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Compile Data Set for Download or QSAR

Found 147 hits Enz. Inhib. hit(s) with Target = 'Monoglyceride lipase (MGL)' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50274152
PNG
((2S,9Z)-octadec-9-ene-1,2-diamine dihydrochloride ...)
Show SMILES CCCCCCCC\C=C/CCCCCC[C@H](N)CN
Show InChI InChI=1S/C18H38N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17-19/h9-10,18H,2-8,11-17,19-20H2,1H3/b10-9-/t18-/m0/s1
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2.18E+4n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat MGL


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50274153
PNG
((2R,9Z)-octadec-9-ene-1,2-diamine dihydrochloride ...)
Show SMILES CCCCCCCC\C=C/CCCCCC[C@@H](N)CN
Show InChI InChI=1S/C18H38N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17-19/h9-10,18H,2-8,11-17,19-20H2,1H3/b10-9-/t18-/m1/s1
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3.90E+4n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat MGL


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50274151
PNG
(CHEMBL473249 | hexadecane-1,2-diamine dihydrochlor...)
Show SMILES CCCCCCCCCCCCCCC(N)CN
Show InChI InChI=1S/C16H36N2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16(18)15-17/h16H,2-15,17-18H2,1H3
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5.87E+4n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat MGL


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM60622
PNG
(BDBM50300355 | US9133148, A)
Show SMILES OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)(c1ccc2OCOc2c1)c1ccc2OCOc2c1
Show InChI InChI=1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,17,31H,9-12,15-16H2
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n/an/a 25n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of rat MAGL expressed in monkey COS7 cells


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50359050
PNG
(CHEMBL1922513)
Show SMILES CCCCCCCCn1sc2ccccc2c1=O
Show InChI InChI=1S/C15H21NOS/c1-2-3-4-5-6-9-12-16-15(17)13-10-7-8-11-14(13)18-16/h7-8,10-11H,2-6,9,12H2,1H3
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n/an/a 59n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant N-terminal his-tagged MAGL expressed in Escherichia coli DH5alpha assessed as 2-oleoylglycerol hydrolysis after 10 mins...


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50359049
PNG
(CHEMBL1922512)
Show SMILES CCCCCCCCN1SCCC1=O
Show InChI InChI=1S/C11H21NOS/c1-2-3-4-5-6-7-9-12-11(13)8-10-14-12/h2-10H2,1H3
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n/an/a 88n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant N-terminal his-tagged MAGL expressed in Escherichia coli DH5alpha assessed as 2-oleoylglycerol hydrolysis after 10 mins...


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81363
PNG
(Pristimerin)
Show SMILES COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=c5c(cc(O)c(O)c5=C)[C@]4(C)CC[C@@]3(C)C2C1
Show InChI InChI=1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,31-32H,1,10-15,17H2,2-7H3/t23?,26-,27-,28+,29-,30+/m1/s1
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n/an/a 93n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM60419
PNG
(BDBM50295658 | NAM)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCN1C(=O)C=CC1=O
Show InChI InChI=1S/C24H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-23(26)20-21-24(25)27/h6-7,9-10,12-13,15-16,20-21H,2-5,8,11,14,17-19,22H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 140n/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Inhibition of MAGL in rat cerebellar membranes


