14-32(30)37-33-25-28(35)17-20-31(33)34/h1,15-20,25-26H,5-14,21-24H2,2-3H3,(H,36,37)/t26-/m1/s1
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0.129n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAOB


J Med Chem 58: 6717-32 (2015)

More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50334292
PNG
(5-(4-Phenylbutyl)isatin | CHEMBL1642678)
Show SMILES O=C1Nc2ccc(CCCCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H17NO2/c20-17-15-12-14(10-11-16(15)19-18(17)21)9-5-4-8-13-6-2-1-3-7-13/h1-3,6-7,10-12H,4-5,8-9H2,(H,19,20,21)
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0.280n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50341160
PNG
(3-(anthracen-9-yl)-5-(3-nitrophenyl)-4,5-dihydro-1...)
Show SMILES [O-][N+](=O)c1cccc(c1)C1CC(N=N1)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C23H17N3O2/c27-26(28)18-9-5-8-17(13-18)21-14-22(25-24-21)23-19-10-3-1-6-15(19)12-16-7-2-4-11-20(16)23/h1-13,21-22H,14H2
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0.310n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50172755
PNG
(1,4-diphenyl-(1E,3E)-1,3-butadiene | CHEMBL198810)
Show SMILES C(\C=C\c1ccccc1)=C/c1ccccc1
Show InChI InChI=1S/C16H14/c1-3-9-15(10-4-1)13-7-8-14-16-11-5-2-6-12-16/h1-14H/b13-7+,14-8+
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0.600n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAOB


J Med Chem 58: 6717-32 (2015)

More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50341152
PNG
(3-(anthracen-9-yl)-5-(4-nitrophenyl)-4,5-dihydro-1...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C1CC(N=N1)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C23H17N3O2/c27-26(28)18-11-9-15(10-12-18)21-14-22(25-24-21)23-19-7-3-1-5-16(19)13-17-6-2-4-8-20(17)23/h1-13,21-22H,14H2
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1.15n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50341161
PNG
(3-(anthracen-9-yl)-5-(4-methoxyphenyl)-4,5-dihydro...)
Show SMILES COc1ccc(cc1)C1CC(N=N1)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C24H20N2O/c1-27-19-12-10-16(11-13-19)22-15-23(26-25-22)24-20-8-4-2-6-17(20)14-18-7-3-5-9-21(18)24/h2-14,22-23H,15H2,1H3
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1.70n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50341154
PNG
(3-(anthracen-9-yl)-5-(4-chlorophenyl)-4,5-dihydro-...)
Show SMILES Clc1ccc(cc1)C1CC(N=N1)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C23H17ClN2/c24-18-11-9-15(10-12-18)21-14-22(26-25-21)23-19-7-3-1-5-16(19)13-17-6-2-4-8-20(17)23/h1-13,21-22H,14H2
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1.80n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50350637
PNG
(CHEMBL1813523)
Show SMILES Brc1ccc(COc2ccc3C(=O)NC(=O)c3c2)cc1
Show InChI InChI=1S/C15H10BrNO3/c16-10-3-1-9(2-4-10)8-20-11-5-6-12-13(7-11)15(19)17-14(12)18/h1-7H,8H2,(H,17,18,19)
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3n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells using kynuramine substrate using Cheng and Prusoff equation by fluorescence spectrosco...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM15579
PNG
(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Show SMILES C[C@H](Cc1ccccc1)N(C)CC#C
Show InChI InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1
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3.30n/an/an/an/an/an/an/an/a



Dart NeuroScience, LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50341155
PNG
(3-(anthracen-9-yl)-5-p-tolyl-4,5-dihydro-1H-pyrazo...)
Show SMILES Cc1ccc(cc1)C1CC(N=N1)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C24H20N2/c1-16-10-12-17(13-11-16)22-15-23(26-25-22)24-20-8-4-2-6-18(20)14-19-7-3-5-9-21(19)24/h2-14,22-23H,15H2,1H3
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3.56n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50029816
PNG
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Show SMILES NCCNC(=O)c1ccc(Cl)cn1
Show InChI InChI=1S/C8H10ClN3O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10/h1-2,5H,3-4,10H2,(H,11,13)
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3.90n/an/an/an/an/an/an/an/a



