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Compile Data Set for Download or QSAR

Found 115 hits Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM35254
PNG
(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2sc(C)cc12
Show InChI InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
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PubMed
26n/an/an/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human muscarinic receptor


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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34n/an/an/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human muscarinic receptor


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM50095890
PNG
(2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperaz...)
Show SMILES OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
Show InChI InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2
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1.02E+3n/an/an/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human muscarinic receptor


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM50187377
PNG
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)
Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1
Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28)
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>2.00E+3n/an/an/an/an/an/an/an/a



Predix Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Binding affinity to muscarinic receptor by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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4.67E+3n/an/an/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human muscarinic receptor


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM50001885
PNG
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human muscarinic receptor


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM50048803
PNG
(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Show SMILES Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12
Show InChI InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)
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>5.00E+3n/an/an/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human muscarinic receptor


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM50001786
PNG
(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Show SMILES Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2cc(Cl)ccc12
Show InChI InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
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>5.00E+3n/an/an/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards human muscarinic receptor


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM50180054
PNG
(CHEMBL199824 | [O-methyl-11C]2-{4-[4-(7-methoxynap...)
Show SMILES COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1
Show InChI InChI=1S/C23H29N5O3/c1-25-22(29)17-24-28(23(25)30)11-4-3-10-26-12-14-27(15-13-26)21-7-5-6-18-8-9-19(31-2)16-20(18)21/h5-9,16-17H,3-4,10-15H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Columbia University College of Physicians and Surgeons

Curated by ChEMBL


Assay Description
Binding affinity to muscarinic receptor


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human)-HUMAN M3)
BDBM50182020
PNG
(2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-m...)
Show SMILES COc1cccc(c1)N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1
Show InChI InChI=1S/C19H27N5O3/c1-21-18(25)15-20-24(19(21)26)9-4-3-8-22-10-12-23(13-11-22)16-6-5-7-17(14-16)27-2/h5-7,14-15H,3-4,8-13H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Columbia University College of Physicians and Surgeons

Curated by ChEMBL


Assay Description
Binding affinity to M receptor by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50452855
PNG
(Isoptpo Hyoscine | SCOPOLAMINE | Scopolamine)
Show SMILES CN1[C@H]2C[C@@H](C[C@@H]1[C@@H]1O[C@@H]21)OC(=O)[C@H](CO)c1ccccc1
Show InChI InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15+,16+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50452855
PNG
(Isoptpo Hyoscine | SCOPOLAMINE | Scopolamine)
Show SMILES CN1[C@H]2C[C@@H](C[C@@H]1[C@@H]1O[C@@H]21)OC(=O)[C@H](CO)c1ccccc1
Show InChI InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15+,16+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048580
PNG
(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Show SMILES CCCN(c1ccncc1)n1ccc2ccccc12
Show InChI InChI=1S/C16H17N3/c1-2-12-18(15-7-10-17-11-8-15)19-13-9-14-5-3-4-6-16(14)19/h3-11,13H,2,12H2,1H3
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n/an/a 460n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against [3H]oxotremorine-M binding to muscarinic receptors in rat forebrain membrane


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048610
PNG
(CHEMBL435034 | Carbazol-9-yl-propyl-pyridin-4-yl-a...)
Show SMILES CCCN(c1ccncc1)n1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H19N3/c1-2-15-22(16-11-13-21-14-12-16)23-19-9-5-3-7-17(19)18-8-4-6-10-20(18)23/h3-14H,2,15H2,1H3
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n/an/a 500n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048590
PNG
(CHEMBL154319 | Indol-1-yl-isopropyl-pyridin-4-yl-a...)
Show SMILES CC(C)N(c1ccncc1)n1ccc2ccccc12
Show InChI InChI=1S/C16H17N3/c1-13(2)19(15-7-10-17-11-8-15)18-12-9-14-5-3-4-6-16(14)18/h3-13H,1-2H3
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n/an/a 630n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
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n/an/a 660n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048611
PNG
((3-Ethyl-indol-1-yl)-propyl-pyridin-4-yl-amine | C...)
Show SMILES CCCN(c1ccncc1)n1cc(CC)c2ccccc12
Show InChI InChI=1S/C18H21N3/c1-3-13-20(16-9-11-19-12-10-16)21-14-15(4-2)17-7-5-6-8-18(17)21/h5-12,14H,3-4,13H2,1-2H3
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n/an/a 710n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048580
PNG
(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Show SMILES CCCN(c1ccncc1)n1ccc2ccccc12
Show InChI InChI=1S/C16H17N3/c1-2-12-18(15-7-10-17-11-8-15)19-13-9-14-5-3-4-6-16(14)19/h3-11,13H,2,12H2,1H3
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n/an/a 940n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50083069
PNG
(6-(3-Methyl-isoxazol-5-ylmethylene)-1-aza-bicyclo[...)
Show SMILES Cc1cc(\C=C2/CN3CC2CCC3)on1
Show InChI InChI=1S/C12H16N2O/c1-9-5-12(15-13-9)6-11-8-14-4-2-3-10(11)7-14/h5-6,10H,2-4,7-8H2,1H3/b11-6+
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n/an/a 950n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration required for in vitro binding affinity to cholinergic central muscarinic receptor on rat brain cortex by using [3H]OXO-M