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379241
PNG
(CHEMBL2011479)
Show SMILES O=C(Cc1ccc(Cc2ccccc2)cc1)OC[C@H]1CO1
Show InChI InChI=1S/C18H18O3/c19-18(21-13-17-12-20-17)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17H,10-13H2/t17-/m1/s1
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n/an/a 275n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379241
PNG
(CHEMBL2011479)
Show SMILES O=C(Cc1ccc(Cc2ccccc2)cc1)OC[C@H]1CO1
Show InChI InChI=1S/C18H18O3/c19-18(21-13-17-12-20-17)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17H,10-13H2/t17-/m1/s1
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n/an/a 280n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379241
PNG
(CHEMBL2011479)
Show SMILES O=C(Cc1ccc(Cc2ccccc2)cc1)OC[C@H]1CO1
Show InChI InChI=1S/C18H18O3/c19-18(21-13-17-12-20-17)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17H,10-13H2/t17-/m1/s1
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n/an/a 288n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379241
PNG
(CHEMBL2011479)
Show SMILES O=C(Cc1ccc(Cc2ccccc2)cc1)OC[C@H]1CO1
Show InChI InChI=1S/C18H18O3/c19-18(21-13-17-12-20-17)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17H,10-13H2/t17-/m1/s1
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n/an/a 290n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379255
PNG
(CHEMBL2011480)
Show SMILES O=C(Cc1ccc(Cc2ccccc2)cc1)OC[C@@H]1CO1
Show InChI InChI=1S/C18H18O3/c19-18(21-13-17-12-20-17)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17H,10-13H2/t17-/m0/s1
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n/an/a 339n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379255
PNG
(CHEMBL2011480)
Show SMILES O=C(Cc1ccc(Cc2ccccc2)cc1)OC[C@@H]1CO1
Show InChI InChI=1S/C18H18O3/c19-18(21-13-17-12-20-17)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17H,10-13H2/t17-/m0/s1
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n/an/a 340n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379250
PNG
(CHEMBL2011307)
Show SMILES O=C(Cc1ccc(cc1)-c1ccccc1)OCC1CO1
Show InChI InChI=1S/C17H16O3/c18-17(20-12-16-11-19-16)10-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16H,10-12H2
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n/an/a 589n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379250
PNG
(CHEMBL2011307)
Show SMILES O=C(Cc1ccc(cc1)-c1ccccc1)OCC1CO1
Show InChI InChI=1S/C17H16O3/c18-17(20-12-16-11-19-16)10-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,16H,10-12H2
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n/an/a 590n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379242
PNG
(CHEMBL2011482)
Show SMILES OCC(CO)OC(=O)Cc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C18H20O4/c19-12-17(13-20)22-18(21)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17,19-20H,10-13H2
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n/an/a 700n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379248
PNG
(CHEMBL2011309)
Show SMILES O=C(CCCc1ccc(cc1)-c1ccccc1)OCC1CO1
Show InChI InChI=1S/C19H20O3/c20-19(22-14-18-13-21-18)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-3,6-7,9-12,18H,4-5,8,13-14H2
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n/an/a 708n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379242
PNG
(CHEMBL2011482)
Show SMILES OCC(CO)OC(=O)Cc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C18H20O4/c19-12-17(13-20)22-18(21)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17,19-20H,10-13H2
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n/an/a 708n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379248
PNG
(CHEMBL2011309)
Show SMILES O=C(CCCc1ccc(cc1)-c1ccccc1)OCC1CO1
Show InChI InChI=1S/C19H20O3/c20-19(22-14-18-13-21-18)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-3,6-7,9-12,18H,4-5,8,13-14H2
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n/an/a 710n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379251
PNG
(CHEMBL2011308)
Show SMILES O=C(CCc1ccc(cc1)-c1ccccc1)OCC1CO1
Show InChI InChI=1S/C18H18O3/c19-18(21-13-17-12-20-17)11-8-14-6-9-16(10-7-14)15-4-2-1-3-5-15/h1-7,9-10,17H,8,11-13H2
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n/an/a 870n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379251
PNG
(CHEMBL2011308)
Show SMILES O=C(CCc1ccc(cc1)-c1ccccc1)OCC1CO1
Show InChI InChI=1S/C18H18O3/c19-18(21-13-17-12-20-17)11-8-14-6-9-16(10-7-14)15-4-2-1-3-5-15/h1-7,9-10,17H,8,11-13H2
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n/an/a 871n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50071058
PNG
((2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,1...)
Show SMILES C[C@]12CC[C@](C)(C[C@H]1[C@]1(C)CC[C@]3(C)C(=CC=c4c3cc(O)c(O)c4=C)[C@@]1(C)CC2)C(O)=O
Show InChI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,30-31H,1,9-14,16H2,2-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379246
PNG
(CHEMBL2011481)
Show SMILES OCC(CO)OC(=O)CCCCCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H26O4/c22-15-20(16-23)25-21(24)10-6-1-3-7-17-11-13-19(14-12-17)18-8-4-2-5-9-18/h2,4-5,8-9,11-14,20,22-23H,1,3,6-7,10,15-16H2
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n/an/a 1.86E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379246
PNG
(CHEMBL2011481)
Show SMILES OCC(CO)OC(=O)CCCCCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H26O4/c22-15-20(16-23)25-21(24)10-6-1-3-7-17-11-13-19(14-12-17)18-8-4-2-5-9-18/h2,4-5,8-9,11-14,20,22-23H,1,3,6-7,10,15-16H2
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n/an/a 1.90E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50295656
PNG
(CHEMBL569368 | dodecylcarbamic acid 4-(1,2,3-thiad...)
Show SMILES CCCCCCCCCCCCNC(=O)Oc1ccc(cc1)-c1csnn1
Show InChI InChI=1S/C21H31N3O2S/c1-2-3-4-5-6-7-8-9-10-11-16-22-21(25)26-19-14-12-18(13-15-19)20-17-27-24-23-20/h12-15,17H,2-11,16H2,1H3,(H,22,25)
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of MGL in Wistar rat cerebral membrane by HPLC