Dart NeuroScience, LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM15579
PNG
(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Show SMILES C[C@H](Cc1ccccc1)N(C)CC#C
Show InChI InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1
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3.90n/an/an/an/an/an/an/an/a



Dart NeuroScience, LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50259619
PNG
((E)-5-Styrylisatin | CHEMBL466872)
Show SMILES O=C1Nc2ccc(\C=C\c3ccccc3)cc2C1=O
Show InChI InChI=1S/C16H11NO2/c18-15-13-10-12(8-9-14(13)17-16(15)19)7-6-11-4-2-1-3-5-11/h1-10H,(H,17,18,19)/b7-6+
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4n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50341156
PNG
(3-(anthracen-9-yl)-5-phenyl-4,5-dihydro-1H-pyrazol...)
Show SMILES C1C(N=NC1c1c2ccccc2cc2ccccc12)c1ccccc1
Show InChI InChI=1S/C23H18N2/c1-2-8-16(9-3-1)21-15-22(25-24-21)23-19-12-6-4-10-17(19)14-18-11-5-7-13-20(18)23/h1-14,21-22H,15H2
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4.21n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM19187
PNG
((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Show SMILES C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
Show InChI InChI=1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1
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5.40n/an/an/an/an/an/an/an/a



Dart NeuroScience, LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50341158
PNG
(4-(3-(anthracen-9-yl)-4,5-dihydro-1H-pyrazol-5-yl)...)
Show SMILES Oc1ccc(C2CC(N=N2)c2c3ccccc3cc3ccccc23)c(O)c1
Show InChI InChI=1S/C23H18N2O2/c26-16-9-10-19(22(27)12-16)20-13-21(25-24-20)23-17-7-3-1-5-14(17)11-15-6-2-4-8-18(15)23/h1-12,20-21,26-27H,13H2
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5.54n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50341159
PNG
(2-(3-(anthracen-9-yl)-4,5-dihydro-1H-pyrazol-5-yl)...)
Show SMILES C1C(N=NC1c1c2ccccc2cc2ccccc12)c1ccccn1
Show InChI InChI=1S/C22H17N3/c1-3-9-17-15(7-1)13-16-8-2-4-10-18(16)22(17)21-14-20(24-25-21)19-11-5-6-12-23-19/h1-13,20-21H,14H2
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5.75n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50350642
PNG
(CHEMBL1813519)
Show SMILES O=C1NC(=O)c2cc(OCCc3ccccc3)ccc12
Show InChI InChI=1S/C16H13NO3/c18-15-13-7-6-12(10-14(13)16(19)17-15)20-9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,17,18,19)
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7n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells using kynuramine substrate using Cheng and Prusoff equation by fluorescence spectrosco...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50017430
PNG
(CHEMBL3288298)
Show SMILES Ic1cccc(COc2ccc3C(=O)CCCc3c2)c1
Show InChI InChI=1S/C17H15IO2/c18-14-5-1-3-12(9-14)11-20-15-7-8-16-13(10-15)4-2-6-17(16)19/h1,3,5,7-10H,2,4,6,11H2
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7.10n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human MAO-B using kynuramine as substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50341157
PNG
(2-(3-(anthracen-9-yl)-4,5-dihydro-1H-pyrazol-5-yl)...)
Show SMILES Oc1ccccc1C1CC(N=N1)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C23H18N2O/c26-22-12-6-5-11-19(22)20-14-21(25-24-20)23-17-9-3-1-7-15(17)13-16-8-2-4-10-18(16)23/h1-13,20-21,26H,14H2
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7.35n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50341153
PNG
(4-(3-(anthracen-9-yl)-4,5-dihydro-1H-pyrazol-5-yl)...)
Show SMILES Oc1ccc(cc1)C1CC(N=N1)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C23H18N2O/c26-18-11-9-15(10-12-18)21-14-22(25-24-21)23-19-7-3-1-5-16(19)13-17-6-2-4-8-20(17)23/h1-13,21-22,26H,14H2
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7.51n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM10989
PNG
((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Show SMILES C#CCN[C@@H]1CCc2ccccc12
Show InChI InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1
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7.60n/an/an/an/an/an/an/an/a