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048574
PNG
(Allyl-indol-1-yl-pyridin-4-yl-amine | CHEMBL347336)
Show SMILES C=CCN(c1ccncc1)n1ccc2ccccc12
Show InChI InChI=1S/C16H15N3/c1-2-12-18(15-7-10-17-11-8-15)19-13-9-14-5-3-4-6-16(14)19/h2-11,13H,1,12H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50081733
PNG
(3-(3-Methyl-isoxazol-5-ylmethylene)-1-aza-bicyclo[...)
Show SMILES Cc1cc(\C=C2/CN3CCC2CC3)on1
Show InChI InChI=1S/C12H16N2O/c1-9-6-12(15-13-9)7-11-8-14-4-2-10(11)3-5-14/h6-7,10H,2-5,8H2,1H3/b11-7+
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration required for in vitro binding affinity to cholinergic central muscarinic receptor on rat brain cortex by using [3H]OXO-M


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50083057
PNG
(3-(3-Methyl-isoxazol-5-ylmethylene)-1-aza-bicyclo[...)
Show SMILES Cc1cc(\C=C2/CN3CCC2C3)on1
Show InChI InChI=1S/C11H14N2O/c1-8-4-11(14-12-8)5-10-7-13-3-2-9(10)6-13/h4-5,9H,2-3,6-7H2,1H3/b10-5+
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration required for in vitro binding affinity to cholinergic central muscarinic receptor on rat brain cortex by using [3H]OXO-M


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048573
PNG
((2-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine | ...)
Show SMILES CCCN(c1ccncc1)n1c(C)cc2ccccc12
Show InChI InChI=1S/C17H19N3/c1-3-12-19(16-8-10-18-11-9-16)20-14(2)13-15-6-4-5-7-17(15)20/h4-11,13H,3,12H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50083079
PNG
(3-(3-Methyl-isoxazol-5-ylmethylene)-1-aza-bicyclo[...)
Show SMILES Cc1cc(\C=C2\CN3CCC2CC3)on1
Show InChI InChI=1S/C12H16N2O/c1-9-6-12(15-13-9)7-11-8-14-4-2-10(11)3-5-14/h6-7,10H,2-5,8H2,1H3/b11-7-
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n/an/a 1.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration required for in vitro binding affinity to cholinergic central muscarinic receptor on rat brain cortex by using [3H]OXO-M


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048576
PNG
(Butyl-indol-1-yl-pyridin-4-yl-amine | CHEMBL155109)
Show SMILES CCCCN(c1ccncc1)n1ccc2ccccc12
Show InChI InChI=1S/C17H19N3/c1-2-3-13-19(16-8-11-18-12-9-16)20-14-10-15-6-4-5-7-17(15)20/h4-12,14H,2-3,13H2,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50052594
PNG
((+) 3-Bromo-5-(1-methyl-pyrrolidin-2-yl)-pyridine ...)
Show SMILES CN1CCCC1c1cncc(Br)c1
Show InChI InChI=1S/C10H13BrN2/c1-13-4-2-3-10(13)8-5-9(11)7-12-6-8/h5-7,10H,2-4H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



SIBIA Neurosciences Inc.

Curated by PDSP Ki Database


Assay Description
The compound was tested on recombinant human alpha4-beta2 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048582
PNG
((5-Bromo-indol-1-yl)-propyl-pyridin-4-yl-amine | C...)
Show SMILES CCCN(c1ccncc1)n1ccc2cc(Br)ccc12
Show InChI InChI=1S/C16H16BrN3/c1-2-10-19(15-5-8-18-9-6-15)20-11-7-13-12-14(17)3-4-16(13)20/h3-9,11-12H,2,10H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50083076
PNG
(6-(3-Methyl-isoxazol-5-ylmethylene)-1-aza-bicyclo[...)
Show SMILES Cc1cc(\C=C2\CN3CC2CCC3)on1
Show InChI InChI=1S/C12H16N2O/c1-9-5-12(15-13-9)6-11-8-14-4-2-3-10(11)7-14/h5-6,10H,2-4,7-8H2,1H3/b11-6-
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n/an/a 1.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration required for in vitro binding affinity to cholinergic central muscarinic receptor on rat brain cortex by using [3H]OXO-M


