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Found 90 hits Enz. Inhib. hit(s) with Target = 'Mucosa-associated lymphoid tissue lymphoma translocation protein 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169049
PNG
(CHEMBL3806155)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1/C18H15ClF3N9O2/c1-9(33-2)15-12(8-23-14-6-13(19)29-30(14)15)28-17(32)27-10-5-11(18(20,21)22)16(24-7-10)31-25-3-4-26-31/h3-9H,1-2H3,(H2,27,28,32)/t9-/s2
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n/an/a 0.00200n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169052
PNG
(CHEMBL3806235)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2CCCO2)cnc1-n1nccn1
Show InChI InChI=1/C19H15ClF3N9O2/c20-14-7-15-24-9-12(16(31(15)30-14)13-2-1-5-34-13)29-18(33)28-10-6-11(19(21,22)23)17(25-8-10)32-26-3-4-27-32/h3-4,6-9,13H,1-2,5H2,(H2,28,29,33)
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n/an/a 0.00400n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169054
PNG
(CHEMBL3805390)
Show SMILES COCC(C1CC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1/C20H19Cl2N9O2/c1-33-10-13(11-2-3-11)18-15(9-23-17-7-16(22)29-30(17)18)28-20(32)27-12-6-14(21)19(24-8-12)31-25-4-5-26-31/h4-9,11,13H,2-3,10H2,1H3,(H2,27,28,32)
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n/an/a 0.00600n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169051
PNG
(CHEMBL3805576)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(N3CCCS3(=O)=O)c(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19ClF3N7O3S/c1-10(2)16-13(9-24-15-7-14(20)28-30(15)16)27-18(31)26-11-6-12(19(21,22)23)17(25-8-11)29-4-3-5-34(29,32)33/h6-10H,3-5H2,1-2H3,(H2,26,27,31)
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n/an/a 0.00600n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169055
PNG
(CHEMBL3806299)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(c(Cl)c2)-n2cc(CN)cn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H20Cl2N8O/c1-11(2)19-15(9-24-18-6-17(22)28-30(18)19)27-20(31)26-13-3-4-16(14(21)5-13)29-10-12(7-23)8-25-29/h3-6,8-11H,7,23H2,1-2H3,(H2,26,27,31)
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n/an/a 0.00800n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169050
PNG
(CHEMBL3806279)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cncc(c2)C(F)(F)F)cnc2cc(C)nn12
Show InChI InChI=1/C17H17F3N6O2/c1-9-4-14-22-8-13(15(10(2)28-3)26(14)25-9)24-16(27)23-12-5-11(6-21-7-12)17(18,19)20/h4-8,10H,1-3H3,(H2,23,24,27)/t10-/s2
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n/an/a 0.0100n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169049
PNG
(CHEMBL3806155)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1/C18H15ClF3N9O2/c1-9(33-2)15-12(8-23-14-6-13(19)29-30(14)15)28-17(32)27-10-5-11(18(20,21)22)16(24-7-10)31-25-3-4-26-31/h3-9H,1-2H3,(H2,27,28,32)/t9-/s2
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n/an/a 0.0230n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169054
PNG
(CHEMBL3805390)
Show SMILES COCC(C1CC1)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Show InChI InChI=1/C20H19Cl2N9O2/c1-33-10-13(11-2-3-11)18-15(9-23-17-7-16(22)29-30(17)18)28-20(32)27-12-6-14(21)19(24-8-12)31-25-4-5-26-31/h4-9,11,13H,2-3,10H2,1H3,(H2,27,28,32)
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n/an/a 0.0280n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169050
PNG
(CHEMBL3806279)
Show SMILES CO[C@@H](C)c1c(NC(=O)Nc2cncc(c2)C(F)(F)F)cnc2cc(C)nn12
Show InChI InChI=1/C17H17F3N6O2/c1-9-4-14-22-8-13(15(10(2)28-3)26(14)25-9)24-16(27)23-12-5-11(6-21-7-12)17(18,19)20/h4-8,10H,1-3H3,(H2,23,24,27)/t10-/s2
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n/an/a 0.0520n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169052
PNG
(CHEMBL3806235)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cnc3cc(Cl)nn3c2C2CCCO2)cnc1-n1nccn1
Show InChI InChI=1/C19H15ClF3N9O2/c20-14-7-15-24-9-12(16(31(15)30-14)13-2-1-5-34-13)29-18(33)28-10-6-11(19(21,22)23)17(25-8-10)32-26-3-4-27-32/h3-4,6-9,13H,1-2,5H2,(H2,28,29,33)
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n/an/a 0.0940n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169055
PNG
(CHEMBL3806299)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(c(Cl)c2)-n2cc(CN)cn2)cnc2cc(Cl)nn12
Show InChI InChI=1S/C20H20Cl2N8O/c1-11(2)19-15(9-24-18-6-17(22)28-30(18)19)27-20(31)26-13-3-4-16(14(21)5-13)29-10-12(7-23)8-25-29/h3-6,8-11H,7,23H2,1-2H3,(H2,26,27,31)
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n/an/a 0.134n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50169051
PNG
(CHEMBL3805576)
Show SMILES CC(C)c1c(NC(=O)Nc2cnc(N3CCCS3(=O)=O)c(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C19H19ClF3N7O3S/c1-10(2)16-13(9-24-15-7-14(20)28-30(15)16)27-18(31)26-11-6-12(19(21,22)23)17(25-8-11)29-4-3-5-34(29,32)33/h6-10H,3-5H2,1-2H3,(H2,26,27,31)
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n/an/a 0.248n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...