Dart NeuroScience, LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50402336
PNG
(CHEMBL2206107)
Show SMILES Cn1c(SCCc2ccc(Cl)cc2)nc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C16H17ClN4O2S/c1-19-12-13(20(2)16(23)21(3)14(12)22)18-15(19)24-9-8-10-4-6-11(17)7-5-10/h4-7H,8-9H2,1-3H3
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9.80n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B expressed in insect cell microsome using kynuramine as substrate by Morrison equation analysis


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50350636
PNG
(CHEMBL1813522)
Show SMILES O=C1NC(=O)c2cc(Oc3ccc4ccccc4c3)ccc12
Show InChI InChI=1S/C18H11NO3/c20-17-15-8-7-14(10-16(15)18(21)19-17)22-13-6-5-11-3-1-2-4-12(11)9-13/h1-10H,(H,19,20,21)
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10n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells using kynuramine substrate using Cheng and Prusoff equation by fluorescence spectrosco...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50402336
PNG
(CHEMBL2206107)
Show SMILES Cn1c(SCCc2ccc(Cl)cc2)nc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C16H17ClN4O2S/c1-19-12-13(20(2)16(23)21(3)14(12)22)18-15(19)24-9-8-10-4-6-11(17)7-5-10/h4-7H,8-9H2,1-3H3
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13n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAO-B expressed in insect cell microsome using kynuramine as substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM10989
PNG
((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Show SMILES C#CCN[C@@H]1CCc2ccccc12
Show InChI InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1
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14n/an/an/an/an/an/an/an/a



Dart NeuroScience, LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50063522
PNG
(CHEMBL3398531)
Show SMILES Cc1ccc(cc1)-c1[nH]c2cc(C#N)c(cc2c1Cl)C#N
Show InChI InChI=1S/C17H10ClN3/c1-10-2-4-11(5-3-10)17-16(18)14-6-12(8-19)13(9-20)7-15(14)21-17/h2-7,21H,1H3
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16n/an/an/an/an/an/an/an/a



Yaroslavl State Technical University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAO-B assessed as kynuramine substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM19187
PNG
((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Show SMILES C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
Show InChI InChI=1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1
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17n/an/an/an/an/an/an/an/a



Dart NeuroScience, LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50350641
PNG
(CHEMBL342357)
Show SMILES O=C1NC(=O)c2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C15H11NO3/c17-14-12-7-6-11(8-13(12)15(18)16-14)19-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,16,17,18)
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19n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells using kynuramine substrate using Cheng and Prusoff equation by fluorescence spectrosco...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50350635
PNG
(CHEMBL1813521)
Show SMILES O=C1NC(=O)c2cc(OC\C=C\c3ccccc3)ccc12
Show InChI InChI=1S/C17H13NO3/c19-16-14-9-8-13(11-15(14)17(20)18-16)21-10-4-7-12-5-2-1-3-6-12/h1-9,11H,10H2,(H,18,19,20)/b7-4+
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20n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells using kynuramine substrate using Cheng and Prusoff equation by fluorescence spectrosco...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50350643
PNG
(CHEMBL1813520)
Show SMILES O=C1NC(=O)c2cc(OCCCc3ccccc3)ccc12
Show InChI InChI=1S/C17H15NO3/c19-16-14-9-8-13(11-15(14)17(20)18-16)21-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11H,4,7,10H2,(H,18,19,20)
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20n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells using kynuramine substrate using Cheng and Prusoff equation by fluorescence spectrosco...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50172756
PNG
(Benzyl-methyl-prop-2-ynyl-amine | CHEMBL673 | Euto...)
Show SMILES CN(CC#C)Cc1ccccc1
Show InChI InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3
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20n/an/an/an/an/an/an/an/a