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048584
PNG
(1-(Propyl-pyridin-4-yl-amino)-1H-indole-3-carbalde...)
Show SMILES CCCN(c1ccncc1)n1cc(C=O)c2ccccc12
Show InChI InChI=1S/C17H17N3O/c1-2-11-19(15-7-9-18-10-8-15)20-12-14(13-21)16-5-3-4-6-17(16)20/h3-10,12-13H,2,11H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048577
PNG
((5-Chloro-indol-1-yl)-propyl-pyridin-4-yl-amine | ...)
Show SMILES CCCN(c1ccncc1)n1ccc2cc(Cl)ccc12
Show InChI InChI=1S/C16H16ClN3/c1-2-10-19(15-5-8-18-9-6-15)20-11-7-13-12-14(17)3-4-16(13)20/h3-9,11-12H,2,10H2,1H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048600
PNG
(CHEMBL154541 | Ethyl-indol-1-yl-pyridin-4-yl-amine)
Show SMILES CCN(c1ccncc1)n1ccc2ccccc12
Show InChI InChI=1S/C15H15N3/c1-2-17(14-7-10-16-11-8-14)18-12-9-13-5-3-4-6-15(13)18/h3-12H,2H2,1H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048578
PNG
((5-Bromo-indol-1-yl)-methyl-pyridin-4-yl-amine | C...)
Show SMILES CN(c1ccncc1)n1ccc2cc(Br)ccc12
Show InChI InChI=1S/C14H12BrN3/c1-17(13-4-7-16-8-5-13)18-9-6-11-10-12(15)2-3-14(11)18/h2-10H,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048602
PNG
(CHEMBL348034 | Indol-1-yl-prop-2-ynyl-pyridin-4-yl...)
Show SMILES C#CCN(c1ccncc1)n1ccc2ccccc12
Show InChI InChI=1S/C16H13N3/c1-2-12-18(15-7-10-17-11-8-15)19-13-9-14-5-3-4-6-16(14)19/h1,3-11,13H,12H2
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n/an/a 2.50E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
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n/an/a 2.70E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048588
PNG
(1-[1-(Propyl-pyridin-4-yl-amino)-1H-indol-3-yl]-et...)
Show SMILES CCCN(c1ccncc1)n1cc(C(C)=O)c2ccccc12
Show InChI InChI=1S/C18H19N3O/c1-3-12-20(15-8-10-19-11-9-15)21-13-17(14(2)22)16-6-4-5-7-18(16)21/h4-11,13H,3,12H2,1-2H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048611
PNG
((3-Ethyl-indol-1-yl)-propyl-pyridin-4-yl-amine | C...)
Show SMILES CCCN(c1ccncc1)n1cc(CC)c2ccccc12
Show InChI InChI=1S/C18H21N3/c1-3-13-20(16-9-11-19-12-10-16)21-14-15(4-2)17-7-5-6-8-18(17)21/h5-12,14H,3-4,13H2,1-2H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50083075
PNG
(3-(3-Methyl-isoxazol-5-ylmethylene)-1-aza-bicyclo[...)
Show SMILES Cc1cc(\C=C2\CN3CCC2C3)on1
Show InChI InChI=1S/C11H14N2O/c1-8-4-11(14-12-8)5-10-7-13-3-2-9(10)6-13/h4-5,9H,2-3,6-7H2,1H3/b10-5-
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n/an/a 2.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration required for in vitro binding affinity to cholinergic central muscarinic receptor on rat brain cortex by using [3H]OXO-M


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048580
PNG
(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Show SMILES CCCN(c1ccncc1)n1ccc2ccccc12
Show InChI InChI=1S/C16H17N3/c1-2-12-18(15-7-10-17-11-8-15)19-13-9-14-5-3-4-6-16(14)19/h3-11,13H,2,12H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048584
PNG
(1-(Propyl-pyridin-4-yl-amino)-1H-indole-3-carbalde...)
Show SMILES CCCN(c1ccncc1)n1cc(C=O)c2ccccc12
Show InChI InChI=1S/C17H17N3O/c1-2-11-19(15-7-9-18-10-8-15)20-12-14(13-21)16-5-3-4-6-17(16)20/h3-10,12-13H,2,11H2,1H3
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n/an/a 3.30E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against [3H]-N-methyl-scopalamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)P