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379234
PNG
(CHEMBL2011323)
Show SMILES O=C(CCc1ccc(Cc2ccccc2)cc1)OCC1CO1
Show InChI InChI=1S/C19H20O3/c20-19(22-14-18-13-21-18)11-10-15-6-8-17(9-7-15)12-16-4-2-1-3-5-16/h1-9,18H,10-14H2
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n/an/a 2.29E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379234
PNG
(CHEMBL2011323)
Show SMILES O=C(CCc1ccc(Cc2ccccc2)cc1)OCC1CO1
Show InChI InChI=1S/C19H20O3/c20-19(22-14-18-13-21-18)11-10-15-6-8-17(9-7-15)12-16-4-2-1-3-5-16/h1-9,18H,10-14H2
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n/an/a 2.30E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50220359
PNG
((+/-)-tetrahydro-2H-pyran-2-ylmethyl benzoate | CH...)
Show SMILES O=C(OCC1CCCCO1)c1ccccc1
Show InChI InChI=1S/C13H16O3/c14-13(11-6-2-1-3-7-11)16-10-12-8-4-5-9-15-12/h1-3,6-7,12H,4-5,8-10H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379245
PNG
(CHEMBL2011312)
Show SMILES O=C(CCCCCCc1ccc(cc1)-c1ccccc1)OCC1CO1
Show InChI InChI=1S/C22H26O3/c23-22(25-17-21-16-24-21)11-7-2-1-4-8-18-12-14-20(15-13-18)19-9-5-3-6-10-19/h3,5-6,9-10,12-15,21H,1-2,4,7-8,11,16-17H2
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n/an/a 3.16E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379245
PNG
(CHEMBL2011312)
Show SMILES O=C(CCCCCCc1ccc(cc1)-c1ccccc1)OCC1CO1
Show InChI InChI=1S/C22H26O3/c23-22(25-17-21-16-24-21)11-7-2-1-4-8-18-12-14-20(15-13-18)19-9-5-3-6-10-19/h3,5-6,9-10,12-15,21H,1-2,4,7-8,11,16-17H2
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n/an/a 3.20E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50295686
PNG
(4-(Dodecylcarbamoyloxy)benzoic acid methyl ester |...)
Show SMILES CCCCCCCCCCCCNC(=O)Oc1ccc(cc1)C(=O)OC
Show InChI InChI=1S/C21H33NO4/c1-3-4-5-6-7-8-9-10-11-12-17-22-21(24)26-19-15-13-18(14-16-19)20(23)25-2/h13-16H,3-12,17H2,1-2H3,(H,22,24)
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of MGL in Wistar rat cerebral membrane by HPLC