Dart NeuroScience, LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50109538
PNG
(CHEMBL3604126)
Show SMILES CN(Cc1ccc(CC(=O)NC2CC(C)(C)N([O])C(C)(C)C2)cc1)C#C
Show InChI InChI=1S/C21H30N3O2/c1-7-23(6)15-17-10-8-16(9-11-17)12-19(25)22-18-13-20(2,3)24(26)21(4,5)14-18/h1,8-11,18H,12-15H2,2-6H3,(H,22,25)
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22n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAOB


J Med Chem 58: 6717-32 (2015)

More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50350639
PNG
(CHEMBL1813525)
Show SMILES Brc1ccc(Oc2ccc3C(=O)NC(=O)c3c2)cc1
Show InChI InChI=1S/C14H8BrNO3/c15-8-1-3-9(4-2-8)19-10-5-6-11-12(7-10)14(18)16-13(11)17/h1-7H,(H,16,17,18)
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24n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells using kynuramine substrate using Cheng and Prusoff equation by fluorescence spectrosco...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50240772
PNG
((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)
Show SMILES N[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2/t8-,9+/m0/s1
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26n/an/an/an/an/an/an/an/a



Dart NeuroScience, LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50334293
PNG
(5-(4-Chlorophenoxy)isatin | CHEMBL1642679)
Show SMILES Clc1ccc(Oc2ccc3NC(=O)C(=O)c3c2)cc1
Show InChI InChI=1S/C14H8ClNO3/c15-8-1-3-9(4-2-8)19-10-5-6-12-11(7-10)13(17)14(18)16-12/h1-7H,(H,16,17,18)
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28n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50246766
PNG
(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Show SMILES NC\C(CCc1ccc(F)cc1)=C\F
Show InChI InChI=1S/C11H13F2N/c12-7-10(8-14)2-1-9-3-5-11(13)6-4-9/h3-7H,1-2,8,14H2/b10-7+
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28n/an/an/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in Pichia pastoris by kinetic assay


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50350638
PNG
(CHEMBL1813524)
Show SMILES Brc1ccc(CCOc2ccc3C(=O)NC(=O)c3c2)cc1
Show InChI InChI=1S/C16H12BrNO3/c17-11-3-1-10(2-4-11)7-8-21-12-5-6-13-14(9-12)16(20)18-15(13)19/h1-6,9H,7-8H2,(H,18,19,20)
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29n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells using kynuramine substrate using Cheng and Prusoff equation by fluorescence spectrosco...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50121456
PNG
(1-[3-(2,4-Dihydroxy-phenyl)-5-o-tolyl-4,5-dihydro-...)
Show SMILES CC(=O)N1N=C(CC1c1ccccc1C)c1ccc(O)cc1O
Show InChI InChI=1S/C18H18N2O3/c1-11-5-3-4-6-14(11)17-10-16(19-20(17)12(2)21)15-8-7-13(22)9-18(15)23/h3-9,17,22-23H,10H2,1-2H3
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30n/an/an/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibiting activityof the compound was determined against human Monoamine oxidase B


Bioorg Med Chem Lett 12: 3629-33 (2002)

More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50326848
PNG
(3,4-Dichloro-N-(2-methyl-1H-indol-5-yl)benzamide |...)
Show SMILES Cc1cc2cc(NC(=O)c3ccc(Cl)c(Cl)c3)ccc2[nH]1
Show InChI InChI=1S/C16H12Cl2N2O/c1-9-6-11-7-12(3-5-15(11)19-9)20-16(21)10-2-4-13(17)14(18)8-10/h2-8,19H,1H3,(H,20,21)
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30n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in baculovirus infected BTI insect cells after 20 mins by spectrofluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50109536
PNG
(CHEMBL3604128)
Show SMILES CN(CC#C)c1nc2nc(CCC3CCN(Cc4ccccc4)CC3)ccc2c(-c2ccccc2)c1C#N
Show InChI InChI=1S/C33H33N5/c1-3-20-37(2)33-30(23-34)31(27-12-8-5-9-13-27)29-17-16-28(35-32(29)36-33)15-14-25-18-21-38(22-19-25)24-26-10-6-4-7-11-26/h1,4-13,16-17,25H,14-15,18-22,24H2,2H3
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32n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAOB


