BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 36 hits Enz. Inhib. hit(s) with Target = 'Monocarboxylate transporter 1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monocarboxylate transporter 10


(Rattus norvegicus)
BDBM50043821
PNG
((S)-2-Acetylamino-3-(1H-indol-3-yl)-propionic acid...)
Show SMILES CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.50E+6n/an/an/an/an/an/an/an/a



Kyorin University School of Medicine

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of L-tryptophan uptake in Xenopus laevis oocytes


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 10


(Rattus norvegicus)
BDBM92690
PNG
(L-Abrine, 12)
Show SMILES [O-]C(=O)C(Cc1c[nH]c2ccccc12)[NH+]=C
Show InChI InChI=1S/C12H12N2O2/c1-13-11(12(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,1,6H2,(H,15,16)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
3.10E+6n/an/an/an/an/an/an/an/a



Kyorin University School of Medicine

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of L-tryptophan uptake in Xenopus laevis oocytes


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092069
PNG
(CHEMBL3582422)
Show SMILES COc1cc(ccc1\C=C(/C#N)C(O)=O)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H13ClN2O4/c1-9(21)15-7-11-10(3-4-14(23-2)16(11)24-15)17(22)20-13-5-6-19-8-12(13)18/h3-8H,1-2H3,(H,19,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092072
PNG
(CHEMBL3582419)
Show SMILES CCCCN(CCCC)c1ccc(\C=C(/C#N)C(O)=O)c(OC)c1
Show InChI InChI=1S/C18H16N2O4/c1-10-5-4-8-19-17(10)20-18(22)12-6-7-14(23-3)16-13(12)9-15(24-16)11(2)21/h4-9H,1-3H3,(H,19,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092058
PNG
(CHEMBL3582408)
Show SMILES CCCN(CCC)c1ccc(\C=C(/C#N)C(O)=O)cc1
Show InChI InChI=1S/C17H12Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-7H,1-2H3,(H,20,21,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092068
PNG
(CHEMBL3582423)
Show SMILES [Na+].COc1cc(ccc1\C=C(/C#N)C([O-])=O)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H14N2O4/c1-10(20)15-9-13-12(3-4-14(22-2)16(13)23-15)17(21)19-11-5-7-18-8-6-11/h3-9H,1-2H3,(H,18,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092071
PNG
(CHEMBL3582420)
Show SMILES COc1cc(ccc1\C=C(/C#N)C(O)=O)N(CC(C)C)CC(C)C
Show InChI InChI=1S/C16H10Cl2N2O5/c1-24-11-3-2-7(8-4-12(16(22)23)25-14(8)11)15(21)20-13-9(17)5-19-6-10(13)18/h2-6H,1H3,(H,22,23)(H,19,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092073
PNG
(CHEMBL3582418)
Show SMILES CCCN(CCC)c1ccc(\C=C(/C#N)C(O)=O)c(OC)c1
Show InChI InChI=1S/C17H13ClN2O4/c1-9(21)14-8-11-10(5-6-13(23-2)15(11)24-14)17(22)20-12-4-3-7-19-16(12)18/h3-8H,1-2H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092065
PNG
(CHEMBL3582426)
Show SMILES [Na+].COc1cc(ccc1\C=C(/C#N)C([O-])=O)N1CCCCC1
Show InChI InChI=1S/C20H20Cl2N2O3/c1-20(2,3)8-11-7-13-12(5-6-16(26-4)18(13)27-11)19(25)24-17-14(21)9-23-10-15(17)22/h5-7,9-10H,8H2,1-4H3,(H,23,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092067
PNG
(CHEMBL3582424)
Show SMILES COc1cc(ccc1\C=C(/C#N)C(O)=O)N(CC=C)CC=C
Show InChI InChI=1S/C17H14Cl2N2O3/c1-3-9-6-11-10(4-5-14(23-2)16(11)24-9)17(22)21-15-12(18)7-20-8-13(15)19/h4-8H,3H2,1-2H3,(H,20,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092057
PNG
(CHEMBL3582409)
Show SMILES CCCCN(CCCC)c1ccc(\C=C(/C#N)C(O)=O)cc1
Show InChI InChI=1S/C22H33NO/c1-7-23-21(24)16-18(3)11-8-10-17(2)13-14-20-19(4)12-9-15-22(20,5)6/h8,10-11,13-14,16H,7,9,12,15H2,1-6H3,(H,23,24)/b11-8+,14-13+,17-10+,18-16+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092076
PNG
(CHEMBL3582415)