ACS Med Chem Lett 7: 205-6 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133328
PNG
(CHEMBL3632807)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(cc1C(=O)C2=O)[N+]([O-])=O
Show InChI InChI=1S/C15H13NO5/c1-15(2)6-5-10-12(17)13(18)11-7-8(16(19)20)3-4-9(11)14(10)21-15/h3-4,7H,5-6H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177661
PNG
(MEPAZINE | Pecazine)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
Show InChI InChI=1/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3
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n/an/a 420n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of GST-MALT1 (325 to 760 residues) (unknown origin) using Ac-LRSR-AMC as substrate by fluorescence analysis


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133350
PNG
(8-methoxy-beta-lapachone | CHEMBL2036880)
Show SMILES COc1ccc2C3=C(CCC(C)(C)O3)C(=O)C(=O)c2c1
Show InChI InChI=1S/C16H16O4/c1-16(2)7-6-11-13(17)14(18)12-8-9(19-3)4-5-10(12)15(11)20-16/h4-5,8H,6-7H2,1-3H3
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n/an/a 600n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177661
PNG
(MEPAZINE | Pecazine)
Show SMILES CN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
Show InChI InChI=1/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3
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n/an/a 830n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length GST-MALT1 (unknown origin) expressed in Escherichia coli using Ac-LRSR-AMC as substrate by fluorescence analysi...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM81348
PNG
(β-Lapachone (A3) | R115 (Reactive Blue 2))
Show SMILES CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O
Show InChI InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177471
PNG
(CHEMBL3813831)
Show SMILES COCCOc1nc(-c2ccc(Br)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18BrClN4O3/c1-27-10-11-28-19-23-18(13-2-4-14(20)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-21/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133331
PNG
(CHEMBL3632804)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(F)cc1C(=O)C2=O
Show InChI InChI=1S/C15H13FO3/c1-15(2)6-5-10-12(17)13(18)11-7-8(16)3-4-9(11)14(10)19-15/h3-4,7H,5-6H2,1-2H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133340
PNG
(CHEMBL3635001)
Show SMILES O=C1C=C(NC2CCN(Cc3ccccc3)C2)c2ccccc2C1=O
Show InChI InChI=1/C21H20N2O2/c24-20-12-19(17-8-4-5-9-18(17)21(20)25)22-16-10-11-23(14-16)13-15-6-2-1-3-7-15/h1-9,12,16,22H,10-11,13-14H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177471
PNG
(CHEMBL3813831)
Show SMILES COCCOc1nc(-c2ccc(Br)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18BrClN4O3/c1-27-10-11-28-19-23-18(13-2-4-14(20)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-21/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 1.51E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177153
PNG
(CHEMBL3814576)
Show SMILES COCCOc1nc(-c2ccc(Cl)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18Cl2N4O3/c1-27-10-11-28-19-23-18(13-2-4-14(21)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-20/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 1.55E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133347
PNG
(CHEMBL3634995)
Show SMILES CN(C)CCNC1=CC(=O)C(=O)c2ccccc12
Show InChI InChI=1S/C14H16N2O2/c1-16(2)8-7-15-12-9-13(17)14(18)11-6-4-3-5-10(11)12/h3-6,9,15H,7-8H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133329
PNG
(CHEMBL3632806)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(cc1C(=O)C2=O)C#N
Show InChI InChI=1S/C16H13NO3/c1-16(2)6-5-11-13(18)14(19)12-7-9(8-17)3-4-10(12)15(11)20-16/h3-4,7H,5-6H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177153
PNG
(CHEMBL3814576)