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048583
PNG
(1-(Propyl-pyridin-4-yl-amino)-1H-indole-3-carbonit...)
Show SMILES CCCN(c1ccncc1)n1cc(C#N)c2ccccc12
Show InChI InChI=1S/C17H16N4/c1-2-11-20(15-7-9-19-10-8-15)21-13-14(12-18)16-5-3-4-6-17(16)21/h3-10,13H,2,11H2,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048599
PNG
(CHEMBL346142 | Indazol-1-yl-propyl-pyridin-4-yl-am...)
Show SMILES CCCN(c1ccncc1)n1ncc2ccccc12
Show InChI InChI=1S/C15H16N4/c1-2-11-18(14-7-9-16-10-8-14)19-15-6-4-3-5-13(15)12-17-19/h3-10,12H,2,11H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against acetylcholinesterase in rat striatal preparation


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048576
PNG
(Butyl-indol-1-yl-pyridin-4-yl-amine | CHEMBL155109)
Show SMILES CCCCN(c1ccncc1)n1ccc2ccccc12
Show InChI InChI=1S/C17H19N3/c1-2-3-13-19(16-8-11-18-12-9-16)20-14-10-15-6-4-5-7-17(15)20/h4-12,14H,2-3,13H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048582
PNG
((5-Bromo-indol-1-yl)-propyl-pyridin-4-yl-amine | C...)
Show SMILES CCCN(c1ccncc1)n1ccc2cc(Br)ccc12
Show InChI InChI=1S/C16H16BrN3/c1-2-10-19(15-5-8-18-9-6-15)20-11-7-13-12-14(17)3-4-16(13)20/h3-9,11-12H,2,10H2,1H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50369150
PNG
(CHEMBL1788226)
Show SMILES CN1CCC[C@@H]1c1cncc(c1)C#C
Show InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m1/s1
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n/an/a 4.50E+3n/an/an/an/an/an/a



SIBIA Neurosciences Inc.

Curated by PDSP Ki Database


Assay Description
The compound was tested on recombinant human alpha4-beta4 cell lines of HUman embryonic kidney for nicotinic acetylcholine receptor agonist functiona...


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048587
PNG
((3-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine | ...)
Show SMILES CCCN(c1ccncc1)n1cc(C)c2ccccc12
Show InChI InChI=1S/C17H19N3/c1-3-12-19(15-8-10-18-11-9-15)20-13-14(2)16-6-4-5-7-17(16)20/h4-11,13H,3,12H2,1-2H3
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n/an/a 4.50E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048578
PNG
((5-Bromo-indol-1-yl)-methyl-pyridin-4-yl-amine | C...)
Show SMILES CN(c1ccncc1)n1ccc2cc(Br)ccc12
Show InChI InChI=1S/C14H12BrN3/c1-17(13-4-7-16-8-5-13)18-9-6-11-10-12(15)2-3-14(11)18/h2-10H,1H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048575
PNG
((5-Methoxy-indol-1-yl)-propyl-pyridin-4-yl-amine |...)
Show SMILES CCCN(c1ccncc1)n1ccc2cc(OC)ccc12
Show InChI InChI=1S/C17H19N3O/c1-3-11-19(15-6-9-18-10-7-15)20-12-8-14-13-16(21-2)4-5-17(14)20/h4-10,12-13H,3,11H2,1-2H3
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n/an/a 4.80E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048589
PNG
(CHEMBL152842 | Indol-1-yl-methyl-pyridin-4-yl-amin...)
Show SMILES CN(c1ccncc1)n1ccc2ccccc12
Show InChI InChI=1S/C14H13N3/c1-16(13-6-9-15-10-7-13)17-11-8-12-4-2-3-5-14(12)17/h2-11H,1H3
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Article
PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048610
PNG
(CHEMBL435034 | Carbazol-9-yl-propyl-pyridin-4-yl-a...)
Show SMILES CCCN(c1ccncc1)n1c2ccccc2c2ccccc12
Show InChI InChI=1S/C20H19N3/c1-2-15-22(16-11-13-21-14-12-16)23-19-9-5-3-7-17(19)18-8-4-6-10-20(18)23/h3-14H,2,15H2,1H3
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PubMed
n/an/a 5.50E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn


Citation and Details
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50048577
PNG
((5-Chloro-indol-1-yl)-propyl-pyridin-4-yl-amine | ...)
Show SMILES CCCN(c1ccncc1)n1ccc2cc(Cl)ccc12
Show InChI InChI=1S/C16H16ClN3/c1-2-10-19(15-5-8-18-9-6-15)20-11-7-13-12-14(17)3-4-16(13)20/h3-9,11-12H,2,10H2,1H3
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PC sid
UniChem

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Article
PubMed
n/an/a 5.80E+3n/an/an/an/an/an/a



Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn


Citation and Details
More data for this
Ligand-Target Pair
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