Show SMILES OC(=O)C(=C\c1ccc(cc1)N(c1ccccc1)c1ccccc1)\C#N
Show InChI InChI=1S/C22H16N2O2/c23-16-18(22(25)26)15-17-11-13-21(14-12-17)24(19-7-3-1-4-8-19)20-9-5-2-6-10-20/h1-15H,(H,25,26)/b18-15+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092070
PNG
(CHEMBL3582421)
Show SMILES CCCCCN(CCCCC)c1ccc(\C=C(/C#N)C(O)=O)c(OC)c1
Show InChI InChI=1S/C18H14Cl2N2O4/c1-9(23)15-6-11-10(4-5-14(25-3)17(11)26-15)18(24)22(2)16-12(19)7-21-8-13(16)20/h4-8H,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092066
PNG
(CHEMBL3582425)
Show SMILES [Na+].COc1cc(ccc1\C=C(/C#N)C([O-])=O)N1CCCC1
Show InChI InChI=1S/C18H14ClNO4/c1-10(21)16-9-12-11(7-8-15(23-2)17(12)24-16)18(22)20-14-6-4-3-5-13(14)19/h3-9H,1-2H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092075
PNG
(CHEMBL3582416)
Show SMILES OC(=O)C(=C\c1ccc(cc1)N1CCCC1)\C#N
Show InChI InChI=1S/C14H14N2O2/c15-10-12(14(17)18)9-11-3-5-13(6-4-11)16-7-1-2-8-16/h3-6,9H,1-2,7-8H2,(H,17,18)/b12-9+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092059
PNG
(CHEMBL3582407)
Show SMILES CCN(CC)c1ccc(\C=C(/C#N)C(O)=O)cc1
Show InChI InChI=1S/C16H12ClN3O4/c1-8(21)13-5-10-9(3-4-12(23-2)14(10)24-13)16(22)20-15-11(17)6-18-7-19-15/h3-7H,1-2H3,(H,18,19,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092018
PNG
(CHEMBL3582410)
Show SMILES CC(C)CN(CC(C)C)c1ccc(\C=C(/C#N)C(O)=O)cc1
Show InChI InChI=1S/C18H24N2O2/c1-13(2)11-20(12-14(3)4)17-7-5-15(6-8-17)9-16(10-19)18(21)22/h5-9,13-14H,11-12H2,1-4H3,(H,21,22)/b16-9+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092078
PNG
(CHEMBL3582413)
Show SMILES OC(=O)C(=C\c1ccc(cc1)N(CC=C)CC=C)\C#N
Show InChI InChI=1S/C16H16N2O2/c1-3-9-18(10-4-2)15-7-5-13(6-8-15)11-14(12-17)16(19)20/h3-8,11H,1-2,9-10H2,(H,19,20)/b14-11+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092017
PNG
(CHEMBL3582411)
Show SMILES CCCCCN(CCCCC)c1ccc(\C=C(/C#N)C(O)=O)cc1
Show InChI InChI=1S/C20H28N2O2/c1-3-5-7-13-22(14-8-6-4-2)19-11-9-17(10-12-19)15-18(16-21)20(23)24/h9-12,15H,3-8,13-14H2,1-2H3,(H,23,24)/b18-15+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM4345
PNG
((2E)-2-cyano-3-[4-(dimethylamino)phenyl]prop-2-eno...)
Show SMILES CN(C)c1ccc(\C=C(/C#N)C(O)=O)cc1
Show InChI InChI=1S/C12H12N2O2/c1-14(2)11-5-3-9(4-6-11)7-10(8-13)12(15)16/h3-7H,1-2H3,(H,15,16)/b10-7+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092074
PNG
(CHEMBL3582417)
Show SMILES OC(=O)C(=C\c1ccc(cc1)N1CCCCC1)\C#N
Show InChI InChI=1S/C15H16N2O2/c16-11-13(15(18)19)10-12-4-6-14(7-5-12)17-8-2-1-3-9-17/h4-7,10H,1-3,8-9H2,(H,18,19)/b13-10+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092077
PNG
(CHEMBL3582414)
Show SMILES OC(=O)C(=C\c1ccc(cc1)N(CC#C)CC#C)\C#N
Show InChI InChI=1S/C16H12N2O2/c1-3-9-18(10-4-2)15-7-5-13(6-8-15)11-14(12-17)16(19)20/h1-2,5-8,11H,9-10H2,(H,19,20)/b14-11+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM4346
PNG
((2E)-2-cyano-3-(4-methylphenyl)prop-2-enoic acid |...)
Show SMILES Cc1ccc(\C=C(/C#N)C(O)=O)cc1
Show InChI InChI=1S/C11H9NO2/c1-8-2-4-9(5-3-8)6-10(7-12)11(13)14/h2-6H,1H3,(H,13,14)/b10-6+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092064
PNG
(CHEMBL3582402)
Show SMILES CCc1ccc(\C=C(/C#N)C(O)=O)cc1
Show InChI InChI=1S/C19H12Cl2N2O4/c1-9(24)16-7-12-11(3-4-15(26-2)18(12)27-16)19(25)23-17-13(20)5-10(8-22)6-14(17)21/h3-7H,1-2H3,(H,23,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM4344
PNG
((2E)-2-cyano-3-(4-fluorophenyl)prop-2-enoic acid |...)
Show SMILES OC(=O)C(=C\c1ccc(F)cc1)\C#N
Show InChI InChI=1S/C10H6FNO2/c11-9-3-1-7(2-4-9)5-8(6-12)10(13)14/h1-5H,(H,13,14)/b8-5+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092063