J Med Chem 58: 6717-32 (2015)

More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50063994
PNG
(CHEMBL338404 | Ro-166491)
Show SMILES NCCNC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C9H11ClN2O/c10-8-3-1-7(2-4-8)9(13)12-6-5-11/h1-4H,5-6,11H2,(H,12,13)
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32n/an/an/an/an/an/an/an/a



Dart NeuroScience, LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM11022
PNG
(2,3-dihydro-1H-indole-2,3-dione | CHEMBL326294 | I...)
Show SMILES O=C1Nc2ccccc2C1=O
Show InChI InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11)
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33n/an/an/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of MAO-B


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM11020
PNG
(1,4-diphenyl-2-butene (DPB) | [(2E)-4-phenylbut-2-...)
Show SMILES C(\C=C\Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H16/c1-3-9-15(10-4-1)13-7-8-14-16-11-5-2-6-12-16/h1-12H,13-14H2/b8-7+
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35n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Competitive inhibition of human liver MAOB expressed in Pichia pastoris


J Med Chem 58: 6717-32 (2015)

More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50264670
PNG
((E)-8-(3,4-dichlorostyryl)-1,3,7-trimethyl-3,4,5,7...)
Show SMILES CN1C2C(N=C1C=Cc1ccc(Cl)c(Cl)c1)N(C)C(=O)N(C)C2=O
Show InChI InChI=1S/C16H16Cl2N4O2/c1-20-12(7-5-9-4-6-10(17)11(18)8-9)19-14-13(20)15(23)22(3)16(24)21(14)2/h4-8,13-14H,1-3H3
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36n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of monoamine oxidase B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50307362
PNG
((+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine | CHEMB...)
Show SMILES C(Oc1ccc(cc1)C1CNCCS1)c1ccccc1
Show InChI InChI=1S/C17H19NOS/c1-2-4-14(5-3-1)13-19-16-8-6-15(7-9-16)17-12-18-10-11-20-17/h1-9,17-18H,10-13H2
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38n/an/an/an/an/an/an/an/a



University of Chile

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB by spectrophotometrically


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50121457
PNG
(1-[3-(2,4-Dihydroxy-phenyl)-5-m-tolyl-4,5-dihydro-...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(C)c1)c1ccc(O)cc1O
Show InChI InChI=1S/C18H18N2O3/c1-11-4-3-5-13(8-11)17-10-16(19-20(17)12(2)21)15-7-6-14(22)9-18(15)23/h3-9,17,22-23H,10H2,1-2H3
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38n/an/an/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibiting activityof the compound was determined against human Monoamine oxidase B


Bioorg Med Chem Lett 12: 3629-33 (2002)

More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50109535
PNG
(CHEMBL3219618)
Show SMILES CN(C)c1ccc(cc1)\N=C\c1ccccn1
Show InChI InChI=1S/C14H15N3/c1-17(2)14-8-6-12(7-9-14)16-11-13-5-3-4-10-15-13/h3-11H,1-2H3/b16-11+
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40n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAOB


J Med Chem 58: 6717-32 (2015)

More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50068025
PNG
(CHEMBL3402197)
Show SMILES Brc1cccc(COc2ccc3OCCOc3c2)c1
Show InChI InChI=1S/C15H13BrO3/c16-12-3-1-2-11(8-12)10-19-13-4-5-14-15(9-13)18-7-6-17-14/h1-5,8-9H,6-7,10H2
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41n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant MAOB using kynuramine substrate assessed as reduction in MAO-generated 4-hydroxyquinoline level by Linewe...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase B (MAO-B)


(Homo sapiens (Human))
BDBM50334284
PNG
(5-Benzyloxyisatin | CHEMBL1642670)
Show SMILES O=C1Nc2ccc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C15H11NO3/c17-14-12-8-11(6-7-13(12)16-15(14)18)19-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,16,17,18)
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44n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB expressed in insect cells by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
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