Show SMILES COCCOc1nc(-c2ccc(Cl)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18Cl2N4O3/c1-27-10-11-28-19-23-18(13-2-4-14(21)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-20/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM81348
PNG
(β-Lapachone (A3) | R115 (Reactive Blue 2))
Show SMILES CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O
Show InChI InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177471
PNG
(CHEMBL3813831)
Show SMILES COCCOc1nc(-c2ccc(Br)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18BrClN4O3/c1-27-10-11-28-19-23-18(13-2-4-14(20)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-21/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 2.09E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177471
PNG
(CHEMBL3813831)
Show SMILES COCCOc1nc(-c2ccc(Br)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18BrClN4O3/c1-27-10-11-28-19-23-18(13-2-4-14(20)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-21/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133351
PNG
(CHEMBL177685)
Show SMILES COc1cc2C(=O)C(=O)C3=C(OC(C)(C)CC3)c2cc1OC
Show InChI InChI=1S/C17H18O5/c1-17(2)6-5-9-14(18)15(19)10-7-12(20-3)13(21-4)8-11(10)16(9)22-17/h7-8H,5-6H2,1-4H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133349
PNG
(CHEMBL3634993)
Show SMILES CN(C)C1=CC(=O)C(=O)c2ccccc12
Show InChI InChI=1S/C12H11NO2/c1-13(2)10-7-11(14)12(15)9-6-4-3-5-8(9)10/h3-7H,1-2H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133338
PNG
(CHEMBL3635003)
Show SMILES CNC(=O)CNC1=CC(=O)C(=O)c2ccccc12
Show InChI InChI=1S/C13H12N2O3/c1-14-12(17)7-15-10-6-11(16)13(18)9-5-3-2-4-8(9)10/h2-6,15H,7H2,1H3,(H,14,17)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177153
PNG
(CHEMBL3814576)
Show SMILES COCCOc1nc(-c2ccc(Cl)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18Cl2N4O3/c1-27-10-11-28-19-23-18(13-2-4-14(21)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-20/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177153
PNG
(CHEMBL3814576)
Show SMILES COCCOc1nc(-c2ccc(Cl)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18Cl2N4O3/c1-27-10-11-28-19-23-18(13-2-4-14(21)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-20/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 3.02E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133336
PNG
(CHEMBL3632800)
Show SMILES O=C(CNC1=CC(=O)C(=O)c2ccccc12)NCCc1ccccc1
Show InChI InChI=1S/C20H18N2O3/c23-18-12-17(15-8-4-5-9-16(15)20(18)25)22-13-19(24)21-11-10-14-6-2-1-3-7-14/h1-9,12,22H,10-11,13H2,(H,21,24)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133332
PNG
(CHEMBL3183233)
Show SMILES COCCOc1nc(-c2ccc(Cl)c(Cl)c2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133337
PNG
(CHEMBL3632799)
Show SMILES O=C(CNC1=CC(=O)C(=O)c2ccccc12)N1CCCC1
Show InChI InChI=1S/C16H16N2O3/c19-14-9-13(11-5-1-2-6-12(11)16(14)21)17-10-15(20)18-7-3-4-8-18/h1-2,5-6,9,17H,3-4,7-8,10H2
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n/an/a 4.10E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133339
PNG
(CHEMBL3635002)
Show SMILES O=C1C=C(NC2CCN(Cc3ccccc3)CC2)c2ccccc2C1=O
Show InChI InChI=1S/C22H22N2O2/c25-21-14-20(18-8-4-5-9-19(18)22(21)26)23-17-10-12-24(13-11-17)15-16-6-2-1-3-7-16/h1-9,14,17,23H,10-13,15H2
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n/an/a 5.40E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177152
PNG
(CHEMBL3814162)
Show SMILES COCCOc1nc(-c2ccc(F)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18ClFN4O3/c1-27-10-11-28-19-23-18(13-2-4-14(21)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-20/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 6.76E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177152
PNG
(CHEMBL3814162)
Show SMILES COCCOc1nc(-c2ccc(F)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H18ClFN4O3/c1-27-10-11-28-19-23-18(13-2-4-14(21)5-3-13)25(24-19)16-8-6-15(7-9-16)22-17(26)12-20/h2-9H,10-12H2,1H3,(H,22,26)