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50220351
PNG
((S,5Z,8Z,11Z,14Z)-N-((tetrahydrofuran-2-yl)methyl)...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NC[C@@H]1CCCO1
Show InChI InChI=1S/C25H41NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21-25(27)26-23-24-20-19-22-28-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-23H2,1H3,(H,26,27)/b7-6-,10-9-,13-12-,16-15-/t24-/m0/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379235
PNG
(CHEMBL2011324)
Show SMILES O=C(CCCc1ccc(Cc2ccccc2)cc1)OCC1CO1
Show InChI InChI=1S/C20H22O3/c21-20(23-15-19-14-22-19)8-4-7-16-9-11-18(12-10-16)13-17-5-2-1-3-6-17/h1-3,5-6,9-12,19H,4,7-8,13-15H2
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n/an/a 3.60E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379235
PNG
(CHEMBL2011324)
Show SMILES O=C(CCCc1ccc(Cc2ccccc2)cc1)OCC1CO1
Show InChI InChI=1S/C20H22O3/c21-20(23-15-19-14-22-19)8-4-7-16-9-11-18(12-10-16)13-17-5-2-1-3-6-17/h1-3,5-6,9-12,19H,4,7-8,13-15H2
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n/an/a 3.63E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379230
PNG
(CHEMBL2011306)
Show SMILES O=C(OCC1CO1)\C=C\c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H16O3/c19-18(21-13-17-12-20-17)11-8-14-6-9-16(10-7-14)15-4-2-1-3-5-15/h1-11,17H,12-13H2/b11-8+
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n/an/a 3.80E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379230
PNG
(CHEMBL2011306)
Show SMILES O=C(OCC1CO1)\C=C\c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H16O3/c19-18(21-13-17-12-20-17)11-8-14-6-9-16(10-7-14)15-4-2-1-3-5-15/h1-11,17H,12-13H2/b11-8+
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n/an/a 3.80E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379239
PNG
(CHEMBL2011477)
Show SMILES O=C(CCCCCc1ccc(cc1)-c1ccccc1)OC[C@H]1CO1
Show InChI InChI=1S/C21H24O3/c22-21(24-16-20-15-23-20)10-6-1-3-7-17-11-13-19(14-12-17)18-8-4-2-5-9-18/h2,4-5,8-9,11-14,20H,1,3,6-7,10,15-16H2/t20-/m1/s1
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n/an/a 3.89E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379229
PNG
(CHEMBL2011318)
Show SMILES O=C(CCCCCCc1ccc(cc1)-c1ccccc1)OCC1CCCCO1
Show InChI InChI=1S/C25H32O3/c26-25(28-20-24-13-8-9-19-27-24)14-7-2-1-4-10-21-15-17-23(18-16-21)22-11-5-3-6-12-22/h3,5-6,11-12,15-18,24H,1-2,4,7-10,13-14,19-20H2
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n/an/a 3.89E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379229
PNG
(CHEMBL2011318)
Show SMILES O=C(CCCCCCc1ccc(cc1)-c1ccccc1)OCC1CCCCO1
Show InChI InChI=1S/C25H32O3/c26-25(28-20-24-13-8-9-19-27-24)14-7-2-1-4-10-21-15-17-23(18-16-21)22-11-5-3-6-12-22/h3,5-6,11-12,15-18,24H,1-2,4,7-10,13-14,19-20H2
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n/an/a 3.90E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379239
PNG
(CHEMBL2011477)
Show SMILES O=C(CCCCCc1ccc(cc1)-c1ccccc1)OC[C@H]1CO1
Show InChI InChI=1S/C21H24O3/c22-21(24-16-20-15-23-20)10-6-1-3-7-17-11-13-19(14-12-17)18-8-4-2-5-9-18/h2,4-5,8-9,11-14,20H,1,3,6-7,10,15-16H2/t20-/m1/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM81364
PNG
(Pristimerol)
Show SMILES COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CCc5c(C)c(O)c(O)cc5[C@]4(C)CC[C@@]3(C)C2C1
Show InChI InChI=1S/C30H42O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h9,16,23,31-32H,8,10-15,17H2,1-7H3/t23?,26-,27-,28+,29-,30+/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/a37



University of California Irvine



Assay Description
Purified recombinant rat MGL was prepared and enzyme activity was assayed.