PNG
(CHEMBL3582403)
Show SMILES OC(=O)C(=C\c1ccc(Cl)cc1)\C#N
Show InChI InChI=1S/C10H6ClNO2/c11-9-3-1-7(2-4-9)5-8(6-12)10(13)14/h1-5H,(H,13,14)/b8-5+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092061
PNG
(CHEMBL3582405)
Show SMILES OC(=O)C(=C\c1ccc(cc1)C#N)\C#N
Show InChI InChI=1S/C21H13Cl2N3O4/c1-29-16-3-2-12(21(28)26-18-14(22)9-25-10-15(18)23)13-8-17(30-20(13)16)19(27)11-4-6-24-7-5-11/h2-10H,1H3,(H,25,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM4347
PNG
((2E)-2-cyano-3-(4-nitrophenyl)prop-2-enoic acid | ...)
Show SMILES OC(=O)C(=C\c1ccc(cc1)[N+]([O-])=O)\C#N
Show InChI InChI=1S/C10H6N2O4/c11-6-8(10(13)14)5-7-1-3-9(4-2-7)12(15)16/h1-5H,(H,13,14)/b8-5+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM4343
PNG
((2E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoic acid ...)
Show SMILES COc1ccc(\C=C(/C#N)C(O)=O)cc1
Show InChI InChI=1S/C11H9NO3/c1-15-10-4-2-8(3-5-10)6-9(7-12)11(13)14/h2-6H,1H3,(H,13,14)/b9-6+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092060
PNG
(CHEMBL3582406)
Show SMILES OC(=O)C(=C\c1ccc2OCOc2c1)\C#N
Show InChI InChI=1S/C18H14Cl2N2O4/c1-8-14-10(18(24)22-15-11(19)6-21-7-12(15)20)4-5-13(25-3)17(14)26-16(8)9(2)23/h4-7H,1-3H3,(H,21,22,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092062
PNG
(CHEMBL3582404)
Show SMILES OC(=O)C(=C\c1ccc(Br)cc1)\C#N
Show InChI InChI=1S/C16H9Cl2N3O3/c1-23-13-3-2-9(10-4-8(5-19)24-15(10)13)16(22)21-14-11(17)6-20-7-12(14)18/h2-4,6-7H,1H3,(H,20,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50092016
PNG
(CHEMBL3582412)
Show SMILES CCCCCCN(CCCCCC)c1ccc(\C=C(/C#N)C(O)=O)cc1
Show InChI InChI=1S/C22H32N2O2/c1-3-5-7-9-15-24(16-10-8-6-4-2)21-13-11-19(12-14-21)17-20(18-23)22(25)26/h11-14,17H,3-10,15-16H2,1-2H3,(H,25,26)/b20-17+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 880n/an/an/an/an/an/a



Medical School Duluth

Curated by ChEMBL


Assay Description
Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



Physiologisch-chemisches Institut der Eberhard-Karls-Universit£t T£bingen

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytes


Biochem J 341: 529-35 (1999)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM50158460
PNG
((3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran...)
Show SMILES CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1
Show InChI InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 2.20E+4n/an/an/an/an/an/a



Physiologisch-chemisches Institut der Eberhard-Karls-Universit£t T£bingen

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytes


Biochem J 341: 529-35 (1999)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM23446
PNG
(3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop...)
Show SMILES Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
Show InChI InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 2.80E+4n/an/an/an/an/an/a



Physiologisch-chemisches Institut der Eberhard-Karls-Universit£t T£bingen

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytes


Biochem J 341: 529-35 (1999)

More data for this
Ligand-Target Pair
Monocarboxylate transporter 1


(Rattus norvegicus)
BDBM4350
PNG
((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid ...)
Show SMILES OC(=O)C(=C\c1ccc(O)cc1)\C#N
Show InChI InChI=1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 4.25E+5n/an/an/an/an/an/a



Physiologisch-chemisches Institut der Eberhard-Karls-Universit£t T£bingen

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytes


Biochem J 341: 529-35 (1999)

More data for this
Ligand-Target Pair