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n/an/a 6.80E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133332
PNG
(CHEMBL3183233)
Show SMILES COCCOc1nc(-c2ccc(Cl)c(Cl)c2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)
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n/an/a 7.76E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133332
PNG
(CHEMBL3183233)
Show SMILES COCCOc1nc(-c2ccc(Cl)c(Cl)c2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)
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n/an/a 7.80E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133346
PNG
(CHEMBL3634996)
Show SMILES COCCNC1=CC(=O)C(=O)c2ccccc12
Show InChI InChI=1S/C13H13NO3/c1-17-7-6-14-11-8-12(15)13(16)10-5-3-2-4-9(10)11/h2-5,8,14H,6-7H2,1H3
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n/an/a 7.80E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177226
PNG
(CHEMBL3813798)
Show SMILES COCCOc1nc(-c2ccc(C)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C20H21ClN4O3/c1-14-3-5-15(6-4-14)19-23-20(28-12-11-27-2)24-25(19)17-9-7-16(8-10-17)22-18(26)13-21/h3-10H,11-13H2,1-2H3,(H,22,26)
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n/an/a 8.13E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177226
PNG
(CHEMBL3813798)
Show SMILES COCCOc1nc(-c2ccc(C)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C20H21ClN4O3/c1-14-3-5-15(6-4-14)19-23-20(28-12-11-27-2)24-25(19)17-9-7-16(8-10-17)22-18(26)13-21/h3-10H,11-13H2,1-2H3,(H,22,26)
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n/an/a 8.20E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 1 to 100 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyphen...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177226
PNG
(CHEMBL3813798)
Show SMILES COCCOc1nc(-c2ccc(C)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C20H21ClN4O3/c1-14-3-5-15(6-4-14)19-23-20(28-12-11-27-2)24-25(19)17-9-7-16(8-10-17)22-18(26)13-21/h3-10H,11-13H2,1-2H3,(H,22,26)
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n/an/a 8.91E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50177226
PNG
(CHEMBL3813798)
Show SMILES COCCOc1nc(-c2ccc(C)cc2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C20H21ClN4O3/c1-14-3-5-15(6-4-14)19-23-20(28-12-11-27-2)24-25(19)17-9-7-16(8-10-17)22-18(26)13-21/h3-10H,11-13H2,1-2H3,(H,22,26)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Malt1 (unknown origin) at 10 to 1000 uM preincubated for 1 hr followed by (S)-1-((6-(4-(4-(5,5-Difluoro-3,7-bis(4-methoxyph...


Bioorg Med Chem 24: 3312-29 (2016)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133352
PNG
(CHEMBL3632808)
Show SMILES COc1ccc2C(=O)C(=O)C3=C(OC(C)(C)CC3)c2c1
Show InChI InChI=1S/C16H16O4/c1-16(2)7-6-11-14(18)13(17)10-5-4-9(19-3)8-12(10)15(11)20-16/h4-5,8H,6-7H2,1-3H3
PDB

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n/an/a 9.20E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133330
PNG
(CHEMBL3632805)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(Br)cc1C(=O)C2=O
Show InChI InChI=1S/C15H13BrO3/c1-15(2)6-5-10-12(17)13(18)11-7-8(16)3-4-9(11)14(10)19-15/h3-4,7H,5-6H2,1-2H3
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n/an/a 9.20E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133354
PNG
(CHEMBL3632809)
Show SMILES CC1(C)CCC2=C(O1)c1cc(O)ccc1C(=O)C2=O
Show InChI InChI=1S/C15H14O4/c1-15(2)6-5-10-13(18)12(17)9-4-3-8(16)7-11(9)14(10)19-15/h3-4,7,16H,5-6H2,1-2H3
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n/an/a 9.30E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens)
BDBM50133335
PNG
(CHEMBL3632801)
Show SMILES CC(C)=CCC1=C(O)C(=O)c2cc(F)ccc2C1=O
Show InChI InChI=1S/C15H13FO3/c1-8(2)3-5-11-13(17)10-6-4-9(16)7-12(10)15(19)14(11)18/h3-4,6-7,18H,5H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...


J Med Chem 58: 8491-502 (2015)

More data for this
Ligand-Target Pair
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