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379240
PNG
(CHEMBL2011478)
Show SMILES O=C(CCCCCc1ccc(cc1)-c1ccccc1)OC[C@@H]1CO1
Show InChI InChI=1S/C21H24O3/c22-21(24-16-20-15-23-20)10-6-1-3-7-17-11-13-19(14-12-17)18-8-4-2-5-9-18/h2,4-5,8-9,11-14,20H,1,3,6-7,10,15-16H2/t20-/m0/s1
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n/an/a 4.47E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379240
PNG
(CHEMBL2011478)
Show SMILES O=C(CCCCCc1ccc(cc1)-c1ccccc1)OC[C@@H]1CO1
Show InChI InChI=1S/C21H24O3/c22-21(24-16-20-15-23-20)10-6-1-3-7-17-11-13-19(14-12-17)18-8-4-2-5-9-18/h2,4-5,8-9,11-14,20H,1,3,6-7,10,15-16H2/t20-/m0/s1
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n/an/a 4.50E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50220347
PNG
((+/-)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OCC1CO1
Show InChI InChI=1S/C23H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(24)26-21-22-20-25-22/h6-7,9-10,12-13,15-16,22H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 4.50E+3n/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379247
PNG
(CHEMBL2011310)
Show SMILES O=C(CCCCc1ccc(cc1)-c1ccccc1)OCC1CO1
Show InChI InChI=1S/C20H22O3/c21-20(23-15-19-14-22-19)9-5-4-6-16-10-12-18(13-11-16)17-7-2-1-3-8-17/h1-3,7-8,10-13,19H,4-6,9,14-15H2
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n/an/a 4.60E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379247
PNG
(CHEMBL2011310)
Show SMILES O=C(CCCCc1ccc(cc1)-c1ccccc1)OCC1CO1
Show InChI InChI=1S/C20H22O3/c21-20(23-15-19-14-22-19)9-5-4-6-16-10-12-18(13-11-16)17-7-2-1-3-8-17/h1-3,7-8,10-13,19H,4-6,9,14-15H2
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n/an/a 4.68E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379239
PNG
(CHEMBL2011477)
Show SMILES O=C(CCCCCc1ccc(cc1)-c1ccccc1)OC[C@H]1CO1
Show InChI InChI=1S/C21H24O3/c22-21(24-16-20-15-23-20)10-6-1-3-7-17-11-13-19(14-12-17)18-8-4-2-5-9-18/h2,4-5,8-9,11-14,20H,1,3,6-7,10,15-16H2/t20-/m1/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50379239
PNG
(CHEMBL2011477)
Show SMILES O=C(CCCCCc1ccc(cc1)-c1ccccc1)OC[C@H]1CO1
Show InChI InChI=1S/C21H24O3/c22-21(24-16-20-15-23-20)10-6-1-3-7-17-11-13-19(14-12-17)18-8-4-2-5-9-18/h2,4-5,8-9,11-14,20H,1,3,6-7,10,15-16H2/t20-/m1/s1
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n/an/a 5.13E+3n/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
Monoglyceride lipase (MGL)


(Rattus norvegicus (Rat))
BDBM50220352
PNG
((+/-)-tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OCC1CCCCO1
Show InChI InChI=1S/C26H42O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-26(27)29-24-25-21-19-20-23-28-25/h6-7,9-10,12-13,15-16,25H,2-5,8,11,14,17-24H2,1H3/b7-6-,10-9-,13-12-,16-15-
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n/an/a 5.60E+3n/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
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